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During industrial processing, heat treatments applied to infant formulas may affect protein digestion. Recently, innovative processing routes have been developed to produce minimally heat-processed infant formula. Our objective was to compare the in vivo protein digestion kinetics and protein quality of a minimally processed (T−) and a heat-treated (T+++) infant formula. Sixty-eight male Wistar rats (21 d) were fed with either a diet containing 40 % T− (n 30) or T+++ (n 30), or a milk protein control diet (n 8) during 2 weeks. T− and T+++ rats were then sequentially euthanised 0, 1, 2, 3 or 6 h (n 6/time point) after ingestion of a meal containing their experimental diet. Control rats were euthanised 6 h after ingestion of a protein-free meal to determine nitrogen and amino acid endogenous losses. Nitrogen and amino acid true caecal digestibility was high for both T− and T+++ diets (> 90 %), but a tendency towards higher nitrogen digestibility was observed for the T− diet (96·6 ± 3·1 %) compared with the T+++ diet (91·9 ± 5·4 %, P = 0·0891). This slightly increased digestibility led to a greater increase in total amino acid concentration in plasma after ingestion of the T− diet (P = 0·0010). Comparable protein quality between the two infant formulas was found with a digestible indispensable amino acid score of 0·8. In conclusion, this study showed that minimal processing routes to produce native infant formula do not modify protein quality but tend to enhance its true nitrogen digestibility and increase postprandial plasma amino acid kinetics in rats.
There has been an increasing interest in exploring the different types of welfare regimes in middle- and low-income countries. However, most of the studies so far seem to neglect the importance of illicit groups as welfare providers. Illicit groups can be so powerful in many of these societies, that they can create extensive social safety nets embedded in parallel governance orders. Considering their importance as fundamental actors in the Global South, it is required to acknowledge their role as welfare deliverers as a missing piece in the literature. Hence I discuss the nature of what I call “clandestine welfare” and three specific forms of social protection provided by illicit groups: direct, involuntary, and forced. In the first form, the illicit groups provide directly to society by delivering goods or services that the formal state fails to provide. In the second, the illicit group’s activities have involuntary but positive spill-overs over society in terms of welfare. In the last one, the illicit groups use violence to force other social actors to provide social protection. By bringing illustrative examples from Latin America, I aim to show that the action of illicit groups represents a tangible source of welfare for a large segment of the population that goes beyond charity.
Let $\mathcal{A}$ be a locally noetherian Grothendieck category. We classify all full subcategories of $\mathcal{A}$ which are thick and closed under taking arbitrary direct sums and injective envelopes by injective spectrum. This result gives a generalization from the commutative noetherian ring to the locally noetherian Grothendieck category.
This paper develops a general equilibrium life-cycle model with endogenous retirement that focuses on the interplay between old-age pensions (OAP) and disability pensions (DP) in Germany. Germany has introduced a phased-in increase of the normal retirement age from age 65 to 67 (Reform 2007) and closed off other routes to early OAP retirement. This reform was followed by a phased-in expansion of future DP benefits (Reform 2018). Our simulation results indicate that the first reform will induce a shift toward DP retirement, while the Reform 2018 will even neutralize the financial and economic gains of the Reform 2007 if current DP eligibility and benefit rules remain unchanged. We therefore highlight the increased relevance of DP when reforming the retirement system and retirement incentives in an aging society. Securing the financial stability of public pensions requires activation and rehabilitation of sick elderly in the workforce and tight access to disability benefits.
The Türkiye–Syria earthquake struck eleven provinces directly in Türkiye on 6 February 2023. Emergency nutrition care is indispensable for sustaining the lives of victims and rescue personnel. To optimally support their well-being, emergency food must be both healthy (i.e. aligned with dietary guidelines) and safe. However, globally, there is a dearth of research on the emergency nutrition conditions in shelters in the immediate aftermath of natural disasters. This lack of scientific evidence could limit the extent to which nutritional gaps can be identified and remedied for future relief efforts. Therefore, the aim of this research was to evaluate the nutrition environment and nutritional quality of emergency meals distributed to survivors in Malatya, a heavily affected province in Türkiye. The rapid assessment was conducted in thirteen locations by using an embedded case–study design to evaluate the nutrition environment both quantitatively and qualitatively. Meals served to earthquake victims and volunteers were found to be insufficient in protein, fat, fibre, vitamin C, Ca and Fe, but Na levels were higher than the maximum threshold in many of the centres. The qualitative analysis illustrated insufficiency in three domains of the emergency food and nutrition environment: foods and beverages offered, cooking/food preparation and food safety and dining areas and other facilities. Given the major nutritional gaps identified in this study, future disaster preparations should implement emergency nutrition plans that ensure healthy, nutritious and safe food for survivors. Better coordination and use of technology are necessary for interventions to prevent malnutrition.
It is a heroic enterprise to develop a systematic reading of Hegel's Doctrine of Being, the first of three books in the Science of Logic. The basic idea of Houlgate's grand interpretation of Hegel's three parts of this Doctrine, which I call the Logic of Quality, Quantity and Measure, is that Hegel demands a ‘presuppositionless derivation of categories’ (II: ix). Hegel on Being (in short: HoB) presents a thoroughgoing and rigorous interpretation in a kind of dialogue (as I would characterize what HoB marks as ‘Excursus’) with Kant (I: 19–46, 307–73; II: 171–79) and especially Frege's formal logic and his attempts of a predicative definition of numbers (II: 25–138). In any case, HoB makes us aware of the really problematic presuppositions in post-Fregean Analytic Philosophy.
Maintaining genomic stability is crucial for normal development. At earlier stages of preimplantation development, as the embryonic genome activation is not fully completed, the embryos may be more prone to abnormalities. Aneuploidies are one of the most common genetic causes of implantation failure or first-trimester miscarriages. Apoptosis is a crucial mechanism to eliminate damaged or abnormal cells from the organism to enable healthy growth. Therefore, this study aimed to determine the relationship between the expression levels of genes involved in apoptosis in human aneuploid and euploid blastocysts. In total, 32 human embryos obtained from 21 patients were used for this study. Trophectoderm biopsies were performed and next-generation screening was carried out for aneuploidy screening. Total RNA was extracted from each blastocyst separately and cDNA was synthesized. Gene expression levels were evaluated using RT-PCR. The statistical analysis was performed to evaluate the gene expression level variations in the euploid and aneuploid embryos, respectively. The expression level of the BAX gene was significantly different between the aneuploid and euploid samples. BAX expression levels were found to be 1.5-fold lower in aneuploid cells. However, the expression levels of BAK and MAD2L1 genes were similar in each group. This study aimed to investigate the possible role of genes involved in apoptosis and aneuploidy mechanisms. The findings of this investigation revealed that the BAX gene was expressed significantly differently between aneuploid and euploid embryos. Therefore, it is possible that the genes involved in the apoptotic pathway have a role in the aneuploidy mechanism.
The present study analysed a total of 272 saffron (Crocus sativus L.) genotypes using multivariate analysis. We carefully observed and recorded information about the floral, morphological and corm attributes. Significant variations were observed among the genotypes for all the traits, indicating a high level of variability and suggesting a great potential for saffron improvement. The phenotypic variances were found to be greater than the estimated genotypic variances. Descriptive data on various morphological traits revealed significant differences in the frequency of phenotype classes as well as a wide distribution range. The high heritability estimates were observed in average number of daughter corms per plant (ANDCPP), initial weight of corms (IWC g), no. of buds/corm (NBPC), – no. of leaves in main sprout, (NLMS), number of sprouted buds per corm (NSBpC) and total number of leaves (TNL), whereas average weight of daughter corms per plant (AWBCPP), corm diameter (CDcm), pistal length (PL) cm, style length (STYLcm), fresh weight of pistals per plant (FWOPPPmg) and stigma length (STML cm), revealed medium sense of heritability. The traits dry weight of pistals per plants (DWOPPP mg), inner tepal width (ITW cm), leaf length (LLcm), number of flowers per corm (NFpC), outer tepal length (OTLcm), parianth length with tube (PLWT cm) and weight of stigma (WSTG mg) exhibited low broad-sense heritability. Principal component analysis (PCA) divulged that the first eight component characters had an eigenvalue greater than one with a contributory cumulative variance of 66.15% to the total variance, while as rest of the 16 components contributed 33.85% of total variation in a set of 272 genotypes of saffron. The eigenvalues for yield attributing traits for significant PCs ranged from 5.48 (PC1) to 1.03(PC8). The current study has revealed that there was a sufficient variability in a set of saffron germplasm lines which forms the basis for performance-based clonal selection. Moreover, identified elite genotypes based on saffron yield and corm attributes could be used in the saffron breeding programme for the development of saffron varieties.
Fluid flow passing a post-buckled sheet placed between two close confining walls induces periodic snap-through oscillations and contacts that can be employed for triboelectric energy harvesting. The responses of a two-dimensional sheet to a uniform flow and wall confinement in both equilibrium and post-equilibrium states are numerically investigated by varying the distance between the two ends of the sheet, gap distance between the confining walls and flow velocity. Cases with strong interactions between the sheet and walls are of most interest for examining how contact with the walls affects the dynamics of the sheet and flow structure. At equilibrium, contact with the wall displaces the sheet to form a nadir on its front part, yielding a lower critical flow velocity for the transition to snap-through oscillations. However, reducing the gap distance between the walls below a certain threshold distinctly shifts the shape of the sheet, alters the pressure distribution and eventually leads to a notable delay in the instability. The contact between the oscillating sheet and the walls at post-equilibrium is divided into several distinct modes, changing from sliding/rolling contact to bouncing contact with increasing flow velocity. During this transition, the time-averaged contact force exerted on the sheet decreases with the flow velocity. The vortices generated at the extrema of the oscillating sheet are annihilated by direct contact with the walls and merging with the shear layers formed by the walls, resulting in a wake structure dominated by the unstable shear layers.
This article brings to the forefront Timothy Brennan’s emphasis on Edward Said’s engagement with philosophy. An attempt is made to reconstruct some of Brennan’s claims about Said’s views on the relationship between mental representations and the external world. It is shown that Said rejected naïve or direct realism in favor of representationalism. It is also argued that, despite being seen as a post-modern thinker, Said subscribed to a version of the correspondence theory of truth. Said embraced some form of standpoint epistemology, but he did not think that this had any direct bearing on how we should think about what makes a given claim true. Finally, an attempt is made to understand the relationship between Said’s project and the classical Marxist project of ideology critique, as well as contemporary attempts to develop an epistemology of ignorance.
This paper explores the vertical integration of oil-producing countries. Attempts at vertical integration were prominent among oil-producing countries throughout most of the twentieth century, but particularly following the surge of resource nationalism in the 1970s. Vertical integration attempts have largely been regarded as a sideshow in the history of global oil. This article argues that vertical integration was a crucial aspect of producer country strategies into the 1970s and 1980s, and that it affected the organization of national oil industries in important ways. It does so by exploring the Norwegian case. The article demonstrates the importance of vertical integration to the long-term development of the Norwegian oil industry. It discusses the implications of these findings for the study of vertical integration in other oil-producing countries.
Evacuation and relocation are key actions used to protect the public in response to natural or technological disasters, but there are inherent risks to both. Unfortunately, these risks have not been fully quantified, which limits the ability of emergency managers and the public to effectively balance the risks and benefits of evacuation or relocation. This work provides quantitative data on the risks of health effects from displacement following evacuation or relocation.
Methods:
Researchers performed a literature review and meta-analysis of published studies and quantified risks of 14 different health effects, including both physical and socio-behavioral outcomes, from studies of 9 different disaster types.
Results:
The findings show statistically significant increases in 9 of the 14 health effects in displaced populations, indicating an increased likelihood of experiencing detrimental health effects compared with nondisplaced populations. A pooled analysis of all negative health effects found an odds ratio of 1.49 (95% confidence interval: 1.24-1.79), which shows a significant relationship between displacement and negative health outcomes.
Conclusions:
These findings demonstrate that evacuated or relocated populations have an increased risk of experiencing negative health effects associated with displacement. The broad number of disaster types included mean that findings are applicable to any emergency evacuation or relocation.
This article concerns the endurance of political traditions brought to Palestine at the turn of the 20th century from the revolutionary milieu in Imperial Russia. The Russian Empire and its neighbors, which form most of today’s Eastern Europe and large swaths of Central Europe, was the homeland of most early Zionist settlers. They had acquired experience in a range of clandestine political organizations in the Russian Empire. It is this revolutionary experience that constitutes the bedrock of Russian Zionists’ influence on the political culture of the pre-state Palestine and Israel. Later, those who found themselves in Poland after Versailles became familiar with parliamentary rituals, even though the Polish state did not enjoy democracy for long. We suggest that this seemingly distant history continues to manifest itself in the political culture of contemporary Israel. We consider epistemology, tradition, ideology, and political action while looking at Israeli politics through the lens of its Russian roots.