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In this article, we adopt assemblage as methodology and as a way to foreground the vitality and relational agency of other species as they encounter humans. Research as assemblage is a process of becoming with others, and we experienced that ontological process during three environmental excursions as we became entangled in multispecies assemblages with children, the Crow, the Sea Eagle and the Bee. The production of the three assemblages and the rhizomic networks that formed materially and discursively across time occurred within an affective milieu characterised by sensory attentiveness and attunement to the affective power of coincidence. Analysing the formation and reformation of the assemblages enabled us to identify the phenomenon of “ontological flickering” where the ontological foundation of experience shifted moment by moment and remained playfully unresolved. We also consider how multispecies encounters relate to wildness, understood in Thoreau’s terms as unsettling encounters with otherness. In concluding, we recognise our incomplete becoming with others as co-authors and acknowledge the Crow the Sea Eagle and the Bee as powerful teachers.
When subjected to a sudden, unanticipated threat, human groups characteristically self-organize to identify the threat, determine potential responses, and act to reduce its impact. Central to this process is the challenge of coordinating information sharing and response activity within a disrupted environment. In this paper, we consider coordination in the context of responses to the 2001 World Trade Center (WTC) disaster. Using records of communications among 17 organizational units, we examine the mechanisms driving communication dynamics, with an emphasis on the emergence of coordinating roles. We employ relational event models (REMs) to identify the mechanisms shaping communications in each unit, finding a consistent pattern of behavior across units with very different characteristics. Using a simulation-based “knock-out” study, we also probe the importance of different mechanisms for hub formation. Our results suggest that, while preferential attachment and pre-disaster role structure generally contribute to the emergence of hub structure, temporally local conversational norms play a much larger role in the WTC case. We discuss broader implications for the role of microdynamics in driving macroscopic outcomes, and for the emergence of coordination in other settings.
The adolescent brain may be susceptible to the influences of illicit drug use. While compensatory network reorganization is a unique developmental characteristic that may restore several brain disorders, its association with methamphetamine (MA) use-induced damage during adolescence is unclear.
Methods
Using independent component (IC) analysis on structural magnetic resonance imaging data, spatially ICs described as morphometric networks were extracted to examine the effects of MA use on gray matter (GM) volumes and network module connectivity in adolescents (51 MA users v. 60 controls) and adults (54 MA users v. 60 controls).
Results
MA use was related to significant GM volume reductions in the default mode, cognitive control, salience, limbic, sensory and visual network modules in adolescents. GM volumes were also reduced in the limbic and visual network modules of the adult MA group as compared to the adult control group. Differential patterns of structural connectivity between the basal ganglia (BG) and network modules were found between the adolescent and adult MA groups. Specifically, adult MA users exhibited significantly reduced connectivity of the BG with the default network modules compared to control adults, while adolescent MA users, despite the greater extent of network GM volume reductions, did not show alterations in network connectivity relative to control adolescents.
Conclusions
Our findings suggest the potential of compensatory network reorganization in adolescent brains in response to MA use. The developmental characteristic to compensate for MA-induced brain damage can be considered as an age-specific therapeutic target for adolescent MA users.
The 2008 Constitution of the Union of Myanmar establishes the framework for a ‘discipline-flourishing’ constitutional democracy in which the Tatmadaw, the Burmese military, retains a significant degree of power. Under this Constitution, the Union Election Commission (UEC) is vested with significant authority to supervise elections, regulate political parties and electoral campaigns, register voters, suspend elections, and to make conclusive determinations in electoral disputes. Between 2010 and 2020, the UEC oversaw three consecutive general elections and three by-elections. Following a term under the former military leadership, the country's major democratic opposition party, the National League for Democracy (NLD), won a resounding victory in the 2015 elections. In the years that followed, civilian-military relations were a source of tension, as the NLD attempted to reform the executive and legislative roles for the military guaranteed by the Constitution. These tensions became in particular tangible during the 2020 elections, which the NLD again won in a landslide victory. The military alleged the election was marred by fraud while the UEC rejected this allegation. On 1 February 2021, hours before the new parliament was to convene, the Tatmadaw staged a coup d’état. This article reviews the UEC in its constitutional and political context. It identifies its institutional features, significant points in its brief history, and the impact of UEC leadership as a contributing factor in fostering confidence in the electoral process.
Major depressive disorder (MDD) and bipolar disorder (BD) are likely to be etiologically diverse, resulting from the contributions of multiple pathophysiologic processes present in affected individuals to varying degrees. In MDD, there is abundant evidence that alterations in serotonin and other monoamines (1) and glutamatergic signaling (2) are implicated in its pathogenesis, and most available treatments target these pathways.
Further to systematic experiments on the flexural strength of laboratory-grown, fresh water ice loaded cyclically, this paper describes results from new experiments of the same kind on lake ice harvested in Svalbard. The experiments were conducted at −12 °C, 0.1 Hz frequency and outer-fiber stress in the range from ~ 0.1 to ~ 0.7 MPa. The results suggest that the flexural strength increases linearly with stress amplitude, similar to the behavior of laboratory-grown ice.
Systematic experiments reveal that the flexural strength of freshwater S2 columnar-grained ice loaded normal to the columns increases upon cyclic loading. Specifically, over the range of stress amplitudes 0.1–2.6 MPa the flexural strength increases linearly with increasing stress amplitude. The experiments were conducted upon both reversed and non-reversed cyclic loading over ranges of frequencies from 0.03 to 2 Hz and temperatures from −25 to −3°C. Strengthening can also be imparted through bending-induced creep. The fundamental requirement for strengthening is that the surface that undergoes maximum tensile stress during failure must have been pre-stressed in tension. Flexural strength is governed by crack nucleation. We suggest that the process is resisted by an internal back-stress that opposes the applied stress and builds up through either crystal dislocations piling up or grain boundaries sliding.
Mefloquine is being used as malaria prevention by Plasmodium Falciparum in chloroquine-resistant zones. We describe a woman who developed a manic episode with psychotic symptoms during mefloquine treatment.
Methods and results
A 26-year-old Spanish woman had been working in Mali for the last six months and had started antimalarial prevention with mefloquine. In Mali, the clinical picture had a sudden debut and she related: excessive happiness, incapacity to sleep, and megalomania (she believed to have special powers and to be the mother of all the children). She was admitted in a hospital in Mali for seven days and received treatment with haloperidol and chlorpromazine. Then, she was repatriated to Spain without treatment and she continued suffering the same symptoms. After 15 days, she went to our hospital and she was admitted. Treatment started with risperidone (up to 6 mg/day) and clonazepam (up to 1.5 mg/day). At admission Young Mania Rating Scale (YMRS) was 25 points. Physical examination and complementary tests were normal, and was orientated as a manic episode with psychotic symptoms secondary to mefloquine. She had a quick symptomatic improvement (after 7 days of treatment YMRS was 5 points) and was discharged after 15 days.
Conclusion
Mefloquine more frequent adverse neuropsychiatric effects are: dizziness, vivid dreams and insomnia. Others are confusion, and auditory hallucinations. Side effects are dose dependent. Psychotic symptoms are frequently auto-limited when mefloquine is suppressed but treatment with atypical antipsychotics is often needed. MDR1/ABCB1 polymorphisms may play a role in neuropsychiatric side effects
Mefloquine is being used as malaria prevention by Plasmodium Falciparum in chloroquine-resistant zones. We describe a woman who developed a manic episode with psychotic symptoms during mefloquine treatment.
Methods and results
The case describes a 26-year-old Spanish woman who had been working in Mali for the last six months and had started antimalarial prevention with mefloquine. In Mali, the clinical picture had a sudden debut and she related: excessive happiness, incapacity to sleep, and megalomania (she believed to have special powers and to be the mother of all the children). She was admitted in a hospital in Mali for seven days and received treatment with haloperidol and chlorpromazine. Then, she was repatriated to Spain without treatment and she continued suffering the same symptoms. After 15 days, she went to our hospital and she was admitted. Treatment started with risperidone (up to 6 mg/day) and clonazepam (up to 1.5 mg/day). At admission Young Mania Rating Scale (YMRS) was 25 points. Physical examination and complementary tests were normal, and was orientated as a manic episode with psychotic symptoms secondary to mefloquine. She had a quick symptomatic improvement (after 7 days of treatment YMRS was 5 points) and was discharged after 15 days.
Conclusion
Mefloquine more frequent adverse neuropsychiatric effects are: dizziness, vivid dreams and insomnia. Others are confusion, and auditory hallucinations. Side effects are dose dependent. Psychotic symptoms are frequently auto-limited when mefloquine is suppressed but treatment with atypical antipsychotics is often needed. MDR1/ABCB1 polymorphisms may play a role in neuropsychiatric side effects.
The late-Victorian and Edwardian East End was an area not only defined by its poverty and destitution, but also by its ethnic and religious diversity. In the neighbourhoods of East London diasporic communities interacted with each other and with the host society in a number of different contexts. In Socialism and the Diasporic 'Other' Daniel Renshaw examines the sometimes turbulent relationships formed between Irish Catholic and Jewish populations and the socialist and labour organisations agitating in the area. Employing a comparative perspective, the book analyses the complex relations between working class migrants, conservative communal hierarchies and revolutionary groups. Commencing and concluding with waves of widespread industrial action in the East End, where politics were conflated with ethnic and diasporic identity, this book aims to reinterpret the attitudes of the turn-of-the-century East London Left towards 'difference'. Concerned with both protecting hard-won gains for the industrial proletariat and championing marginalised minority groups, the 'correct' path to be taken by socialist movements was unclear throughout the period. The book simultaneously compares the experiences of the Irish and Jewish working classes between 1889 and 1912, and the relationships formed, at work, at worship, in political organisations or at school, between these diasporic groups.
The permeability of sea ice can strongly affect the dissipation of wave energy into the ice pack. Sea-ice permeability is known to be impacted by the brine volume fraction and the blockage of flow pathways by the freezing of infiltrating lower salinity water. Here we investigate another process impacting sea-ice permeability, namely, inelastic deformation. We report the results of a first-of-its-kind field-scale deformation experiment to investigate the impact of compressive loading on sea-ice permeability. We observed that deformation decreased permeability by four orders of magnitude or more in some locations, while elsewhere permeability was unaffected or possibly increased. We show that the observed changes in permeability are consistent with expected changes in stress state and, as a result, in the mechanisms of deformation.
Having considered the agency and actions of outsiders, be they socialist organisers, communal leaderships, minority nationalists, or missionaries, this book will conclude by examining the interactions on the ground between the men and women who had migrated from Eastern Europe or Ireland to the East End and their descendants. This was the grass roots for whom and on whose behalf the protagonists of this study, whether revolutionary firebrands, trade union officials, or conservative religious leaders, claimed to be speaking and working. The Irish and Jewish diasporic working class were not mere passive receptacles as portrayed on occasion by both the socialist movement and the communal leaderships. Instead, they took an active part in defining the relationships formed with the city around them and with their neighbours in the streets and courts in which they lived. Radical politics provided one sphere in which these interactions could take place. In describing these interactions there is a difficult path to be navigated. It is necessary to avoid the rose-tinted narrative that stresses unproblematic inter-ethnic cooperation under the influence of a benevolent progressive movement, and an unbroken line of East End solidarity from the Dock Strike in 1889 to Cable Street in 1936. We must also be wary of the counter-argument, an account focusing only on ethnic tensions, racism, exclusion, and violence. The reality lies somewhere in between, and it is on the complex and sometimes ambiguous personal relationships formed between individuals and communities that this chapter focuses. Violence and industrial unrest, as well as more peaceful facilitators of integration, could serve as a conduit for the creation of new East End identities, and shape Irish and Jewish communal and radical politics at a grass-roots level.
The Roles of the Priest and the Rabbi in East London
The perceived power of the priest in the working-class Catholic communities of London throughout the nineteenth century, and the influence supposedly wielded by these communal leaders when compared with their Anglican or Nonconformist counterparts, was a source both of grudging admiration and suspicion for contemporary commentators. The degree to which many Catholic priests involved themselves in their flocks’ day to day lives and shared in their hardships was compared favourably with the disconnection and indifference between those preaching and those being preached to felt by many in the Anglican Church.