This article proposes an analysis of the Book of the Desert (Kitāb al-Bādiya), a nineteenth-century legal treatise composed by Muḥammad al-Māmī (d. 1282/1865), a Muslim scholar from the Tiris desert in present-day Mauritania. Al-Māmī’s text reflects on the adaptation of sharia—the religious law of Islam—to the needs of pastoral populations in the Saharan West. How to embrace a normative system seemingly incompatible with nomadic life, given that it presupposes a state governed by an Islamic ruler (imām) and considers the city the natural environment of legal institutions? Challenging the narratives of center-periphery and the so-called post-classical “decline” that continue to structure the field of Islamic intellectual history, the article explores the different contextual layers of al-Māmī’s reasoning. He was a religious notable deeply involved in power struggles between nomadic groups and a fervent supporter of eighteenth- and nineteenth-century jihad movements in West Africa. But he was also a jurist of the Maliki school, who approached his society from the perspective of Islamic legal thought, and a Bedouin preoccupied with the legal and religious implications of the cultural gulf between his world and that of the towns.

This Special Issue celebrates the 50th anniversary of Review of International Studies. Since 1975, the Review has published over 200 issues and over 1300 articles. The journal has played a key role in shaping the discipline of International Relations (IR), leading, or critically intervening in, key debates. To celebrate 50 years of Review of International Studies, we have curated a Special Issue examining the challenges facing global politics for the next 50 years. IR has regularly turned its attention backwards towards its historical origins. Instead, we look to the future. In this Introduction, we start by outlining four traditions of future-oriented thinking: positivist, realist prediction; planning, forecasting, and scenario-building; utopian dreams of an ideal political future; and prefigurative thinking in activist politics. From these traditions, we learn that thinking about the future is always thinking about the present. We then outline four themes in the Special Issue articles: How do we think about the future at all? How do we think about imperial pasts and the ongoing questions of colonization and racialization in the present? How will technological change mediate and generates geopolitical change? How are socioecological crises, and in particular climate change, increasingly shaping how we think about the future of global politics? Overall, these provide us with a diverse, stimulating, and thought-provoking set of essays about the future of global politics, as both discipline and set of empirical problems.

OBJECTIVES/GOALS: Buprenorphine (BUP) is used for opioid use disorder during pregnancy but causes neonatal opioid withdrawal syndrome (NOWS). The goal of this study was to determine the contribution of the active metabolite, norbuprenorphine (NorBUP), to the development of NOWS when the parent drug, BUP, is administered during pregnancy. METHODS/STUDY POPULATION: Subcutaneously implanted osmotic minipumps delivered BUP (0, 0.01, 0.1 or 1 mg/kg/day) ± NorBUP (1 mg/kg/day) to pregnant Long-Evans rats from gestation day 9 until after delivery. NOWS was measured between 3 and 12 hours after delivery. Withdrawal was precipitated by an intraperitoneal injection of a mu opioid receptor antagonist naltrexone (NTX; 0, 1 or 10 mg/kg), and movement duration (MD; a validated proxy for NOWS) was measured using Noldus Ethovision. Concentrations of BUP, NorBUP, and their glucuronide conjugates in the brains of neonatal littermates not undergoing withdrawal testing were determined using LC/MS/MS. Two-way ANOVA and multiple linear regression analyses tested for interactions between BUP and NorBUP on MD and related brain concentrations to MD, respectively. RESULTS/ANTICIPATED RESULTS: There was no interaction effect between BUP and NorBUP on MD for either sex or at any dose of naltrexone. In females, but not males, BUP (1 mg/kg/day) significantly increased NorBUP-induced MD by 58% following an injection with 1 mg/kg NTX. A multiple linear regression model that included BUP and NorBUP brain concentrations as predictors of MD was significant and well-fitting [FEMALES: F (2, 40) = 23.97, P < .0001, adj R2 = 0.52; MALES: F (2, 40) = 5.84, P = .0059, adj R2 = 0.19]. There was a differential contribution of NorBUP brain concentrations to MD based on sex. The partial regression coefficient for NorBUP was 51.34 (p < .0001) for females and 19.21 (p = 0.093) for males. The partial regression coefficient for BUP was similar for females and males (FEMALES:βBUP = 10.62, p = .0017; MALES:βBUP = 11.38, p = .009). DISCUSSION/SIGNIFICANCE: We show for the first time a differential contribution of NorBUP to BUP-associated NOWS in each sex, suggesting sex differences in NorBUP susceptibility and implicating that treatment strategies reducing prenatal NorBUP exposure may be more effective for females than males.

Avian influenza (AI) is an important disease that has significant implications for animal and human health. High pathogenicity AI (HPAI) has emerged in consecutive seasons within the UK to cause the largest outbreaks recorded. Statutory measures to control outbreaks of AI virus (AIV) at poultry farms involve disposal of all birds on infected premises. Understanding of the timing of incursions into the UK could facilitate decisions on improved responses. During the autumnal migration and wintering period (autumn 2019– spring 2020), three active sampling approaches were trialled for wild bird species considered likely to be involved in captive AI outbreaks with retrospective laboratory testing undertaken to define the presence of AIV.

Faecal sampling of birds (n = 594) caught during routine and responsive mist net sampling failed to detect AIV. Cloacal sampling of hunter-harvested waterfowl (n = 146) detected seven positive samples from three species with the earliest detection on the 17 October 2020. Statutory sampling first detected AIV in wild and captive birds on 3 November 2020. We conclude that hunter sourced sampling of waterfowl presents an opportunity to detect AI within the UK in advance of outbreaks on poultry farms and allow for early intervention measures to protect the national poultry flock.

The 2016–17 European outbreak of H5N8 HPAIV (Clade 2.3.4.4b) affected a wider range of avian species than the previous H5N8 outbreak (2014–15), including an incursion of H5N8 HPAIV into gamebirds in England. Natural infection of captive-reared pheasants (Phasianus colchicus) led to variable disease presentation; clinical signs included ruffled feathers, reluctance to move, bright green faeces, and/or sudden mortality. Several birds exhibited neurological signs (nystagmus, torticollis, ataxia). Birds exhibiting even mild clinical signs maintained substantial levels of virus replication and shedding, with preferential shedding via the oropharyngeal route. Gross pathology was consistent with HPAIV, in gallinaceous species but diphtheroid plaques in oropharyngeal mucosa associated with necrotising stomatitis were novel but consistent findings. However, minimal or modest microscopic pathological lesions were detected despite the systemic dissemination of the virus. Serology results indicated differences in the timeframe of exposure for each case (n = 3). This supported epidemiological conclusions confirming that the movement of birds between sites and other standard husbandry practices with limited hygiene involved in pheasant rearing (including several fomite pathways) contributed to virus spread between premises.

Gravitational waves from coalescing neutron stars encode information about nuclear matter at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced by the presence of tides, which depend on the neutron star equation of state. Neutron star mergers are expected to often produce rapidly rotating remnant neutron stars that emit gravitational waves. These will provide clues to the extremely hot post-merger environment. This signature of nuclear matter in gravitational waves contains most information in the 2–4 kHz frequency band, which is outside of the most sensitive band of current detectors. We present the design concept and science case for a Neutron Star Extreme Matter Observatory (NEMO): a gravitational-wave interferometer optimised to study nuclear physics with merging neutron stars. The concept uses high-circulating laser power, quantum squeezing, and a detector topology specifically designed to achieve the high-frequency sensitivity necessary to probe nuclear matter using gravitational waves. Above 1 kHz, the proposed strain sensitivity is comparable to full third-generation detectors at a fraction of the cost. Such sensitivity changes expected event rates for detection of post-merger remnants from approximately one per few decades with two A+ detectors to a few per year and potentially allow for the first gravitational-wave observations of supernovae, isolated neutron stars, and other exotica.

The discovery of the first electromagnetic counterpart to a gravitational wave signal has generated follow-up observations by over 50 facilities world-wide, ushering in the new era of multi-messenger astronomy. In this paper, we present follow-up observations of the gravitational wave event GW170817 and its electromagnetic counterpart SSS17a/DLT17ck (IAU label AT2017gfo) by 14 Australian telescopes and partner observatories as part of Australian-based and Australian-led research programs. We report early- to late-time multi-wavelength observations, including optical imaging and spectroscopy, mid-infrared imaging, radio imaging, and searches for fast radio bursts. Our optical spectra reveal that the transient source emission cooled from approximately 6 400 K to 2 100 K over a 7-d period and produced no significant optical emission lines. The spectral profiles, cooling rate, and photometric light curves are consistent with the expected outburst and subsequent processes of a binary neutron star merger. Star formation in the host galaxy probably ceased at least a Gyr ago, although there is evidence for a galaxy merger. Binary pulsars with short (100 Myr) decay times are therefore unlikely progenitors, but pulsars like PSR B1534+12 with its 2.7 Gyr coalescence time could produce such a merger. The displacement (~2.2 kpc) of the binary star system from the centre of the main galaxy is not unusual for stars in the host galaxy or stars originating in the merging galaxy, and therefore any constraints on the kick velocity imparted to the progenitor are poor.

To investigate the Arctic Ocean Circulation, results from a high-resolution fully global ocean model have been analyzed. The results come from two runs of the Ocean Circulation and Climate Advanced Modelling project (OCCAM) model, developed and run by the Southampton Oceanography Centre, at 1/4° × 1/4° and 1/8° × 1/8° resolution. The model is based on the Bryan-Semtner-Cox model and has 36 vertical levels. Enhancements include a free surface, an improved advection scheme and an improved treatment of the surface fresh-water flux. The model is forced with a monthly European Centre for Medium-range Weather Forecasts wind-stress climatology. It reproduces many of the fine-scale features found in the Arctic Ocean. The analysis concentrates on several of the key features, including the highly energetic eddy system in the western part of the Beaufort Sea, East Greenland West and Spitsbergen Currents and the detailed structure of the marginal currents along the Siberian and Canadian coasts. Much of the paper is focused on the water transport through the Bering and Fram Straits and through the Canadian Archipelago. Comparisons of the model net fluxes through the straits against observations are presented. The analyses of the results demonstrate the ability of the fine-resolution model to simulate features such as small-scale eddies and jets, which have some agreement with the limited observations available.