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Respiratory virus testing is routinely performed and ways to obtain specimens aside from a nasopharyngeal swab are needed for pandemic preparedness. The main objective is to validate a self-collected oral-nasal swab for the detection of Influenza and respiratory syncytial virus (RSV).
Design:
Diagnostic test validation of a self-collected oral nasal swab as compared to a provider-collected nasopharyngeal swab.
Setting:
Emergency Department at Michael Garron Hospital.
Participants:
Consecutive individuals who presented to the Emergency Department with a suspected viral upper respiratory tract infection were included if they self-collected an oral-nasal swab. Individuals testing positive for Influenza or RSV along with randomly selected participants who tested negative were eligible for inclusion.
Interventions:
All participants had the paired oral-nasal swab tested using a multiplex respiratory virus polymerase chain reaction for the three respiratory pathogens and compared to the nasopharyngeal swab.
Results:
48 individuals tested positive for Influenza, severe acute respiratory coronavirus virus 2 (SARS-CoV-2) or RSV along with 80 who tested negative. 110 were symptomatic with the median time from symptom onset to testing of 1 day (interquartile range 2–5 days). Using the clinical nasopharyngeal swab as the reference standard, the sensitivity was 0.75 (95% CI, 0.43–0.95) and specificity was 0.99 (95% CI, 0.93–1.00) for RSV, sensitivity is 0.67 (95% CI, 0.49–0.81) and specificity is 0.96 (95% CI, 0.89–0.99) for Influenza.
Conclusions:
Multiplex testing with a self-collected oral-nasal swab for Influenza and RSV is not an acceptable substitute for a healthcare provider collected nasopharyngeal swab primarily due to suboptimal Influenza test characteristics.
How are LGBTQ+ issues represented within labor organizing and how are they linked to broader debates about inequality? We answered these questions by examining press releases, internal resolutions, and online resources from the American Federation of Labor and Congress of Industrial Organizations (AFL-CIO) and the Pride at Work (PAW) constituency group. We find that they significantly differ in their approaches to symbolic and substantive representation and agenda setting. Across all three outcomes, PAW and the AFL-CIO vary in LGBTQ+ issue representation. The AFL-CIO engages in more symbolic representation but also devotes resources to collective action that can improve the lives of LGBTQ+ people. PAW places greater emphasis on the interconnectedness of LGBTQ+ and labor issues to mobilize LGBTQ+ people. Our findings highlight the marginal position of LGBTQ+ labor activism in the labor and LGBTQ+ movements, and they demonstrate the challenges associated with linking LGBTQ+ issues to broader debates about inequality in American politics.
The aim of this study is to investigate whether 25-hydroxyvitamin D (25(OH)D) is associated with periodontitis and tooth loss in older adults. A total of 2346 adults underwent a detailed dental examination as part of the health assessment of a national population study – The Irish Longitudinal Study of Ageing. 25(OH)D analysis was performed on frozen non-fasting total plasma using LC-MS. The analysis included both multiple logistic regression and multinominal logistic regression to investigate associations between 25(OH)D concentration, periodontitis and tooth loss, adjusting for a range of potential confounders. Results of the analysis found the mean age of participants was 65·3 years (sd 8·2) and 55·3 % of the group were female. Based on the quintile of 25(OH)D concentration, participants in the lowest v. highest quintile had an OR of 1·57 (95 % CI 1·16, 2·13; P < 0·01) of having periodontitis in the fully adjusted model. For tooth loss, participants in the lowest v. highest quintile of 25(OH)D had a RRR of 1·55 (95 % CI 1·12, 2·13; P < 0·01) to have 1–19 teeth and a RRR of 1·96 (95 % CI 1·20, 3·21; P < 0·01) to be edentulous, relative to those with ≥ 20 teeth in the fully adjusted models. These findings demonstrate that in this cross-sectional study of older men and women from Ireland, 25(OH)D concentration was associated with both periodontitis and tooth loss, independent of other risk factors.
Sour foods, such as citrus fruits, some berries and fermented foods provide a range of nutrients and benefits important to mental health [1]. When sourness is perceived as unpleasant, intake of these foods may be reduced affecting mental health. Early research has shown changes to sour taste perception in depression and stress however, changes in anxiety have not been studied [4-8]. To address this gap and build on the knowledge base, a survey was conducted in which participants (n = 424) rated recalled intensity and liking of sour index foods and completed the Depression, Anxiety, and Stress Scale (DASS-21) to measure these states. Variations in sour taste and mood have been demonstrated between females and males, hence the data were explored for sex-differences. Standard least squares regression (post hoc Tukey’s HSD) compared means between groups, and nominal logistic regression assessed differences in distributions between categories. Recalled sour intensity was 16-19.2% higher in those with scores indicative of mild depression than in those with normal scores in the total sample (p range 0.03-0.04), and 17.9-21.3% higher in females (p values were 0.03). There were no differences in sour taste intensity between the intergroup means for anxiety or stress and no associations between sour liking and any of the mood states. The results suggest that the sourness of index foods increases in depression. Further research to elucidate the biological processes and possible taste-related genetic influences that may be occurring would be beneficial. With this knowledge it may be possible to screen for mood conditions by measuring changes to sour taste that appear alongside other signs and symptoms, create more tailored dietary interventions and develop additional therapeutics.
This chapter explores the Histories’ interest in human nature on the battlefield in terms of valour. It reviews instances in which the historical actors – including Pixodarus, Xerxes, and Themistocles – foreground the strategic importance of "surpassing nature." This is a motif that places the speakers in a network of sophistic and later, Platonic, theories on man’s desire to outstrip his own nature. At stake is a philosophy of "superior nature" that is strongly undercut by the complexity of the action on the battlefield.
This chapter surveys the evidence for the sophistic debate on relativism as evident in the fragments of the sophists, including comic and tragic poets. A widespread interpretation of the Histories claims that Herodotus supports nomos without qualification. By contrast, this chapter argues that this claim fails to capture the complexity of Herodotus’ engagement with those figures who use nomos as a rhetorical ploy to justify what is contrary to popular ethics. Similarly, Presocratic thinkers were working through the challenges presented by those who identified nomos as only a relative set of values as opposed to an objective norm to be followed. The Histories’ exploration of the problem of relating custom and law to justice takes place in the context of the rise and expansion of Persian imperialism. Further, it implicates the despot in a relativizing of justice and constitutes a key explanatory paradigm in the Persian attack against the Greek mainland in the Greco-Persian Wars.
This final chapter shifts to look to Herodotus’ reception in the early fourth century in the Dissoi Logoi. What questions does Herodotus raise for subsequent philosophers? How does allusion to the Histories in a treatise that is explicitly philosophical expand our understanding of his project? What is the consequence of this for Herodotus’ generic positionality? The Dissoi Logoi offers a case study in the reception of the Histories as an example of its prominence in intellectual culture. The second half of the chapter reprises the conclusions of the book and reexamines the value of reading what will become early Greek "historiography" alongside philosophy.
This chapter turns to Herodotus’ unique narratorial reticence in making firm truth claims. "What is said" and "what seems" are found with much greater frequency than "what is true." Juxtaposing the Histories with contemporary discussions on epistemology will demonstrate the extent to which truth was problematized as a standard of inquiry in the fifth century. The narrator’s response to this is to use truth as an elusive criterion in order to highlight the difficulty of meeting its conditions. The final portion of this chapter looks to the frequency of "veridical" εἰμί in the Histories and points to its status as a criterion of accuracy in Presocratic epistemology. It argues for its incorporation in historical narrative as a distinctive marker of epistemic certainty.
Starting from the Solon-Croesus episode, this chapter argues that Herodotus’ inquiry establishes a horizon of expectation in which historical memory (through the narratives of Tellus and Cleobis and Biton) opens up a new space for philosophical knowledge. The second half of the chapter suggests that the Histories’ generic affiliation with history over philosophy is anachronistic in the fifth century BCE. It demonstrates that Herodotus was not interpreted as a historian in his own time and that "inquiry" and "love of wisdom" characterize the dynamic and highly experimental intellectual culture of this period.
The study of nature as an object of scientific interest matured through the investigations of Presocratic philosophers on the observable world. Herodotus is in dialogue with those expanding its domain into the spheres of natural science and the human. Physis embraces the interior and exterior regularities of subjects as diverse as landmasses, rivers, seas, elements, animals, and men. Unique to Herodotus, however, is the use of nature as a category of historical explanation; it is a standard of measurement that permits historical inference.