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18 results

  • Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank

  • Kylie P. Glanville, Jonathan R. I. Coleman, David M. Howard, Oliver Pain, Ken B. Hanscombe, Bradley Jermy, Ryan Arathimos, Christopher Hübel, Gerome Breen, Paul F. O'Reilly, Cathryn M. Lewis
  • Journal:
    BJPsych Open / Volume 7 / Issue 2 / March 2021
    Published online by Cambridge University Press:
    05 February 2021, e44
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  • Background

    The UK Biobank contains data with varying degrees of reliability and completeness for assessing depression. A third of participants completed a Mental Health Questionnaire (MHQ) containing the gold-standard Composite International Diagnostic Interview (CIDI) criteria for assessing mental health disorders.

    Aims

    To investigate whether multiple observations of depression from sources other than the MHQ can enhance the validity of major depressive disorder (MDD).

    Method

    In participants who did not complete the MHQ, we calculated the number of other depression measures endorsed, for example from hospital episode statistics and interview data. We compared cases defined this way with CIDI-defined cases for several estimates: the variance explained by polygenic risk scores (PRS), area under the curve attributable to PRS, single nucleotide polymorphisms (SNPs)-based heritability and genetic correlations with summary statistics from the Psychiatric Genomics Consortium MDD genome-wide association study.

    Results

    The strength of the genetic contribution increased with the number of measures endorsed. For example, SNP-based heritability increased from 7% in participants who endorsed only one measure of depression, to 21% in those who endorsed four or five measures of depression. The strength of the genetic contribution to cases defined by at least two measures approximated that for CIDI-defined cases. Most genetic correlations between UK Biobank and the Psychiatric Genomics Consortium MDD study exceeded 0.7, but there was variability between pairwise comparisons.

    Conclusions

    Multiple measures of depression can serve as a reliable approximation for case status where the CIDI measure is not available, indicating sample size can be optimised using the entire suite of UK Biobank data.

  • Sweat Lithium in Manic-Depression

  • E. B. Miller, R. W. Pain, P. J. Skripal
  • Journal:
    The British Journal of Psychiatry / Volume 133 / Issue 5 / November 1978
    Published online by Cambridge University Press:
    29 January 2018, pp. 477-478
    Print publication:
    November 1978
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