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As composer, theoretician, conductor and founder of institutions, Pierre Boulez’s irrepressible desire for modernity marked the second half of the twentieth century. From immediately after the Second World War, he set himself the task of bringing to the fore a France that was deemed musically retrogressive and sclerotic. A man of action, both visionary and pragmatic, fêted and detested, he waged throughout his life collective and altruistic battles and engaged in numerous controversies, all with the explicit goal of shaking the dust off of musical practice and of stimulating a new model of creation and dissemination: the Domaine Musical in the 1950s; IRCAM and the Ensemble Intercontemporain in the 1970s; the Opéra Bastille in the 1980s and both the Cité de la musique and the beginnings of La Philharmonie de Paris in the 1990s. His unique journey remains relevant to our understanding of recent French political history, the history of ideas and of art.
The goals of this investigation were to 1) identify and measure exposures inside homes of individuals with chemical intolerance (CI), 2) provide guidance for reducing these exposures, and 3) determine whether our environmental house calls (EHCs) intervention could reduce both symptoms and measured levels of indoor air contaminants.
Background:
CI is an international public health and clinical concern, but few resources are available to address patients’ often disabling symptoms. Numerous studies show that levels of indoor air pollutants can be two to five (or more) times higher than outdoor levels. Fragranced consumer products, including cleaning supplies, air fresheners, and personal care products, are symptom triggers commonly reported by susceptible individuals.
Methods:
A team of professionals trained and led by a physician/industrial hygienist and a certified indoor air quality specialist conducted a series of 5 structured EHCs in 37 homes of patients reporting CI.
Results:
We report three case studies demonstrating that an appropriately structured home intervention can teach occupants how to reduce indoor air exposures and associated symptoms. Symptom improvement, documented using the Quick Environmental Exposure and Sensitivity Inventory Symptom Star, corresponded with the reduction of indoor air volatile organic compounds, most notably fragrances. These results provide a deeper dive into 3 of the 37 cases described previously in Perales et al. (2022).
Discussion:
We address the long-standing dilemma that worldwide reports of fragrance sensitivity have not previously been confirmed by human or animal challenge studies. Our ancient immune systems’ ‘first responders’, mast cells, which evolved 500 million years ago, can be sensitized by synthetic organic chemicals whose production and use have grown exponentially since World War II. We propose that these chemicals, which include now-ubiquitous fragrances, trigger mast cell degranulation and inflammatory mediator release in the olfactory-limbic tract, thus altering cerebral blood flow and impairing mood, memory, and concentration (often referred to as ‘brain fog’). The time has come to translate these research findings into clinical and public health practice.
Food-based dietary guidelines (FBDG) are an important resource to improve population health; however, little is known about the types of strategies to disseminate them. This study sought to describe dissemination strategies and content of dissemination plans that were available for FBDG.
Design:
A cross-sectional audit of FBDG with a published English-language version sourced from the United Nations FAO repository. We searched for publicly available dissemination strategies and any corresponding plans available in English language. Two authors extracted data on strategies, which were grouped according to the Model for Dissemination Research Framework (including source, audience, channel and message). For guidelines with a dissemination plan, we described goals, audience, strategies and expertise and resources according to the Canadian Institute for Health Research guidance.
Setting:
FBDG from fifty-three countries mostly from high-income (n 28, 52·8 %), and upper-middle income (n 18, 34 %) areas were included.
Participants:
n/a.
Results:
The source of guidelines was most frequently health departments (79·2 %). The message included quantities and types of foods, physical activity recommendations and 88·7 % included summarised versions of main messages. The most common channels were infographics and information booklets, and the main end-users were the public. For twelve countries (22·6 %), we were able to source an English-language dissemination plan, where none met all recommendations outlined by the Canadian Institute for Health Research.
Conclusions:
The public was the most frequently identified end-user and thus most dissemination strategies and plans focused on this group. Few FBDG had formal dissemination plans and of those there was limited detailed provided.
There are numerous potential benefits associated with electrified aircraft propulsion (EAP). Achieving economical and safe EAP in transport aircraft would constitute an enormous leap forward in aviation. However, as with all potential engineering breakthroughs, the devil is in the details. This chapter begins to examine some of these details by introducing the electric power system (EPS) and summarizing its design, control, and protection functions. With the electrification of propulsion systems, EPS power levels (i.e., generation, distribution, and loads) are expected to increase by at least an order of magnitude, with far-reaching implications on the overall system design. Since all aspects of the EPS will be impacted, a thorough understanding and appreciation of the EPS and its functions is necessary to fully comprehend the challenges ahead. Several key EPS components and functions are described, and the solid foundation provided by the material in this chapter prepares the reader for the focused discussions of individual system components that follow in subsequent chapters.
Non-invasive 3D methods for imaging cementum increments using synchrotron radiation sources are one of the most promising new avenues for cementum research. This technique offers the opportunity to overcome the major caveats to traditional thin section imaging, and provides volumetric datasets of sub-micrometer resolution that can be investigated in new ways. Such studies can unlock the 3D structure of cementum increments, and 3D measures may allow for new inferences on the relationship between cementum growth and life history. However, as a new field of research, synchrotron X-ray imaging of cementum must ensure reproducibility by employing quantitative approaches to develop optimal experimental procedures and settings for imaging cementum in different samples. The quantitative parameter optimisation procedure we introduce in this chapter should form a crucial part of the imaging protocol that we present here, in which we outline the major steps in preparing for, performing and concluding a synchrotron imaging experiment, based on our own experience.
Explore the interrelationship between teachers’ personal and professional socio-ecological structures while examining Head Start (HS) teachers’ experiences with (1) trying to eat healthy and engage in physical activity (PA) and (2) promote healthy eating and PA in their classrooms.
Design:
In-depth semi-structured interviews were collected from March through June 2017. Researchers designed the data collection and analysis methods using a phenomenological approach. All interviews were recorded using digital audio and transcribed verbatim.
Setting:
Seven HS centres in two rural eastern North Carolina counties.
Participants:
Teachers (n 15) who had recently participated in a healthy eating and physical activity intervention. Participants were 100 % female, an average age of 43 years (sd 9·6) and primarily Black/African American (93·3 %).
Results:
Eighteen primary themes were identified providing unique insight into individual, social and environmental determinants that may influence teachers’ personal health behaviours and professional health promotion practices. Findings indicated that teachers want to improve health behaviours personally (individual/family health) and professionally (children/families served); however, barriers exist at all levels impacting their ability to improve their own health and facilitate positive behaviours among the children/families they serve. Many teachers observed connections between their personal and professional experiences, but not beyond the individual level.
Conclusions:
Study findings highlight the importance of considering and emphasising the potential relationship between personal and professional determinants of health when working with early childhood teachers. Findings from this study may be useful for informing the development, implementation and evaluation of future health promotion interventions using teachers as implementers.
Food matrix is known to interact with some dietary constituents and microconstituents during digestion. These interactions may potentially affect the metabolism and bioavailability of some compounds, and as a consequence modulate their biological effects. In this context, the aim of this study was to determine the effect of apple food matrix on the bioavailability of flavan-3-ols and on the ability of these compounds to modulate the nutrigenomic response to a high fat challenge in minipigs.
Adult male Yucatan minipigs (n = 5) were assigned to a random treatment sequence of high-fat meals non supplemented or supplemented with 250 g of raw apple, 250 g of apple puree or 1.4 g of apple polyphenols extract, with a 7-days washout period between each treatment. Each supplementation provided 155 mg flavan-3-ol monomers. At each treatment period, fasting- and 1h-, 2h-, 3h-postprandial blood samples were collected, and the concentration in flavan-3-ol monomers was measured on hydrolyzed serum, using UPLC-Q-TOF MS. The ability of apple-derived products to modulate the postprandial gene expression profile was assessed and compared in circulating PBMCs collected at 3 h after consumption of the four tested meals using a microarray analysis.
Results show that the apple matrix did not affect the kinetic of the postprandial absorption of flavan-3-ol monomers. The total flavan-3-ols concentrations measured at peak were significantly higher in the extract (x1.75), suggesting an impact of the apple matrix on flavan-3-ols absorption. However, no significant difference in total flavanols was observed between raw apple and apple puree.
Principal Component Analysis of the microarray data from PBMCs identified three distinct clusters of gene expression patterns: one corresponding to gene expression profiles after the high-fat meal, one for meal supplemented with raw apples or apple puree, and a third cluster for meal supplemented with polyphenol extract. A set of 309 genes was identified as differentially expressed by apple-derived products compared to high-fat meal alone, including 93 modulated with the three apple products. The variations in gene expression were similar for only 75% of the 93 genes, suggesting that the apple matrix affects the nutrigenomic response to flavan-3-ols. A bioinformatics analysis revealed that genes affected by apple-derived products are involved in inflammation and leukocyte transendothelial migration, suggesting a beneficial impact of apple-derived products.
In conclusion, these results raise awareness for considering the impact of food matrix on the biological responsiveness of polyphenols in future nutritional studies.
Schizophrenia is the psychiatric disorder in which the awareness of pathology is most frequently altered. This merits particular attention, because related to medication compliance and clinical outcome.
Objectives
To improve the level of insight in stabilized schizophrenia patients by means of two cognitive remediation techniques: Cognitive remediation program for patients with a schizophrenia spectrum disease - ReCoS and autobiographical memory program - RemAu.
Methods
The study is based on the results of neurocognitive and insight evaluations before and after treatment of two groups of ten patients with RemAu and twenty patients with ReCoS. The level of insight is evaluated using the SUMD and the PANSS scales. For cognitive capacity we test their concentration level (Trail Making Test, TMT, Stroop), executive functions (Wisconsin Card Sorting Test, WCST), memory (CVLT), autobiographical memory (TempAu) and their global cognitive capacity (WAIS III).
Results
The results have enabled us to highlight the beneficial effects of the RemAu autobiographical reminiscence program on these patients’ insight. Although the ReCoS program does not significantly improve the level of insight, it produces results which are most satisfying with regard to the cognitive profile of each patient.
Conclusions
The patients who have most benefited from the program are those who already had a reasonable cognitive capacity before the treatment. This allows us to conclude that we should deliver a treatment which is directed simultaneously at persistent cognitive disorders and autobiographical memory in order to obtain optimal effect on the level of insight in this pathology.
Taking up the Bleulerian view of a clinical description based on a pathogenic model, we propose a rating scale for the assessment of communication disorders in schizophrenic patients. The scale consists of clinical items that could be the direct expression of the three hypotheses of cognitive dysfunction which have been postulated to explain communication dysfunction in these patients. We assessed the frequency of the 16 items in the scale in a total of 80 subjects (43 schizophrenic subjects, ten manic subjects, 17 depressive subjects and ten normal control subjects). The results of this study showed that this item schedule was specific to schizophrenic patients and, in particular, could statistically significantly discriminate schizophrenic patients from psychotic patients with affective disorder. The methodological qualities of the scale were explored and proved accurate, except for the reliability which is too low for some items and the item-to-total correlation which is too low for one item of the scale.
Researchers tried to explain the overlap between anxiety and depression by suggesting that some items of self-administered questionnaires were badly selected and that both constructs should rather be considered as multidimensional. Thus, we hypothesise that the Spielberger trait anxiety inventory (TAI) includes items related to depression.
Method
A non-clinical sample of 193 subjects filled out the TAI and the Hospitalised Anxiety–Depression Scale. Factors were postulated on the basis of item content and submitted to confirmatory factor analysis (CFA).
Results
We found five factors: a 10-item anxiety factor containing three factors, a four-item unsuccessfulness factor correlated with the HADS anhedonia factor, and a six-item happiness factor.
Conclusion
The TAI scale encompasses measures of anxiety, depression and well-being. Consequently, the overlap with other measures of depression may result from item selection. This work awaits replication in independent normal and pathological samples.
Schizophrenia is associated with profound communication disorders resulting in a major social handicap. Hardy-Baylé and colleagues hypothesized that such impairments are related to a failure to process contextual integration. Previous studies based on event related potentials recordings (ERP) during semantic priming tasks have shown that schizophrenic patients have abnormal modulation of the N400 component. Supposedly, this electrical characteristic reflects an abnormal use of semantic context during word processing. However, the neural substratum underlying this pathological phenomenon remains poorly understood. To enrich knowledge inherited from ERP studies, we used magneto-encephalography (MEG) to determine the peculiarities (in anatomical and temporal terms) of the neural generators involved in semantic context integration in schizophrenia. The current study consisted in recording ERP and MEG signals during a French word-pairs lexical decision task (LDT). Subjects had to decide whether “target words” belonged to the lexicon or not, those words being preceded by word primes. The semantic relatedness between primes and targets varied (presence or absence) across two experimental conditions. Data obtained from a group of treated schizophrenic patients are compared to those from a healthy population. We report the preliminary results of schizophrenic subjects demonstrating that semantic priming elicits magnetic signals in the 300 to 500ms time window. Single subject's analysis of ERP and MEG profiles shows that the latter offers a different and complementary access to the brain response associated with LTD. Thus, MEG technique is suitable for investigating schizophrenic semantic priming abnormalities.
Attention Deficit Disorder with/without Hyperactivity (ADD/ADHD) is a neuro-developmental disorder that affects up to 6% of the children and the adolescents, and up to 4% of the adults in the general population. In French-speaking countries and in France more specifically, there is almost no validated instrument for the diagnosis of ADD/ADHD. Thomas E. Brown created scales to rate symptoms of ADD/ADHD from age 3 to adulthood. There are observer-rated forms (teacher and parent) and self-rated forms (adolescent and adult). Following WHO's guidelines all the forms of the BADDS were translated into French and back-translated into English. Dr Brown compared both English forms to ensure that the meaning of all items had been correctly caught. Students in Paris and children diagnosed with ADD/ADHD in Nice filled out the BADDS. Preliminary analyses are presented. A large epidemiologic study is planned to collect normative data in the French general population.
According to a recent large-scale Swedish epidemiological study, 5 % of violent crimes are attributable to patients suffering from psychosis., We present the preliminary results of a feasibility study comparing violent and non-violent schizophrenics on underlying potential process such as impulsivity, emotionality using both, psychometrics and neuropsychological correlates.
Methods:
Male Violents subjects where selected by clinicians on their life time histories of violence and control where paired according to age. Assessment include selected neuropsychological and psychometrics tests: BPRS (Brief Psychiatric Rating Scale), PCL-R (Psychopathy Checklist-Revised), BREF (Frontal Assessment Battery), WCST (Wisconsin Card Sorting Test), Iowa Gambling Task, BIS-11 (Impulsivity Scale).
Results:
Violent's performed better in the executive functions (WCST and the BREF), showing a better use of the dorso-side prefrontal cerebral cortex.
Their less good performances in the orbitofrontal functions, (Iowa Gambling Task, BREF), show cortical abnormalities involved in the processes of decision. Lesser capacity to recognize the appropriate feelings seems more present in deliberate violence, determined by the emotional coolness and the absence of fault, than in impulsive violence.
The PCL-R identifies the defect of orbitofrontal activation as the origin of the perturbed emotional integration and the bigger impulsiveness, by the slightest capacity of inhibition of the impulsive decisions.
Conclusion:
Our results, especially when compared to literature data, show the existence of dysfunctional cerebral process in schizophrenic violent patients similar to those observed in psychopathy. They outline the need for further clinical and neuropsychological studies to identify pathophysiological processes and estimate the potential recurrence of such behaviours.
This study was designed to evaluate the effect of semantic priming with a lexical decision task in 22 depressed patients (DSM-III-R, 1987) and 30 control subjects. These patients were evaluated twice: first when they arrived at the hospital, and secondly, after clinical improvement. Clinical improvement was evaluated using standard depression rating scales. A lexical decision task involving semantic relations (related vs. unrelated, e.g., apple-pear) was used to evaluate the processing of semantic information. The results showed that, for the first evaluation, the depressives presented similar semantic priming to control subjects. When we compared semantic priming in the first and the second passes, we observed that its amplitude was identical. The sole difference between the two passes concerns the global reaction time in the depressive group. This last result suggested that, with clinical improvement, the characteristic psychomotor retardation declines. One of the major results concerns the fact that severe depressive patients (first pass) exhibit normal semantic priming in a lexical decision task. These results indicate, in this clinical population, the preservation of controlled processes implicated in this lexical decision task.
Shared Mental Health care between Psychiatry and Primary care has been developed to improve the care of common mental health problems. Following a consultation-liaison intervention, this study evaluated one-year outcome for patients following the intervention to obtain objective data reflecting the “real-world” of shared mental health care.
Method:
95 patients from September 2006 to September 2007 (follow-up rate: 66%) were invited one year after the intervention to complete a paper questionnaire and a telephone short questionnaire about their mental health status, their care during the last year and their satisfaction with care.
Results:
89% of patients evaluated their current mental health as better then in the previous year. 44.5% were still managed by their GP as the psychiatric care provider (13.8% with a psychologist), 27.8% by a private psychiatrist, 11.1% by public psychiatry and 16.7% had no care anymore. 78.3% of patients evaluated the intervention as helpful for them.
Conclusions:
The intervention was helpful for primary care patients with common mental health problems, supporting primary care without GPs’ de-motivation or disqualification. This study conducted among patients confirmed a previous study conducted among GPs.