Matrix methods may be applied to the analysis of experimental data concerning group structure when these data indicate relationships which can be depicted by line diagrams such as sociograms. One may introduce two concepts, n-chain and clique, which have simple relationships to the powers of certain matrices. Using them it is possible to determine the group structure by methods which are both faster and more certain than less systematic methods. This paper describes such a matrix method and applies it to the analysis of practical examples. At several points some unsolved problems in this field are indicated.

Background: We evaluated vorasidenib (VOR), a dual inhibitor of mIDH1/2, in patients with mIDH1/2 glioma (Phase 3; NCT04164901). Methods: Patients with residual/recurrent grade 2 mIDH1/2 oligodendroglioma or astrocytoma were enrolled (age ≥12; Karnofsky Performance Score ≥80; measurable non-enhancing disease; surgery as only prior treatment; not in immediate need of chemoradiotherapy). Patients were stratified by 1p19q status and baseline tumor size and randomized 1:1 to VOR 40 mg or placebo (PBO) daily in 28-day cycles. Endpoints included imaging-based progression-free survival (PFS), time to next intervention (TTNI), tumor growth rate (TGR), health-related quality of life (HRQoL), neurocognition and seizure activity. Results: 331 patients were randomized (VOR, 168; PBO, 163). The median age was 40.0 years. 172 and 159 patients had histologically confirmed oligodendroglioma and astrocytoma, respectively. Treatment with VOR significantly improved PFS and TTNI. Median PFS: VOR, 27.7 mos; PBO, 11.1 mos (P=0.000000067). Median TTNI: VOR, not reached; PBO, 17.8 mos (P=0.000000019). Treatment with VOR resulted in shrinkage of tumor volume. Post-treatment TGR: VOR, -2.5% (95% CI: -4.7, -0.2); PBO, 13.9% (95% CI: 11.1, 16.8). HRQoL and neurocognition were preserved and seizure control was maintained. VOR had a manageable safety profile. Conclusions: VOR was effective in mIDH1/2 diffuse glioma not in immediate need of chemoradiotherapy.

Providing access to food in schools can serve as a platform for food system transformation, while simultaneously improving educational outcomes and livelihoods. Locally grown and procured food is a nutritious, healthy, and efficient way to provide schoolchildren with a daily meal while, at the same time, improving opportunities for smallholder farmers(1). While there is significant potential for school food provision activities to support healthy dietary behaviours in the Pacific Islands region, there is limited evidence of these types of activities(2), including scope and links to local food production in the region. Therefore, the aim of this scoping study was to understand the current state of school food activities (school feeding, gardening and other food provision activities) and any current, and potential links to local agriculture in the Pacific Islands. A regional mapping activity was undertaken, initially covering 22 Pacific Island countries. The mapping included two steps: 1) a desk based scoping review including peer-reviewed and grey literature (2007-2022) and 2) One-hour semi-structured online Zoom interviews with key country stakeholders. Twelve sources were identified, predominately grey literature (n = 9). Thirty interviews were completed with at least 1 key stakeholder from 15 countries. A variety of school food provision activities were identified, including school feeding programs (n = 16, of varying scale), programs covering both school feeding and school gardens (n = 2), school garden programs (n = 12), and other school food provision activities (n = 4, including taste/sensory education, food waste reduction, increasing canteen capacity for local foods, supply chain distribution between local agriculture and schools). Existing links to local agriculture varied for the different programs. Of the 16 school feeding programs, 8 had a requirement for the use of local produce (policy requirement n = 6, traditional requirement from leaders n = 2). Of the 12 school garden programs, 6 used local or traditional produce in the garden and 5 involved local farmers in varying capacities. Challenges to linking local agriculture into school food provision programs were reported for 17 activities and were context dependent. Common challenges included limited funding, inflation, Covid-19, inadequate produce supply for the scale of program, limited farmer capacity, limited institutional support for local produce, low produce storage life, climatic conditions and disasters, water security, delayed procurement process, and limited professional development and upskilling opportunities. Modernisation and colonisation of food systems resulting in a preference for hyperpalatable foods and challenges in incorporating local produce in a way that is accepted by students was also identified as a challenge. This evidence can be used to develop a pathway to piloting and implementing models of school food provision programs and promoting opportunities for shared learning and collaboration with key stakeholders across the Pacific Islands region.

Schools provide a unique opportunity to educate and motivate Pacific Island students and the wider Pacific Island community about food systems, food production activities (e.g., gardening and cooking) and to focus on the knowledge and skills needed to make healthy and sustainable food choices. Recent work(1) has identified limited access to appropriate and credible learning and teaching resources and varying integration of food and nutrition in the curriculum across the Pacific Islands (P.I) region. Teachers reported an ardent desire to incorporate nutrition into the curriculum, but were not sure how to do this, or where to source assistance, including credible learning materials. Stakeholders also reported requiring assistance to develop contextualised learning materials, and that there were limited options for upskilling in food, nutrition and agriculture. Recommendations from this work included the development of a tool to assist teachers to bridge the gap between understanding the benchmark or learning outcomes provided in curriculum and designing engaging and authentic activities and assessment to meet these. Therefore, this project aimed to identify food and nutrition curriculum materials available for Pacific Island educators, to inform the development of a web-based resource. In 2022, a systematic desk-based scoping activity was undertaken to identify any resources available to teach food and nutrition in Pacific Island schools (primary and secondary level) and professional development opportunities relevant for educators. The mapping identified over 70 resources, with resources from almost all countries identified. Some are available for specific countries, but few that are designed for use regionally. Some of these resources are directly aligned to food-based dietary guidelines, while others appear to be developed for specific activities by non-governmental organisations. Very few professional development activities were identified. Once a resource was identified, the project team used the CRAAP test(2) to evaluate the credibility of this. If deemed credible, the resource was tagged with key words (e.g., Tonga, gardening) and added for inclusion. The key resource categories (for tagging) were cooking, ocean and waterway foods, food in schools, food safety, healthy eating, sustainability, pacific research, teaching practice, gardening and WASH. A web designer developed the web-based resource through collaboration with the project team. Users can search for resources by country and/or topic. Based on the mapping of professional development activities, a professional development activity based on assessing the credibility of information was developed and added to the L&T toolkit. Users of the hub can share resources (their own) or identify other resources that could be added to the hub. There are limited resources and opportunities for Pacific Island food and nutrition teachers to upskill in food and nutrition education. School educators may benefit from more food and nutrition resources and professional development activities to complement those that are currently available.

Chemical denudation and chemical weathering rates vary under climatic, bedrock, biotic, and topographic conditions. Constraints for landscape evolution models must consider changes in these factors on human and geologic time scales. Changes in nutrient dynamics, related to the storage and exchange of K+ in clay minerals as a response to land use change, can affect the rates of chemical weathering and denudation. Incorporation of these changes in landscape evolution models can add insight into how land use changes affect soil thickness and erodibility. In order to assess changes in soil clay mineralogy that result from land-use differences, the present study contrasts the clay mineral assemblages in three proximal sites that were managed differently over nearly the past two centuries where contemporary vegetation was dominated by old hardwood forest, old-field pine, and cultivated biomes. X-ray diffraction (XRD) of the oriented clay fraction using K-, Mg-, and Na-saturation treatments for the air-dried, ethylene glycol (Mg-EG and K-EG) solvated, and heated (100, 350, and 550°C) states were used to characterize the clay mineral assemblages. XRD patterns of degraded biotite (oxidized Fe and expelled charge-compensating interlayer K) exhibited coherent scattering characteristics similar to illite. XRD patterns of the Mg-EG samples were, therefore, accurately modeled using NEWMOD2® software by the use of mineral structure files for discrete illite, vermiculite, kaolinite, mixed-layer kaolinite-smectite, illite-vermiculite, kaolinite-illite, and hydroxy-interlayered vermiculite. The soil and upper saprolite profiles that formed on a Neoproterozoic gneiss in the Calhoun Experimental Forest in South Carolina, USA, revealed a depth-dependence for the deeply weathered kaolinitic to the shallowly weathered illitic/vermiculitic mineral assemblages that varied in the cultivated, pine, and hardwood sites, respectively. An analysis of archived samples that were collected over a five-decade growth period from the pine site suggests that the content of illite-like layers increased at the surface within 8 y. Historical management of the sites has resulted in different states of dynamic equilibrium, whereby deep rooting at the hardwood and pine sites promotes nutrient uplift of K from the weathering of orthoclase and micas. Differences in the denudation rates at the cultivated, pine, and hardwood sites through time were reflected by changes in the soil clay mineralogy. Specifically, an increased abundance of illite-like layers in the surface soils can serve as a reservoir of K+.

Advance consent could allow individuals at high risk of stroke to provide consent before they might become eligible for enrollment in acute stroke trials. This survey explores the acceptability of this novel technique to Canadian Research Ethics Board (REB) chairs that review acute stroke trials. Responses from 15 REB chairs showed that majority of respondents expressed comfort approving studies that adopt advance consent. There was no clear preference for advance consent over deferral of consent, although respondents expressed significant concern with broad rather than trial-specific advance consent. These findings shed light on the acceptability of advance consent to Canadian ethics regulators.

Standardised methodologies for assessing reef-derived sediment generation rates do not presently exist. This represents a major knowledge gap relevant to better predicting reef-derived shoreline sediment supply. The census-based SedBudget method introduced here generates estimates of sediment composition and grain-size production as a function of the abundance and productivity of the major sediment-generating taxa at a reef site. Initial application of the method to several reefs in the northern Chagos Archipelago, Indian Ocean, generated total sediment generation estimates ranging from (mean ± SE) 0.7 ± 0.1 to 4.3 ± 1.3 kg CaCO3 m−2 yr−1. Sediment production was dominated by parrotfishes (>90% at most sites), with site-variable secondary contributions from sea urchins (up to 20%), endolithic sponges (~1–7%) and benthic foraminifera (~0.5–3.5%). These taxa-level contributions are predicted to generate sediments that at all sites are coral- (83–94%) and crustose coralline algae-dominated (range ~ 5–12%). Comparisons between these estimates and sedimentary data from proximal reef and island beach samples generally show a high degree of consistency, suggesting promise in the SedBudget approach. We conclude by outlining areas where additional datasets and revised methodologies are most needed to improve rate estimates and hope that the methodology will stimulate research on questions around sediment production, transport and shoreline maintenance.

In ad 872–3 a large Viking Army overwintered at Torksey, on the River Trent in Lincolnshire. We have previously published the archaeological evidence for its camp, but in this paper we explore what happened after the Army moved on. We integrate the findings of previous excavations with the outcomes of our fieldwork, including magnetometer and metal-detector surveys, fieldwalking and targeted excavation of a kiln and cemetery enclosure ditch. We provide new evidence for the growth of the important Anglo-Saxon town at Torksey and the development of its pottery industry, and report on the discovery of the first glazed Torksey ware, in an area which has a higher density of Late Saxon kilns than anywhere else in England. Our study of the pottery industry indicates its continental antecedents, while stable isotope analysis of human remains from the associated cemetery indicates that it included non-locals, and we demonstrate artefactual links between the nascent town and the Vikings in the winter camp. We conclude that the Viking Great Army was a catalyst for urban and industrial development in Torksey and suggest the need to reconsider our models for Late Saxon urbanism.

Advance consent presents a potential solution to the challenge of obtaining informed consent for participation in acute stroke trials. Clinicians in stroke prevention clinics are uniquely positioned to identify and seek consent from potential stroke trial participants. To assess the acceptability of advance consent to Canadian stroke clinic physicians, we performed an online survey. We obtained 58 respondents (response rate 35%): the vast majority (82%) expressed comfort with obtaining advance consent and 92% felt that doing so would not be a significant disruption to clinic workflow. These results support further study of advance consent for acute stroke trials.

It has been shown that, in small groups of intact male domestic turkeys, supplementary ultraviolet (UV-A) radiation, visual barriers, and added straw (environmental enrichment) minimize the incidence of injurious pecking under incandescent light at 5 lux. This paper describes two experiments, each involving eight groups of 100 non beak-trimmed birds up to 5 weeks of age, that assessed the effectiveness of these procedures at higher light intensities and with fluorescent light. Experiment 1 examined 5 or 10 lux of incandescent or fluorescent light. Experiment 2 studied responses to 5, 10, 36 or 70 lux of fluorescent light. Individual inspections of the birds, for wing, tail and head injuries due to pecking, were conducted daily.

Fluorescent light significantly reduced the incidence of tail injuries (P = 0.03), and tended to reduce those to the wings (P = 0.08), compared with incandescent light. No difference was observed between 5 and 10 lux for either tail or wing injuries. In Experiment 2, the incidence of tail and wing injuries was significantly and positively correlated with light intensity (tail, P = 0.05; wing, P = 0.02). Injuries to the head were minimal in all treatments. These results suggest that turkey poults may be kept with minimal injurious pecking, under fluorescent light at an intensity of 10 lux, with appropriate environmental enrichment.

The 2022 update of the Canadian Stroke Best Practice Recommendations (CSBPR) for Acute Stroke Management, 7th edition, is a comprehensive summary of current evidence-based recommendations, appropriate for use by an interdisciplinary team of healthcare providers and system planners caring for persons with an acute stroke or transient ischemic attack. These recommendations are a timely opportunity to reassess current processes to ensure efficient access to acute stroke diagnostics, treatments, and management strategies, proven to reduce mortality and morbidity. The topics covered include prehospital care, emergency department care, intravenous thrombolysis and endovascular thrombectomy (EVT), prevention and management of inhospital complications, vascular risk factor reduction, early rehabilitation, and end-of-life care. These recommendations pertain primarily to an acute ischemic vascular event. Notable changes in the 7th edition include recommendations pertaining the use of tenecteplase, thrombolysis as a bridging therapy prior to mechanical thrombectomy, dual antiplatelet therapy for stroke prevention,1 the management of symptomatic intracerebral hemorrhage following thrombolysis, acute stroke imaging, care of patients undergoing EVT, medical assistance in dying, and virtual stroke care. An explicit effort was made to address sex and gender differences wherever possible. The theme of the 7th edition of the CSBPR is building connections to optimize individual outcomes, recognizing that many people who present with acute stroke often also have multiple comorbid conditions, are medically more complex, and require a coordinated interdisciplinary approach for optimal recovery. Additional materials to support timely implementation and quality monitoring of these recommendations are available at www.strokebestpractices.ca.