For an open subset Ω of the Euclidean space Rn, a measurable non-singular transformation T: Ω → Ω and a real-valued measurable function u on Rn, we study the weighted composition operator uCτ: f ↦ u · (f º T) on the Orlicz-Sobolev space W1·Ψ (Ω) consxsisting of those functions of the Orlicz space LΨ (Ω) whose distributional derivatives of the first order belong to LΨ (Ω). We also discuss a sufficient condition under which uCτ is compact.