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Providing a succinct overview of Lindenmayer system (L-system) topology optimization, this book focuses on the methods and theory underlying this novel bioinspired approach. Starting from basic principles, the book outlines how topology optimization can be utilized at the conceptual design stage and shows how it offers straightforward applicability to multi-objective and/or multi-physical industrial problems. Design strategies are clearly demonstrated using a host of case studies and real-world examples, and their potential challenges and solutions are discussed. Written from an optimization and design perspective, the authors both summarize the latest advances in this field and suggest potential avenues of research and development for future work. This will be the ideal resource for engineering practitioners, researchers, and students wanting to gain a new perspective on using topology optimization to improve product design.
Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.
The Australian SKA Pathfinder (ASKAP) offers powerful new capabilities for studying the polarised and magnetised Universe at radio wavelengths. In this paper, we introduce the Polarisation Sky Survey of the Universe’s Magnetism (POSSUM), a groundbreaking survey with three primary objectives: (1) to create a comprehensive Faraday rotation measure (RM) grid of up to one million compact extragalactic sources across the southern ∼ 50 per cent of the sky (20,630 deg2); (2) to map the intrinsic polarisation and RM properties of a wide range of discrete extragalactic and Galactic objects over the same area; and (3) to contribute interferometric data with excellent surface brightness sensitivity, which can be combined with single-dish data to study the diffuse Galactic interstellar medium. Observations for the full POSSUM survey commenced in May 2023 and are expected to conclude by mid-2028. POSSUM will achieve an RM grid density of around 30–50 RMs per square degree with a median measurement uncertainty of ∼1 rad m−2. The survey operates primarily over a frequency range of 800–1088 MHz, with an angular resolution of 20″ and a typical RMS sensitivity in Stokes Q or U of 18 μJy beam−1. Additionally, the survey will be supplemented by similar observations covering 1296–1440 MHz over 38 per cent of the sky. POSSUM will enable the discovery and detailed investigation of magnetized phenomena in a wide range of cosmic environments, including the intergalactic medium and cosmic web, galaxy clusters and groups, active galactic nuclei and radio galaxies, the Magellanic System and other nearby galaxies, galaxy halos and the circumgalactic medium, and the magnetic structure of the Milky Way across a very wide range of scales, as well as the interplay between these components. This paper reviews the current science case developed by the POSSUM Collaboration and provides an overview of POSSUM’s observations, data processing, outputs, and its complementarity with other radio and multi-wavelength surveys, including future work with the SKA.
We present the Evolutionary Map of the Universe (EMU) survey conducted with the Australian Square Kilometre Array Pathfinder (ASKAP). EMU aims to deliver the touchstone radio atlas of the southern hemisphere. We introduce EMU and review its science drivers and key science goals, updated and tailored to the current ASKAP five-year survey plan. The development of the survey strategy and planned sky coverage is presented, along with the operational aspects of the survey and associated data analysis, together with a selection of diagnostics demonstrating the imaging quality and data characteristics. We give a general description of the value-added data pipeline and data products before concluding with a discussion of links to other surveys and projects and an outline of EMU’s legacy value.
Traditional foods are increasingly being incorporated into modern diets. This is largely driven by consumers seeking alternative food sources that have superior nutritional and functional properties. Within Australia, Aboriginal and Torres Strait Islander peoples are looking to develop their traditional foods for commercial markets. However, supporting evidence to suggest these foods are safe for consumption within the wider general population is limited. At the 2022 NSA conference a keynote presentation titled ‘Decolonising food regulatory frameworks to facilitate First Peoples food sovereignty’ was presented. This presentation was followed by a manuscript titled ‘Decolonising food regulatory frameworks: Importance of recognising traditional culture when assessing dietary safety of traditional foods’, which was published in the conference proceedings journal(1). These pieces examined the current regulatory frameworks that are used to assess traditional foods and proposed a way forward that would allow Traditional Custodians to successfully develop their foods for modern markets. Building upon the previously highlighted works, this presentation will showcase best practice Indigenous engagement and collaboration principles in the development of traditionally used food products. To achieve this, we collaborated with a collective of Gamilaraay peoples who are looking to reignite their traditional grain practices and develop grain-based food products. To meet the current food safety regulatory requirements, we needed to understand how this grain would fit into modern diets, which included understanding the history of use, elucidating the nutritional and functional properties that can be attributed to the grain, and developing a safety dossier(2) so that the Traditional Custodians can confidently take their product to market. To aid the Traditional Custodians in performing their due diligence, we have systemically analysed the dietary safety of the selected native grain and compared it side-by-side with commonly consumed wheat in a range of in vitro bioassays and chemical analyses. From a food safety perspective, we show that the native grain is equivalent to commonly consumed wheat. The native grain has been shown to be no more toxic than wheat within our biological screening systems. Chemical analysis showed that the level of contaminants are below tolerable limits, and we were not able to identify any chemical classes of concern. Our initial findings support the history of safe use and suggest that the tested native grain species would be no less safe than commonly consumed wheat. This risk assessment and previously published nutritional study(3) provides an overall indication that the grain is nutritionally superior and viable for commercial development. The learnings from this project can direct the future risk assessment of traditional foods and therefore facilitate the safe market access of a broader range of traditionally used foods. Importantly, the methods presented are culturally safe and financially viable for the small businesses hoping to enter the market.
The World Cancer Research Fund and the American Institute for Cancer Research recommend a plant-based diet to cancer survivors, which may reduce chronic inflammation and excess adiposity associated with worse survival. We investigated associations of plant-based dietary patterns with inflammation biomarkers and body composition in the Pathways Study, in which 3659 women with breast cancer provided validated food frequency questionnaires approximately 2 months after diagnosis. We derived three plant-based diet indices: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI) and unhealthful plant-based diet index (uPDI). We assayed circulating inflammation biomarkers related to systemic inflammation (high-sensitivity C-reactive protein [hsCRP]), pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, IL-13). We estimated areas (cm2) of muscle and visceral and subcutaneous adipose tissue (VAT and SAT) from computed tomography scans. Using multivariable linear regression, we calculated the differences in inflammation biomarkers and body composition for each index. Per 10-point increase for each index: hsCRP was significantly lower by 6·9 % (95 % CI 1·6%, 11·8%) for PDI and 9·0 % (95 % CI 4·9%, 12·8%) for hPDI but significantly higher by 5·4 % (95 % CI 0·5%, 10·5%) for uPDI, and VAT was significantly lower by 7·8 cm2 (95 % CI 2·0 cm2, 13·6 cm2) for PDI and 8·6 cm2 (95 % CI 4·1 cm2, 13·2 cm2) for hPDI but significantly higher by 6·2 cm2 (95 % CI 1·3 cm2, 11·1 cm2) for uPDI. No significant associations were observed for other inflammation biomarkers, muscle, or SAT. A plant-based diet, especially a healthful plant-based diet, may be associated with reduced inflammation and visceral adiposity among breast cancer survivors.
Posttraumatic stress disorder (PTSD) has been associated with advanced epigenetic age cross-sectionally, but the association between these variables over time is unclear. This study conducted meta-analyses to test whether new-onset PTSD diagnosis and changes in PTSD symptom severity over time were associated with changes in two metrics of epigenetic aging over two time points.
Methods
We conducted meta-analyses of the association between change in PTSD diagnosis and symptom severity and change in epigenetic age acceleration/deceleration (age-adjusted DNA methylation age residuals as per the Horvath and GrimAge metrics) using data from 7 military and civilian cohorts participating in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (total N = 1,367).
Results
Meta-analysis revealed that the interaction between Time 1 (T1) Horvath age residuals and new-onset PTSD over time was significantly associated with Horvath age residuals at T2 (meta β = 0.16, meta p = 0.02, p-adj = 0.03). The interaction between T1 Horvath age residuals and changes in PTSD symptom severity over time was significantly related to Horvath age residuals at T2 (meta β = 0.24, meta p = 0.05). No associations were observed for GrimAge residuals.
Conclusions
Results indicated that individuals who developed new-onset PTSD or showed increased PTSD symptom severity over time evidenced greater epigenetic age acceleration at follow-up than would be expected based on baseline age acceleration. This suggests that PTSD may accelerate biological aging over time and highlights the need for intervention studies to determine if PTSD treatment has a beneficial effect on the aging methylome.
In contrast to the previous two chapters, which detailed L-system topology optimization approaches that interpret gene-informed rules into a complex set of layout-building instructions, this chapter introduces a grammar-to-layout approach known as the Arrangement L-system (ALS). Here, developmental operations that mimic the processes of cellular division, growth, and movement are directly informed by the genes and then iteratively applied to an iteratively changing topological layout that, once complete, represents an individual. The differences between formulations of the L-system, parameterized L-system, and ALS are discussed; examples of how the cellular division processes are used to develop a topological layout are provided; and extensions to the ALS such as directed search cellular dynamics and cellular division via the two-point topological derivative are detailed. The applicability of the ALS to a variety of structural design problems will be demonstrated, and it will be shown that this approach compares favorably with both conventional topology optimization methods discussed throughout this work as well as the graph-based SPIDRS approach introduced in the previous chapter.
Topology optimization is a powerful tool that, when employed at the preliminary stage of the design process, can determine potential structural configurations that best satisfy specified performance objectives. This chapter explores both the different classifications of topology optimization methodologies and their implementation within the design process, specifically highlighting potential areas where such techniques may fall short. This motivates a discussion on the relevance of a bioinspired approach to topology optimization known as EvoDevo, where topologies developed by interpreting instructions from a Lindenmayer system (L-system) encoding are evolved using a genetic algorithm. Such an approach can lend itself well to multiobjective design problems with a vast design space and for which users have little/no experience or intuition.
To this point, the proposed L-system topology optimization methods have been considered in the context of benchmark structural topology optimization problems, as such problems afford an opportunity for comparison to both other topology optimization methodologies and mathematically proven optimal or ideal solutions. However, the motivation behind the development of these approaches stems from the need for preliminary design method capable of considering complex multiobjective problems involving multiple physics for which the user may not have an intuition. This chapter briefly summarizes several multiphysical problems that have been approached using L-system topology optimization, including fluid transport, heat transfer, electrical, and aeroelastic applications. By no means an exhaustive survey, these examples are intended to provide an overview of potential applications and hopefully provoke opportunities for future efforts.
To address the need for an inherently multiobjective preliminary design tool, this chapter introduces a heuristic alternative to the conventional topology optimization approaches discussed in the previous chapter. Specifically, a parallel rewriting system known as a Lindenmayer system (L-system) is used to encode a limited number of design variables into a string of characters which, when interpreted using a deterministic algorithm, governs the development of a topology. The general formulation of L-systems is provided before discussing how L-system encodings can be interpreted using a graphical method known as turtle graphics. Turtle graphics constructs continuous, straight line segments by tracking the spatial position and orientation of a line-constructing agent, leading to the creation of branched structures that mimic those found in numerous natural systems. The performance of the proposed method is then assessed using simple, well-known topology optimization problems and comparisons to mathematically known optimal or ideal solutions as well as those generated using conventional topology optimization methodologies.
While the L-system approach introduced in the previous chapter exhibits potential for topology optimization applications, the modeling power of the turtle graphics interpretation is severely limited due to its reliance on limited parameters and its inability to guarantee the deliberate formation of load paths. Based on these characteristics, this chapter introduces a graph-based interpretation approach known as Spatial Interpretation for the Development of Reconfigurable Structures (SPIDRS) that uses principles of graph theory to allow an edge-constructing agent to introduce deliberate topological modifications. Furthermore, SPIDRS operates using instructions generated by a parametric L-system, which enhances modeling power and affords greater design freedom. This approach can also be extended to consider a three-dimensional structural design domain. It will be demonstrated that this interpretation approach results in configurations comparable to known optimal/ideal solutions as well as those found using conventional topology optimization methods, especially when coupled with a sizing optimization scheme to determine optimal structural member thicknesses.