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Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and functioning in patients with first episode psychosis (FEP), their siblings, and controls.
Methods
We analyzed a sample of 543 participants with FEP, 203 siblings, and 1168 controls from the EU-GEI study using a correlational design. We used logistic regression analyses to examine the influence of clinical group, lifetime cannabis use frequency, and potency of cannabis use on cognitive biases, accounting for demographic and cognitive variables.
Results
FEP patients showed increased odds of facial recognition processing (FRP) deficits (OR = 1.642, CI 1.123–2.402) relative to controls but not of speech illusions (SI) or jumping to conclusions (JTC) bias, with no statistically significant differences relative to siblings. Daily and occasional lifetime cannabis use were associated with decreased odds of SI (OR = 0.605, CI 0.368–0.997 and OR = 0.646, CI 0.457–0.913 respectively) and JTC bias (OR = 0.625, CI 0.422–0.925 and OR = 0.602, CI 0.460–0.787 respectively) compared with lifetime abstinence, but not with FRP deficits, in the whole sample. Within the cannabis user group, low-potency cannabis use was associated with increased odds of SI (OR = 1.829, CI 1.297–2.578, FRP deficits (OR = 1.393, CI 1.031–1.882, and JTC (OR = 1.661, CI 1.271–2.171) relative to high-potency cannabis use, with comparable effects in the three clinical groups.
Conclusions
Our findings suggest increased odds of cognitive biases in FEP patients who have never used cannabis and in low-potency users. Future studies should elucidate this association and its potential implications.
Tobacco is a highly prevalent substance of abuse in patients with psychosis. Previous studies have reported an association between tobacco use and schizophrenia. The aim of this study was to analyze the relationship between tobacco use and first-episode psychosis (FEP), age at onset of psychosis, and specific diagnosis of psychosis.
Methods
The sample consisted of 1105 FEP patients and 1355 controls from the European Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study. We assessed substance use with the Tobacco and Alcohol Questionnaire and performed a series of regression analyses using case-control status, age of onset of psychosis, and diagnosis as outcomes and tobacco use and frequency of tobacco use as predictors. Analyses were adjusted for sociodemographic characteristics, alcohol, and cannabis use.
Results
After controlling for cannabis use, FEP patients were 2.6 times more likely to use tobacco [p ⩽ 0.001; adjusted odds ratio (AOR) 2.6; 95% confidence interval (CI) [2.1–3.2]] and 1.7 times more likely to smoke 20 or more cigarettes a day (p = 0.003; AOR 1.7; 95% CI [1.2–2.4]) than controls. Tobacco use was associated with an earlier age at psychosis onset (β = −2.3; p ⩽ 0.001; 95% CI [−3.7 to −0.9]) and was 1.3 times more frequent in FEP patients with a diagnosis of schizophrenia than in other diagnoses of psychosis (AOR 1.3; 95% CI [1.0–1.8]); however, these results were no longer significant after controlling for cannabis use.
Conclusions
Tobacco and heavy-tobacco use are associated with increased odds of FEP. These findings further support the relevance of tobacco prevention in young populations.
The comprehensive implementation of digital technologies in product manufacturing leads to changes in engineering processes and requires new approaches to data management. An important role belongs to the processes of organizing the collection, storage and reuse of research data obtained and used in the process of product, system or technology development, taking into account the FAIR data principles. This article describes a Research Data Management System for the organization of documentation and measurement requests in the research and development of new oxygen-free production technologies.
A fundamental question for theories of massive star formation is whether OB stars can form in isolation. We assess the contribution of any in-situ OB star formation by using 210 field OB stars in the Small Magellanic Cloud (SMC) from the Runaways and Isolated O-Type Star Spectroscopic Survey of the SMC (RIOTS4). We search for tiny, sparse clusters around our target OB stars using cluster-finding algorithms. Employing statistical tests, we compare these observations with random-field data sets. We find that ∼5% of our target fields do show evidence of higher central stellar densities, implying the presence of small clusters. This frequency of small clusters is low and within errors, it is also consistent with the field OB population being composed entirely of runaway and walkaway stars. Assuming this small cluster fraction is real, it implies that some OB stars may form in highly isolated conditions. The low frequency could be caused by these clusters evaporating on a short timescale. However, another interpretation is that the low fraction of small clusters is observed because these form rarely, or not at all, implying a higher cluster lower-mass limit and generally consistent with a relationship between maximum stellar mass (mmax) and the cluster mass (Mcl).
The objective of this study was to analyse the dynamics of spatial dispersion of the coronavirus disease 2019 (COVID-19) in Brazil by correlating them to socioeconomic indicators. This is an ecological study of COVID-19 cases and deaths between 26 February and 31 July 2020. All Brazilian counties were used as units of analysis. The incidence, mortality, Bayesian incidence and mortality rates, global and local Moran indices were calculated. A geographic weighted regression analysis was conducted to assess the relationship between incidence and mortality due to COVID-19 and socioeconomic indicators (independent variables). There were confirmed 2 662 485 cases of COVID-19 reported in Brazil from February to July 2020 with higher rates of incidence in the north and northeast. The Moran global index of incidence rate (0.50, P = 0.01) and mortality (0.45 with P = 0.01) indicate a positive spatial autocorrelation with high standards in the north, northeast and in the largest urban centres between cities in the southeast region. In the same period, there were 92 475 deaths from COVID-19, with higher mortality rates in the northern states of Brazil, mainly Amazonas, Pará and Amapá. The results show that there is a geospatial correlation of COVID-19 in large urban centres and regions with the lowest human development index in the country. In the geographic weighted regression, it was possible to identify that the percentage of people living in residences with density higher than 2 per dormitory, the municipality human development index (MHDI) and the social vulnerability index were the indicators that most contributed to explaining incidence, social development index and the municipality human development index contributed the most to the mortality model. We hope that the findings will contribute to reorienting public health responses to combat COVID-19 in Brazil, the new epicentre of the disease in South America, as well as in other countries that have similar epidemiological and health characteristics to those in Brazil.
Bipolar disorder is a chronic, recurrent and debilitating mood disorder with a major impact on several aspects of everyday life. Although pharmacotherapy plays a central role in bipolar disorder treatment, psychosocial interventions are essential to a more complete and successful treatment.
Aims:
To present a psychoeducation program for bipolar patients runned in a Portuguese psychiatric hospital - Hospital de Magalhães Lemos, Oporto. To review the impact of psychoeducative measures on bipolar patients.
Methods:
A psychoeducative program for bipolar patients was developed and adapted, based on the Barcelona Bipolar Disorders Program"s experience. The psychoeducative program was applied to bipolar patients as an adjuvant of maintenance treatment.
Results:
Fifteen sessions were runned during 15 weeks. Twelve patients were recruited to integrate the psychoeducative group. The sessions addressed several topics including information about the illness, early detection of prodromal symptoms and symptoms management, stress management and the importance of maintaining routines.
Conclusions:
The best treatment available for patients with bipolar disorder includes, along with the pharmacological treatment, psychosocial interventions aimed to target issues as early identification of prodromal symptoms, coping skills, medication adherence and understanding of the disorder. This broader approach of bipolar disorder treatment has proved to be efficient in reducing relapse rates, and improving patients’ feelings of self-efficacy and quality of life.
The bovine appeasing substance (BAS) is expected to have calming effects in cattle experiencing stressful situations. Therefore, this study investigated the impacts of BAS administration during two of the most stressful events within beef production systems: weaning and feedlot entry. In experiment 1, 186 Bos indicus-influenced calves (73 heifers, 113 bulls) were weaned at 211 ± 1 days of age (day 0). At weaning, calves were ranked by sex and BW, and assigned to receive BAS (Nutricorp, Araras, SP, Brazil; n = 94) or water (CON; n = 92). Treatments (5 ml) were topically applied to the nuchal skin area of each animal. Calf BW was recorded and samples of blood and tail-switch hair were collected on days 0, 15 and 45. Calves that received BAS had greater (P < 0.01) BW gain from day 0 to 15 compared with CON. Overall BW gain (days 0 to 45) and BW on days 15 and 45 were also greater (P ≤ 0.03) in BAS v. CON. Plasma haptoglobin concentration was less (P < 0.01) in BAS v. CON on day 15, whereas cortisol concentrations in plasma and tail-switch hair did not differ between treatments (P ≥ 0.13). In experiment 2, 140 B. indicus-influenced bulls (∼27 months of age) from 2 different pasture-based systems (70 bulls/origin) were transported to a commercial feedlot (≤ 200-km transport; day -1). On day 0, bulls were ranked by source and BW, and assigned to receive BAS (n = 70) or CON (n = 70) and the same sampling procedures as in experiment 1. Bulls receiving BAS had greater (P = 0.04) BW gain from day 0 to 15, but less (P < 0.01) BW gain from day 15 to 45 compared to CON. No other treatment effects were detected (P > 0.14). Therefore, BAS administration to beef calves alleviated the haptoglobin response associated with weaning, and improved calf growth during the subsequent 45 days. Administration of BAS to beef bulls at feedlot entry improved BW gain during the initial 15 days, but these benefits were not sustained throughout the 45-day experiment.
The B fields in OB stars (BOB) survey is an ESO large programme collecting spectropolarimetric observations for a large number of early-type stars in order to study the occurrence rate, properties, and ultimately the origin of magnetic fields in massive stars. As of July 2014, a total of 98 objects were observed over 20 nights with FORS2 and HARPSpol. Our preliminary results indicate that the fraction of magnetic OB stars with an organised, detectable field is low. This conclusion, now independently reached by two different surveys, has profound implications for any theoretical model attempting to explain the field formation in these objects. We discuss in this contribution some important issues addressed by our observations (e.g., the lower bound of the field strength) and the discovery of some remarkable objects.
This study investigated the effects of maternal separation on the feeding behavior of rats. A maternal separation model was used on postnatal day 1 (PND1), forming the following groups: in the maternal separation (MS) group, pups were separated from their mothers each day from PND1 to PND14, whereas in the control (C) group pups were kept with their mothers. Subgroups were formed to study the effects of light and darkness: control with dark and light exposure, female and male (CF and CM), and maternal separation with dark and light exposure, female and male (SDF, SDM, SLF and SLM). Female rats had higher caloric intake relative to body weight compared with male controls in the dark period only (CF=23.3±0.5 v. CM=18.2±0.7, P<0.001). Macronutrient feeding preferences were observed, with male rats exhibiting higher caloric intake from a protein diet as compared with female rats (CF=4.1±0.7, n=8 v. CM=7.0±0.5, n=8, P<0.05) and satiety development was not interrupted. Female rats had a higher adrenal weight as compared with male rats independently of experimental groups and exhibited a higher concentration of serum triglycerides (n=8, P<0.001). The study indicates possible phenotypic adjustments in the structure of feeding behavior promoted by maternal separation, especially in the dark cycle. The dissociation between the mother’s presence and milk intake probably induces adjustments in feeding behavior during adulthood.
A continuously monitored system is considered, which is subject to accumulating deterioration modelled as a gamma process. The system fails when its degradation level exceeds a limit threshold. At failure, a delayed replacement is performed. To shorten the down period, a condition-based maintenance strategy is applied, with imperfect repair. Mimicking virtual age models used for recurrent events, imperfect repair actions are assumed to lower the system degradation through a first-order arithmetic reduction of age model. Under these assumptions, Markov renewal equations are obtained for several reliability indicators. Numerical examples illustrate the behaviour of the system.
The Ultra-Fast Flash Observatory (UFFO), which will be launched onboard theLomonosov spacecraft, contains two crucial instruments: UFFO BurstAlert & Trigger Telescope (UBAT) for detection and localization of Gamma-Ray Bursts(GRBs) and the fast-response Slewing Mirror Telescope (SMT) designed for the observationof the prompt optical/UV counterparts. Here we discuss the in-space calibrations of theUBAT detector and SMT telescope. After the launch, the observations of the standard X-raysources such as pulsar in Crab nebula will provide data for necessary calibrations ofUBAT. Several standard stars will be used for the photometric calibration of SMT. Thecelestial X-ray sources, e.g. X-ray binaries with bright optical sourcesin their close angular vicinity will serve for the cross-calibration of UBAT and SMT.
The Ultra-Fast Flash Observatory (UFFO) Pathfinder for Gamma-Ray Bursts (GRBs) consistsof two telescopes. The UFFO Burst Alert & Trigger Telescope (UBAT) handles thedetection and localization of GRBs, and the Slewing Mirror Telescope (SMT) conducts themeasurement of the UV/optical afterglow. UBAT is equipped with an X-ray detector, analogand digital signal readout electronics that detects X-rays from GRBs and determines thelocation. SMT is equipped with a stepping motor and the associated electronics to rotatethe slewing mirror targeting the GRBs identified by UBAT. First the slewing mirror pointsto a GRB, then SMT obtains the optical image of the GRB using the intensified CCD and itsreadout electronics. The UFFO Data Acquisition system (UDAQ) is responsible for theoverall function and operation of the observatory and the communication with the satellitemain processor. In this paper we present the design and implementation of the electronicsof UBAT and SMT as well as the architecture and implementation of UDAQ.
One of the unexplored domains in the study of gamma-ray bursts (GRBs) is the early timephase of the optical light curve. We have proposed Ultra-Fast Flash Observatory (UFFO) toaddress this question through extraordinary opportunities presented by a series of smallspace missions. The UFFO is equipped with a fast-response Slewing Mirror Telescope thatuses a rapidly moving mirror or mirror array to redirect the optical beam rather thanslewing the entire spacecraft or telescope to aim the optical instrument at the GRBposition. The UFFO will probe the early optical rise of GRBs with sub-second response, forthe first time, opening a completely new frontier in GRB and transient studies. Its fastresponse measurements of the optical emission of dozens of GRB each year will provideunique probes of the burst mechanism and test the prospect of GRB as a new standardcandle, potentially opening up the z > 10 universe. We describe the current limit inearly photon measurements, the aspects of early photon physics, our soon-to-be-launchedUFFO-pathfinder mission, and our next planned mission, the UFFO-100.
GRB 110715A had a bright afterglow that was obscured in the optical by a high Galactic extinction. We discovered the submillimeter counterpart with APEX and followed it in radio with ATCA for over 2 months. Additional submm observations were performed with ALMA as a test of the ToO procedures during commissioning, becoming the first GRB afterglow to be detected by the observatory. UV, optical and NIR observations were performed with Swift/UVOT and 2.2 m/GROND in La Silla and X-ray data were obtained by Swift/XRT. The dataset is complemented with spectroscopic data from the VLT/X-shooter spectrograph. The absorption features present in the intermediate resolution optical/nIR spectra reveal a redshift of 0.8224 and a host galaxy environment with low ionization. We fit in the host galaxy absorption features two velocity components separated by 30 km/s, implying a host galaxy with low dynamical activity.
The UFFO (Ultra-Fast Flash Observatory) is a GRB detector on board the Lomonosovsatellite, to be launched in 2013. The GRB trigger is provided by an X-ray detector,called UBAT (UFFO Burst Alarm & Trigger Telescope), which detects X-rays from the GRBand then triggers to determine the direction of the GRB and then alerts the Slewing MirrorTelescope (SMT) to turn in the direction of the GRB and record the optical photon fluxes.This report details the calibration of the two components: the MAPMTs and the YSO crystalsand simulations of the UBAT. The results shows that this design can observe a GRB within afield of view of ±35° and can trigger in a time scale as short as 0.2 – 1.0 safter the appearance of a GRB X-ray spike.
The Burst Observer and Optical Transient Exploring System (BOOTES), is a global roboticobservatory network, which started in 1998 with Spanish leadership devoted to studyoptical emissions from gamma ray bursts (GRBs) that occur in the Universe. We present shothistory and current status of BOOTES network. The Network philosophy, science and somedetails of 117 GRBs followed-up are discussed.
The Ultra-Fast Flash Observatory (UFFO) is a space observatory for optical follow-ups ofgamma ray bursts (GRBs), aiming to explore the first 60 seconds of GRBs optical emission.UFFO is utilized to catch early optical emissions from GRBs within few sec after triggerusing a Gimbal mirror which redirects the optical path rather than slewing entirespacecraft. We have developed a 15 cm two-axis Gimbal mirror stage for the UFFO-Pathfinderwhich is going to be on board the Lomonosov satellite which is to be launched in 2013. Thestage is designed for fast and accurate motion with given budgets of 3 kg of mass and 3Watt of power. By employing stepping motors, the slewing mirror can rotate faster than 15deg/sec so that objects in the UFFO coverage (60 deg × 60 deg) can be targeted in~1 sec. The obtained targeting resolution is better 2 arcmin using a close-loopcontrol with high precision rotary encoder. In this presentation, we will discuss detailsof design, manufacturing, space qualification tests, as well as performance tests.
After 22 yr of the low-level liquid scintillation counting 14C laboratory at the Center for Nuclear Energy in Agriculture (CENA) at São Paulo University (USP), Piracicaba, Brazil, and several collaborative projects with Brazilian and international researchers from distinct scientific areas, the first 14C accelerator mass spectrometry (AMS) laboratory in Latin America was installed at the Physics Institute of the Universidade Federal Fluminense (UFF), Niterói, Brazil. A 250kV single stage accelerator produced by National Electrostatics Corporation began its operation in 2012. In this work, we compare measurements performed at the AMS Radiocarbon Laboratory at UFF (LAC-UFF) with those performed at CENA and the University of Georgia (UGAMS), Georgia, USA. All the results obtained from distinct inorganic and organic samples were in very good agreement.
The Ultra-Fast Flash Observatory (UFFO) aims to detect the earliest moment of Gamma-RayBursts (GRBs) which is not well known, resulting into the enhancement of GRB mechanismunderstanding. The pathfinder mission was proposed to be a scaled-down version of UFFO,and only contains the UFFO Burst Alert & Trigger Telescope (UBAT) measuring theX-ray/gamma-ray with the wide-field of view and the Slewing Mirror Telescope (SMT) with arapid-response for the UV/optical photons. Once the UBAT detects a GRB candidate with theposition accuracy of 10 arcmin, the SMT steers the UV/optical photons from the candidateto the telescope by the fast rotatable mirror and provides the early UV/optical photonsmeasurements with 4 arcsec accuracy. The SMT has a modified Ritchey-Chrètien telescopewith the aperture size of 10 cm diameter including the rotatable mirror and the imagereadout by the intensified charge-coupled device. There is a key board called the UFFOData Acquisition system (UDAQ) that manages the communication of each telescope and alsoof the satellite and the UFFO overall operation. This pathfinder is designed and builtwithin the limited size and weight of ~20 kg and the low power consumption up to ~30 W. We will discuss the design and performance of the UFFO-pathfinder, and itsintegration to the Lomonosov satellite.