We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Following the recent report of strongyloidiasis caused by Strongyloides fuelleborni within a semi-captive colony of baboons in a UK safari park, we investigated the genetic relationships of this isolate with other Strongyloides isolates across the world. Whole-genome sequencing data were generated with later phylogenetic analysis of mitochondrial (mt) cytochrome oxidase subunit 1 (cox1) and nuclear ribosomal 18S sequences against 300 published Strongyloides reference genotypes. The putative African origin of the UK S. fuelleborni was confirmed and full-length mt genome sequences were assembled to facilitate a more detailed phylogenetic analysis of 14 mt coding regions against all available Strongyloides species. Our analyses demonstrated that the UK isolate represented a novel African lineage not previously described. Additional complete mt genomes were assembled for several individual UK safari park worms to reveal a slightly altered mt genome gene arrangement, allowing clear separation from Asian S. fuelleborni. Furthermore, these UK worms possessed expanded intergenic regions of unknown function that increase their mt genome size to approximately 24 kilobases (kb) as compared with some 16 kb for Asian S. fuelleborni; this may have arisen from unique populational founder and genetic drift effects set within the peculiar mixed species baboon and drill ancestry of this semi-captive primate colony. A maximum likelihood phylogeny constructed from 14 mt coding regions also supported an evolutionary distinction between Asian and African S. fuelleborni.
At first glance, the handful of Tokyo rightists who created a furor about a graphic scene of the Nanjing Massacre in two September issues of the popular manga magazine Young Jump Weekly are a surprisingly tolerant lot. They restricted their complaint to technical issues in “My Country is Burning” (Kuni ga moeru!) by Motomiya Hiroshi, the only remotely educational series in a popular weekly comic book, and ignored 400 pages of gratuitous sex, violence, scatology and gore that dominates this illustrated publication with a reported circulation of 2 million.
Clashing views about Thailand's future are being played out on the streets of Bangkok, taking the form of forceful demonstrations, contentious commemorations and populist grandstanding by red shirted and yellow shirted rivals. Behind the searing rhetoric and policy clashes are battles of personality, in which patron-client links coalesce, regroup and solidify, rewarding loyalty with a top-down sharing of power and spoils.
What follows is an account of a return visit to Tiananmen Square in commemoration of the 25th anniversary of the peaceful demonstrations and violent crackdown that I witnessed in Beijing in 1989.
Initially I had planned to go to Hong Kong, as I had been invited to join the well-publicized commemoration in Victoria Park where the people of Hong Kong have held a candlelight vigil for the lost souls and lost dreams of 1989 on an annual basis for a quarter of a century now. In past years I have marched with the conscientious objectors of Hong Kong, lit candles in the warm tropical air and drawn strength from the distant but principled and persistent expression of solidarity with the uprising at Tiananmen.
The sniper shooting of Seh Daeng, Maj. Gen. Khattiya Sawasdipol, on May 13, 2010 by an unknown assailant while chatting with foreign reporters has brought to rupture the standoff between Reds and Yellows in the heart of Bangkok and signals a new stage in the movement and its repression. Seh Daeng, whose nickname means “red commander”, was the reddest of the red shirts. His daughter, who sat at his bedside in the hospital until he succumbed to his grievous wounds on May 17, 2010, has been a staunch supporter of the yellow shirts, illustrative of the convoluted politics of the era. To better put in context the convoluted color-coded politics of the present day, and to identify some of the key heroes and villains and historic reference points being talked about on both sides of the barricades in Bangkok, a brief review of Thai political activism over the years will follow.
“Ladies and gentlemen, your attention please. We have just experienced an earthquake. Please move away from the buildings to an open area…We will provide more detailed information as soon as possible…”
The polite but authoritative “we” was the voice of the Tokyo DisneySea theme park in this instance, but similar, oddly reassuring warnings of peril were being echoed across Japan, mostly following the lead of television broadcaster NHK.
A retrospective tour of the haunts and hideouts of the 1989 Tiananmen student uprising would not be complete without a visit to Beijing University, known simply as Beida. Arguably the most prestigious university in China, Beida has long been home to creative thinkers and intellectual ferment ever since the days a young Mao Zedong worked in its associated library and literati such as Hu Shih and Lu Xun graced its grounds.
In 1989 Beida was the fount of discussion and discontent that spread to other campuses. Among Beijing colleges, it was the most distant from Tiananmen, but the Beida contingent always seemed to show up first.
A comment by the female star of the Disney film Mulan, supporting Hong Kong police crackdown on democratic protests has led to a massive boycott of the film in Hong Kong.
My novel, excerpted here, is set in old Beijing, a city of walls in their contemporary incarnations. By old Beijing I don't mean so much the remnants of the Qing Dynasty capital described by twentieth-century writers. The story is contemporary but much of it is set within the confines of the Mongol Dynasty summer capital described by Marco Polo as Cambaluc, and celebrated by Samuel Coleridge in a euphonic fit of imagination in “Kubla Khan.”
This article provides a close examination of a recent CCTV program on the Russian invasion of Ukraine and China-Russian relations in the wake of the war.
With China’s Chang’e 5 rocket launch, which landed on the moon on December 1, the long US-Russian domination of space has a major challenger. The issues extend beyond national pride to a global leadership initiative in rocketry whose implications extend to military, economic and diverse scientific applications at a time of mounting US-China rivalry in all spheres.
With China's Chang'e 5 rocket launch, which landed on the moon on December 1 and deposited a capsule in Inner Mongolia early in the morning on December 17 Beijing time after a 23 day voyage to the moon and back, the long US-Russian domination of space has a major challenger. The issues extend beyond national pride to a global leadership initiative in rocketry whose implications extend to military, economic and diverse scientific applications at a time of mounting US-China rivalry in all spheres.
People with psychosis experience worse cardiometabolic health than the same-aged general population. In New Zealand, Indigenous Māori experiencing psychosis have greater risk of cardiometabolic and other physical health problems.
Aims
To identify a cohort of adults accessing secondary mental health and addiction services in New Zealand, with a previous psychosis diagnosis as of 1 January 2018, and compare odds of hospital admission outcomes, mortality and receipt of cardiometabolic blood screening between Māori and non-Māori in the following 2 years.
Method
Crude and adjusted logistic regression models compared odds of hospital admission outcomes, mortality and receipt of cardiometabolic blood screening (lipids and haemoglobin A1c) between Māori and non-Māori, occurring between 1 January 2018 and 31 December 2019.
Results
A cohort (N = 21 214) of Māori (n = 7274) and non-Māori (n = 13 940) was identified. Māori had higher adjusted risk of mortality (odds ratio 1.26, 95% CI 1.03–1.54), and hospital admission with diabetes (odds ratio 1.64, 95% CI 1.43–1.87), cardiovascular disease (odds ratio 1.54, 95% CI 1.25–1.88) and any physical health condition (odds ratio 1.07, 95% CI 1.00–1.15) than non-Māori. Around a third of people did not receive recommended cardiometabolic blood screening, with no difference between Māori and non-Māori after covariate adjustment.
Conclusions
Māori experiencing psychosis are more likely to die and be admitted to hospital with cardiovascular disease or diabetes than non-Māori. Because of the higher cardiometabolic risk borne by Māori, it is suggested that cardiometabolic screening shortfalls will lead to worsening physical health inequities for Māori experiencing psychosis.
Few studies have examined the genetic population structure of vector-borne microparasites in wildlife, making it unclear how much these systems can reveal about the movement of their associated hosts. This study examined the complex host–vector–microbe interactions in a system of bats, wingless ectoparasitic bat flies (Nycteribiidae), vector-borne microparasitic bacteria (Bartonella) and bacterial endosymbionts of flies (Enterobacterales) across an island chain in the Gulf of Guinea, West Africa. Limited population structure was found in bat flies and Enterobacterales symbionts compared to that of their hosts. Significant isolation by distance was observed in the dissimilarity of Bartonella communities detected in flies from sampled populations of Eidolon helvum bats. These patterns indicate that, while genetic dispersal of bats between islands is limited, some non-reproductive movements may lead to the dispersal of ectoparasites and associated microbes. This study deepens our knowledge of the phylogeography of African fruit bats, their ectoparasites and associated bacteria. The results presented could inform models of pathogen transmission in these bat populations and increase our theoretical understanding of community ecology in host–microbe systems.
From the safety inside vehicles, Knowsley Safari offers visitors a close-up encounter with captive olive baboons. As exiting vehicles may be contaminated with baboon stool, a comprehensive coprological inspection was conducted to address public health concerns. Baboon stools were obtained from vehicles, and sleeping areas, inclusive of video analysis of baboon–vehicle interactions. A purposely selected 4-day sampling period enabled comparative inspections of 2662 vehicles, with a total of 669 baboon stools examined (371 from vehicles and 298 from sleeping areas). As informed by our pilot study, front-line diagnostic methods were: QUIK-CHEK rapid diagnostic test (RDT) (Giardia and Cryptosporidium), Kato–Katz coproscopy (Trichuris) and charcoal culture (Strongyloides). Some 13.9% of vehicles were contaminated with baboon stool. Prevalence of giardiasis was 37.4% while cryptosporidiosis was <0.01%, however, an absence of faecal cysts by quality control coproscopy, alongside lower than the expected levels of Giardia-specific DNA, judged RDT results as misleading, grossly overestimating prevalence. Prevalence of trichuriasis was 48.0% and strongyloidiasis was 13.7%, a first report of Strongyloides fuelleborni in UK. We advise regular blanket administration(s) of anthelminthics to the colony, exploring pour-on formulations, thereafter, smaller-scale indicator surveys would be adequate.
We assessed the implementation of telehealth-supported stewardship activities in acute-care units and long-term care (LTC) units in Veterans’ Administration medical centers (VAMCs).
Design:
Before-and-after, quasi-experimental implementation effectiveness study with a baseline period (2019–2020) and an intervention period (2021).
Setting:
The study was conducted in 3 VAMCs without onsite infectious disease (ID) support.
Participants:
The study included inpatient providers at participating sites who prescribe antibiotics.
Intervention:
During 2021, an ID physician met virtually 3 times per week with the stewardship pharmacist at each participating VAMC to review patients on antibiotics in acute-care units and LTC units. Real-time feedback on prescribing antibiotics was given to providers. Additional implementation strategies included stakeholder engagement, education, and quality monitoring.
Methods:
The reach–effectiveness–adoption–implementation–maintenance (RE-AIM) framework was used for program evaluation. The primary outcome of effectiveness was antibiotic days of therapy (DOT) per 1,000 days present aggregated across all 3 sites. An interrupted time-series analysis was performed to compare this rate during the intervention and baseline periods. Electronic surveys, periodic reflections, and semistructured interviews were used to assess other RE-AIM outcomes.
Results:
The telehealth program reviewed 502 unique patients and made 681 recommendations to 24 providers; 77% of recommendations were accepted. After program initiation, antibiotic DOT immediately decreased in the LTC units (−30%; P < .01) without a significant immediate change in the acute-care units (+16%; P = .22); thereafter DOT remained stable in both settings. Providers generally appreciated feedback and collaborative discussions.
Conclusions:
The implementation of our telehealth program was associated with reductions in antibiotic use in the LTC units but not in the smaller acute-care units. Overall, providers perceived the intervention as acceptable. Wider implementation of telehealth-supported stewardship activities may achieve reductions in antibiotic use.