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42 results

Page 1 of 3

  • New Approaches to Herbicide and Bioherbicide Discovery

  • Stephen O. Duke, Alyssa Twitty, Claire Baker, David Sands, Louis Boddy, María Lucía Travaini, Gustavo Sosa, Alexander L.A. Polidore, Amit J. Jhala, Jack M. Kloeber, Xavier Jacq, Lucas Lieber, Maria Celeste Varela, Martina Lazzaro, Ana P. Alessio, Christopher C. Ladner, Denis Fourches, Itai Bloch, Maayan Gal, Jonathan Gressel, Karthik Putta, Yael Phillip, Ifat Shub, Eyal Ben-Chanoch, Franck E. Dayan
  • Journal:
    Weed Science / Volume 72 / Issue 5 / September 2024
    Published online by Cambridge University Press:
    09 October 2024, pp. 444-464
    • Article
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  • During the past 30 yr an impasse has developed in the discovery and commercialization of synthetic herbicides with new molecular targets and novel chemistries. Similarly, there has been little success with bioherbicides, both microbial and chemical. These bioherbicides are needed to combat fast-growing herbicide resistance and to fulfill the need for more environmentally and toxicologically safe herbicides. In response to this substantial and growing opportunity, numerous start-up companies are utilizing novel approaches to provide new tools for weed management. These diverse new tools broaden the scope of discovery, encompassing advanced computational, bioinformatic, and imaging platforms; plant genome–editing and targeted protein degradation technologies; and machine learning and artificial intelligence (AI)-based strategies. This review contains summaries of the presentations of 10 such companies that took part in a symposium held at the WSSA annual meeting in 2024. Four of the companies are developing microbial bioherbicides or natural product–based herbicides, and the other six are using advanced technologies, such as AI, to accelerate the discovery of herbicides with novel molecular target sites or to develop non-GMO, herbicide-resistant crops.

Seismic Hazard and Risk Analysis
  • Jack Baker, Brendon Bradley, Peter Stafford
  • Published online:
    14 December 2021
    Print publication:
    21 October 2021
  • Seismic hazard and risk analyses underpin the loadings prescribed by engineering design codes, the decisions by asset owners to retrofit structures, the pricing of insurance policies, and many other activities. This is a comprehensive overview of the principles and procedures behind seismic hazard and risk analysis. It enables readers to understand best practises and future research directions. Early chapters cover the essential elements and concepts of seismic hazard and risk analysis, while later chapters shift focus to more advanced topics. Each chapter includes worked examples and problem sets for which full solutions are provided online. Appendices provide relevant background in probability and statistics. Computer codes are also available online to help replicate specific calculations and demonstrate the implementation of various methods. This is a valuable reference for upper level students and practitioners in civil engineering, and earth scientists interested in engineering seismology.

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