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Methamphetamine (METH) dependence is a globally significant public health concern with no efficacious treatment. Trait impulsivity is associated with the initiation, maintenance, and recurrence of substance abuse. However, the presence of these associations in METH addiction, as well as the underlying neurobiological mechanisms, remains incompletely understood.
Methods
We scanned 110 individuals with METH use disorder (MUDs) and 55 matched healthy controls (HCs) using T1-weighted imaging and assessed their drug use characteristics and trait impulsivity. Surface-based morphometry and graph theoretical analysis were used to investigate group differences in brain morphometry and network attributes. Partial correlations were conducted to investigate the relationships between brain morphometric changes, drug use parameters, and trait impulsivity. Mediation analyses examined how trait impulsivity and drug craving influenced the link between brain morphometric change and MUD severity in patients.
Results
MUDs exhibited thinner thickness in the left fusiform gyrus and right pars opercularis, as well as diminished small-world properties in their structural covariance networks (SCNs) compared to HCs. Furthermore, reduced cortical thickness in the right pars opercularis was linked to motor impulsivity (MI) and MUD severity, and the association between the right pars opercularis thickness and MUD severity was significantly mediated by both MI and cue-induced craving.
Conclusions
These findings suggest that MUDs exhibit distinct brain structural abnormalities in both the cortical thickness and SCNs and highlight the critical role of impulse control in METH addiction. This insight may offer a potential neurobiological target for developing therapeutic interventions to treat addiction and prevent relapse.
Vessel collision risk estimation is crucial in navigation manoeuvres, route planning, risk control, safety management and forewarning issues. The interaction possibility is a good method to quantify the near-miss collision risks of multi-ships. Current models, however, are mostly concerned about the movements in an unrestricted isotropic travel environment or network environment. This article simultaneously addresses these issues by developing a novel environment–kinetic compound space–time prism to capture potential spatial–temporal interactions of multi-ships in constrained dynamic environments. The approach could significantly reduce the overestimation of the individual vessel’s potential travel area and the interaction possibility of encountering vessels in restricted water. The proposed environmental–kinetical compound space–time prism (EKC-STP)-based method enables identifying where and when multi-ships possibly interacted in the constraint water area, as well as how the interaction possibility pattern changed from day to day. The collision risk evaluation results were validated through comparison with other methods. The full picture of hierarchical collision risk distribution in port areas is determined and could be employed to provide quantifiable references for efficient and practical anti-collision measures establishment.
Germplasm resources are the foundation for improving crop varieties and a strategic asset for global food security. They also advance plant breeding, agricultural biotechnology and the production of essential agricultural goods. To assess the distribution, diversity and conservation status of food crop germplasm in the Hainan Province, China, we conducted a detailed survey of the Hainan Island. Between 2017 and 2022, we collected 330 food crop germplasm resources, encompassing 16 cereal crops, including rice, maize, sweet potato. The collected germplasm resources exhibited traits of high resistance to both biotic and abiotic stresses, including common diseases and drought stress, as well as superior quality and adaptability to poor soil conditions such as sandy land. However, challenges such as low productivity and hybrid degradation were identified. These resources were primarily found in Haikou City, Baisha County, Danzhou City, Wuzhishan City and Sanya City. Additionally, we collected several ancient local varieties and endangered germplasm resources such as ‘Jiezi rice’ and ‘Wuzhishan maize’. This study serves as a reference for the conservation, development and utilization of local food crop germplasm resources in Hainan Province and lays the foundation for breeding and developing new varieties.
The relationship between emotional symptoms and cognitive impairments in major depressive disorder (MDD) is key to understanding cognitive dysfunction and optimizing recovery strategies. This study investigates the relationship between subjective and objective cognitive functions and emotional symptoms in MDD and evaluates their contributions to social functioning recovery.
Methods
The Prospective Cohort Study of Depression in China (PROUD) involved 1,376 MDD patients, who underwent 8 weeks of antidepressant monotherapy with assessments at baseline, week 8, and week 52. Measures included the Hamilton Depression Rating Scale (HAMD-17), Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16), Chinese Brief Cognitive Test (C-BCT), Perceived Deficits Questionnaire for Depression-5 (PDQ-D5), and Sheehan Disability Scale (SDS). Cross-lagged panel modeling (CLPM) was used to analyze temporal relationships.
Results
Depressive symptoms and cognitive measures demonstrated significant improvement over 8 weeks (p < 0.001). Baseline subjective cognitive dysfunction predicted depressive symptoms at week 8 (HAMD-17: β = 0.190, 95% CI: 0.108–0.271; QIDS-SR16: β = 0.217, 95% CI: 0.126–0.308). Meanwhile, baseline depressive symptoms (QIDS-SR16) also predicted subsequent subjective cognitive dysfunction (β = 0.090, 95% CI: 0.003-0.177). Recovery of social functioning was driven by improvements in depressive symptoms (β = 0.384, p < 0.0001) and subjective cognition (β = 0.551, p < 0.0001), with subjective cognition contributing more substantially (R2 = 0.196 vs. 0.075).
Conclusions
Subjective cognitive dysfunction is more strongly associated with depressive symptoms and plays a significant role in social functioning recovery, highlighting the need for targeted interventions addressing subjective cognitive deficits in MDD.
This paper examines the impact of financially constrained intermediate inputs on within-industry total factor productivity loss. Utilizing exogenous tax reforms in China as a natural experiment, our difference-in-difference analysis reveals that reduced tax burdens lead to increased firm-level intermediate inputs, particularly among financially constrained firms. We incorporate financially constrained intermediate inputs into a partial equilibrium model of firm dynamics. Our calibration suggests that financially constrained intermediate inputs play a quantitatively more important role in accounting for misallocation than financially constrained capital. The presence of financially constrained intermediate inputs introduces a downward bias in the measurement of value-added productivity, especially for firms in the top decile of gross-output productivity. As a result, the average “efficient” levels of capital and labor for the top decile firms in the standard Hsieh and Klenow (2009) exercise are lower than what is truly efficient.
The recent expansion of cross-cultural research in the social sciences has led to increased discourse on methodological issues involved when studying culturally diverse populations. However, discussions have largely overlooked the challenges of construct validity – ensuring instruments are measuring what they are intended to – in diverse cultural contexts, particularly in developmental research. We contend that cross-cultural developmental research poses distinct problems for ensuring high construct validity owing to the nuances of working with children, and that the standard approach of transporting protocols designed and validated in one population to another risks low construct validity. Drawing upon our own and others’ work, we highlight several challenges to construct validity in the field of cross-cultural developmental research, including (1) lack of cultural and contextual knowledge, (2) dissociating developmental and cultural theory and methods, (3) lack of causal frameworks, (4) superficial and short-term partnerships and collaborations, and (5) culturally inappropriate tools and tests. We provide guidelines for addressing these challenges, including (1) using ethnographic and observational approaches, (2) developing evidence-based causal frameworks, (3) conducting community-engaged and collaborative research, and (4) the application of culture-specific refinements and training. We discuss the need to balance methodological consistency with culture-specific refinements to improve construct validity in cross-cultural developmental research.
Survey instruments and assessments are frequently used in many domains of social science. When the constructs that these assessments try to measure become multifaceted, multidimensional item response theory (MIRT) provides a unified framework and convenient statistical tool for item analysis, calibration, and scoring. However, the computational challenge of estimating MIRT models prohibits its wide use because many of the extant methods can hardly provide results in a realistic time frame when the number of dimensions, sample size, and test length are large. Instead, variational estimation methods, such as Gaussian variational expectation–maximization (GVEM) algorithm, have been recently proposed to solve the estimation challenge by providing a fast and accurate solution. However, results have shown that variational estimation methods may produce some bias on discrimination parameters during confirmatory model estimation, and this note proposes an importance-weighted version of GVEM (i.e., IW-GVEM) to correct for such bias under MIRT models. We also use the adaptive moment estimation method to update the learning rate for gradient descent automatically. Our simulations show that IW-GVEM can effectively correct bias with modest increase of computation time, compared with GVEM. The proposed method may also shed light on improving the variational estimation for other psychometrics models.
Latent class models with covariates are widely used for psychological, social, and educational research. Yet the fundamental identifiability issue of these models has not been fully addressed. Among the previous research on the identifiability of latent class models with covariates, Huang and Bandeen-Roche (Psychometrika 69:5–32, 2004) studied the local identifiability conditions. However, motivated by recent advances in the identifiability of the restricted latent class models, particularly cognitive diagnosis models (CDMs), we show in this work that the conditions in Huang and Bandeen-Roche (Psychometrika 69:5–32, 2004) are only necessary but not sufficient to determine the local identifiability of the model parameters. To address the open identifiability issue for latent class models with covariates, this work establishes conditions to ensure the global identifiability of the model parameters in both strict and generic sense. Moreover, our results extend to the polytomous-response CDMs with covariates, which generalizes the existing identifiability results for CDMs.
Establishing the invariance property of an instrument (e.g., a questionnaire or test) is a key step for establishing its measurement validity. Measurement invariance is typically assessed by differential item functioning (DIF) analysis, i.e., detecting DIF items whose response distribution depends not only on the latent trait measured by the instrument but also on the group membership. DIF analysis is confounded by the group difference in the latent trait distributions. Many DIF analyses require knowing several anchor items that are DIF-free in order to draw inferences on whether each of the rest is a DIF item, where the anchor items are used to identify the latent trait distributions. When no prior information on anchor items is available, or some anchor items are misspecified, item purification methods and regularized estimation methods can be used. The former iteratively purifies the anchor set by a stepwise model selection procedure, and the latter selects the DIF-free items by a LASSO-type regularization approach. Unfortunately, unlike the methods based on a correctly specified anchor set, these methods are not guaranteed to provide valid statistical inference (e.g., confidence intervals and p-values). In this paper, we propose a new method for DIF analysis under a multiple indicators and multiple causes (MIMIC) model for DIF. This method adopts a minimal \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$L_1$$\end{document} norm condition for identifying the latent trait distributions. Without requiring prior knowledge about an anchor set, it can accurately estimate the DIF effects of individual items and further draw valid statistical inferences for quantifying the uncertainty. Specifically, the inference results allow us to control the type-I error for DIF detection, which may not be possible with item purification and regularized estimation methods. We conduct simulation studies to evaluate the performance of the proposed method and compare it with the anchor-set-based likelihood ratio test approach and the LASSO approach. The proposed method is applied to analysing the three personality scales of the Eysenck personality questionnaire-revised (EPQ-R).
With the growing attention on large-scale educational testing and assessment, the ability to process substantial volumes of response data becomes crucial. Current estimation methods within item response theory (IRT), despite their high precision, often pose considerable computational burdens with large-scale data, leading to reduced computational speed. This study introduces a novel “divide- and-conquer” parallel algorithm built on the Wasserstein posterior approximation concept, aiming to enhance computational speed while maintaining accurate parameter estimation. This algorithm enables drawing parameters from segmented data subsets in parallel, followed by an amalgamation of these parameters via Wasserstein posterior approximation. Theoretical support for the algorithm is established through asymptotic optimality under certain regularity assumptions. Practical validation is demonstrated using real-world data from the Programme for International Student Assessment. Ultimately, this research proposes a transformative approach to managing educational big data, offering a scalable, efficient, and precise alternative that promises to redefine traditional practices in educational assessments.
Cognitive Diagnosis Models (CDMs) are a special family of discrete latent variable models that are widely used in educational and psychological measurement. A key component of CDMs is the Q-matrix characterizing the dependence structure between the items and the latent attributes. Additionally, researchers also assume in many applications certain hierarchical structures among the latent attributes to characterize their dependence. In most CDM applications, the attribute–attribute hierarchical structures, the item-attribute Q-matrix, the item-level diagnostic models, as well as the number of latent attributes, need to be fully or partially pre-specified, which however may be subjective and misspecified as noted by many recent studies. This paper considers the problem of jointly learning these latent and hierarchical structures in CDMs from observed data with minimal model assumptions. Specifically, a penalized likelihood approach is proposed to select the number of attributes and estimate the latent and hierarchical structures simultaneously. An expectation-maximization (EM) algorithm is developed for efficient computation, and statistical consistency theory is also established under mild conditions. The good performance of the proposed method is illustrated by simulation studies and real data applications in educational assessment.
The breaking and energy distribution of mode-1 depression internal solitary wave interactions with Gaussian ridges are examined through laboratory experiments. A series of processes, such as shoaling, breaking, transmission and reflection, are captured completely by measuring the velocity field in a large region. It is found that the maximum interface descent ($a_{max}$) during wave shoaling is an important parameter for diagnosing the type of wave–ridge interaction and energy distribution. The wave breaking on the ridge depends on the modified blockage parameter $\zeta _m$, the ratio of the sum of the upper layer depth and $a_{max}$ to the water depth at the top of the ridge. As $\zeta _m$ increases, the interaction type transitions from no breaking to plunging and mixed plunging–collapsing breaking. Within the scope of this experiment, the energy distribution can be characterized solely by $\zeta _m$. The transmission energy decreases monotonically with increasing $\zeta _m$, and there is a linear relationship between $\zeta _m^2$ and the reflection coefficient. The value of $a_{max}$ can be determined from the basic initial parameters of the experiment. Based on the incident wave parameters, the depth of the upper and lower layers, and the topographic parameters, two new simple methods for predicting $a_{max}$ on the ridge are proposed.
In hypersonic flight the shock wave and turbulent boundary layer interaction (STBLI) sharply increases wall heat transfer that intensifies the aerodynamic heating problems. In this work the STBLI is modelled by compression ramp flow with a Mach number of 5, a Reynolds number based on momentum thickness of 4652 and a wall to recovery temperature ratio of 0.5. The aerodynamic heat generation and transport mechanisms are investigated in the interaction based on theoretical analysis and direct numerical simulation (DNS) that agrees with previous studies. A prediction correlation of wall heat flux in STBLI is deduced theoretically and validated by some representative data including the present DNS, which improves the prediction accuracy and can be applied to a wider $Ma$ range compared with the canonical Q-P theory. The correlation indicates that the sharp increase of wall heat transfer in the STBLI can be explained by the boundary layer compression and the convection transport enhancement. Based on the DNS results, the aerodynamic heat generation and transport mechanisms are revealed in the separation, recirculation and reattachment zones in the STBLI. From this perspective, the peak heat flux can be further explained by the enhancement of near-wall turbulent energy dissipation, compression aerodynamic heat generation and the near-wall turbulent transport. The generation and transport of compression aerodynamic heat reveal the underlying mechanism of the strong correlation between the peak heat flux ratios and the pressure ratios in STBLIs.
First-episode schizophrenia (FES) is a progressive psychiatric disorder influenced by genetics, environmental factors, and brain function. The functional gradient deficits of drug-naïve FES and its relationship to gene expression profiles and treatment outcomes are unknown.
Methods
In this study, we engaged a cohort of 116 FES and 100 healthy controls (HC), aged 7 to 30 years, including 15 FES over an 8-week antipsychotic medication regimen. Our examination focused on primary-to-transmodal alterations in voxel-based connection gradients in FES. Then, we employed network topology, Neurosynth, postmortem gene expression, and support vector regression to evaluate integration and segregation functions, meta-analytic cognitive terms, transcriptional patterns, and treatment predictions.
Results
FES displayed diminished global connectome gradients (Cohen's d = 0.32–0.57) correlated with compensatory integration and segregation functions (Cohen's d = 0.31–0.36). Predominant alterations were observed in the default (67.6%) and sensorimotor (21.9%) network, related to high-order cognitive functions. Furthermore, we identified notable overlaps between partial least squares (PLS1) weighted genes and dysregulated genes in other psychiatric conditions. Genes linked with gradient alterations were enriched in synaptic signaling, neurodevelopment process, specific astrocytes, cortical layers (layer II and IV), and developmental phases from late/mid fetal to young adulthood. Additionally, the onset age influenced the severity of FES, with discernible differences in connection gradients between minor- and adult-FES. Moreover, the connectivity gradients of FES at baseline significantly predicted treatment outcomes.
Conclusions
These results offer significant theoretical foundations for elucidating the intricate interplay between macroscopic functional connection gradient changes and microscopic transcriptional patterns during the onset and progression of FES.
This chapter introduces my research questions, framework, and main findings. It begins with two striking vignettes to engage the readers and outline the significance of the two basic questions that motivate this book and intersect at children's social cognition: How do humans learn morality? How do we make sense of fieldnotes? The chapter situates the book in intellectual history, including the Wolfs’ original research, its connections to the Six Cultures Study, and its legacies. It then presents a new framework of cognitive anthropology distinctive from the behaviorist paradigm that motivated the original research. I situate the book in three broad streams of discussions: (1) theoretical conversations between anthropology and psychology on morality; (2) cross-cultural research on childhood learning; (3) studies of Chinese kinship, families, and childhood. I explain why it is important to study children to understand morality, human relatedness, and cultural transmission. I also make the case for reanalyzing historical fieldnotes. I then lay out a methodology that incorporates computational approaches into ethnography, summarize my main arguments, and outline the book structure.