We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Ixodid ticks are obligate blood-feeding arthropods and important vectors of pathogens. In Mallorca, almost no data on the tick fauna are available. Herein, we investigated ticks and tick-borne pathogens in ticks collected from dogs, a cat and humans in Mallorca as result of a citizen science project. A total of 91 ticks were received from German tourists and residents in Mallorca. Ticks were collected from March to October 2023 from dogs, cat and humans, morphologically and genetically identified and tested for pathogens by PCRs. Six tick species could be identified: Ixodes ricinus (n = 2), Ixodes ventalloi (n = 1), Hyalomma lusitanicum (n = 7), Hyalomma marginatum (n = 1), Rhipicephalus sanguineus s.l. (n = 71) and Rhipicephalus pusillus (n = 9). Rhipicephalus sanguineus s.l. adults were collected from dogs and four females from a cat and the 16S rDNA sequences identified it as Rh. sanguineus s.s. Hyalomma lusitanicum was collected from 1 human, 1 dog and 5 specimens were collected from the ground in the community of Santanyi, together with one H. marginatum male. This is the first report of Hyalomma marginatum in Mallorca. Both I. ricinus were collected from humans and I. ventalloi female was collected from a dog. All ticks tested negative for Anaplasma phagocytophilum, Coxiella spp., Francisella spp., and piroplasms. In 32/71 (45%) specimens of Rh. sanguineus s.s., Rickettsia spp. could be detected and in 18/32 (56.2%) sequenced tick DNAs R. massiliae was identified. Ixodes ventalloi female and both I. ricinus tested positive in the screening PCR, but the sequencing for the identification of the Rickettsia sp. failed.
In this paper, we prove Kato’s main conjecture for $CM$ modular forms for primes of potentially ordinary reduction under certain hypotheses on the modular form.
Having a child with cancer is a burdensome experience for parents. Nurses need to better understand beliefs, hopes, and values of parents to holistically support them, which may have an impact on grief and depression. Thus, the aim of this paper was to highlight the social and spiritual dimensions of parental experiences on end-of-life care of their child with cancer.
Method
A narrative literature review was conducted by systematically searching databases (CINAHL Complete, Academic Search Elite, MEDLINE) for relevant literature. The contents of included studies were critically appraised regarding their methodological quality.
Results
Eleven studies were included. In terms of the social dimension, three categories emerged that are important for parents: Being a Parent, Being in Relationship with the Child, and Being in Relationship with Health Professionals. Parents tried to maintain normality and joy for their child, but also kept control over the situation. They wanted to protect their child from suffering but also felt the need to talk to them about dying. Parents had ambivalent experiences with helpful but also burdensome staff. The spiritual dimension comprised two main categories, Hope and Faith and a Unique Bond. Hope was found to be an important source of strength, while Faith was only mentioned by some parents. For parents the emotional connection with their child constituted a source of meaning as well as a foundation, on which they based their decisions on.
Significance of results
A therapeutic relationship and a supportive environment can be established by healthcare professionals by noticing, encouraging the unique bond between parents and their children, as well as by reflecting and addressing the parents’ challenging situation.
Recent studies have shown that the low seismicity of northern Germany is characterized by fault activity caused by the decay of the Late Pleistocene (Weichselian) ice sheet. Several faults and fault systems show evidence of neotectonic activity, all of which are oriented parallel to the margin of the Pleistocene ice sheets. The timing of fault movements implies that the seismicity in northern Germany is likely induced by varying lithospheric stress conditions related to glacial isostatic adjustment, and the faults thus can be classified as glacially induced faults. For the Osning, Harz Boundary and Schaabe faults, this is supported by numerical simulation of glacial isostatic adjustment-related stress field changes. Glacial isostatic adjustment is also a likely driver for the historical and parts of the recent fault activity. Glacial isostatic adjustment is also described for the Alps, but it is difficult to clearly distinguish between reactivation of faults in the foreland of the Alps due to the Alpine collision and glacial isostatic adjustment.
This chapter gives an overview of the use of soft-sediment deformation structures (SSDS) as palaeoearthquake indicators in formerly glaciated and periglacial areas. We review the most important processes of soft-sediment deformation and the different nomenclature used in the scientific communities.
So-called seismites are beds with SSDS that formed because of seismic shaking. However, in regions that were affected by glacial and periglacial processes, the use of SSDS as palaeoearthquake indicator is challenging and interpretation must be done with care. Earthquakes are only one trigger process of many that can cause liquefaction and/or fluidization of sediments, leading to the formation of SSDS. Ice-sheet loading, glaciotectonism and freeze and thaw processes in glacial and periglacial environments are also potential trigger processes that can cause the formation of similar types of SSDS, which can be easily mistaken for seismites. Therefore, we provide clear criteria to recognize seismites in the field. The combination of deformation bands that occur in the vicinity of basement faults with carefully evaluated SSDS is a robust indicator for palaeoearthquakes.
We compare the Pontryagin duals of fine Selmer groups of two congruent p-adic Galois representations over admissible pro-p, p-adic Lie extensions $K_\infty $ of number fields K. We prove that in several natural settings the $\pi $-primary submodules of the Pontryagin duals are pseudo-isomorphic over the Iwasawa algebra; if the coranks of the fine Selmer groups are not equal, then we can still prove inequalities between the $\mu $-invariants. In the special case of a $\mathbb {Z}_p$-extension $K_\infty /K$, we also compare the Iwasawa $\lambda $-invariants of the fine Selmer groups, even in situations where the $\mu $-invariants are nonzero. Finally, we prove similar results for certain abelian non-p-extensions.
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
Aims
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Method
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Results
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
Conclusions
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
MRI-derived cortical folding measures are an indicator of largely genetically driven early developmental processes. However, the effects of genetic risk for major mental disorders on early brain development are not well understood.
Methods
We extracted cortical complexity values from structural MRI data of 580 healthy participants using the CAT12 toolbox. Polygenic risk scores (PRS) for schizophrenia, bipolar disorder, major depression, and cross-disorder (incorporating cumulative genetic risk for depression, schizophrenia, bipolar disorder, autism spectrum disorder, and attention-deficit hyperactivity disorder) were computed and used in separate general linear models with cortical complexity as the regressand. In brain regions that showed a significant association between polygenic risk for mental disorders and cortical complexity, volume of interest (VOI)/region of interest (ROI) analyses were conducted to investigate additional changes in their volume and cortical thickness.
Results
The PRS for depression was associated with cortical complexity in the right orbitofrontal cortex (right hemisphere: p = 0.006). A subsequent VOI/ROI analysis showed no association between polygenic risk for depression and either grey matter volume or cortical thickness. We found no associations between cortical complexity and polygenic risk for either schizophrenia, bipolar disorder or psychiatric cross-disorder when correcting for multiple testing.
Conclusions
Changes in cortical complexity associated with polygenic risk for depression might facilitate well-established volume changes in orbitofrontal cortices in depression. Despite the absence of psychopathology, changed cortical complexity that parallels polygenic risk for depression might also change reward systems, which are also structurally affected in patients with depressive syndrome.
Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood.
Methods
We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors.
Results
We did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy.
Conclusions
This important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).
Let 𝕂n be the intermediate steps in the cyclotomic ℤp-extension of a CM number field 𝕂. For p ⧧ 2 the minus part of the p-class groups is given by An− = $\frac{1}{2}$(1 − j)An. We will give a new definition of the minus part for p = 2 and will prove that there is no finite submodule in lim∞←nAn−. Furthermore we will show that μ = 0 if and only if μ− = 0 in this new definition.
The European Union (EU) aims to increase its share of renewable energy whilst reducing CO2 emissions. In order to reach the EU-wide target of 20 per cent renewables in 2020, the energy sector needs to replace fossil fuels by using more renewable energy sources. This process of energy transition is one of the most important challenges of the coming decades. It requires engineers to develop the required technologies, economists to establish the most efficient approaches, and politicians to communicate goals to society and agree on the political will. Further, this energy transition requires the contribution of lawyers. Taking into account the findings of other disciplines and the political will, they need to analyze and understand the current legal regimes, identify the barriers to energy transition, and develop solutions of how to address the barriers and how to enable the required energy transition.
The Member States of the EU are required to reach a certain share of renewable energy in their final energy consumption by 2020. In reaching the renewable energy targets, the North Sea states consider increasingly offshore wind as an important renewable energy source. So far the development of offshore wind energy is still in its early stages and all offshore wind farms in the North Sea are consequently connected directly to the national grids, ie the coast where a connection to the national grid can be made (so-called radial connections). With the increasing scale of wind farms and their increasing distance from shore, it is considered more economical to connect wind farms to the grids of two or more countries. In the long term this could result in a transnational offshore electricity grid.
This chapter concentrates on the legal issues and requirements relating to such a transnational offshore electricity grid. The research this chapter builds on shows that the current international and national legal regimes contain legal barriers to the development of cross-border offshore wind energy projects. The most important barriers to the materialization of such projects are the legal uncertainty concerning applicable definitions of the various parts of the offshore infrastructure and responsibilities, the lack of incentives for the relevant parties to initiate such projects and operational issues. If the main legal and regulatory barriers were removed, a first set of cross-border offshore projects could be built, eventually leading to a transnational offshore grid.
We present a new method to analyze party manifestos to benefit the placement of political parties per se and to advance the study of elections. Our method improves on existing manual coding approaches by (1) generating semantically complete units based on syntax, (2) standardizing units into a subject–predicate–object structure, and (3) employing a fine-grained and flexible hierarchical coding scheme. We evaluate our approach by comparing estimates for the 2002, 2006, and 2008 Austrian national elections with those yielded by previous studies that employ the entire range of available measurement strategies. We also demonstrate how we link our new manifesto data with other kind of data produced in theAustrian National Election Study, especially mass and elite (party candidate) surveys.
We report on the extraction of carrier type, and mobility in semiconductor nanowires by adopting experimental nanowire field-effect transistor device data to a long channel MISFET device model. Numerous field-effect transistors were fabricated using n-InAs nanowires of a diameter of 50 nm as a channel. The I-V data of devices were analyzed at low to medium drain current in order to reduce the effect of extrinsic resistances. The gate capacitance is determined by an electro-static field simulation tool. The carrier mobility remains as the only parameter to fit experimental to modeled device data. The electron mobility in n-InAs nanowires is evaluated to µ = 13,000 cm2/Vs while for comparison n-ZnO nanowires exhibit a mobility of 800 cm2/Vs.
Latin America has been a world pioneer of neoliberal, structural reform of social security pensions (‘privatisation’). This article focuses on the diverse political economy circumstances that enabled such reform, analysing why policy makers have chosen such a costly strategy and how they have managed to implement it. First, in nine countries with diverse regimes (authoritarian and democratic) it examines the internal political process that led to the adoption of reform. There tends to be an inverse relationship between the degree of democratisation and that of privatisation, but the political regime alone cannot fully explain the reform outcomes in all cases. To expand the search for explanatory variables, other key factors that might have influenced the reform design are studied, among them relevant political actors (driving and opposing forces), existing institutional arrangements, legal constraints, internal and external economics and policy legacy.
The present study concerns the deposition of α–Al2O3 for diffusion barrier applications on superalloy substrates. The growth of α–Al2O3 has been achieved by chemical vapor deposition (CVD) using an AlCl3/CO2/H2 gas mixture at 1080 °C. Among several growth-controlling parameters with potential importance for the whisker growth process, the reactor pressure during deposition seems to be highly influential on the resulting film structure. Deposited films at low pressure presented solely a fine whisker structure. This non-closed structure is not suitable as diffusion barrier; however, the observed high porosity makes the deposit a potential candidate as a catalysis support. An increase of the deposition pressure led to a competitive growth of whiskers and grains. A suitable microstructure was attained at relatively high pressure (100 mbar) where the surface was fully covered by 2 μm large alumina crystals that formed a closed structure. Further increase of the pressure led to an irregular and rough surface microstructure.
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.