With the widespread democratic decline and the rise of autocratic regimes, global humanitarian assistance efforts have often fallen short of expectations. Historical humanitarian assistance efforts have changed, becoming less effective, or disappearing. Given the direction that global health crisis risks are taking today, it is crucial that diplomatic, structural, logistical, security, and operational questions be asked and appropriate global solutions sought for the future management of pandemics and climate change crises.

Using the dual-pathway framework (Beach et al., 2022a), we tested a Neuro-immune Network (NIN) hypothesis: i.e., that chronically elevated inflammatory processes may have delayed (i.e., incubation) effects on young adult substance use, leading to negative health outcomes. In a sample of 449 participants in the Family and Community Health Study who were followed from age 10 to age 29, we examined a non-self-report index of young adult elevated alcohol consumption (EAC). By controlling self-reported substance use at the transition to adulthood, we were able to isolate a significant delayed (incubation) effect from childhood exposure to danger to EAC (β = −.157, p = .006), which contributed to significantly worse aging outomes. Indirect effects from danger to aging outcomes via EAC were: GrimAge (IE = .010, [.002, .024]), Cardiac Risk (IE = −.004, [−.011, −.001]), DunedinPACE (IE = .002, [.000, .008]). In exploratory analyses we examined potential sex differences in effects, showing slightly stronger incubation effects for men and slightly stronger effects of EAC on aging outcomes for women. Results support the NIN hypothesis that incubation of immune pathway effects contributes to elevated alcohol consumption in young adulthood, resulting in accelerated aging and elevated cardiac risk outcomes via health behavior.

Objectives/Goals: Cerebral amyloid angiopathy (CAA) characterized by the accumulation of amyloid-beta in the cerebrovasculature, affects blood vessel integrity leading to brain hemorrhages and an accelerated cognitive decline in Alzheimer’s disease patients. In this study, we are conducting a genome-wide association study to identify genetic risk factors for CAA. Methods/Study Population: We genotyped 1253 additional AD cases using and curated existing genome-wide genotype data from 110 AD and 502 non-AD donors from the Mayo Clinic Brain Bank. We performed QC and imputation of all datasets. We conducted GWAS in AD only (N =  1,363), non-AD only, as well as the combined cohort (N = 1,865) by testing imputed variant dosages for association with square root transformed CAA using linear regression, adjusting for relevant covariates. To assess associations in the context of major CAA risk factors, we performed interaction analysis with APOEe4 presence and sex; and pursued stratified analyses. We collected peripheral gene expression measures using RNA isolated from 188 PAXgene tube samples of 95 donors collected across multiple time points. More than 1/3 of these participants have MRI measures collected. Results/Anticipated Results: Variants at the APOE locus were identified as the most significant in our study. In addition, several other variants with suggestive association were found under the main model adjusting for AD neuropathology (Braak and Thal). LINC-PINT splice variant remained associated with lower CAA scores in AD cases without the APOEe4 risk allele. To enhance the robustness of our findings, we are pursuing further expansion of our study cohort. In the periphery, we expect to identify expression changes associated with neuroimaging indicators of CAA and determine if variants and genes discovered via GWAS are implicated in these changes. Discussion/Significance of Impact: We expect this study will provide further insight into the genetic architecture underlying risk for CAA both in the context of significant AD pathology and without. Characterization of genetic variants and functional outcomes in the context of neuropathology may lead to new avenues of research aimed at identifying biomarkers and therapies to treat CAA

Objectives/Goals: 1) Discuss process of pilot integration of Community Health Worker (CHW) services as a component of patient-centered healthcare service delivery in 3 clinic models. 2) Summarize profiles of patients who self-select to utilize CHW services. 3) Discuss social determinants of health impacts of underserved and historically marginalized populations. Methods/Study Population: The priority population consists of individuals living in Mobile AL at or below poverty level. USA Health Center for Healthy Communities (CHC) piloted the integration of CHW services at USA Health Stanton Road Clinic (SRC), at USA Student Run Free Clinic (SRFC), and as part of a Medi Hub Outreach Clinic with the historically underserved MOWA Choctaw native American population. SRC is a high-utilization clinic for uninsured or underinsured patients across the breadth of the Gulf Coast. The other 2 sites serve similar clientele. Social determinants of health (SDOH) screenings at intake facilitate CHW referral for a clients’ unique needs for support at healthcare or social care agencies. Referral summaries can then be used to guide planning, community collaborating partner intervention, and clinical quality certification, Results/Anticipated Results: Results include identification of referrals process by which CHWs are able to provide culturally competent support to persons accessing healthcare services at the 3 clinic models identified. Identification of top SDOH needs that preclude access to care among the patients served during a 24-month pilot period, e.g., (i) housing insecurity, (ii) food insecurity, (iii) transportation, (iv) health Ins, and (v) pharmacy access and payment assistance. Discussion of beneficial impacts for health care service delivery with other members of the multidisciplinary clinical teams as recorded referrals can be used to guide planning, clinic certification efforts Discussion/Significance of Impact: Patient utilization of CHW services though self-selective offers opportunities for equity in access to care services from direct SDOH impacts, where CHWs act as responsive resource coordinators within the multi-disciplinary service delivery team.

Health care and health security are the fundamental pillars of disaster preparedness and crisis management. An established routine health care is necessary for any society, enabling full access to care and fulfilling the rights of every individual. Health security, on the other hand, is what a society needs to be flexible in managing an unexpected situation. To overcome a disaster with minimal damage or to avert such a critical situation, health care and health security should exist simultaneously. Thus, resilience in disaster preparedness and crisis management requires investment in both health care and health security. This ensures local public health services and infrastructure, local ambulances, both acute and chronic care referral systems, prompt vaccinations, and prevention of communicable diseases to name but a few. These measures which have proven to be the most sensitive evaluation of fair governance are critically absent in several nations, particularly in areas with long-standing conflicts. Strengthening health care and health security measures are paramount to the maintenance of the health system in peace and recovery of health delivery post-conflict and require political and economic considerations.

The purpose of World Health Organization (WHO) Emergency Medical Teams (EMT) is to provide timely, high-quality health services in the immediate aftermath of disasters and during disease outbreaks and other emergencies, including conflict and insecurity.

The war in Ukraine has presented all health-care providers with many unique challenges. This assessment addresses the importance and the complexities of the global spread of the Emergency Medical Team system challenges to meet a wide variety of crises including war, those that are unique to this very complex crisis in Ukraine, and the essential role of educational initiatives, not only in professional development but also in teamwork and cultural integration.

Synthetic aluminous hematites and goethites have been examined by Fourier-transform infrared spectroscopy. For aluminous hematites prepared at 950°C a linear relationship exists between Al content and the location of the band near 470 cm−1, up to 10 mole % Al substitution which is shown to be the solubility limit. The spectra of aluminous goethites prepared in two different ways are qualitatively similar to each other, but differ as to the relationship between the position of the band near 900 cm−1 and the Al content. The spectra of the two series of hematites produced by calcining the goethites at 590°C also show a strong dependence of band position and intensity on the goethite preparative method.

The trilobite faunas that occur with the Steptoean Positive Isotope Carbon Excursion (SPICE) at Smithfield Canyon, Utah, have been reported, but not illustrated. Given the importance of the SPICE at this section for international correlations, the trilobites from new collections from the upper Nounan Dolomite to lower St. Charles Formation at Smithfield Canyon are reported herein and integrated with the previously reported taxa. Trilobite assemblages indicate that the upper Cedaria to the Ellipsocephaloides biozones (Miaolingian Series, Guzhangian Stage to Furongian Series, Jiangshanian Stage) are present stratigraphically below or above the SPICE.

Some of the taxa reported herein may represent new species, but they are not represented by well-enough preserved specimens and are left in open nomenclature. However, Kingstonia smithfieldensis n. sp. and Bromella utahensis n. sp. are named on the basis of common and well-preserved specimens.

New carbon isotope data from Smithfield Canyon from an overlapping section of the lower St. Charles Formation, that add to the overall shape of the SPICE curve, are presented. The new δ13C values above the Elvinia Biozone range from –0.36‰ to +1.5‰, confirming that the SPICE concludes within the Elvinia Biozone.

UUID: http://zoobank.org/ad4fd372-8da4-4caa-98ed-ea82700cca60

What India produced others wanted. Others therefore wanted India. Although this by no means entirely explains India’s role in a polycentric world, it explains a great deal. It also helps us understand India as a fulcrum, at least within Indian Ocean trade. That is, the means by which India’s visual products became known and then coveted as well as the means by which India absorbed visual products from other centers of the world long before the age of call centers and other forms of outsourcing by which India engages in the present-day polycentric world.

My article for Diogenes examines four periods in India’s history that present opportunities to explore India’s role in a polycentric world as documented by visual examples. The first is the third-century BCE Maurya empire, which emerged in response to Alexander’s march toward the east. While we have some written documentation for India’s engagement with the Mediterranean, shared motifs and even the export of luxury goods beautifully fashioned from ivory document the engagement of two of the most important civilizations of the time. The second is the powerful seafaring and sea-trading Chola empire, which left its mark across Southeast Asia with the expansion of Buddhism and Hinduism, with scripts based on those of India, and with a Hindu temple of the thirteenth century, one very possibly designed and carved by Indian artists, whose remains are still to be seen in Quanzhou, China, the Zayton of Marco Polo’s writing. The third is India’s role in producing export textiles designed specifically for markets outside of India, for example, those of Southeast Asia but extending to the so-called Paisley prints and the plethora of words for textiles derived from Indian languages, e.g. Calico and Seersucker. Finally, the article examines Mughal paintings that incorporate European works and European artists, including Rembrandt, who copied Mughal paintings.