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Rates of prescriptions of antidepressants and suicide are inversely correlated at an epidemiological level. Less attention has been paid to relationships between other drugs used in mental health and suicide rates. Here we tested relationships between prescriptions of anxiolytics and antipsychotics and suicide rates in Scotland.
Results
Suicide rates were inversely correlated with prescriptions of antidepressants and antipsychotics over 14 years (2004–2018), and positively with prescriptions of anxiolytics.
Clinical implications
This illustrates the role of medications used in mental health in suicide prevention, and highlights the importance of identifying causal mechanisms that link anxiolytics with suicide.
A new species, Oocephalus pubescens A.Soares & Harley, from Chapada dos Veadeiros, Goiás, Brazil, is described and illustrated. The characteristics that distinguish it from a similar taxon, Oocephalus foliosus, are listed, and comments on its distribution and an occurrence map are provided.
Dengue is the world's most prevalent mosquito-borne disease, with more than 200 million people each year becoming infected. We used a mechanistic virus transmission model to determine whether climate warming would change dengue transmission in Australia. Using two climate models each with two carbon emission scenarios, we calculated future dengue epidemic potential for the period 2046–2064. Using the ECHAM5 model, decreased dengue transmission was predicted under the A2 carbon emission scenario, whereas some increases are likely under the B1 scenario. Dengue epidemic potential may decrease under climate warming due to mosquito breeding sites becoming drier and mosquito survivorship declining. These results contradict most previous studies that use correlative models to show increased dengue transmission under climate warming. Dengue epidemiology is determined by a complex interplay between climatic, human host, and pathogen factors. It is therefore naive to assume a simple relationship between climate and incidence, and incorrect to state that climate warming will uniformly increase dengue transmission, although in general the health impacts of climate change will be negative.
We have had experience with diaphragm pacing in 24 patients at the Toronto Western Hospital. Fourteen patients have undergone bilateral implants to treat chronic ventilatory insufficiency (CVI) caused by traumatic tetraplegia at the C1/2 level (eight patients), neurogenic apnea (five) and one case of neonatal apnea. Unilateral stimulators for nocturnal pacing have been implanted in five patients with central alveolar hypoventilation (sleep apnea) and five patients who suffered CVI resulting from various etiologies. Of the patients who were ventilatory dependent, 80% were successfully weaned and in the entire series, 58% of the patients are living. Diaphragm pacing was successful in 67%, partially successful in 8% and ineffective in 25%. The major complications were: death by pneumonia, failure of the radio receivers, and infection. Diaphragm pacing is the treatment of choice for patients who are ventilator dependent and tetraplegic from upper cervical trauma or in some cases of neurogenic apnea; it may be life saving for patients who suffer central alveolar hypoventilation.
We aimed to reparameterize and validate an existing dengue model, comprising an entomological component (CIMSiM) and a disease component (DENSiM) for application in Malaysia. With the model we aimed to measure the effect of importation rate on dengue incidence, and to determine the potential impact of moderate climate change (a 1 °C temperature increase) on dengue activity. Dengue models (comprising CIMSiM and DENSiM) were reparameterized for a simulated Malaysian village of 10 000 people, and validated against monthly dengue case data from the district of Petaling Jaya in the state of Selangor. Simulations were also performed for 2008-2012 for variable virus importation rates (ranging from 1 to 25 per week) and dengue incidence determined. Dengue incidence in the period 2010–2012 was modelled, twice, with observed daily weather and with a 1 °C increase, the latter to simulate moderate climate change. Strong concordance between simulated and observed monthly dengue cases was observed (up to r = 0·72). There was a linear relationship between importation and incidence. However, a doubling of dengue importation did not equate to a doubling of dengue activity. The largest individual dengue outbreak was observed with the lowest dengue importation rate. Moderate climate change resulted in an overall decrease in dengue activity over a 3-year period, linked to high human seroprevalence early on in the simulation. Our results suggest that moderate reductions in importation with control programmes may not reduce the frequency of large outbreaks. Moderate increases in temperature do not necessarily lead to greater dengue incidence.
Fundamentals of Engineering Programming with C and Fortran, first published in 1998, is a beginner's guide to problem solving with computers which shows how to quickly prototype a program for a particular engineering application. The book's side by side coverage of C and Fortran, the predominant computer languages in engineering, is unique. It emphasizes the importance of developing programming skills in C while carefully presenting the importance of maintaining a good reading knowledge of Fortran. Beginning with a brief description of computer architecture, the book then covers the fundamentals of computer programming for problem solving. It devotes separate chapters to data types and operators, control flow, type conversion, arrays, and file operations. The final chapter contains case studies that illustrate particular elements of modeling and visualization. Also included are a number of appendices covering C and Fortran language summaries and other useful topics. This concise and accessible book can be used as a text for introductory-level undergraduate courses on engineering programming or as a self-study guide for practising engineers.
Orogenesis, the process of mountain building, occurs when two tectonic plates collide – either forcing material upwards to form mountain belts such as the Alps or Himalayas or causing one plate to be subducted below the other, resulting in volcanic mountain chains such as the Andes. Integrating the approaches of structural geology and metamorphism, this book provides an up-to-date overview of orogenic research and an introduction to the physico-chemical properties of mountain belts. Global examples are explored, the interactioning roles of temperature and deformation in the orogenic process are reviewed, and important new concepts such as channel flow are explained. This book provides a valuable introduction to this fast-moving field for advanced undergraduate and graduate students of structural geology, plate tectonics and geodynamics, and will also provide a vital overview of research for academics and researchers working in related fields including petrology geochemistry and sedimentology.
Research over a 2-year period indicated that female pecan weevils, Curculio caryae Horn, tended to fly higher than males. Male pecan weevils were observed to be clumsy flyers and crawled to the pecan tree more often than females. Significant differences were noted among replicates, height flown by sexes, and distances from the tree where weevils were released. Pecan weevils do have definite habits in reaching the tree and this study seems to indicate that further investigations might be conducted to establish a method of control for the less mobile male weevils as well as for the higher flying females.
A familiar feature of orogens is the presence of a sedimentary basin, termed a foredeep basin, situated ahead of the orogen. The foredeep basins are filled in the main by the erosional detritus from the adjacent orogen, and good examples are the Siwalik basin of the Himalaya and the molasse basins of the Alps and Andes. The driving force for the erosion is mountain uplift. Before considering examples of foredeep basins we must first look at the controls on basin formation.
Isostasy and Bouguer anomalies
A full understanding of the physical relations between a mountain chain and the adjacent foreland basins calls for some knowledge of the gravitational factors involved in mountain building. The famous experiments in the Peruvian Andes by Bouguer in 1735 and 1745 established that there is a mass deficiency in mountain belts. Bouguer demonstrated this by measuring the deflection of a plumb line towards the Andes and showing that it was much less than expected from the huge bulk of the mountains. The gravity anomalies thus demonstrated are now named after him. Thus under mountains there is a negative Bouguer anomaly (Figs. 9.1, 9.2).
In 1928 Arthur Holmes suggested that the mechanism for continental drift is cells of convection in the mantle. This was a remarkable insight, although many would now question the one-to-one connection between plate motion and mantle convection. So what is the modern view on the driving force for plate movements? There are two models in which the plates drive themselves. The first is called ‘slab pull’, which means that the dense ocean crust exerts a pull on the ocean floor during subduction as it plunges into hot asthenosphere. In contrast, the less dense continental crust is relatively buoyant. Sometimes the subducted slab of ocean crust breaks off and sinks into the hot asthenosphere, but if it survives it will exert a traction and in effect pull the ocean crust away from the Mid Ocean Rise. The opposite view is ‘slab push’, which means that the driving force for the moving ocean floor is situated at the Mid Ocean Rise which is opening under extension to allow in the new ocean crust.
Perhaps it should not be either/or here. Phillip England (1982) calculated the required stresses at the Mid Ocean Rise in the Indian Ocean if slab push were to be responsible for the northward movement of the Indian plate carrying the Indian continent. The forces acting on a plate boundary must do work against gravity during the raising of high mountains and plateaux. The force balance must take into account the Argand number, which expresses the relative magnitudes of the buoyancy forces arising from contrasts in crustal thickness and the forces required to deform the medium. England's results show that the horizontal stress arising from slab push is enough to explain not only the motion of the Indian plate before collision but also the continuation of motion after the India–Asia collision, with the result that India indents Asia, and a wave of deformation has spread across the Asian continent for over 2000 km north of the Himalaya.
This chapter addresses the question of mountain support, isostasy and the tectonometamorphic and rheological processes operating in the deep structure of mountains that greatly influence their evolution. Referring to the outer part of the Earth, Barrell (1914) coined the terms lithosphere, the rocky part, and asthenosphere, the weaker lower part. This perceptive observation together with the concept of isostasy forms the basis for most of our thinking about mountains and their support. Clearly the mass of a mountain range or high plateau standing high above sea level requires a mechanism for its support. The creation of an elevated terrane means that work is done against gravity. The Tibetan Plateau could not stand at its present height without the support of a horizontal deviatoric stress, in this case the continuing plate convergence between India and Eurasia. Removal of this support would mean that the plateau would flow away – this is called orogenic collapse. It has been pointed out that the paradox in the Himalaya–Tibet example is that although the plate convergence continues steadily and the horizontal stress is maintained, the plateau is undergoing normal faulting which for many scientists implies that it is collapsing. This observation led to the idea that the lower part of the mantle lithosphere below Tibet has been delaminated and hence the Tibetan lithosphere acquired buoyancy.
Before going into the details of the geophysics of orogens it is necessary to consider models which show strength profiles through the lithosphere. There is ongoing debate between the ‘jelly sandwich’ model for the lithospheric rheology and the newer ‘crème brûlée’ model (Fig. 10.1). The jelly sandwich model is well established and might be regarded as the standard model for the rheology of the lithosphere; it is so called because it postulates a strong upper crust and upper mantle and a weak lower crust, whereas the more recent crème brûlée model, as proposed by Jackson (2002) and others, invokes a strong upper layer made up of the entire crust above a weak mantle.
The effects that mountain building may have on global climates and climate change have received considerable attention in recent years. However, the jury is still out on whether a direct causal link has been established between mountain building and climate or climate change, or at least the degree of influence of the one on the other. Many other factors are involved, not least the amount of CO2 in the Earth's atmosphere. There is agreement that the proposition calls for not only high mountains but also ones covering a large area of the Earth's surface. Climatic modelling has emphasised that in order to influence climate a huge area of high ground is needed, and the modellers consider that the Alps or Himalaya are not big enough, although they may well disrupt a north–south air flow and thereby cause local climatic effects.
Mountains influence climate because they are obstacles to air circulation. Additionally, they are sources of elevated latent heat and they change the water exchanges between continental surfaces and the atmosphere. In this chapter there is no room for an expansive account of this topic, but we will highlight some features and in particular enter the discussion of the role of orogenesis in changing the climate in southern Asia. Most of this chapter is devoted to the ongoing controversies surrounding the hypothesis that the rise of the Tibetan Plateau influenced and strengthened the monsoon in the late Miocene.
In this chapter we will be looking at the evolution of several types of Phanerozoic orogenic belts. Precambrian orogenesis will be dealt with in Chapter 12. The Himalaya and the Alps are part of a huge belt of Cenozoic age which runs from the Pyrenees through the Balkans into Turkey and on to the Middle East, Pakistan and India into Burma. There is also a leg from the Betic Cordillera to the Rif in North Africa and via Corsica to the Ligurian and Internal Western Alps. These parts were the result of the collision of Gondwanaland (the Late Palaeozoic assemblage of South America, Africa, India and Antarctic) and Eurasia (Europe and Asia). We also consider the Andes and the Caledonides in order to illustrate different types of orogens. For the present, examples are confined to the Cenozoic orogens because, as mentioned above, the younger mountain belts offer a better chance of understanding evolutionary processes in orogenesis than the older deeply eroded belts in which much of the evidence is missing (see Chapter 12).
In the now discarded geosynclinal theory of orogenesis as set out for example in Holmes's Principles of Physical Geology (Holmes, 1944), the pre-orogenic phase was a precursor of the orogenesis because the sedimentary and igneous rocks deposited in the geosyncline were already undergoing compression and so were predestined to become involved in orogeny, the point being reinforced by the postulated downward flow of mantle convection cells which led the whole process. Plate tectonics introduced a paradigm shift which included a denial of any link between the events occurring before orogenesis and the orogeny itself; this is well demonstrated by the Swiss Alps which were undergoing extension not compression before orogeny. The attempt to separate temporally extensional and compressional strain events is much too simple. For example, compressional strain in forearc wedges may be synchronous with extensional strain in the back arc, as for example in South America where overall convergence during the Jurassic–Early Cretaceous between the oceanic and continental plates involved synchronous extensional and compressional strains. This is a common feature around the Pacific where back-arc basins are opening during subduction. In addition, as Royden (1993 a,b) has shown, the roll-back and advance of the subduction zone produces alternations of extension and compression of continental margins.
Mountains have attracted the attention of mankind at least since Rousseau (or did Petrarch precede him?*) who devoted much thought to nature, perhaps because the height and scale of mountains induced a sense of awe. A love of nature showed itself in the fairly recent desire to get to the top of mountains. George Mallory gave his reason for wanting to climb Everest as “because it is there”, but long before that mountains were important for humankind, because they formed natural barriers for trade and the movement of armies. Perhaps the ancient Egyptians tried to simulate mountains in the pyramids of Giza. The same is true of builders of Gothic cathedrals, which were built ever higher so as to imitate mountains which reach up to heaven. The Greeks worshipped the gods on Mount Olympus, and mountains appeared often in Greek mythology; Prometheus, for example, was chained to a mountain side. The Greeks saw mountains as mysterious and frightening places, and even today for Hindus and Buddhists there are sacred mountains in the Himalaya such as Nanda Devi, Kailas and Everest – Qomolungma, the goddess mother of the Earth. Badrinath near the source of the Ganges in the High Himalaya is the home of the gods and a place of pilgrimage. Moses came down from a mountain bearing his famous tablets. Noah is supposed to have docked his ship on Mount Ararat. The Bible states “the mountains shall melt before the Lord” (Judges 5:5), but perhaps the reference was to volcanoes rather than orogenic mountains.
Many artists, too, have been fascinated by mountains. Leonardo Da Vinci realised that the fossils in the rocks of the Apennines showed that the rocks were once below sea level, and he and other painters used mountain scenes as backgrounds. Cezanne painted many pictures of Mont St. Victoire in Provence.