Metastructures composed of a closely spaced plate array have been widely used in bespoke manipulation of waves in contexts of acoustics, electromagnetics, elasticity and water waves. This paper focuses on wave scattering by discrete plate array metastructures of arbitrary cross-sections, including isolated vertical metacylinders, periodic arrays and horizontal surface-piercing metacylinders. A suitable transform-based method has been applied to each problem to reduce the influence of barriers in a two-dimensional problem to a set of points in a one-dimensional wave equation wherein the solution is constructed using a corresponding Green's function. A key difference from the existing work is the use of an exact description of the plate array rather than an effective medium approximation, enabling the exploration of wave frequencies above resonance where homogenisation models fail but where the most intriguing physical findings are unravelled. The new findings are particularly notable for graded plate array metastructures that produce a dense spectrum of resonant frequencies, leading to broadband ‘rainbow reflection’ effects. This study provides new ideas for the design of structures for the bespoke control of waves with the potential for innovative solutions to coastal protection schemes or wave energy converters.

With the development of overall design methodologies for hypersonic vehicles and their propulsion systems, nozzles should expand airflow in a short length and provide sufficient thrust. Therefore, the large expansion ratio single expansion ramp nozzle (LSERN) is widely used. The form of the overexpanded flow field in the nozzle is complex, under the conditions of nozzle start-up, low speed and low nozzle pressure ratio (NPR), thereby negatively influencing the entire propulsion system. Thus, the nozzle flow separation pattern and the key factors affecting the flow separation pattern also deserve considerable attention. In this study, the design of SERN is completed using the cubic curve design method, and the model is numerically simulated for specific operating conditions to study the flow separation patterns and the transition processes of different patterns. Furthermore, the key factors affecting the various flow separation patterns in the nozzle are investigated in detail. Results show that the LSERN in different NPRs appeared in two types of restricted shock separation (RSS) pattern and free shock separation (FSS) pattern, as well as their corresponding flow separation pattern transition processes. The initial expansion angle and the nozzle length affect the range of NPRs maintained by the FSS pattern. The initial expansion angle affects the pattern of flow separation, whereas the nozzle length remarkably influences the critical NPR during transition.

We first sequenced and characterised the complete mitochondrial genome of Toxocara apodeme, then studied the evolutionary relationship of the species within Toxocaridae. The complete mitochondrial genome was amplified using PCR with 14 specific primers. The mitogenome length was 14303 bp in size, including 12 PCGs (encoding 3,423 amino acids), 22 tRNAs, 2 rRNAs, and 2 NCRs, with 68.38% A+T contents. The mt genomes of T. apodemi had relatively compact structures with 11 intergenic spacers and 5 overlaps. Comparative analyses of the nucleotide sequences of complete mt genomes showed that T. apodemi had higher identities with T. canis than other congeners. A sliding window analysis of 12 PCGs among 5 Toxocara species indicated that nad4 had the highest sequence divergence, and cox1 was the least variable gene. Relative synonymous codon usage showed that UUG, ACU, CCU, CGU, and UCU most frequently occurred in the complete genomes of T. apodemi. The Ka/Ks ratio showed that all Toxocara mt genes were subject to purification selection. The largest genetic distance between T. apodemi and the other 4 congeneric species was found in nad2, and the smallest was found in cox2. Phylogenetic analyses based on the concatenated amino acid sequences of 12 PCGs demonstrated that T. apodemi formed a distinct branch and was always a sister taxon to other congeneric species. The present study determined the complete mt genome sequences of T. apodemi, which provide novel genetic markers for further studies of the taxonomy, population genetics, and systematics of the Toxocaridae nematodes.

The effect of treatment with praziquantel (PZQ) on the tegument of adult Schistosoma mansoni worms and on liver egg-granulomas has been examined in mice infected with PZQ-resistant and -susceptible parasite isolates. Two PZQ-resistant S. mansoni isolates, one selected by passage in the laboratory under drug pressure and one from Senegal established from eggs excreted by an uncured patient, were compared with PZQ-susceptible control isolates. Scanning electron microscopic observations on the tegument of Schistosoma adult worms treated in vivo with PZQ showed that more severe damage was inflicted by PZQ on susceptible worms than on drug-resistant worms. Observations on the pathology of Schistosoma egg-granulomas in the liver of infected mice after treatment with PZQ indicated that eggs from susceptible control isolates were more sensitive to PZQ than those from drug-resistant isolates.

In this paper, we study wave scattering and radiation by a surface-piercing vertical truncated metamaterial cylinder composed of a closely spaced array of thin vertical barriers, between which fluid can flow. A theoretical model is developed under full depth-dependent linearised water wave theory, where an effective medium equation and effective boundary conditions are employed, respectively, to describe the fluid motion inside the cylinder and match the flow between the fluid regions in and outside the metamaterial cylinder. A damping mechanism is introduced at the surface of the fluid occupied by the metamaterial cylinder to consider the wave power dissipation in narrow gaps between the thin vertical plates. The wave excitation forces acting on the cylinder and the hydrodynamic coefficients can be calculated straightforwardly in terms of the velocity potential inside the cylinder. An alternative way is by using the velocity potential outside the cylinder, the expression of which has the reduction of the integral and an infinite accumulation that are included in the straightforward expression. The results highlight the patterns of the radiated waves induced by the oscillation of the cylinder and the characteristics of the hydrodynamic coefficients. The metamaterial cylinder when fixed in place and with a damping mechanism included is found to capture more wave power than that of a traditional axisymmetric heaving wave energy converter over a wide range of wave frequencies.

We used a strand-specific RT-qPCR to evaluate viral replication as a surrogate for infectiousness among 242 asymptomatic inpatients with a positive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) admission test. Only 21 patients (9%) had detectable SARS-CoV-2 minus-strand RNA. Because most patients were found to be noninfectious, our findings support the suspension of asymptomatic admission testing.

In China, government at all levels relies on the specially selected graduates (SSG) scheme to recruit elite university students as future political leaders. This article examines the mechanism of the SSG scheme and the relationship between elite university education and political selection in China. We show that elite education is increasingly stratified, such that graduates from top elite universities have significant selection advantages in the SSG competition and are more likely to be offered incentives and preferences. We argue that taking elite university education as a hard eligibility criterion reinforces the homophily effects in selection of future political elites and strengthens the political influence of top elite universities on China's politics. Further, because poor and lower-class students have little chance of entering elite universities, the SSG does not provide an effective route of upward mobility for non-elite classes. Merit-based political recruitment as a channel of upward mobility for non-elite classes is largely an illusion.

Studies on humans that exploit contemporary data-intensive, high-throughput ‘omic’ assay technologies, such as genomics, transcriptomics, proteomics and metabolomics, have unequivocally revealed that humans differ greatly at the molecular level. These differences, which are compounded by each individual’s distinct behavioral and environmental exposures, impact individual responses to health interventions such as diet and drugs. Questions about the best way to tailor health interventions to individuals based on their nuanced genomic, physiologic, behavioral, etc. profiles have motivated the current emphasis on ‘precision’ medicine. This review’s purpose is to describe how the design and execution of N-of-1 (or personalized) multivariate clinical trials can advance the field. Such trials focus on individual responses to health interventions from a whole-person perspective, leverage emerging health monitoring technologies, and can be used to address the most relevant questions in the precision medicine era. This includes how to validate biomarkers that may indicate appropriate activity of an intervention as well as how to identify likely beneficial interventions for an individual. We also argue that multivariate N-of-1 and aggregated N-of-1 trials are ideal vehicles for advancing biomedical and translational science in the precision medicine era since the insights gained from them can not only shed light on how to treat or prevent diseases generally, but also provide insight into how to provide real-time care to the very individuals who are seeking attention for their health concerns in the first place.

In view of the cooperative guidance problem with time delay, this paper proposes a two-stage time-delay prescribed-time cooperative guidance law in the three-dimensional (3D) space. In the first stage, by introducing a time scaling function and time-delay consensus, the proposed cooperative guidance law can overcome the negative influence of time delay to guaranteed the desired convergence performance. Derived from the Lyapunov convergence analysis, the time-delay stability of the first stage can be ensured and the convergence time can be described as the relationship between delayed time and mission-assigned convergence time. Then, taking the prescribed-time-related convergence time as the switching point, the second stage begins with suitable initial conditions and all interceptors are governed by proportional navigation guidance. Finally, comparative simulations are performed to demonstrate the effectiveness and superiority of the proposed time-delay guidance law.

We report the experimental results of the commissioning phase in the 10 PW laser beamline of the Shanghai Superintense Ultrafast Laser Facility (SULF). The peak power reaches 2.4 PW on target without the last amplifying during the experiment. The laser energy of 72 ± 9 J is directed to a focal spot of approximately 6 μm diameter (full width at half maximum) in 30 fs pulse duration, yielding a focused peak intensity around 2.0 × 1021 W/cm2. The first laser-proton acceleration experiment is performed using plain copper and plastic targets. High-energy proton beams with maximum cut-off energy up to 62.5 MeV are achieved using copper foils at the optimum target thickness of 4 μm via target normal sheath acceleration. For plastic targets of tens of nanometers thick, the proton cut-off energy is approximately 20 MeV, showing ring-like or filamented density distributions. These experimental results reflect the capabilities of the SULF-10 PW beamline, for example, both ultrahigh intensity and relatively good beam contrast. Further optimization for these key parameters is underway, where peak laser intensities of 1022–1023 W/cm2 are anticipated to support various experiments on extreme field physics.

We report on experimental observation of non-laminar proton acceleration modulated by a strong magnetic field in laser irradiating micrometer aluminum targets. The results illustrate the coexistence of ring-like and filamentation structures. We implement the knife edge method into the radiochromic film detector to map the accelerated beams, measuring a source size of 30–110 μm for protons of more than 5 MeV. The diagnosis reveals that the ring-like profile originates from low-energy protons far off the axis whereas the filamentation is from the near-axis high-energy protons, exhibiting non-laminar features. Particle-in-cell simulations reproduced the experimental results, showing that the short-term magnetic turbulence via Weibel instability and the long-term quasi-static annular magnetic field by the streaming electric current account for the measured beam profile. Our work provides direct mapping of laser-driven proton sources in the space-energy domain and reveals the non-laminar beam evolution at featured time scales.

Sarcopenic obesity is regarded as a risk factor for the progression and development of non-alcoholic fatty liver disease (NAFLD). Since male sex is a risk factor for NAFLD and skeletal muscle mass markedly varies between the sexes, we examined whether sex influences the association between appendicular skeletal muscle mass to visceral fat area ratio (SVR), that is, an index of skeletal muscle mass combined with abdominal obesity, and the histological severity of NAFLD. The SVR was measured by bioelectrical impedance in a cohort of 613 (M/F = 443/170) Chinese middle-aged individuals with biopsy-proven NAFLD. Multivariable logistic regression and subgroup analyses were used to test the association between SVR and the severity of NAFLD (i.e. non-alcoholic steatohepatitis (NASH) or NASH with the presence of any stage of liver fibrosis). NASH was identified by a NAFLD activity score ≥5, with a minimum score of 1 for each of its categories. The presence of fibrosis was classified as having a histological stage ≥1. The SVR was inversely associated with NASH in men (adjusted OR 0·62; 95 % CI 0·42, 0·92, P = 0·017 for NASH, adjusted OR 0·65; 95 % CI 0·43, 0·99, P = 0·043 for NASH with the presence of fibrosis), but not in women (1·47 (95 % CI 0·76, 2·83), P = 0·25 for NASH, and 1·45 (95 % CI 0·74, 2·83), P = 0·28 for NASH with the presence of fibrosis). There was a significant interaction for sex and SVR (Pinteraction = 0·017 for NASH and Pinteraction = 0·033 for NASH with the presence of fibrosis). Our findings show that lower skeletal muscle mass combined with abdominal obesity is strongly associated with the presence of NASH only in men.