Changing practice patterns caused by the pandemic have created an urgent need for guidance in prescribing stimulants using telepsychiatry for attention-deficit hyperactivity disorder (ADHD). A notable spike in the prescribing of stimulants accompanied the suspension of the Ryan Haight Act, allowing the prescribing of stimulants without a face-to-face meeting. Competing forces both for and against prescribing ADHD stimulants by telepsychiatry have emerged, requiring guidelines to balance these factors. On the one hand, factors weighing in favor of increasing the availability of treatment for ADHD via telepsychiatry include enhanced access to care, reduction in the large number of untreated cases, and prevention of the known adverse outcomes of untreated ADHD. On the other hand, factors in favor of limiting telepsychiatry for ADHD include mitigating the possibility of exploiting telepsychiatry for profit or for misuse, abuse, and diversion of stimulants. This Expert Consensus Group has developed numerous specific guidelines and advocates for some flexibility in allowing telepsychiatry evaluations and treatment without an in-person evaluation to continue. These guidelines also recognize the need to give greater scrutiny to certain subpopulations, such as young adults without a prior diagnosis or treatment of ADHD who request immediate-release stimulants, which should increase the suspicion of possible medication diversion, misuse, or abuse. In such cases, nonstimulants, controlled-release stimulants, or psychosocial interventions should be prioritized. We encourage the use of outside informants to support the history, the use of rating scales, and having access to a hybrid model of both in-person and remote treatment.

The U.S. Department of Agriculture–Agricultural Research Service (USDA-ARS) has been a leader in weed science research covering topics ranging from the development and use of integrated weed management (IWM) tactics to basic mechanistic studies, including biotic resistance of desirable plant communities and herbicide resistance. ARS weed scientists have worked in agricultural and natural ecosystems, including agronomic and horticultural crops, pastures, forests, wild lands, aquatic habitats, wetlands, and riparian areas. Through strong partnerships with academia, state agencies, private industry, and numerous federal programs, ARS weed scientists have made contributions to discoveries in the newest fields of robotics and genetics, as well as the traditional and fundamental subjects of weed–crop competition and physiology and integration of weed control tactics and practices. Weed science at ARS is often overshadowed by other research topics; thus, few are aware of the long history of ARS weed science and its important contributions. This review is the result of a symposium held at the Weed Science Society of America’s 62nd Annual Meeting in 2022 that included 10 separate presentations in a virtual Weed Science Webinar Series. The overarching themes of management tactics (IWM, biological control, and automation), basic mechanisms (competition, invasive plant genetics, and herbicide resistance), and ecosystem impacts (invasive plant spread, climate change, conservation, and restoration) represent core ARS weed science research that is dynamic and efficacious and has been a significant component of the agency’s national and international efforts. This review highlights current studies and future directions that exemplify the science and collaborative relationships both within and outside ARS. Given the constraints of weeds and invasive plants on all aspects of food, feed, and fiber systems, there is an acknowledged need to face new challenges, including agriculture and natural resources sustainability, economic resilience and reliability, and societal health and well-being.

OBJECTIVES/GOALS: Supported by the State of Alabama, the Alabama Genomic Health Initiative (AGHI) is aimed at preventing and treating common conditions with a genetic basis. This joint UAB Medicine-HudsonAlpha Institute for Biotechnology effort provides genomic testing, interpretation, and counseling free of charge to residents in each of Alabama’s 67 counties. METHODS/STUDY POPULATION: Launched in 2017, as a state-wide population cohort, AGHI (1.0) enrolled 6,331 Alabamians and returned individual risk of disease(s) related to the ACMG SF v2.0 medically actionable genes. In 2021, the cohort was expanded to include a primary care cohort. AGHI (2.0) has enrolled 750 primary care patients, returning individual risk of disease(s) related to the ACMG SF v3.1 gene list and pre-emptive pharmacogenetics (PGx) to guide medication therapy. Genotyping is done on the Illumina Global Diversity Array with Sanger sequencing to confirm likely pathogenic / pathogenic variants in medically actionable genes and CYP2D6 copy number variants using Taqman assays, resulting in a CLIA-grade report. Disease risk results are returned by genetic counselors and Pharmacogenetics results are returned by Pharmacists. RESULTS/ANTICIPATED RESULTS: We have engaged a statewide community (>7000 participants), returning 94 disease risk genetic reports and 500 PGx reports. Disease risk reports include increased predisposition to cancers (n=38), cardiac diseases (n=33), metabolic (n=12), other (n=11). 100% of participants harbor an actionable PGx variant, 70% are on medication with PGx guidance, 48% harbor PGx variants and are taking medications affected. In 10% of participants, pharmacists sent an active alert to the provider to consider/ recommend alternative medication. Most commonly impacted medications included antidepressants, NSAIDS, proton-pump inhibitors and tramadol. To enable the EMR integration of genomic information, we have developed an automated transfer of reports into the EMR with Genetics Reports and PGx reports viewable in Cerner. DISCUSSION/SIGNIFICANCE: We share our experience on pre-emptive implementation of genetic risk and pharmacogenetic actionability at a population and clinic level. Both patients and providers are actively engaged, providing feedback to refine the return of results. Real time alerts with guidance at the time of prescription are needed to ensure future actionability and value.

In this paper, we answer the multiple calls for systematic analysis of paradigms and subdisciplines in political science—the search for coherence within a fragmented field. We collected a large dataset of over seven hundred thousand writings in political science from Web of Science since 1946. We found at least two waves of political science development, from behaviorism to new institutionalism. Political science appeared to be more fragmented than literature suggests—instead of ten subdisciplines, we found 66 islands. However, despite fragmentation, there is also a tendency for integration in contemporary political science, as revealed by co-existence of several paradigms and coherent and interconnected topics of the “canon of political science,” as revealed by the core-periphery structure of topic networks. This was the first large-scale investigation of the entire political science field, possibly due to newly developed methods of bibliometric network analysis: temporal bibliometric analysis and island methods of clustering. Methodological contribution of this work to network science is evaluation of islands method of network clustering against a hierarchical cluster analysis for its ability to remove misleading information, allowing for a more meaningful clustering of large weighted networks.

In this paper, we examine the contribution of Network Science journal to the network science discipline. We do so from two perspectives. First, expanding the existing taxonomy of article contribution, we examine trends in theory testing, theory building, and new method development within the journal’s articles. We find that the journal demands a high level of theoretical contribution and methodological rigor. High levels of theoretical and methodological contribution become significant predictors of article citation rates. Second, we look at the composition of the studies in Network Science and determine that the journal has already established a solid “hard core” for the new discipline.

This paper introduces historical aspects of the concepts correspondence and coherence with emphasis on the nineteenth century when key aspects of modern science were emerging. It is not intended to be a definitive history of the concepts of correspondence and coherence as they have been used across the centuries in the field of inquiry that we now call science. Rather it is a brief history that highlights the apparent origins of the concepts and provides a discussion of how these concepts contributed to two important science related controversies. The first relates to aspects of evolution in which correspondence and coherence, as competing theories of truth, played a central role. The controversy about evolution continues into the beginning of the twenty-first century in forms that are recognizably similar to those of the middle of the nineteenth century. The second controversy relates to the etiology of blood-born infections (sepsis) during childbirth (childbed fever). In addition to correspondence and coherence, the authors introduce other theories of truth and discuss an evolutionarily cogent theory of truth, the pragmatic theory of truth.

Archival charcoal tree-ring segments from the Mississippian center of Kincaid Mounds provide chronometric information for the history of this important site. However, charcoal recovered from Kincaid was originally treated with a paraffin consolidant, a once common practice in American archaeology. This paper presents data on the efficacy of a solvent pretreatment protocol and new wiggle-matched 14C dates from the largest mound (Mound 10) at Kincaid. FTIR and 14C analysis on known-age charcoal intentionally contaminated with paraffin, as well as archaeological material, show that a chloroform pretreatment is effective at removing paraffin contamination. Wiggle-matched cutting dates from the final construction episodes on Mound 10 at Kincaid, indicate that the mound was used in the late 1300s with the construction of a unique structure on the apex occurring around 1390. This study demonstrates the potential for museum collections of archaeological charcoal to contribute high-resolution chronological information despite past conservation practices that complicate 14C dating.