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Grounded in institutional theory, this study delves into the heterogeneous responses of politically connected top executives (PCTEs) to uniform institutional requirements for corporate environmental responsibility (CER). Specifically, we scrutinized the moderating role of organizational visibility in shaping the association between PCTEs and both environmentally responsible and irresponsible practices. Analyzing data from listed Chinese firms in heavily polluting industries spanning from 2010 to 2018, the findings indicate that PCTEs contribute to an increase in firms’ environmentally responsible activities and a decrease in their environmentally irresponsible activities. Notably, the impact on environmentally responsible activities is significant only for privately controlled PCTEs. Furthermore, the moderating influence of organizational visibility is validated. The implications of these findings for the broader research on political connections and CER are thoroughly discussed.
Metabolic enzymes are the catalysts that drive the biochemical reactions essential for sustaining life. Many of these enzymes are tightly regulated by feedback mechanisms. To fully understand their roles and modulation, it is crucial to investigate the relationship between their structure, catalytic mechanism, and function. In this perspective, by using three examples from our studies on Mycobacterium tuberculosis (Mtb) isocitrate lyase and related proteins, we highlight how an integrated approach combining structural, activity, and biophysical data provides insights into their biological functions. These examples underscore the importance of employing fast-fail experiments at the early stages of a research project, emphasise the value of complementary techniques in validating findings, and demonstrate how in vitro data combined with chemical, biochemical, and physiological knowledge can lead to a broader understanding of metabolic adaptations in pathogenic bacteria. Finally, we address the unexplored questions in Mtb metabolism and discuss how we expand our approach to include microbiological and bioanalytical techniques to further our understanding. Such an integrated and interdisciplinary strategy has the potential to uncover novel regulatory mechanisms and identify new therapeutic opportunities for the eradication of tuberculosis. The approach can also be broadly applied to investigate other biochemical networks and complex biological systems.
This chapter focuses on literacy development in East Asia, the eastern region of the Asian continent. Students in most East Asian countries perform well in literacy. However, migrant communities still face struggles, leading to fewer opportunities in the labor market. East Asia has a very long history of literary practice. With China being the largest and oldest country in East Asia, its writing system has a profound impact in the region. The modern Chinese writing system is used not only by the 1.4 billion people in Mainland China but also in Chinese-speaking regions such as Hong Kong, Macau, and Taiwan. It is further used by Chinese-heritage speakers in Singapore, Malaysia, and countries around the world. However, most East Asian countries are biscriptal. This chapter starts out with an overview of the writing systems used in China, Japan, Korea, and Mongolia, followed by a description of the educational system in relation to literacy in each country. In the remaining part of the chapter the focus is on individual variation, neurological foundations and environmental factors related to literacy development in Chinese. Finally, the chapter presents a comparison of the factors related to literacy development in Chinese, Japanese, and Korean.
People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.
Methods:
We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other) and PSY. We pre-specified NfL > 582 pg/mL as indicative of ND/MCI/other.
Results:
Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone.
Conclusions:
CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.
Glutamatergic dysfunction has been implicated in sensory integration deficits in schizophrenia, yet how glutamatergic function contributes to behavioural impairments and neural activities of sensory integration remains unknown.
Methods
Fifty schizophrenia patients and 43 healthy controls completed behavioural assessments for sensory integration and underwent magnetic resonance spectroscopy (MRS) for measuring the anterior cingulate cortex (ACC) glutamate levels. The correlation between glutamate levels and behavioural sensory integration deficits was examined in each group. A subsample of 20 pairs of patients and controls further completed an audiovisual sensory integration functional magnetic resonance imaging (fMRI) task. Blood Oxygenation Level Dependent (BOLD) activation and task-dependent functional connectivity (FC) were assessed based on fMRI data. Full factorial analyses were performed to examine the Group-by-Glutamate Level interaction effects on fMRI measurements (group differences in correlation between glutamate levels and fMRI measurements) and the correlation between glutamate levels and fMRI measurements within each group.
Results
We found that schizophrenia patients exhibited impaired sensory integration which was positively correlated with ACC glutamate levels. Multimodal analyses showed significantly Group-by-Glutamate Level interaction effects on BOLD activation as well as task-dependent FC in a ‘cortico-subcortical-cortical’ network (including medial frontal gyrus, precuneus, ACC, middle cingulate gyrus, thalamus and caudate) with positive correlations in patients and negative in controls.
Conclusions
Our findings indicate that ACC glutamate influences neural activities in a large-scale network during sensory integration, but the effects have opposite directionality between schizophrenia patients and healthy people. This implicates the crucial role of glutamatergic system in sensory integration processing in schizophrenia.
‘Recurrence’ of coronavirus disease 2019 (COVID-19) has triggered numerous discussions of scholars at home and abroad. A total of 44 recurrent cases of COVID-19 and 32 control cases admitted from 11 February to 29 March 2020 to Guanggu Campus of Tongji Hospital affiliated to Tongji Medical College Huazhong University of Science and Technology were enrolled in this study. All the 44 recurrent cases were classified as mild to moderate when the patients were admitted for the second time. The gender and mean age in both cases (recurrent and control) were similar. At least one concomitant disease was observed in 52.27% recurrent cases and 34.38% control cases. The most prevalent comorbidity among them was hypertension. Fever and cough being the most prevalent clinical symptoms in both cases. On comparing both the cases, recurrent cases had markedly elevated concentrations of alanine aminotransferase (ALT) (P = 0.020) and aspartate aminotransferase (AST) (P = 0.007). Moreover, subgroup analysis showed mild to moderate abnormal concentrations of ALT and AST in recurrent cases. The elevated concentrations of ALT and AST may be recognised as predictive markers for the risk of ‘recurrence’ of COVID-19, which may provide insights into the prevention and control of COVID-19 in the future.
In individuals with latent tuberculosis (TB) infection, those living with human immunodeficiency virus (HIV) had a 20–37 times higher risk of developing active TB compared to those without HIV infection. Systematic testing and treatment of latent TB infection are priorities in HIV-infected persons. In China, the prevalence of HIV infection in men who have sex with men (MSM) has gradually increased in the past decade. However, the prevalence of TB infection has been studied sparsely in HIV-infected MSM. Hence, we conducted a pilot study in MSM living with HIV infection in Xi'an city to evaluate TB infection status by means of interferon-γ release assay (IGRA). A total of 182 HIV-infected MSM were included in this study, the prevalence of IGRA positivity was observed to be 8·79% (16/182). IGRA quantitative results were not statistically influenced by the CD4 cell counts of the study participants. However, IGRA positivity was found to be lower than our previously reported data from the general population. This suggests that immunological deficiency might decrease the sensitivity of IGRA and thus increase the number of false negatives. Our primary results, suggesting systematic testing and treatment of latent TB infection together with active case-finding, were equally important for TB control in persons living with HIV infection.
Light intensity, spectrum and pattern may affect laying hen behaviors and production performance. However, requirements of these lighting parameters from the hens’ standpoint are not fully understood. This study was conducted to investigate hens’ needs for light intensity and circadian rhythm using a light tunnel with five identical compartments each at a different fluorescent light intensity of <1, 5, 15, 30 or 100 lux. The hens were able to move freely among the respective compartments. A group of four W-36 laying hens (23 to 30 weeks of age) were tested each time, and six groups or replicates were conducted. Behaviors of the hens were continuously recorded, yielding data on daily time spent, daily feed intake, daily feeding time, and eggs laid under each light intensity and daily inter-compartment movement. The results show that the hens generally spent more time in lower light intensities. Specifically, the hens spent 6.4 h (45.4%) at 5 lux, 3.0 h (22.1%) at 15 lux, 3.1 h (22.2%) at 30 lux and 1.5 h (10.3%) at 100 lux under light condition; and an accumulation of 10.0 h in darkness (<1 lux) per day. The 10-h dark period was distributed intermittently throughout the day, averaging 25.0±0.4 min per hour. This hourly light-dark rhythm differs from the typical commercial practice of providing continuous dark period for certain part of the day (e.g. 8 h at night). Distributions of daily feed intake (87.3 g/hen) among the different light conditions mirrored the trend of time spent in the respective light intensity, that is, highest at 5 lux (28.4 g/hen, 32.5% daily total) and lowest at 100 lux (5.8 g/hen, 6.7%). Hen-day egg production rate was 96.0%. Most of the eggs were laid in <1 lux (61.9% of total) which was significantly higher than under other light intensities (P<0.05). Findings from this study offer insights into preference of fluorescent light intensity by the laying hens. Further studies to assess or verify welfare and performance responses of the hens to the preferred lighting conditions and rhythm over extended periods are recommended.
In this paper, we present an adaptive, analysis of variance (ANOVA)-based data-driven stochastic method (ANOVA-DSM) to study the stochastic partial differential equations (SPDEs) in the multi-query setting. Our new method integrates the advantages of both the adaptive ANOVA decomposition technique and the data-driven stochastic method. To handle high-dimensional stochastic problems, we investigate the use of adaptive ANOVA decomposition in the stochastic space as an effective dimension-reduction technique. To improve the slow convergence of the generalized polynomial chaos (gPC) method or stochastic collocation (SC) method, we adopt the data-driven stochastic method (DSM) for speed up. An essential ingredient of the DSM is to construct a set of stochastic basis under which the stochastic solutions enjoy a compact representation for a broad range of forcing functions and/or boundary conditions.
Our ANOVA-DSM consists of offline and online stages. In the offline stage, the original high-dimensional stochastic problem is decomposed into a series of low-dimensional stochastic subproblems, according to the ANOVA decomposition technique. Then, for each subproblem, a data-driven stochastic basis is computed using the Karhunen-Loève expansion (KLE) and a two-level preconditioning optimization approach. Multiple trial functions are used to enrich the stochastic basis and improve the accuracy. In the online stage, we solve each stochastic subproblem for any given forcing function by projecting the stochastic solution into the data-driven stochastic basis constructed offline. In our ANOVA-DSM framework, solving the original highdimensional stochastic problem is reduced to solving a series of ANOVA-decomposed stochastic subproblems using the DSM. An adaptive ANOVA strategy is also provided to further reduce the number of the stochastic subproblems and speed up our method. To demonstrate the accuracy and efficiency of our method, numerical examples are presented for one- and two-dimensional elliptic PDEs with random coefficients.
We perform a computationl study of front speeds of G-equation models in time dependentcellular flows. The G-equations arise in premixed turbulent combustion, and areHamilton-Jacobi type level set partial differential equations (PDEs). The curvature-strainG-equations are also non-convex with degenerate diffusion. The computation is based onmonotone finite difference discretization and weighted essentially nonoscillatory (WENO)methods. We found that the large time front speeds lock into the frequency of timeperiodic cellular flows in curvature-strain G-equations similar to what occurs in thebasic inviscid G-equation. However, such frequency locking phenomenon disappears inviscous G-equation, and in the inviscid G-equation if time periodic oscillation of thecellular flow is replaced by time stochastic oscillation.
Based on the vector angular spectrum theory of electromagnetic waves and the method of stationary phase, analytical vector structures of four-petal Gaussian beams (FPGB) in the far field are derived. The energy flux for the TE term, TM term and the whole beam are represented and illustrated with numerical examples. Effects of beam orders and paraxial degrees on energy flux distributions are discussed in detail, and the corresponding analytical explanations are also given. These results may provide a new approach to manipulate other higher-order laser beams in the far field.
The presence of blue straggler stars (BSs) as secure members of Galactic open clusters (OCs) poses a major challenge to the conventional picture of evolutionary population synthesis (EPS) based on the stellar evolution theory of single stars, since the major formation ways of BSs are all correlated with stellar interactions. With a working sample including 100 Galactic OCs with age ranging from 0.1 to 10 Gyr, the contributions of BSs to the integrated light of their host clusters are calculated on an individual cluster base. We also show in this work that the intrinsic evolutionary stages of OCs can be enormously misunderstood by the conventional simple stellar population (SSP) models, if the real/observed integrated spectral energy distributions (ISEDs) of OCs are the only thing that we can depend on and are fitted with ISEDs of conventional SSPs, and consequently the huge uncertainties in age and/or metallicity can be conservatively estimated at 50%. Thus, we strongly confirm that when the conventional EPS technique is used to study the properties of stellar populations in complicated systems such as galaxies, the contributions of BSs should be definitely taken into account in order to avoid big fitting mistake.
By using synthetic integrated spectral energy distribution (ISED) of open clusters and a new evolutionary scenario involving interactive binaries, the theoretical model of simple stellar population (SSP) models are tested. Blue stragglers stars are commonly present in open clusters, which are usually around 2 magnitudes brighter and much bluer than the MS turn-off of the cluster, and they certainly belong to the same population as the host cluster. Considering the cluster as the nearest counterpart the concept of SSP, inclusion of such stars may have significant consequences on the integrated of properties of the population. We are showing in the present work that if one is to fit the real stellar population using the classical model based only on single star evolution theory, large errors in either age or metallicity (or both) can be made. The new theoretical SSP incorporated with interactive binaries can explain part of the difference between classical SSP model and synthetic ISED built up with open clusters. This suggests that the formation of blue stragglers in real clusters is more complicated as usually assumed in binary stellar population synthesis.
The influence of the crystallization condition - temperature and time - on the structure of poly (vinylidene fluoride chlorotrifluoroethylene), P(VDF-CTFE), was studied using DSC and XRD. The DSC results of all studied polymers show three peaks. One peak, which is associated with crystallization temperature, represents the appearance of unstable phase in the polymers. Both XRD and DSC data indicate the coexistence of different phases in the polymers, which may be the reason for the high electrostrictive performance obtained in the polymers.
Taking advantages of short pulse excitation and time-resolved photoluminescence (PL), we have studied the exciton localization effect in a number of GaAsN alloys and GaAsN/GaAs quantum wells (QWs). In the PL spectra, an extra transition located at the higher energy side of the commonly reported N-related emissions is observed. By measuring PL dependence on temperature and excitation power along with PL dynamics study, the new PL peak has been identified as a transition of the band edge-related recombination in dilute GaAsN alloy and delocalized transition in QWs. Using selective excitation PL we further attribute the localized emission in QWs to the excitons localized at the GaAsN/GaAs interfaces. This interface-related exciton localization could be greatly reduced by a rapid thermal annealing.
The microstructure of La1–xAx(A = Ca or Sr)MnO3–δ thin films grown by liquid-delivery metalorganic chemical vapor deposition on (001) MgO and (110)pseudo-cubic LaAlO3 were studied by transmission electron microscopy. The La1–xCaxMnO3–δ thin film on large lattice mismatched MgO exhibited very defective microstructures and consisted of two typical regions. The first region was close to the film–substrate interface and had an epitaxial relationship to the substrate with many differently oriented domains nucleated on the substrate surface. The second region consisted of columnar grains with some degree of texture. In contrast, the smaller lattice-mismatched La1–xSrxMnO3–δ/(110)pseudo-cubic LaAlO3 film had good crystalline quality with highly oriented columnar grains but exhibited complicated dislocation structures. Apart from the misfit dislocations formed at the film–substrate interface, two types of anomalous dislocations with limited contribution to relieving misfit stresses were also observed. One type of dislocation had extra planes in the film and some climbed into the substrate. These dislocations were considered to form from dislocation loops during nucleation of the film. The other type of dislocations had extra planes parallel to the film–substrate interface and glided into the substrate side resulting in a 2° tilt of the film with respect to the substrate. The complicated dislocation configurations present in the sample were related to the complex strain field in the film. The relative strains along the interface measured in the film were heterogeneous. The variations of the strains in the film were related to the local Curie temperature changes and second-order phase transitions of the film.
In the present work we studied the depth of damage layer in machined silicon wafers that was incorporated with chemical etching using micro-Raman spectroscopy. Subsurface damage causes changes in the shape and intensity for the shoulder (450–570 cm−1) of the most intense band (519 cm−1) and the second band (300 cm−1) regions of the Raman spectrum. Etching reduces the thickness of the damage layer and, hence, the intensities at the shoulder and the second band. The intensities at the shoulder and the second band become stable when the damage layer is completely etched out. The shoulder consists of two Gaussian profiles: the major and the minor. The band for the major profile is independent of etching depth, but the band for the minor profile shifts toward the longer wave numbers with increasing etching period until the damage layer is completely etched out. The depth of the damage layer is determined by the profiles of the shoulder and the second band and confirmed by the band shift of the minor profile. Transmission electron microscopy (TEM) further verified the results with respect to the depth of the damage layer. TEM observation showed that dislocations and stacking faults are responsible for the subsurface damage.
An In(Ga)As-based self-assembled quantum dot laser test structure grown on strain-relief Al0.5Ga0.5As1-ySby strain-relief buffer layers (0≤y ≤ 0.24) on a GaAs substrate is investigated in an effort to increase dot size and therefore extend the emission wavelength over conventional InAs quantum dots on GaAs platforms. Cross-section transmission electron microscopy, and high-resolution x-ray diffraction are used to monitor the dislocation filtering process and morphology in the buffer layers. Results show that the buffer layers act as an efficient dislocation filter by drastically reducing threading dislocations, thus providing a relaxed, low dislocation, compositionally modulated Al0.5Ga0.5Sb0.24As0.76 substrate for large (500Å height x 300Å width) defect -free InAs quantum dots. Photoluminescence shows a ground-state emission of the InAs quantum dots at 1.45 μm.
A complete understanding of the complexities behind the structure-property relationships at materials interfaces requires the structure, composition and bonding to be characterized on the fundamental atomic scale. This level of characterization is beyond the scope of a single imaging or microanalysis technique and so to solve practical interface problems, correlation between multiple techniques must be achieved. Here we describe recent advances in the JEOL 2010F 200kV field-emission STEM/TEM that now allow atomic resolution imaging and analysis to be obtained in both TEM and STEM mode and discuss two applications of these techniques
GaN/(0001)Sapphire grown by low pressure MOVPE is studied by high resolution Z-contrast imaging using STEM. First direct observation of the threading dislocation with edge character shows the atomic core structure, which appears to have a similar configuration to the {10–10} surface. The surfaces of the nanopipe walls are on {10–10} with the terminating layer between the atoms with one bond per pair. In addition, the high resolution Z-contrast image of the prismatic stacking fault confirms the results by conventional HRTEM.