A new encapsulated saflufenacil formulation has been developed and premixed as a single product with pyroxasulfone to provide control of small-seeded annual grass and broadleaf weeds and to extend the application window to early postemergence when applied to field corn. Pyroxasulfone + encapsulated saflufenacil applied preemergence alone and in mixtures with other herbicides were examined for crop response and weed control efficacy. We hypothesized that applying pyroxasulfone + encapsulated saflufenacil with a tank-mix partner would expand the spectrum of weed species that can be controlled and improve overall weed control efficacy compared to pyroxasulfone + encapsulated saflufenacil applied alone. Six field experiments were completed at three locations in southwestern Ontario in 2022 and 2023. Pyroxasulfone + encapsulated saflufenacil was applied alone, at 146 g ai ha−1 (pyroxasulfone 90 g ai ha−1, saflufenacil 56 g ai ha−1) or 245 g ai ha−1 (pyroxasulfone 150, saflufenacil 95 g ai ha−1), and with the following herbicide partners: atrazine, dicamba, or mesotrione + atrazine. All herbicide treatments were applied prior to corn and weed emergence. Weed control, density and biomass, and corn injury and yield were assessed. All pyroxasulfone + encapsulated saflufenacil treatments caused no injury to corn. At 8 wk after emergence (WAE) pyroxasulfone + encapsulated saflufenacil (245 g ai ha−1) controlled common lambsquarters, redroot pigweed, and foxtail species by 42%, 59%, and 41%, respectively. Applications of pyroxasulfone + encapsulated saflufenacil (146 or 245 g ai ha−1) with dicamba or mesotrione + atrazine improved common lambsquarters and redroot pigweed control at 8 WAE compared with pyroxasulfone + encapsulated saflufenacil applied alone. Pyroxasulfone + encapsulated saflufenacil (146 or 245 g ai ha−1) applied with dicamba or mesotrione + atrazine provided similar control of common lambsquarters, redroot pigweed, and foxtail species to that of S-metolachlor/atrazine/mesotrione/bicyclopyrone, which is a standard herbicide used to control these weeds. Corn yield for all pyroxasulfone + encapsulated saflufenacil herbicide mixtures was similar to that of the weed-free control and the standard herbicide.