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The importance of palliative care in cancer care is underscored, yet there is a significant gap in research specifically focusing on the role of social workers in palliative cancer care. This qualitative study aims to better articulate the specific roles of social workers within palliative oncology settings.
Methods
Data were collected by semi-structured Zoom interviews with social workers in palliative cancer care between November 2023 and January 2024. Thematic analysis was used to identify unique themes.
Results
Ten social workers in palliative cancer care were recruited for this study. Eight key themes related to social workers’ role emerged from the interviews. These were the following: (1) mapping out holistic needs through a biopsychosocial–spiritual assessment, (2) providing individual and family counseling, (3) patient and family psychoeducation, (4) resource identification and referral, (5) building communication bridges between patients, families, and oncology teams, (6) promoting patient and family engagement and voice in shared decision-making in cancer care, (7) providing anticipatory grief and bereavement counseling, and (8) strengthening team resilience and fostering well-being.
Significance of results
This study builds upon prior work by focusing specifically on the roles of palliative care social workers in oncology. The findings highlight the multifaceted roles of social workers, demonstrating their capacity to deliver holistic care to cancer patients, families, and healthcare providers to enhance quality of care. The findings may help inform the development of training curricula and practice standards for the subspecialty of oncology-focused palliative social work.
To investigate whether taste perception of two artificial sweeteners—aspartame and neohesperidin dihydrochalcone (NHDC)—is causally associated with the risk of site-specific cancers.
Design:
A two-sample Mendelian randomization (MR) study.
Setting:
Genetic instruments for taste perception (6 for aspartame; 13 for NHDC) were obtained from a genome-wide association study (GWAS) of Australian adolescents, and cancer outcome data were sourced from publicly available GWAS datasets.
Participants:
Genetic data for taste perception from 1,757 Australian adolescents and genetic data for cancers from large-scale GWAS cohorts, including UK Biobank (n=500,000) and FinnGen (n=500,000).
Results:
A one standard deviation increase in the genetically predicted perceived intensity of NHDC was associated with an increased risk of male genital cancer (OR = 1.11, 95% CI: 1.04–1.19) and prostate cancer (OR = 1.03, 95% CI: 1.01–1.08) based on FinnGen data. These associations persisted after multivariable MR adjustment for glucose and aspartame perception but were not replicated in the UK Biobank. A weak protective association between aspartame perception and cervical cancer (OR = 0.998, 95% CI: 0.997–0.999) was observed, but this attenuated to null in sensitivity analyses.
Conclusions:
This study found no compelling evidence that perception of aspartame or NHDC during adolescence causally influences later-life cancer risk. The findings highlight the importance of evaluating individual artificial sweeteners separately in future research examining potential health effects.
Communicating a cancer diagnosis to a child is a complex challenge for parents. This study aims to explore (1) the communication strategies and beliefs of parents with cancer when communicating with their children and (2) the needs of these parents.
Methods
Semi-structured interviews were conducted with parents with cancer being treated at an Italian comprehensive cancer center and their healthy partners, when present. The interviews were analyzed through a constructivist approach using reflexive thematic analysis. The number of parents to be interviewed was not predetermined, but the meaning saturation procedure was followed.
Results
Ten parents were interviewed, meaning saturation was reached at the seventh interview. Five themes were created: (1) the challenges parents faced at this sensitive time; (2) the emotions parents experienced; (3) the beliefs that may have influenced how they communicate the illness to their children; (4) the strategies parents used to communicate the illness to their children and (5) parents’ perception of their children’s understanding of the illness. Fifty-seven needs, often unmet, were also identified and were grouped into three categories: (1) “existential” needs; (2) support needs; and (3) needs related to continuing to be and act as parents.
Significance of results
This study provides important insights for healthcare professionals to consider in order to better support and care for these parents.
The effect of the Japanese diet on cancer incidence remains unclear. The purpose of this study was to examine the association between the Japanese diet and the risk of all-cause and site-specific cancer. We analysed 14-year follow-up data from the Osaki Cohort study of 25 570 Japanese men and women aged 40–79 years. The Japanese diet was evaluated using a thirty-nine-item FFQ at baseline. Based on a previous study, we used eight food items to calculate the Japanese Diet Index score: rice, miso soup, seaweed, pickles, green and yellow vegetables, seafood, green tea and beef and pork. The participants were divided into quartiles based on their Japanese Diet Index scores. The Cox proportional hazards model was used to estimate the hazard ratios and 95 % CI of cancer incidence. During the mean 10·4 years of follow-up, we identified 3161 incident cases of all-cause cancer. Multivariable analysis showed that the Japanese Diet Index score was not associated with cancer incidence. In comparison with Q1 (the lowest), the multivariable hazard ratios and 95 % CI were 1·01 (0·92, 1·12) for Q2, 0·94 (0·85, 1·04) for Q3 and 1·06 (0·95, 1·18) for Q4 (the highest). Furthermore, separate analyses of nine common cancer sites demonstrated no association with the Japanese Diet Index score. The results were consistent even after a sensitivity analysis using multiple imputation. This prospective study showed that the Japanese diet was not associated with cancer incidence. The results suggest that the Japanese diet could contribute to a person’s overall health and well-being without increasing cancer risk.
Cancer clinical research networks (CRNs) play a vital role in medical research globally by generating investigator-initiated research, pooling expertise, and enabling recruitment across multiple sites. Completing clinical trials is challenging. Delays can slow the generation of evidence needed to refine the best patient treatments. The aim of this review was to identify factors that have been either proposed or shown by research to influence the performance of cancer CRNs to improve trial success, outcomes and impact. A scoping review was conducted using a systematic search across five databases [PROSPERO CRD42023414241]. Records were screened for eligibility. For included articles, data on factors and research methods were extracted independently by up to three reviewers, and disagreements resolved by discussion. 1928 articles were returned, 13 were included. Articles reported on 11 membership-based cancer CRNs with headquarters in four countries (eight in the USA). Factors influencing CRN performance broadly fell into six categories: site, CRN, patient, regulatory, policy and industry factors, with subcategories in each case. These findings may help to inform future research to prioritize and improve the day-to-day performance of membership-based cancer CRNs and other trial sponsors to optimize clinical trial success. Further research is warranted.
Unpaid cancer caregivers (UCCs) are the primary caretakers of individuals with cancer, often shouldering caregiver responsibilities without prior preparation, which leads to a sense of isolation, particularly in remote and rural areas where healthcare access is challenging. Thus, this systematic review aimed to explore the perceived and/or received peer support needs of UCCs residing in rural and remote areas with a specific focus on informational, practical, and emotional needs.
Method
Seven databases (CINAHL, ScienceDirect, PUBMED/MEDLINE, PROQUEST, Web of Science, Scopus, and Informit) were searched from 2004 to 2024. Peer-reviewed qualitative, quantitative, and mixed-method studies published in English were considered for this review. Data were extracted using the Joanna Briggs Institute System for Unified Management, Assessment, and Review of Information and presented using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram. Quality and bias were assessed with the Mixed Methods Appraisal Tool.
Results
In total, 8 primary studies were included: 4 qualitative, 2 mixed methods, 1 cross-sectional, and 1 prospective survey. Four themes were identified: (1) Emotional, practical, and informational unmet needs; (2) Lack of peer support on the physical and emotional well-being of UCCs in remote and rural areas; (3) Lack of supportive services in remote and rural areas; and (4) Access to flexible peer support.
Significance of results
This review revealed the unique unmet needs of UCCs in remote and rural areas, where a lack of reliable and accessible resources adversely leads to impaired UCCs’ overall well-being. Addressing these unmet needs is essential to enhance the support system for UCCs living in such regions. By identifying the gaps, the review underscores the need for developing a peer support model tailored to the specific needs of UCCs in rural and remote communities.
Chapter 7 provides an overview of best practices in dyadic health interventions that seek to leverage the interpersonal context to optimize the health and well-being of the dyad (both couples and care dyads). The chapter begins with a brief discussion of dyadic interventions, including partner-supported interventions and ripple-effect interventions. We discuss the advantages of taking a dyadic approach to health interventions and provide the findings and key recommendations from recent reviews and meta-analyses across different health (e.g., physical activity, diet) and illness (e.g., cancer, dementia, heart failure, diabetes, pain) contexts. The chapter concludes by providing some specific examples of both established and emerging dyadic health interventions (e.g., Couples Coping Enhancement Training, Exercising Together, FOCUS, SHARE, Recovering Together, Taking Care of Us, Partners in Coping Program, SUCCEED, REPAIR, Let’s Talk Tech). Throughout this chapter, we highlight some of the limitations that have continued to characterize this literature as well as offer recommendations for future research in dyadic health interventions.
The burden of cancer worldwide is rising, with 20 million new cases diagnosed in 2022. In Europe, 1.2 million women are diagnosed with cancer annually and an estimated 600,000 women die from cancer each year. International research and data from Ireland demonstrate that women with cancer face a particular set of challenges, including increased psychological distress compared to men. As a result, Ireland’s Model of Care for Psycho-Oncology could usefully place greater emphasis on gender-specific provisions which address the increased psychological needs of women. To date, Ireland has made some progress in recognising the physical and mental healthcare needs of women and developing gender-informed policies. It is essential that such policies are implemented fully so as to reduce and eliminate disparities in care. A more tailored, gender-informed approach would also help ensure the provision of gender-aware psycho-oncological care for all women and men as they navigate their cancer journeys.
This study examined the changes in intimacy and sexuality amongst cancer patients at the end of life, including those in the final stage, and the distress they raised while experiencing those changes.
Methods
A phenomenological qualitative study, based on interviews with 35 dying cancer patients. The results were analyzed by Constant Comparison Analysis method.
Results
Some of the dying patients reported absence of essential change in their sexual needs and ability. while others reported about changes. The changes caused seven various forms of distress to the majority of patients, for example grief due to diminution of sexuality, impact on the partner due to lack of sex and distress resulting from consciousness of the end of life. A minority did not experience distress from the sexuality changes. About a third of the interviewees were interested in sexual counseling during their dying period, and about 80% considered it important for the palliative care team to raise the issue of sexuality.
Conclusions
End of life patients and even those in final stages may have needs related to their intimate and sexual life. As long as the person breathes, even towards death, he can continue to live, even in the intimate aspect, so the palliative team has an important role in answering the specific and complex needs related to sexuality at the end of life. Recommendations were formulated specifically based on this research, for professional intervention regarding sexuality at the end of life, by a PASSION model.
Patients’ involvement in the decision-making process is essential for shared decision-making and optimal patient-centered care. However, when there are concerns about a patient’s cognition and judgmen, the complexity of providing patient-centered care increases. It is often necessary to evaluate patients’ decision-making capacity (DMC) to determine whether they are able to make a particular decision or whether to rely on their previously expressed wishes or the patient’s caregivers.
Methods
In this article, we present a case of an older adult with colon cancer who presented to the emergency room.
Results
We describe how multidisciplinary care can enhance the evaluation of DMC and improve quality of care for older patients with advanced cancer.
Significance of results
Multidisciplinary discussions and good communication skills are essential for navigating these complex situations, reducing potential harm and maximizimizing quality of life.
This study was conducted to examine the relationship between cancer patients’ spiritual needs and their quality of life and depression levels.
Methods
This cross-sectional, exploratory study was conducted between March 2023 and November 2024. The study population consisted of cancer patients hospitalized in medical oncology departments at a university hospital in eastern Turkey. The sample consisted of 250 patients, determined by power analysis. To collect data, the “Demographic Information Form,” “Spiritual Needs Assessment Scale,” “EORTC QLQ-C30 Version 3.0 Quality of Life Scale,” and “Beck Depression Scale” were used to evaluate the patients’ sociodemographic characteristics and disease process.
Results
There was a weak, negative, statistically significant relationship between patients’ spiritual needs and the subdimensions of the quality of life scale, specifically the general perceived health status (r = −0.297, p < 0.001), physical (r = −0.446, p < 0.001), role (r = −0.423, p < 0.001), emotional (r = −0.472, p < 0.001), cognitive (r = −0.458, p < 0.001) and social (r = −0.443, p < 0.001) functions, and finally, a weak positive correlation was found between the symptoms experienced (r = 0.376, p < 0.001) and depression levels. Additionally, a weak positive correlation between spiritual needs and depression level (r = 0.374, p < 0.001) was identified. Functional areas, depression, education level, diagnosis duration, and symptoms were identified as variables predicting spiritual needs.
Significance of results
In conclusion, it was determined that as the spiritual needs of cancer patients increased, their quality of life decreased and the severity of depression increased.
Diagnosis of cancer can be a stressful and life-threatening event that is associated with suicide risk.
Aims
To investigate how suicide risk changes over time after cancer diagnosis, and, specifically, when it becomes similar to that of matched controls.
Method
Using a nationwide population-based database, we identified a total of 171 474 individuals aged ≥20 years newly diagnosed with cancer between 2009 and 2017 and 1:5 age- and sex-matched controls. We calculated adjusted hazard ratios (aHRs) with 95% confidence intervals of suicide in cancer patients for the full period and with a 1- to 5-year lag period.
Results
During a mean follow-up of 6.7 years, 0.3% of cancer patients (491 of 171 474) died by suicide, with incidence rates of 0.4 per 1000 person-years. Cancer patients had higher risk of suicide (aHR 1.64, 95% CI 1.48–1.81) compared with matched controls. Suicide risk remained higher than that of matched controls with a 1- or 2-year lag period (aHR 1.38, 95% CI 1.23–1.55 and aHR 1.32, 95% CI 1.16–1.50, respectively), but there was no significant difference with a 5-year lag period (aHR 1.13, 95% CI 0.93–1.38). However, those with haematologic cancers were at higher suicide risk than matched controls even 5 years after diagnosis (e.g. aHR 9.26, 95% CI 1.30–65.87 for Hodgkin lymphoma).
Conclusions
In cancer patients, suicide risk remained elevated for several years after diagnosis, but decreased over time and became similar to that of matched controls after 5 years. However, the temporal pattern varied by cancer type, and suicide risk remained high for patients with haematological cancers. Suicide risk screening is necessary from the time of cancer diagnosis, even in long-term survivors.
Cancer, a multifactorial and heterogeneous disease, poses a significant global health challenge. Despite current treatments such as surgery, radiotherapy, and chemotherapy, tumour recurrence and treatment side effects are common. These pitfalls necessitate a dire need for alternative therapeutic strategies with minimal side effects. This necessity has broadened the horizons of drug discovery into the marine domain, an exciting frontier for novel therapeutic agents. The marine ecosystem serves as a hub of diverse chemical groups with potential anti-cancer properties. Few marine-derived drugs are approved for cancer, and preliminary studies show that marine lead compounds can inhibit cancer cell growth and induce apoptosis. In this context, this review encapsulates an overview of ‘the current state of marine biodiscovery’. It explores the ‘potential of marine natural products in combating cancer’ with a particular focus on glioblastoma multiforme as a case study. Additionally, it discusses the ‘key strategies for advancing marine-derived anti-cancer compounds from the research stage to clinical use’. By tapping into the vast, unlocking the hidden treasures of the ocean, marine natural compounds could offer a hopeful perspective in the fight against cancer.
Chapter 6 shows how it is possible to use demographic metadata to study identities in health-related corpora. We present two case studies, based on research on patient feedback on NHS services in England. The first study compares how cancer patients of different age and sex groups evaluate healthcare services and, specifically, how they use distinct linguistic and rhetorical strategies to do this. The corpus was encoded with demographic metadata which allowed the researchers to explore the language used by people of different age and sex identity groups. For the second study, a different corpus of more general patient feedback was used, one which did not contain demographic information metadata. Instead, targeted searches were used to identify patients’ demographic characteristics based on cases where they made those characteristics explicit within their feedback. In contrasting these case studies, we also evaluate the two different approaches taken, considering the affordances and limitations of both. Taken together, the case studies demonstrate how language and identity can be explored in corpora with and without reliable demographic metadata.
Chapter 5 is concerned with sequential aspects of health-oriented interactions and the challenges this poses for corpus research. Two case studies demonstrate how conventional corpus procedures can be augmented with other linguistic approaches to facilitate a critical examination of the relationships between parts of the data that might otherwise be separated in corpus analysis. The first study is an investigation of a thread from an online forum dedicated to cancer – one that is explicitly dedicated to irreverent verbal play. We show how a corpus approach enabled the identification of humourous metaphors and helped us reveal recurrent lexical and grammatical features that facilitate discussion around sensitive topics, enable a coherent identity, and contribute to a sense of community. In the second study we use an approach that was originally applied to the Spoken BNC 2014 corpus to examine interactional data in terms of functional discourse units. We apply this coding framework to a sample of anxiety support forum data in order to document, quantify, and evaluate how various communicative purposes are formulated in forum posts and are met with different types of response.
Chapter 9 considers how the experience of illness is represented linguistically, focussing on two contexts. In the first case study, collocational patterns were examined in order to show how people represented the word anxiety. Different patterns around anxiety were grouped together in order to identify oppositional pairs of representation (e.g., medicalising/normalising). The second case study involved an examination of the ways in which cancer was constructed in a corpus of interviews with and online forum posts by people with cancer, family carers, and healthcare professionals. Using a combination of manual analysis and corpus searches, we considered how metaphors were used to convey a sense of empowerment or disempowerment in the experience of cancer. More specifically, the analysis of metaphors around cancer revealed insights into people’s identity construction and the relationships between doctors and patients.
This chapter uses the context of Michael Field’s letters and shared journal to discuss fin-de-siècle illness and disability, focusing on ‘hysterical blindness’ and cancer. The long-standing notion of Michael Field as an isolated dyad is placed in tension with Talia Schaffer’s work on Victorian ‘communities of care’. The chapter asserts that we need to consider audience when we read Michael Field’s representations of illness, and, using a queer, crip, lens suggests that Bradley and Cooper’s writing about their embodied selves is strategic, like the name Michael Field itself.
Clozapine is the gold standard for treatment-resistant schizophrenia. In the setting of malignancy with concurrent anti-cancer agent use, clozapine use may be of increased concern. Clozapine cessation holds its own risks. This study aims to systematically review all cases of concurrent pharmacotherapy with clozapine and anti-cancer agents and analyze the psychiatric and physical health outcomes. PubMed, EMBASE, CINAHL, and PsycINFO databases were searched from inception to February 2025. Descriptive statistics and narrative analysis of the included cases occurred. There were 53 cases of clozapine use with anti-cancer agents, with a male to female ratio of 1.7:1 and a mean age of 45.0 years. In 30 cases, clozapine was continued without interruption, and in additional 16 cases, clozapine was recommenced after a period of interruption. In cases with clozapine interruption or discontinuation, 90% noted significant deterioration in mental state despite alternative antipsychotic treatments. There were 34 cases of neutropenia, mostly (94%) in the setting of cytotoxic chemotherapy, with low rates of neutropenic complications. The successful continuation of clozapine with anti-cancer agents can occur, although risk-benefit analysis taking into account individual, clozapine, psychiatric, and physical health factors is required. Consideration of prophylactic neutropenia protective measures should form part of the discussion with the individual and their family.
This study aimed to investigate healthcare professionals’ experiences with using the PRO Palliative Care questionnaire (PRO-Pall) to identify palliative care symptoms and problems in non-specialized palliative care settings among patients with heart, lung, and kidney disease, and cancer. The study also investigated the PRO-Pall’s potential to ensure further initiatives and care.
Methods
A national, multicenter, observational study employing a mixed-methods approach. It includes quantitative analysis using an evaluation survey (n = 286) and qualitative analysis from workshops (n = 11). Quantitative data were analyzed descriptively, while qualitative data were analyzed thematically.
Results
Quantitative and qualitative data were organized according to 3 a priori-defined themes: Theme 1: Assessment of palliative symptoms, Theme 2: Support for dialogue, and Theme 3: Timely initiation of initiatives and care. The evaluation survey and qualitative interviews with healthcare professionals indicated that it was valuable to use PRO-Pall in a non-specialist palliative context to screen for symptoms and problems, as well as to initiate actions. PRO-Pall helped to structure the dialogue and had a positive effect on the quality of the conversation.
Significance of results
The findings highlight that it can be valuable to utilize the PRO-Pall in general palliative care settings for patients with heart, lung, or kidney diseases as well as cancer. When implementing PRO-Pall in practice, it is crucial to carefully consider the entire process, from administering the questionnaire to planning initiatives informed by patients’ PRO responses.