To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The velocity that can be attained by a solar sail is limited by the Sun’s intensity. In this chapter we examine replacing the Sun with a much more intense artificial radiation source, such as a laser, to achieve a higher velocity. We look more closely at the mechanics of photons incident on sails, taking into account relativistic effects and the finite travel time of light. Diffraction of the directed radiation source is a major issue, because it limits the amount of light intercepted by the sail, requires large optics, or demands high laser power, or some combination of these. We look into achieving the kilometre-scale optical systems required using aperture synthesis and adaptive optics. Given the large laser powers involved (tens to hundreds of gigawatts), sail heating becomes a limiting factor, and the choice of materials is critical. Having looked at the theoretical issues, I summarize a few of the numerous laser sail designs that have been published that bring together many of the issues discussed.
The mechanisms governing generation and amplification of laser-driven electromagnetic pulses (EMPs) in the picosecond (ps) regime remain insufficiently understood. Here, we present a unified theoretical and experimental framework that demonstrates dual-picosecond laser irradiation of solid targets can synergistically enhance EMP emission. By integrating particle-in-cell simulations with three-dimensional electromagnetic modeling, we reveal that the increasing laser focal power density amplifies hot electron emission and strengthens neutralization currents, leading to giant EMP radiations. Experimentally, we validate these predictions at the XG-III and SG-II U picosecond petawatt laser facilities, achieving a record-breaking EMP field strength of 3.08 MV/m – substantially exceeding previously reported values from ps-laser–solid interactions. Furthermore, we demonstrate that EMP characteristics can be precisely tuned via laser and target parameters, enabling controllable, high-field electromagnetic sources. Our findings provide deep insight into the physics of laser-driven EMP amplification and establish a robust platform for developing next-generation high-intensity electromagnetic emitters.
We analyse Einstein’s introduction of the processes of light–atom interactions to explain Planck’s law of thermal emission and, in particular, the mechanism of stimulated (or induced) emission. We define the statistical Einstein coefficients he introduced to describe these processes and analyse their relative importance. We then discuss how to amplify an electromagnetic wave by inversion of atomic populations, and thus how masers and various lasers work, and look at laser cooling and extremely stable standards for frequency (time) measurements.
This study aimed to compare long-term audiological outcomes of diode laser stapedotomy, microdrill stapedotomy and combined potassium titanyl phosphate laser–microdrill stapedotomy, and to identify predictors of surgical success.
Methods
Surgical, audiological and complications data were collected. Surgical success was analysed via the measurement of post-operative air–bone gap, air conduction gain.
Results
A total of 615 patients were included; median follow-up was 16 months (range 1–1319). Overall, the 94.3 per cent achieved surgical success (air–bone gap < 15 dB). Median air–bone gap closure was 5 dB (interquartile range: 2.50–8.12), and median air conduction gain was 27.5dB (interquartile range: 19.37–36.25).
Compared across techniques, success rates were similar; however, post-operative air–bone gap was significantly better with laser techniques than with microdrill alone (p = 0.016). Longer prostheses were associated with improved outcomes.
Conclusion
All the examined techniques showed excellent audiological results. Laser use was associated with better post-operative air–bone gap than stapedotomy with microdrill only.
This chapter provides an overview of minimally invasive approaches in neurosurgery. It explores the history of minimally invasive techniques and their current state and discusses the authors’ beliefs regarding future advancements. We highlight the transformative impact of minimally invasive approaches, including improved patient outcomes, quality of life, and reduced morbidity.
The generation of intense radio-frequency and microwave electromagnetic pulses (EMPs) by the interaction of a high-power laser with a target is an interesting phenomenon, the exact mechanisms of which remain inadequately explained. In this paper we present a detailed characterization of the EMP emission at a sub-nanosecond kilojoule laser facility, the Prague Asterix Laser System. The EMPs were detected using a comprehensive set of broadband diagnostics including B-dot and D-dot probes, various antennas, target current and voltage probes and oscilloscopes with 100 and 128 GS/s sampling. Measurements show that the EMP spectrum was strongly dependent on the laser energy: the maximum frequency of the spectrum and the frequency of the spectrum centroid increased with increasing laser beam energy in the signals from all detectors used. The highest observed frequencies exceeded 9 GHz. The amplitude and energy of the detected EMP signals were scaled as a function of laser energy, power and number of emitted electrons.
Few studies have investigated stapedotomy using 1470 nm diode laser, and the present article contributes with clinical experience.
Methods
A retrospective analysis was conducted to investigate hearing performance of 22 patients undergoing 1470 nm diode laser-assisted primary stapedotomy.
Results
In 8/22 cases, accidental breaches to the inner ear by the laser and in 14/22 cases the stapedotomy was performed as planned only by drill. Air–bone gap and loss of sensorineural hearing were low and with no significant differences for groups at follow-up. No patients with breaches by laser reported new or worse tinnitus.
Conclusion
Accidental breaches in the stapes footplate using this diode laser did not appear to equate with inner ear damage within this limited cohort. Hearing outcomes were not significantly affected. These findings should be interpreted with caution. Further studies evaluating this laser wavelength in stapedotomy is required.
Edited by
Rebecca Leslie, Royal United Hospitals NHS Foundation Trust, Bath,Emily Johnson, Worcester Acute Hospitals NHS Trust, Worcester,Alex Goodwin, Royal United Hospitals NHS Foundation Trust, Bath,Samuel Nava, Severn Deanery, Bristol
The final chapter in the book covers some specific electrical devices used in surgery, anaesthesia and critical care. Firstly, we discuss defibrillators where exam candidates are expected to have a good working knowledge and be able to both draw and explain the relevant electrical circuit. Secondly we discuss surgical equipment in LASER and diathermy, both of which carry detail in their different types, risks of harm and safety requirements. Finally the chapter discusses medical ultrasound, how it is generated and used in clinical practice.
Tightly focused proton beams generated from helical coil targets have been shown to be highly collimated across small distances, and display characteristic spectral bunching. We show, for the first time, proton spectra from such targets at high resolution via a Thomson parabola spectrometer. The proton spectral peaks reach energies above 50 MeV, with cutoffs approaching 70 MeV and particle numbers greater than 10${}^{10}$. The spectral bunch width has also been measured as low as approximately 8.5 MeV (17% energy spread). The proton beam pointing and divergence measured at metre-scale distances are found to be stable with the average pointing stability below 10 mrad, and average half-angle beam divergences of approximately 6 mrad. Evidence of the influence of the final turn of the coil on beam pointing over long distances is also presented, corroborated by particle tracing simulations, indicating the scope for further improvement and control of the beam pointing with modifying target parameters.
Recurrent respiratory papillomatosis is a rare disease characterised by growth of papilloma within the respiratory tract. The disease course is variable but can require frequent surgical interventions alongside adjuvant medical treatments. There is no definitive curative treatment or gold-standard guidelines for management. We aimed to evaluate current and potential future adjuvant treatments and propose a management guideline for adult patients.
Methods
Relevant articles were identified through searching databases, reference lists and grey literature.
Results
Systemic bevacizumab appears to be the most effective adjuvant treatment currently available. However, intralesional cidofovir also achieves a high complete-response rate in adults and the Gardasil vaccine demonstrates preventative and therapeutic value. The INO-3107 DNA vaccine is a promising potential future adjuvant treatment.
Conclusions
This review provides a detailed examination of current and potential future adjuvant treatments. Based on the literature, we have developed a management guideline for adult patients with recurrent respiratory papillomatosis.
Premature infants have a risk of neurodevelopmental deficits. Little is known, however, about how retinopathy of prematurity (ROP) affects visual motor integration (VMI), which is necessary for both fine motor skills and further school abilities. Due to the systemic escape of bevacizumab in the treatment of ROP, concerns regarding the long-term neurodevelopmental effect of the drug have arisen. The aim is to evaluate VMI and motor development long-term outcomes after intravitreal bevacizumab (IVB) injection and laser treatment for ROP. Two groups of premature children were included: Bevacizumab group – 16 premature children who received IVB treatment and laser group – 23 premature children who underwent laser photocoagulation treatment in this single center cross-sectional study. At 2–6 years of age, VMI (Beery–Buktenica Developmental Test), motor development (Peabody Developmental Motor Scales-2), visual acuity, and refractive status were assessed. The incidence of abnormal visual function was significantly higher in bevacizumab group than in laser group (p = 0.022). The incidence of abnormal VMI skill was significantly higher in bevacizumab group than in laser group (p = 0.024). Incidences of abnormal gross, fine, and total motor skills were significantly higher in bevacizumab group compared to laser group (p < 0.05). Premature children who received bevacizumab for ROP demonstrated significantly lower VMI and motor development features than those with laser treatment at preschool age. Although our results suggest the relevance of bevacizumab injection in impaired VMI and motor development outcomes, general level of sickness rather than treatment might be the cause of delayed motor development.
The production of broadband, terawatt terahertz (THz) pulses has been demonstrated by irradiating relativistic lasers on solid targets. However, the generation of extremely powerful, narrow-band and frequency-tunable THz pulses remains a challenge. Here, we present a novel approach for such THz pulses, in which a plasma wiggler is elaborated by a table-top laser and a near-critical density plasma. In such a wiggler, the laser-accelerated electrons emit THz radiations with a period closely related to the plasma thickness. The theoretical model and numerical simulations predict that a THz pulse with a laser–THz energy conversion of over 2.0%, an ultra-strong field exceeding 80 GV/m, a divergence angle of approximately 20° and a center frequency tunable from 4.4 to 1.5 THz can be generated from a laser of 430 mJ. Furthermore, we demonstrate that this method can work across a wide range of laser and plasma parameters, offering potential for future applications with extremely powerful THz pulses.
To analyse the comparative clinical outcomes and clinicopathological significance of vocal fold leukoplakia lesions treated by appearance classification and traditional methods.
Method
A total of 1442 vocal fold leukoplakia patients were enrolled. Group A patients were treated according to appearance classification and Group B patients were treated according to traditional methods.
Results
In Group A, 24.4, 14.9 and 60.6 per cent of patients had grade I, II and III dysplasia, respectively. Grade I dysplasia (63.4 per cent) was more than twice as frequent in Group B patients than in Group A patients, while grade II dysplasia (20.4 per cent) and grade III dysplasia (16.2 per cent) were significantly less frequent in Group B patients than in Group A patients (p = 0.000). There was a significant correlation between vocal fold leukoplakia appearance and the degree of dysplasia (p = 0.000). The recurrence and malignant transformation rates (17.6 and 31 per cent, respectively) in Group B were significantly greater than those in Group A (10.8 and 25.9 per cent, respectively) (p = 0.000).
Conclusion
Vocal fold leukoplakia appearance classification is useful for guiding treatment decision-making and could help to improve therapeutic accuracy.
Sperm motility is an important factor for successful fertilization and embryo development. If a patient presents only immotile sperm in the ejaculate or in a testicular sample, a viability test can help to identify among the immotile sperm those that are viable and suitable for intracytoplasmic sperm injection (ICSI). Different sperm viability tests have been introduced, and if they are applied properly, there is a good chance for successful treatment.
Exploiting high-energy electron beams colliding into high-intensity laser pulses brings an opportunity to reach high values of the dimensionless rest-frame acceleration $\chi$ and thereby invoke processes described by strong-field quantum electrodynamics (SFQED). Measuring deviations from the results of Furry-picture perturbation theory in SFQED at high $\chi$ can be valuable for testing existing predictions, as well as for guiding further theoretical developments. Nevertheless, such experimental measurements are challenging due to the probabilistic nature of the interaction processes, dominating signals of low-$\chi$ interactions and limited capabilities to control and measure the alignment and synchronization in such collision experiments. Here we elaborate a methodology of using approximate Bayesian computations for drawing statistical inferences based on the results of many repeated experiments despite partially unknown collision parameters that vary between experiments. As a proof-of-principle, we consider the problem of inferring the effective mass change due to coupling with the strong-field environment.
The photon signal-to-noise ratio (SNR) is defined in terms of statistical quantities, and the Poisson and Gaussian probability distribution functions are defined and described. Those distributions are applied to lidar measurements, and the effect of background light on lidar SNR is quantified. The signal-limited and background-limited SNR regimes are defined. The lidar equation is then introduced as a model of the range-dependent lidar signal, and the background model is a constant additional term. All the variables in both models are introduced and defined. They include the number of photons in each laser pulse, the optical efficiencies of the transmitter and receiver, the geometrical function, the receiver solid angle, the range bin length, the volume backscatter coefficient, the extinction coefficient, the spectral radiance of the background, the receiver field of view, the receiver optical bandpass, and the sampling interval of the data system. Finally, a lidar system known as the Eye safe Atmospheric Research Lidar (EARL) is introduced because it is used as an example throughout the rest of the book.
Around a third of patients have drug-resistant epilepsy (DRE). This is crucially and easily determined if a patient continues to have seizures after being on two adequately dosed and appropriately selected antiseizure medicines (ASMs). For these patients, your initial efforts to make a specific and localized diagnosis will inform next treatment decisions. If a patient presents suddenly with DRE, it is key to assess for a possible autoimmune cause, as a separate treatment pathway should be considered. Otherwise, consider epilepsy surgery as an effective treatment. These treatments include brain resections and neuromodulation. Minimally invasive techniques have recently become more common, including laser surgery as well as stereotactically placed depth electrodes. Given the prevalence of neurostimulators, consideration for obtaining MRIs in patients with these devices is addressed, as pathways exist for all of these patients to safely undergo MRI testing.
We learn time-dependent perturbation theory, where we focus on finding the probability that an applied perturbation causes a transition between energy levels of the unperturbed Hamiltonian. We calculate the probability amplitude for a transition from an initial state to a final state subject to a time-dependent perturbation. We learn that an excited state in an atom has a finite lifetime due to spontaneous emission. We learn that electric dipole transitions obey selection rules.
This appendix situates quantum technologies as a product of the merger of quantum mechanics, the theory of the very small; and information theory, the theory of how information is communicated and quantified. These intersections of these fields create quantum information science (QIS), provide a basis for understanding quantum sensing, computing, and communication. This appendix explains quantum scale and starts an exploration as to why effects at the quantum scale are so radically different from humans' day-to-day experience.
Micromanipulation technology has evolved rapidly over the past 30 years to meet the needs of assisted reproduction practitioners. The clinical outcome of micromanipulation and microinjection procedures is highly dependent upon practitioner skills as well as the quality and reliability of the equipment used. Well engineered mechanical, hydraulic and electronic micromanipulation systems are available and can be mounted upon inverted microscopes supplied by all of the major microscope companies. These systems are complemented by a range of oil and air injectors in addition to anti-vibration tables and lasers. In future, it is possible that some micromanipulation systems will become automated using computer algorithms, enabling robotic procedures to be performed, eliminating variability in practitioner performance.