To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The human brain makes up just 2% of body mass but consumes closer to 20% of the body’s energy. Nonetheless, it is significantly more energy-efficient than most modern computers. Although these facts are well-known, models of cognitive capacities rarely account for metabolic factors. In this paper, we argue that metabolic considerations should be integrated into cognitive models. We distinguish two uses of metabolic considerations in modeling. First, metabolic considerations can be used to evaluate models. Evaluative metabolic considerations function as explanatory constraints. Metabolism limits which types of computation are possible in biological brains. Further, it structures and guides the flow of information in neural systems. Second, metabolic considerations can be used to generate new models. They provide: a starting point for inquiry into the relation between brain structure and information processing, a proof-of-concept that metabolic knowledge is relevant to cognitive modeling, and potential explanations of how a particular type of computation is implemented. Evaluative metabolic considerations allow researchers to prune and partition the space of possible models for a given cognitive capacity or neural system, while generative considerations populate that space with new models. Our account suggests cognitive models should be consistent with the brain’s metabolic limits, and modelers should assess how their models fit within these bounds. Our account offers fresh insights into the role of metabolism for cognitive models of mental effort, philosophical views of multiple realization and medium independence, and the comparison of biological and artificial computational systems.
This chapter introduces the reader to the big picture of what analytics science is. What is analytics science? What types does it have, and what is its scope? How can analytics science be used to improve various tasks that society needs to carry out? Is analytics science all about using data? Or can it work without data? What is the role of data versus models? How can one develop and rely on a model to answer essential questions when the model can be wrong due to its assumptions? What is ambiguity in analytics science? Is that different from risk? And how do analytics scientists address ambiguity? What is the role of simulation in analytics science? These are some of the questions that the chapter addresses. Finally, the chapter discusses the notion of "centaurs" and how a successful use of analytics science often requires combining human intuition with the power of strong analytical models.
This chapter explores how metaphysical models, particularly the compositional and transformational approaches, can help elucidate the doctrine of the Incarnation. While these models face challenges, such as the Nestorian and Attributes Problems, various solutions have been proposed to address these issues and align the models with orthodox Christology. Ultimately, metaphysical models aim to provide coherence and plausibility to the mystery of the Incarnation, contributing to the ongoing work of analytic theology in understanding this central Christian doctrine.
The chapter will help you to be able to explain what Social Anxiety Disorder is and how it typically presents, including distorted mental representations and selective focus of attention, describe and use evidence-based CBT protocols for Social Anxiety Disorder, choose and use appropriate formulation models for CBT for Social Anxiety Disorder, describe the importance of using exposure to social situations in any treatment plan, develop a treatment plan for CBT for Social Anxiety Disorder, using appropriate measures, and take account of comorbidity in managing CBT for Social Anxiety Disorder
The chapter will help you to be able to explain what panic disorder is and how it typically presents, including unexpected panic attacks, and subsequent fear and attempted avoidance of further attacks, describe and use evidence-based CBT protocols for panic disorder, choose and use appropriate formulation models for CBT for panic disorder, describe the importance of using exposure to panic symptoms in any treatment plan, develop a treatment plan for CBT for panic disorder, using appropriate measures, and take account of comorbidity in managing CBT for panic disorder
The National Institute for Health and Care Excellence (NICE) in England introduced early value assessments (EVAs) as an evidence-based method of accelerating access to promising health technologies that could address unmet needs and contribute to the National Health Service’s Long Term Plan. However, there are currently no published works considering differences and commonalities in methods used between Assessment Reports for EVAs.
Methods
This rapid scoping review included all completed EVAs published on the NICE website up to 23 July 2024. One reviewer screened potentially relevant records for eligibility, checked by a second reviewer. Pairs of independent reviewers extracted information on the methods used in included EVAs using a prepiloted form; these were checked for accuracy. Data were described in graphical or tabular format with an accompanying narrative summary.
Results
In total, seventeen EVA Reports of sixteen EVAs were included in this scoping review. Five Reports did not specify how many reviewers undertook screening, whereas five did not report data extraction methods. Five EVAs planned to conduct meta-analyses, nine planned narrative syntheses, and seven planned narrative summaries. Eleven conceptual decision models were presented, with available evidence used to construct cost-utility analyses (N = 5); cost-effectiveness analyses (CEAs; N = 4); a mix of CEAs and cost-consequence analyses (CCA; N = 2); one CCA; and one cost-comparison.
Conclusion
Future EVA Reports should enhance the transparency of the methods used. Furthermore, EVAs could provide opportunities for the adoption of innovative methodological approaches and more flexible communication between EVA authors and key stakeholders, including patients and clinicians, companies, and NICE.
Chapter 2 explores an important premise which underlies this critique of the law: it examines the idea that disfigurement inequality is a problem which merits a legal response – namely the granting of protective rights under the Act. It concludes that, despite some uncomfortable distinctions, there is a compelling case for a legal response in this area. The nature of law’s current response is then laid out. Relevant parts of the international legal framework – including EU law, the UN Convention on the Rights of Persons with Disabilities (‘CRPD’) and decisions of the European Court of Human Rights (‘ECtHR’) applying the European Convention on Human Rights – are explained by reference to the models of disability which implicitly inform them.
What is the nature of discovery? As a human being and a physicist, I can only observe one mind at work first-hand. This mind accepts every new scrap as a discovery, whether it originates in the external world of knowledge or springs from an internal process. To explore the nature of discovery from the point of view of the inner observer, I chose to turn over past experiences, fitting together days on which years of determined and dogged plodding resulted in a finished equation, or finally, a coherent assembly of disparate ideas gave the clue to why storm damage in breakwaters is like a phase change in liquid crystals. Old, unfashionable methods are suddenly useful with new computer architectures. Theory, experiment, observation, and simulation fit together as aids to thinking. The properties of complex systems can provide intuitive insight into the social science of science. We will need every ability to assemble the puzzle pieces in the coming years to discover how to extricate the planet from the difficulties in which we have placed it: as an observer and actor, I suggest that the evolution of human thinking, and of aids to thinking, are critical.
Cost-effectiveness models fully informed by real-world epidemiological parameters yield the best results, but they are costly to obtain. Model calibration using real-world data/evidence (RWD/E) on routine health indicators can provide an alternative to improve the validity and acceptability of the results. We calibrated the transition probabilities of the reference chemotherapy treatment using RWE on patient overall survival (OS) to model the survival benefit of adjuvant trastuzumab in Indonesia.
Methods
A Markov model comprising four health states was initially parameterized using the reference-treatment transition probabilities, obtained from published international evidence. We then calibrated these probabilities, targeting a 2-year OS of 86.11 percent from the RWE sourced from hospital registries. We compared projected OS duration and life-years gained (LYG) before and after calibration for the Nelder–Mead, Bound Optimization BY Quadratic Approximation, and generalized reduced gradient (GRG) nonlinear optimization methods.
Results
The pre-calibrated transition probabilities overestimated the 2-year OS (92.25 percent). GRG nonlinear performed best and had the smallest difference with the RWD/E OS. After calibration, the projected OS duration was significantly lower than their pre-calibrated estimates across all optimization methods for both standard chemotherapy (~7.50 vs. 11.00 years) and adjuvant trastuzumab (~9.50 vs. 12.94 years). LYG measures were, however, similar (~2 years) for the pre-calibrated and calibrated models.
Conclusions
RWD/E calibration resulted in realistically lower survival estimates. Despite the little difference in LYG, calibration is useful to adapt external evidence commonly used to derive transition probabilities to the policy context, thereby enhancing the validity and acceptability of the modeling results.
Psychiatric disorders are complex and multifaceted conditions that profoundly impact various aspects of an individual’s life. Although the neurobiology of these disorders is not fully understood, extensive research suggests intricate interactions between genetic factors, changes in brain structure, disruptions in neurotransmitter pathways, as well as environmental influence.
In the case of psychotic disorders, such as schizophrenia, strong genetic components have been identified as a key feature in the development of psychosis. Moreover, alterations in dopamine function and structural brain changes that result in volume loss seem to be pervasive in people affected by these disorders. Meanwhile, mood disorders, including major depressive disorder and bipolar disorder, are characterized by disruptions in neurotransmitter systems responsible for mood regulation, such as serotonin, norepinephrine, and dopamine. Anxiety and personality disorders also exhibit neurotransmitter dysfunction and neuroanatomical changes, in addition to showing a genetic overlap with mood and psychotic disorders.
Understanding the underlying mechanisms in the pathophysiology of these conditions is of paramount importance and involves integrating findings from various research areas, including at the molecular and cellular levels. This brief overview aims to highlight some of the important developments in our current understanding of psychiatric disorders. Future research should aim to incorporate a comprehensive approach to further unravel the complexity of these disorders and pave the way for targeted therapeutic strategies and effective treatments to improve the lives of individuals afflicted by them.
Working memory encompasses the limited incoming information that can be held in mind for cognitive processing. To date, we have little information on the effects of bilingualism on working memory because, absent evidence, working memory tasks cannot be assumed to measure the same constructs across language groups. To garner evidence regarding the measurement equivalence in Spanish and English, we examined second-grade children with typical development, including 80 bilingual Spanish–English speakers and 167 monolingual English speakers in the United States, using a test battery for which structural equation models have been tested – the Comprehensive Assessment Battery for Children – Working Memory (CABC-WM). Results established measurement invariance across groups up to the level of scalar invariance.
This Element surveys the various lines of work that have applied algorithmic, formal, mathematical, statistical, and/or probabilistic methods to the study of phonology and the computational problems it solves. Topics covered include: how quantitative and/or computational methods have been used in research on both rule- and constraint-based theories of the grammar, including questions about how grammars are learned from data, how to best account for gradience as observed in acceptability judgments and the relative frequencies of different structures in the lexicon, what formal language theory, model theory, and information theory can and have contributed to the study of phonology, and what new directions in connectionist modeling are being explored. The overarching goal is to highlight how the work grounded in these various methods and theoretical orientations is distinct but also interconnected, and how central quantitative and computational approaches have become to the research in and teaching of phonology.
This is a revision of John Trimmer’s English translation of Schrödinger’s famous ‘cat paper’, originally published in three parts in Naturwissenschaften in 1935.
Estimates of the economic costs of climate change rely on guesswork in the face of huge uncertainties, and arbitrary judgements about what is important. The models can produce any number their creators want them to; and typically, they trivialise the risks. Despite being described as ‘worse than useless’ by leading academics, economic analysis of this kind has been credited with a Nobel Prize, and it continues to inform government policy.
Amino acids have been detected in some meteorites and are readily synthesized in prebiotic experiments. These molecules may have been precursors of oligomers and polymers in the early Earth. These reactions were likely to happen in the protected confined spaces on the porous surface of olivine and in the interlayer nanospace of montmorillonite. This study describes experimental and theoretical research on the sorption of l-alanine onto surfaces of silicate minerals, olivine and montmorillonite. Kinetics of the sorption of this amino acid at different pH media was performed. This sorption has been also studied at atomic scale by means of quantum mechanical calculations finding that this sorption is energetically favourable. These results strongly support the premise that minerals could have actively participated in prebiotic reactions.
Over the years, the Serengeti has been a model ecosystem for answering basic ecological questions about the distribution and abundance of organisms, populations, and species, and about how different species interact with each other and with their environment. Tony Sinclair and many other researchers have addressed some of these questions, and continue to work on understanding important biotic and abiotic linkages that influence ecosystem functioning. In common with all types of scientific inquiry, ecologists use predictions to test hypotheses about ecological processes; this approach is highlighted by Sinclair’s research that explored why buffalo and wildebeest populations were rapidly expanding. Like other scientists, ecologists use observation, modeling, and experimentation to generate and test hypotheses. However, in contrast with much biological inquiry, ecologists ask questions that link numerous levels of the biological hierarchy, from molecular to global ecology.
Forecasting elections is a high-risk, high-reward endeavor. Today’s polling rock star is tomorrow’s has-been. It is a high-pressure gig. Public opinion polls have been a staple of election forecasting for almost ninety years. But single source predictions are an imperfect means of forecasting, as we detailed in the preceding chapter. One of the most telling examples of this in recent years is the 2016 US presidential election. In this chapter, we will examine public opinion as an election forecast input. We organize election prediction into three broad buckets: (1) heuristics models, (2) poll-based models, and (3) fundamentals models.
How do children process language as they get older? Is there continuity in the functions assigned to specific structures? And what changes in their processing and their representations as they acquire more language? They appear to use bracketing (finding boundaries), reference (linking to meanings), and clustering (grouping units that belong together) as they analyze the speech stream and extract recurring units, word classes, and larger constructions. Comprehension precedes production. This allows children to monitor and repair production that doesn’t match the adult forms they have represented in memory. Children also track the frequency of types and tokens; they use types in setting up paradigms and identifying regular versus irregular forms. Amount of experience with language, (the diversity of settings) plus feedback and practice, also accounts for individual differences in the paths followed during acquisition. Ultimately, models of the process of acquisition need to incorporate all this to account for how acquisition takes place.
This chapter introduces you to foundational knowledge regarding frameworks and models which is applied in later chapters. Theoretical models and frameworks serve as the ‘connective tissue that meshes theory and practice’. The chapter presents an overview of some of the most pertinent models and frameworks that can support you in designing lessons or learning experiences that incorporate digital technologies. It also highlights how you can reflect on the integration of technology into your teaching.
This chapter begins with models of educator knowledge, TPACK and the UNESCO ICT model, followed by the WHO workflow that helps you plan for using digital technologies in learning. The chapter also examines models and frameworks for considering the degree of integration of technology into teaching (SAMR and RAT/PICRAT) and concludes with educator acceptance models (TAM and CBAM).
Inferences are never assumption free. Data summaries that do not account for all relevant effects readily mislead. Distributions for the Pearson correlation and for counts, and extensions accounting for handling extra-binomial and extra-Poisson variation are noted. Notions of statistical power are introduced. Resampling methods, the bootstrap, and permutation tests, extend available inferential approaches. Regression with a single explanatory variable is used as a context in which to introduce residual plots, outliers, influence, robust regression, and standard errors of predicted values. There are two regression lines – that of y on x and that of x on y. Power transformations, with the logarithmic transformation as a special case, are often effective in giving a linear relationship. The training/test approach, and the closely allied of cross-validation approach, can be important for avoiding over-fitting. Other topics include one- and two-way comparisons, adjustments when there are multiple comparisons, and the estimation of false discovery rates when there is severe multiplicity. Discussions of theories of inference, including likelihood, and Bayes Factor and other Bayesian perspectives, ends the chapter.