Climate-related worry is increasingly recognized as a mental health concern and a potential correlate of pro-environmental behavior (PEB). However, little is known about these associations in the Global South or the potential role of mindfulness. This crosssectional study examined relationships among climate change anxiety, psychological distress, mindfulness, and PEB in 340 university students (aged 19–25 years) from Islamabad and Rawalpindi, Pakistan. Data were collected between January and June 2024 using validated measures of climate change anxiety (Climate Change Anxiety Scale), psychological distress (DASS-21), dispositional mindfulness (MAAS), and PEB. Analyses included bivariate correlations, block-wise linear regression, and mediation models (PROCESS Model 4; 5,000 bootstrap resamples). Climate change anxiety was positively correlated with psychological distress (r = .47, p < .001) and indirectly associated with lower PEB through distress (ab = −.09, 95% CI [−.15, −.04]). Regression analyses showed that mindfulness was positively associated with PEB (β = .27, p < .001), whereas distress (β = −.22, p = .002) and climate change anxiety (β = −.18, p = .018) were negatively associated with PEB. Mindfulness was indirectly associated with higher PEB through lower distress (ab = .11, 95% CI [.05, .19]) and lower climate change anxiety (ab = .08, 95% CI [.02, .15]), while also showing a direct positive association with PEB. These findings highlight mindfulness as a relevant factor for understanding climate-related distress and environmental engagement among young adults.