This research evaluated the influence of adjuvants on hexazinone efficacy for smut grass control in greenhouse and field conditions. The greenhouse experiment was established in 2023 with two runs, comprising hexazinone (1.12 kg ai ha−1) applied alone or with adjuvants (Grounded, NanoPro, and Sorbyx), and six simulated volumes of rain accumulation (0, 6, 12, 25, 50, and 100 mm). In field trials in 2022 and 2023, hexazinone (1.12 kg ai ha−1) was applied with various adjuvants (BREAK-THRU, Grounded, NanoPro, and Sorbyx) to a nontreated control and to small smut grass at Marianna, Florida, and to giant smut grass at Ona, Florida. In greenhouse experiments, all adjuvants added to hexazinone improved the herbicide’s efficacy, resulting in >78% control at 30 d after treatment (DAT), <50% biomass (% of the nontreated control 30 DAT), and little to no regrowth by 60 DAT. Applying hexazinone without an adjuvant resulted in <70% control at 30 DAT and >52% biomass, and regrowth by 60 DAT. Similarly, adding Grounded, NanoPro, and Sorbyx to hexazinone in field experiments resulted in a reduction in smut grass density of >63% reduction. However, adding BREAK-THRU to hexazinone did not enhance the herbicide’s efficacy. The adjuvants Grounded, NanoPro, and Sorbyx enhanced the effectiveness of hexazinone in both greenhouse and field experiments, indicating their potential for effective smut grass management.