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Chapter 13 - Management of postoperative nausea and vomiting in inpatients and ambulatory patients

Published online by Cambridge University Press:  05 March 2016

Tong Joo Gan
Affiliation:
Duke University Medical Center, Durham
Ashraf S. Habib
Affiliation:
Duke University Medical Center, Durham
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Postoperative Nausea and Vomiting
A Practical Guide
, pp. 131 - 145
Publisher: Cambridge University Press
Print publication year: 2016

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References

Apfel, CC, Laara, E, Koivuranta, M, et al. A simplified risk score for predicting postoperative nausea and vomiting. Anesthesiology 1999; 91:693700.CrossRefGoogle ScholarPubMed
Gan, TJ, Diemunsch, P, Habib, AS, et al. Consensus Guidelines for the Management of Postoperative Nausea and Vomiting. Anasth Analg 2014; 118:85113.CrossRefGoogle ScholarPubMed
Fortier, J, Chung, F, Su, J. Unanticipated admission after ambulatory surgery – a prospective study. Can J Anaesth 1998; 45:612–9.CrossRefGoogle ScholarPubMed
Gold, BS, Kitz, DS, Lecky, JH, et al. Unanticipated admission to the hospital following ambulatory surgery. JAMA 1989; 262:3008–10.CrossRefGoogle Scholar
Brenner, WG, Kumar, CM. Delayed surgical emphysema, pneumomediastinum and bilateral pneumothoraces after postoperative vomiting. Br J Anaesth 1993; 71: 296–7.Google Scholar
Eberhart, LHJ, Morin, AM, Kranke, P, et al. Prevention and control of post-operative nausea and vomiting in post-craniotomy patients. Best Pract Res Clin Anaesthesiol 2008; 22(1): 575593.Google Scholar
Apfel, CC, Heidrich, FM, Jukar-Rao, S, et al. Evidence-based analysis of risk factors for postoperative nausea and vomiting. Br J Anaesth 2012; 109:742–53CrossRefGoogle ScholarPubMed
Apfel, CC, Kortilla, K, Abdalla, M, et al. IMPACT Investigators. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004; 350:2441–51.CrossRefGoogle Scholar
Liu, SS, Strodtbeck, WM, Richman, JM, et al. A comparison of regional versus general anesthesia for ambulatory anesthesia: a meta-analysis of randomized controlled trials. Anesth Analg 2005; 101:1634–42.Google ScholarPubMed
Sinclair, DR, Chung, F, Mezei, G. Can postoperative nausea and vomiting be predicted. Anesthesiology 1999; 91:109–18.CrossRefGoogle ScholarPubMed
Tramer, MR, Fuchs-Buder, T. Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis: a systematic review. Br J Anaesth 1999; 82:379–86.CrossRefGoogle ScholarPubMed
Cheng, CR, Sessler, DI, Apfel, CC. Does neostigmine administration produce a clinically important increase in postoperative nausea and vomiting? Anesth Analg 2005; 101:1349–55.CrossRefGoogle ScholarPubMed
Wheeler, M, Oderda, GM, Ashburn, MA, et al. Adverse events associated with postoperative opioid analgesia: a systematic review. J Pain 2002; 3:159–80.CrossRefGoogle ScholarPubMed
Roberts, GW, Bekker, TB, Carlsen, HH, et al. Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a dose-related manner. Anesth Analg 2005; 101:1343–8.CrossRefGoogle Scholar
Marret, E, Kurdi, O, Zufferey, P, et al. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 2005; 102:1249–60.CrossRefGoogle ScholarPubMed
Gan, TJ, Joshi, GP, Zhao, SZ, et al. Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects. Acta Anaesthesiol Scand 2004; 48:1194–207.CrossRefGoogle ScholarPubMed
Lee, SJ, Lee, JN. The effect of perioperative esmolol infusion on the post-operative nausea, vomiting and pain after laparoscopic appendectomy. Korean J Anesthesiol 2010; 59:179–84.Google Scholar
Collard, V, Mistraletti, G, Taqi, A, et al. Intraoperative esmolol infusion in the absence of opioids spares postoperative fentanyl in patients undergoing ambulatory Laparoscopic cholecystectomy. Anesth Analg 2007; 105:1255–62.CrossRefGoogle ScholarPubMed
Gurbet, A, Basagan-Mogol, E, Turker, G, et al. Intraoperative infusion of dexemedetomodine reduces perioperative analgesic requirements. Can J Anaesth 2006; 53:646–52.CrossRefGoogle ScholarPubMed
Tiippana, EM, Hamunen, K, Kontinen, VK, et al. Do surgical patients benefit from perioperative gabapenin/pregabalin? A systematic review of efficacy and safety. Anesth Anal 2007; 104:1545–57.CrossRefGoogle Scholar
Hurley, RW, Cohen, SP, Williams, KA, et al. The analgesic effect of perioperative gabapentin on postoperative pain: a meta-analysis. Reg Anesth Pain Med 2006; 31:237–47.Google ScholarPubMed
Bell, RF, Dahl, JB, Moore, RA, et al. Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anesthesiol Scand 2005; 49:1405–28.CrossRefGoogle ScholarPubMed
Pierre, S, Corno, G, Benais, H, et al. A risk score-dependent antiemetic approach effectively reduces postoperative nausea and vomiting – a continuous quality improvement initiative. Can J Anaesth 2004; 51:320–5CrossRefGoogle ScholarPubMed
Kovac, AL, Eberhart, L, Kotarski, J, et al. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period. Anesth Analg 2008; 107:439–44.CrossRefGoogle Scholar
Tramer, MR, Reynolds, JM, Moore, RA, et al. Efficacy, dose–response and safety of ondansetron in prevention of postoperative nausea and vomiting. Anesthesiology 1997; 87:1277–89.CrossRefGoogle ScholarPubMed
Kovac, AL, O’Connor, TA, Pearman, MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial. J Clin Anesth 1999; 11:453–9.CrossRefGoogle ScholarPubMed
Henzi, I, Walder, B, Tramer, MR. Dexamethasone for the prevention of postoperative nausea and vomiting. A quantitative systematic review. Anesth Analg 2000; 90:186–94.CrossRefGoogle ScholarPubMed
Wang, JJ, Ho, ST, Tzeng, JI, et al. The effect of timing of dexamethasone administration on its efficacy as a prophylactic antiemetic for postoperative nausea and vomiting. Anesth Analg 2000; 91:136–39.CrossRefGoogle ScholarPubMed
De Oliveira, GS, Almeida, MD, Benzon, HT, et al. Perioperative single dose systemic dexamethasone for postoperative pain. Anesthesiology 2011; 115:575–88.CrossRefGoogle ScholarPubMed
De Oliveira, GS, Ahmad, S, Fitzgerald, PC, et al. Dose ranging study on the effect of preoperative dexamethasone on postoperative quality of recovery and opioid consumption after ambulatory gynaecologic surgery. Br J Anaesth 2011; 107:362–71.CrossRefGoogle Scholar
Murphy, GS, Szokol, JW, Greenberg, MD, et al. Preoperative dexamethasone enhances quality of recovery after laparoscopic cholecytectomy. Anesthesiology 2011; 114:882–90.CrossRefGoogle Scholar
Khan, SA, McDonagh, DL, Gan, TJ. Wound complications with dexamethasone for postoperative nausea and vomiting prophylaxis: a moot point? Anesth Analg 2013; 116:966–7.Google Scholar
Cowie, BS, Allen, KJ, Said, SA, et al. Anti-emetic doses of dexamethasone suppress cortisol response in laparoscopic cholecystectomy. Anaesth Intensive Care 2010; 38:667–70.CrossRefGoogle ScholarPubMed
Dieleman, JM, Nierich, AP, Rosseel, et al. Dexamethasone for Cardiac Surgery (DECS) Study Group. Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA 2012; 308:1761–7.CrossRefGoogle ScholarPubMed
Abdelmalak, B, Bonilla, AM, Yang, D, et al. The hyperglycemic response to major noncardiac surgery and the added effect of steroid administration in patients with and without diabetes. Anesth Analg 2013; 116:1116–22.CrossRefGoogle ScholarPubMed
Pergolizzi, JV, Philip, BK, Taylor, RJ. Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting. J Clin Anesth 2012; 24:334–45.CrossRefGoogle ScholarPubMed
White, PF, Tang, J, Song, D, et al. Transdermal scopolamine: an alternative to ondansetron and droperidol for the prevention of postoperative and postdischarge emetic symptoms. Anesth Analg 2007; 104:9296.CrossRefGoogle ScholarPubMed
Kranke, P, Morin, AM, Roewer, N, et al. The efficacy and safety of transdermal scopolamine for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2002; 95:133–43.CrossRefGoogle ScholarPubMed
Apfel, CC, Zhang, K, George, E, et al. Transdermal scopolamine for the prevention of postoperative nausea and vomiting: a systematic review and meta-analysis. Clin Ther 2010; 32:1987–2002.CrossRefGoogle ScholarPubMed
White, P. Droperidol: a cost-effective antiemetic for over thirty years. Anesth Analg 2002; 95:789–90.CrossRefGoogle ScholarPubMed
Henzi, I, Sonderegger, J, Tramer, M. Efficacy, dose–response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting. Can J Anaesth 2000; 47:537551.CrossRefGoogle ScholarPubMed
Fortney, J, Gan, TJ, Graczyk, S, et al. A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures. Anesth Analg 1998; 86:731–8.Google ScholarPubMed
Charbit, B, Albaladejo, P, Funck-Brentano, C, et al. Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. Anesthesiology 2005; 102:1094–100.CrossRefGoogle ScholarPubMed
Buttner, M, Walder, B, von Elm, E, et al. Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials. Anesthesiology 2004; 101:1454–63.CrossRefGoogle ScholarPubMed
Lee, Y, Wang, PK, Lai, HY, et al. Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Can J Anaesth 2007; 54:349–54.CrossRefGoogle ScholarPubMed
Yang, YL, Lai, HY, Wang, JJ, et al. The timing of haloperidol administration does not affect is prophylactic antiemetic efficacy. Can J Anaesth 2008; 55:270–5.CrossRefGoogle Scholar
Khalil, S, Philbrook, L, Rabb, M, et al. Ondansetron/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery. J Clin Anesth 1999; 11:596600.CrossRefGoogle ScholarPubMed
Gan, TJ, Meyer, TA, Apfel, CC, et al. Society for Ambulatory Anesthesia Guidelines for the Management of Postoperative Nausea and Vomiting. Anesth Analg 2007; 105:1615–24.CrossRefGoogle ScholarPubMed
Moser, JD, Caldwell, JB, Rhule, FJ. No more than necessary: safety and efficacy of low-dose promethazine. Ann Pharmacother 2006; 40:45–8.CrossRefGoogle ScholarPubMed
Chia, YY, Lo, Y, Liu, K, et al. The effect of promethazine on postoperative pain: a comparison of preoperative, postoperative, and placebo administration in patients following total abdominal hysterectomy. Acta Anaesthesiol Scand 2004; 48:625–30.CrossRefGoogle ScholarPubMed
Kovac, AL. Prevention and treatment of postoperative nausea and vomiting. Drugs 2000; 59: 213–43.CrossRefGoogle ScholarPubMed
Chen, JJ, Frame, DG, White, TJ. Efficacy of ondansetron and prochlorperazine for the prevention of postoperative nausea and vomiting after total hip replacement or total knee replacement produres. Arch Intern Med 1998; 158:2124–29.CrossRefGoogle ScholarPubMed
Gan, TJ, Apfel, CC, Kovac, A, et al. Aprepitant-PONV Study Group. A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting. Anesth Analg 2007; 104:1082–9.CrossRefGoogle ScholarPubMed
Apfel, CC, Malhotra, A, Leslie, JB. The role of neurokinin-1 receptor antagonists for the management of postoperative nausea and vomiting. Curr Opin Anesth 2008; 21:427–32.CrossRefGoogle ScholarPubMed
Diemunsch, P, Gan, TJ, Philip, BK, et al. Aprepitant-PONV Protocol 091 International Study Group. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery. Br J Anaesth 2007; 99:202–11.CrossRefGoogle ScholarPubMed
Henzi, I, Walder, B, Tramer, MR. Metoclopramide in the prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized, placebo-controlled studies. Br J Anaesth 1999; 83:761–7.CrossRefGoogle ScholarPubMed
Gralla, RJ, Itri, LM, Pisko, SE, et al. Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 1981; 305:905–9.CrossRefGoogle ScholarPubMed
Monagle, J, Barnes, R, Goodchild, C, et al. Ondansetron is not superior to moderate dose metoclopramide in the prevention of post-operative nausea and vomiting after gynaecologic surgery. Eur J Anaesth 1997; 14:604–9.CrossRefGoogle ScholarPubMed
Rothenberg, DM, Parnass, SM, Litwack, K, et al. Efficacy of ephedrine in the prevention of postoperative nausea and vomiting. Anesth Analg 1991; 72:5861.CrossRefGoogle ScholarPubMed
Hageman, E, Halvorson, A, Holgersen, O, et al. Intramuscular ephedrine reduces emesis during the first three hours after abdominal hysterectomy. Acta Anaesthesiol Scand 2000; 44:107–11.Google Scholar
Kranke, P, Morin, AM, Roewer, N, et al. Dimenhydrinate for prophylaxis of postoperative nausea and vomiting: a meta-analysis of randomized controlled trials. Acta Anaesthesiol Scand 2002; 46:238–44.CrossRefGoogle ScholarPubMed
Eberhart, HJ, Seeling, W, Bopp, TI, et al. Dimenhydrinate for prevention of post-operative nausea and vomiting in female in-patients. Eur J Anaesthesiol 1999; 16:284–9.CrossRefGoogle ScholarPubMed
Gan, TJ, Glass, PSA, Howell, ST, et al. Determination of plasma concentration of propofol associated with 50% reduction in postoperative nausea. Anesthesiology 1997; 87:779–84.CrossRefGoogle ScholarPubMed
Borgeat, A, Wilder-Smith, OHG, Saiah, M, et al. Subhypnotic doses of propofol possess direct antiemetic properties. Anesth Analg 1992; 74:539–41.CrossRefGoogle ScholarPubMed
Ostman, PL, Faure, E, Glosten, B, et al. Is the antiemetic effect of the emulsion formulation of propofol due to the lipid emulsion? Anesth Analg 1990; 71:536–40.Google Scholar
Gan, TJ, Ginsberg, B, Grant, P, et al. Double-blind, randomized comparison of ondansetron and intraoperative propfol to prevent postoperative nausea and vomiting. Anesthesiology 1996; 85:1036–42.CrossRefGoogle Scholar
Unlugenc, H, Guler, T, Gunes, Y, et al. Comparative study of the antiemetic efficacy of ondansetron, propofol and midazolam in the early postoperative period. Eur J Anaesthesiol 2004; 21:60–5.CrossRefGoogle ScholarPubMed
Diab, A, Gelb, AW, Cechetto, DF. Effects of the anesthetic propofol on 5-HT and FOS in the rat brain [Abstract]. Neuroscience 1994; 20:1169.Google Scholar
Kain, ZN, Mayes, LC, Bell, C, et al. Premedication in the United States: a status report. Anesth Analg 1997; 84:427–32.CrossRefGoogle ScholarPubMed
Bauer, KP, Dom, PM, Ramirez, AM, et al. Preoperative intravenous midazolam: benefits beyond anxiolysis. J Clin Anesth 2004; 16:177–83.CrossRefGoogle ScholarPubMed
Lee, Y, Wang, JJ, Yang, YL, et al. Midazolam vs ondansetron for preventing postoperative nausea and vomiting: a randomised controlled trial. Anaesthesia 2007; 62:1822.CrossRefGoogle ScholarPubMed
Lee, A, Fan, LT. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev 2009; (2):CD003281.Google Scholar
White, PF, Hamza, MA, Recart, A, et al. Optimal timing of acustimulation for antiemetic prophylaxis as an adjunct to ondansetron in patients undergoing plastic surgery. Anesth Analg 2005; 100:367–72CrossRefGoogle ScholarPubMed
Arnberger, M, Stadelmann, K, Alischer, P, et al. Monitoring of neuromuscular blockade at the P6 acupuncture point reduces the incidence of postoperative nausea and vomiting. Anesthesiology 2007; 107:903908CrossRefGoogle ScholarPubMed
Yogendran, S, Asokumar, B, Cheng, DCH, et al. A prospective randomized double-blinded study of the effect of intravenous fluid therapy on adverse outcomes on outpatient surgery. Anesth Analg 1995; 80:682–6.Google ScholarPubMed
Maharaj, CH, Kallam, SR, Malik, A, et al. Preoperative intravenous fluid therapy decreases postoperative nausea and pain in high risk patients. Anesth Analg 2005; 100:675–82.CrossRefGoogle ScholarPubMed
Gan, TJ, Soppitt, A, Maroof, M, et al. Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology 2002; 97:820–26.CrossRefGoogle ScholarPubMed
Gupta, A, Wu, CL, Elkassabany, N, et al. Does the routine prophylactic use of antiemetics affect the incidence of postdischarge nausea and vomiting following ambulatory surgery? Anesthesiology 2003; 99:488–95.Google ScholarPubMed
Apfel, C, Philip, B, Cakmakkaya, OS, et al. Who is at risk for postdischarge nausea and vomiting after ambulatory surgery? Anesthesiology 2012; 117: 475–86.CrossRefGoogle ScholarPubMed
Kovac, AL, Eberhart, L, Kotarski, J, et al. Palonosetron 04-07 Study Group. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period. Anesth Analg 2008; 107:439–44.CrossRefGoogle Scholar
George, E, Hornuss, C, Apfel, CC. Neurokinin-1 and novel seratonin antagonists for postoperative and postdischarge nausea and vomiting. Curr Opin Anesth 2010; 23:714–21.CrossRefGoogle Scholar
Apfel, CC, Kranke, P, Katz, MH, et al. Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anesth 2002; 88:659–68.CrossRefGoogle Scholar
Gan, TJ, Gu, J, Singla, N, et al. Rolapitant Investigation Group. Rolapitant for the prevention of postoperative nausea and vomiting: a prospective, double-blinded, placebo-controlled randomized trial. Anesth Analg 2011; 112:804–12.CrossRefGoogle ScholarPubMed
Habib, A, Gan, TJ. The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. J Clin Anesth 2005; 17:62–5.CrossRefGoogle ScholarPubMed
Kovac, A, O’Connor, TA, Pearman, MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial. J Clin Anesth 1999; 11:453–9.CrossRefGoogle ScholarPubMed
Kazemi-Kjellberg, F, Henzi, I, Tramer, MR. Treatment of established postoperative nausea and vomiting: a quantitative systematic review. BMC Anesthesiol 2001; 1:2. http://www.biomedcentral.com/1471–2253/1/2.CrossRefGoogle ScholarPubMed

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