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We exhibit some explicit co-adapted couplings for n-dimensional Brownian motion and all its Lévy stochastic areas. In the two-dimensional case we show how to derive exact asymptotics for the coupling time under various mixed coupling strategies, using Dufresne's formula for the distribution of exponential functionals of Brownian motion. This yields quantitative asymptotics for the distributions of random times required for certain simultaneous couplings of stochastic area and Brownian motion. The approach also applies to higher dimensions, but will then lead to upper and lower bounds rather than exact asymptotics.
It is a pleasure to present this paper as a homage to my DPhil supervisor John Kingman, in grateful acknowledgement of the formative period which I spent as his research student at Oxford, which launched me into a deeply satisfying exploration of the world of mathematical research. It seems fitting in this paper to present an overview of a particular aspect of probabilistic coupling theory which has fascinated me for a considerable time; given that one can couple two copies of a random process, when can one in addition couple other associated functionals of the processes? How far can one go?
Unlimited access to a motorway network can, in overloaded conditions, cause a loss of capacity. Ramp metering (signals on slip roads to control access to the motorway) can help avoid this loss of capacity. The design of ramp metering strategies has several features in common with the design of access control mechanisms in communication networks.
Inspired by models and rate control mechanisms developed for Internet congestion control, we propose a Brownian network model as an approximate model for a controlled motorway and consider it operating under a proportionally fair ramp metering policy. We present an analysis of the performance of this model.
The study of heavy traffic in queueing systems began in the 1960s, with three pioneering papers by Kingman [26, 27, 28]. These papers, and the early work of Prohorov [35], Borovkov [5, 6] and Iglehart [20], concerned a single resource. Since then there has been significant interest in networks of resources, with major advances by Harrison and Reiman [19], Reiman [37], Williams [43] and Bramson [7]. For discussions, further references and overviews of the very extensive literature on heavy traffic for networks, Williams [42], Bramson and Dai [8], Harrison [17, 18] and Whitt [41] are recommended.
Research in this area is motivated in part by the need to understand and control the behaviour of communications, manufacturing and service networks, and thus to improve their design and performance.
This paper proves certain results from the ‘appetizer for non-linear Wiener–Hopf theory’ [5]. Like that paper, it considers only the simplest possible case in which the underlying Markov process is a two-state Markov chain. Key generating functions provide solutions of a simple two-dimensional dynamical system, and the main interest is in the way in which Probability Theory and ODE theory complement each other. No knowledge of either ODE theory or Wiener–Hopf theory is assumed. Theorem 1.1 describes one aspect of a phase transition which is more strikingly conveyed by Figures 4.1 and 4.2.
AMS subject classification (MSC2010) 60J80, 34A34
Introduction
This paper is a development of something I mentioned briefly in talks I gave at Bristol, when John Kingman was in the audience, and at the Waves conference in honour of John Toland at Bath. I thanked both John K and John T for splendid mathematics and for their wisdom and kindness.
The main point of the paper is to prove Theorem 1.1 and related results in a way which emphasizes connections with a simple dynamical system. The phase transition between Figures 4.1 and 4.2 looks more dramatic than the famous 1-dimensional result we teach to all students.
The model studied here is a special case of the model introduced in Williams [5]. I called that paper, which contained no proofs, an ‘appetizer’; but before writing a fuller version, I became caught up in Jonathan Warren's enthusiasm for the relevance of complex dynamical systems (in ℂ2).
We survey classical kernel methods for providing nonparametric solutions to problems involving measurement error. In particular we outline kernel-based methodology in this setting, and discuss its basic properties. Then we point to close connections that exist between kernel methods and much newer approaches based on minimum contrast techniques. The connections are through use of the sinc kernel for kernel-based inference. This ‘infinite order’ kernel is not often used explicitly for kernel-based deconvolution, although it has received attention in more conventional problems where measurement error is not an issue. We show that in a comparison between kernel methods for density deconvolution, and their counterparts based on minimum contrast, the two approaches give identical results on a grid which becomes increasingly fine as the bandwidth decreases. In consequence, the main numerical differences between these two techniques are arguably the result of different approaches to choosing smoothing prameters.
Keywords bandwidth, inverse problems, kernel estimators, local linear methods, local polynomial methods, minimum contrast methods, non-parametric curve estimation, nonparametric density estimation, non-parametric regression, penalised contrast methods, rate of convergence, sinc kernel, statistical smoothing
Our aim in this paper is to give a brief survey of kernel methods for solving problems involving measurement error, for example problems involving density deconvolution or regression with errors in variables, and to relate these ‘classical’ methods (they are now about twenty years old) to new approaches based on minimum contrast methods.
We review old and new uses of exchangeability, emphasizing the general theme of exchangeable representations of complex random structures. Illustrations of this theme include processes of stochastic coalescence and fragmentation; continuum random trees; second-order limits of distances in random graphs; isometry classes of metric spaces with probability measures; limits of dense random graphs; and more sophisticated uses in finitary combinatorics.
Kingman's write-up of his 1977 Wald Lectures drew attention to the subject of exchangeability, and further indication of the topics of interest around that time can be seen in the write-up of my 1983 Saint-Flour lectures. As with any mathematical subject, one might expect some topics subsequently to wither, some to blossom and new topics to emerge unanticipated. This Festschrift paper aims, in informal lecture style,
(a) to recall the state of affairs 25 years ago (sections 2.1–2.3, 3.1);
(b) to briefly describe three directions of subsequent development that have recently featured prominently in monographs (sections 2.4, 3.1–3.2);
(c) to describe 3 recent rediscoveries, motivated by new theoretical topics outside mainstream mathematical probability, of the theory of representations of partially exchangeable arrays (sections 2.5, 5.1–5.2);
(d) to emphasize a general program that has interested me for 20 years. It doesn't have a standard name, but let me here call it exchangeable representations of complex random structures (section 4).
A number of tricky problems in probability are discussed, having in common one or more infinite sequences of coin tosses, and a representation as a problem in dependent percolation. Three of these problems are of ‘Winkler’ type, that is, they are challenges for a clairvoyant demon.
Keywords clairvoyant demon, dependent percolation, multiscale analysis, percolation, percolation of words, random walk
Probability theory has emerged in recent decades as a crossroads where many sub-disciplines of mathematical science meet and interact. Of the many examples within mathematics, we mention (not in order): analysis, partial differential equations, mathematical physics, measure theory, discrete mathematics, theoretical computer science, and number theory. The International Mathematical Union and the Abel Memorial Fund have recently accorded acclaim to probabilists. This process of recognition by others has been too slow, and would have been slower without the efforts of distinguished mathematicians including John Kingman.
JFCK's work looks towards both theory and applications. To single out just two of his theorems: the subadditive ergodic theorem [22, 23] is a piece of mathematical perfection which has also proved rather useful in practice; his ‘coalescent’ [24, 25] is a beautiful piece of probability, now a keystone of mathematical genetics. John is also an inspiring and devoted lecturer, who continued to lecture to undergraduates even as the Bristol Vice-Chancellor, and the Director of the Isaac Newton Institute in Cambridge.
Kingman's Theorem on skeleton limits—passing from limits as n → ∞ along nh (n ∈ ℕ) for enough h > 0 to limits as t → ∞ for t ∈ ℝ— is generalized to a Baire/measurable setting via a topological approach. We explore its affinity with a combinatorial theorem due to Kestelman and to Borwein and Ditor, and another due to Bergelson, Hindman and Weiss. As applications, a theory of ‘rational’ skeletons akin to Kingman's integer skeletons, and more appropriate to a measurable setting, is developed, and two combinatorial results in the spirit of van der Waerden's celebrated theorem on arithmetic progressions are given.
The background to the theme of the title is Feller's theory of recurrent events. This goes back to Feller in 1949 [F1], and received its first textbook synthesis in [F2] (see e.g. [GS] for a recent treatment). One is interested in something (‘it’, let us say for now—we can proceed informally here, referring to the above for details) that happens (by default, or by fiat) at time 0, may or may not happen at discrete times n = 1, 2, …, and is such that its happening ‘resets the clock’, so that if one treats this random time as a new time-origin, the subsequent history is a probabilistic replica of the original situation.
It is a great honour to have been given this fine collection, and I am most grateful to the Editors and to my friends who have contributed to it. It is poor thanks to inflict on them this self-centred account, and I have tried to mitigate the offence by limiting it to a particular decade, which begins as a new student arrives at Pembroke College in Cambridge to start a degree course in mathematics, and ends with him as a professor in the new University of Sussex. It was obviously a crucial time in my own mathematical life, but it happens also to have been a very interesting period in the development of probability theory in Britain, in which I was fortunate to play a junior part.
With little reluctance I have restricted myself to the mathematical aspects of my life. The reader will seek in vain for any details of my transition from a schoolboy to a happy husband soon to be a proud father; the latter conditions have proved lasting.
Of course the story goes back long before 1957. It might be said to have started in about 1920, when Charles Kingman, a miner on the small but prosperous North Somerset coalfield, summoned his two sons William and Frank for a serious talk. Charles came of a family of Mendip villagers, his grandfather having been the carter of Ston Easton.
Mathematical population genetics is only one of Kingman's many research interests. Nevertheless, his contribution to this field has been crucial, and moved it in several important new directions. Here we outline some aspects of his work which have had a major influence on population genetics theory.
AMS subject classification (MSC2010) 92D25
Introduction
In the early years of the previous century, the main aim of population genetics theory was to validate the Darwinian theory of evolution, using the Mendelian hereditary mechanism as the vehicle for determining how the characteristics of any daughter generation depended on the corresponding characteristics of the parental generation. By the 1960s, however, that aim had been achieved, and the theory largely moved in a new, retrospective and statistical, direction.
This happened because, at that time, data on the genetic constitution of a population, or at least on a sample of individuals from that population, started to become available. What could be inferred about the past history of the population leading to these data? Retrospective questions of this type include: “How do we estimate the time at which mitochondrial Eve, the woman whose mitochondrial DNA is the most recent ancestor of the mitochondrial DNA currently carried in the human population, lived? How can contemporary genetic data be used to track the ‘Out of Africa’ migration? How do we detect signatures of past selective events in our contemporary genomes?” Kingman's famous coalescent theory became a central vehicle for addressing questions such as these.
The coalescent revolutionised theoretical population genetics, simplifying, or making possible for the first time, many analyses, proofs, and derivations, and offering crucial insights about the way in which the structure of data in samples from populations depends on the demographic history of the population. However statistical inference under the coalescent model is extremely challenging, effectively because no explicit expressions are available for key sampling probabilities. This led initially to approximation of these probabilities by ingenious application of modern computationally-intensive statistical methods. A key breakthrough occurred when Li and Stephens introduced a different model, similar in spirit to the coalescent, for which efficient calculations are feasible. In turn, the Li and Stephens model has changed statistical inference for the wealth of data now available which documents molecular genetic variation within populations. We briefly review the coalescent and associated measure-valued diffusions, describe the Li and Stephens model, and introduce and apply a generalisation of it for inference of population structure in the presence of linkage disequilibrium.
John Kingman made a number of incisive and elegant contributions to modelling in the field of genetics, several of which are described elsewhere in this volume. But it is probably the coalescent, or ‘Kingman coalescent’ as it is often known, which has had the greatest impact. Several authors independently developed related ideas around the same time but it was Kingman's description and formulation, together with his proofs of the key robustness results which had the greatest impact in the mathematical genetics community.
The peripartal period is characterized by dramatic alterations in metabolism and function of key tissues such as liver, adipose and mammary. Metabolic regulation relies partly on transcriptional control of gene networks, a collection of DNA segments, which interact with a transcription factor or nuclear receptor, as a mechanism controlling the concentration of key enzymes in cells. These ‘global’ interactions can govern the rates at which genes in the network are transcribed into mRNA. The study of the entire genome, sub-networks or candidate genes at the mRNA level encompasses the broad field of genomics. Genomics of peripartal metabolic adaptations has traditionally been focused on candidate genes and more recently, using microarrays, on the broader transcriptome landscape. The candidate gene approach has expanded our knowledge on the functional adaptations of ureagenesis, fatty acid oxidation, gluconeogenesis, inflammation and growth hormone signaling in liver. More recent work with peripartal mammary tissue has used a gene network approach to study milk fat synthesis regulation as well as a candidate gene approach to study lipid transport, glucose uptake and inflammatory response. Network and pathway analysis of microarray data from cows fed different levels of dietary energy pre partum has revealed unique clusters encompassing functional categories including signal transduction, endoplasmic reticulum stress, peroxisome proliferator-activated receptors (PPARγ) signaling, PPARα signaling, immune or inflammatory processes and cell death in subcutaneous adipose tissue as well as liver. Of interest from a nutritional perspective is the potential to alter PPARγ signaling in adipose and PPARα signaling in liver as a means to enhance insulin sensitivity as well as fatty acid oxidation post partum. Major advances in understanding the metabolic adaptations of peripartal cows will come from using a systems biology approach to integrate data generated at the mRNA, protein, metabolite and tissue level across different nutritional management approaches and with cows of different genetic merit. This will allow the assembly of the important components needed to improve existing metabolic models of the peripartal cow and provide the tools to manipulate complex processes that could have significant long-term economic impact including lactation persistency, fertility and efficiency. An important goal of the future will be to apply additional experimental tools (e.g. gene silencing) and bioinformatics (e.g. transcription factor binding site identification) to studies focused on peripartal cows.
Three fattening systems were evaluated from weaning to slaughter in order to find alternatives to grain feeding in young bulls, and to test the reliability of carcass subcutaneous fat colour to discriminate among them. After weaning (224 kg), one group of animals was fed concentrates and straw until they reached the target slaughter weight (450 kg; Feedlot), another group grazed rotationally on lucerne supplemented with 1.8 kg DM/day barley until slaughter (LUC), and the third group had the same management as LUC animals for 3 months (period 1) and thereafter was finished on concentrates and straw until slaughter (period 2; LUC + Feedlot). Animals were weighed weekly and sampled monthly for serum IGF-I and leptin, and plasma non-esterified fatty acids and carotenoid pigment concentration analyses. Carcass characteristics and subcutaneous fat colour were recorded after slaughter. In period 1, Feedlot animals had slightly greater weight gains than their grazing counterparts (P < 0.10), and at the end of period 1 they had 66% greater IGF-I and 35% greater leptin concentration (P < 0.01). Plasma carotenoid pigments were undetectable in Feedlot animals, but increased during grazing in LUC and LUC + Feedlot treatments. In period 2, weight gains were lowest for LUC, intermediate for Feedlot and greatest for LUC + Feedlot animals (P < 0.001), conditioning the time taken to reach slaughter weight (73, 58 and 47 days, respectively; P < 0.05). Leptin and IGF-I concentrations increased in all management systems during period 2. Plasma carotenoid pigment concentration reached its maximum at the end of period 2 in LUC animals, but it decreased sharply in LUC + Feedlot animals in this period. Management did not affect carcass traits except for subcutaneous fat colour. Yellowness, Chroma (C*) and the value of the integral of the translated reflectance spectrum (SUM), estimator of carotenoid pigment content in fat, were higher in LUC than in LUC + Feedlot and Feedlot animals (P < 0.001). Two logistic regressions were obtained to discriminate carcasses from LUC treatment: P (LUC) = (1 + e18.8–5.6 × lightness–36.9 × redness + 0.3 × SUM + 29.8 × C*)−1 and LUC + Feedlot treatment: P (LUC + Feedlot)=(1 + e833.7–11.8 × lightness + 4.7 × redness + 0.2 × SUM−2.5 × C*)−1. The economic margin, calculated as income achieved minus costs, was greatest for LUC, intermediate for LUC + Feedlot and lowest for Feedlot treatment. Therefore, grazing lucerne supplemented with barley was an interesting alternative for fattening young bulls in these conditions, producing carcasses of similar quality, which could be accurately traced by measuring subcutaneous fat colour.
Massese is an Italian dairy sheep breed characterized by animals with black skin and horns and black or apparent grey hairs. Owing to the presence of these two coat colour types, this breed can be considered an interesting model to evaluate the effects of coat colour gene polymorphisms on this phenotypic trait. Two main loci have been already shown to affect coat colour in sheep: Agouti and Extension coding for the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes, respectively. The Agouti locus is affected by a large duplication including the ASIP gene that may determine the Agouti white and tan allele (AWt). Other disrupting or partially inactivating mutations have been identified in exon 2 (a deletion of 5 bp, D5; and a deletion of 9 bp, D9) and in exon 4 (g.5172T>A, p.C126S) of the ASIP gene. Three missense mutations in the sheep MC1R gene cause the dominant black ED allele (p.M73K and p.D121N) and the putative recessive e allele (p.R67C). Here, we analysed these ASIP and MC1R mutations in 161 Massese sheep collected from four flocks. The presence of one duplicated copy allele including the ASIP gene was associated with grey coat colour (P = 9.4E-30). Almost all animals with a duplicated copy allele (37 out of 41) showed uniform apparent grey hair and almost all animals without a duplicated allele (117 out of 120) were completely black. Different forms of duplicated alleles were identified in Massese sheep including, in almost all cases, copies with exon 2 disrupting or partially inactivating mutations making these alleles different from the AWt allele. A few exceptions were observed in the association between ASIP polymorphisms and coat colour: three grey sheep did not carry any duplicated copy allele and four black animals carried a duplicated copy allele. Of the latter four sheep, two carried the ED allele of the MC1R gene that may be the cause of their black coat colour. The coat colour of all other black animals may be determined by non-functional ASIP alleles (non-agouti alleles, Aa) and in a few cases by the EDExtension allele. At least three frequent ASIP haplotypes ([D5:g.5172T], [N:g.5172A] and [D5:g.5172A]) were detected (organized into six different diplotypes). In conclusion, the results indicated that coat colours in the Massese sheep breed are mainly derived by combining ASIP and MC1R mutations.
Muscle metabolism (in interaction with other organs and tissues, including adipose tissue) plays an important role in the control of growth and body composition. Muscle ontogenesis has been described in different genotypes of cattle for myofibres, connective tissue and intramuscular depots. The ontogenesis or the action of putatively important factors controlling muscle development (IGF-II expression, IGF receptors, growth hormone (GH) receptor, myostatin, basic fibroblast growth factor, transforming growth factor-β1, insulin and thyroid hormones) has also been studied on bovine foetal muscle samples and satellite cells. The glucose/insulin axis has been specifically studied in both the bovine adipose tissue and heart. Clearly, cattle, like sheep, are mature species at birth based on their muscle characteristics compared to other mammalian or farm animal species. The different myoblast generations have been well characterised in cattle, including the second generation which is liable to be affected by foetal undernutrition at least in sheep. Interesting genotypes, for example, double-muscled genotype, have been characterised by an altered metabolic and endocrine status associated with a reduced fat mass, specific muscle traits and different foetal characteristics. Finally, the recent development of genomics in cattle has allowed the identification of novel genes controlling muscle development during foetal and postnatal life. Generally, a high muscle growth potential is associated with a reduced fat mass and a switch of muscle fibres towards the glycolytic type. The possibility and the practical consequences of manipulating muscle growth and, hence, body composition by nutritional and hormonal factors are discussed for bovines based on our current biological knowledge.