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We investigate the consequences of periodic, on–off glucose infusion on the glucose–insulin regulatory system based on a system-level mathematical model with two explicit time delays. Studying the effects of such infusion protocols is mathematically challenging yet a promising direction for probing the system response to infusion. We pay special attention to the interplay of periodic infusion with intermediate-time-scale, ultradian oscillations that arise as a result of the physiological response of glucose uptake and back-release into the bloodstream. By using numerical solvers and numerical continuation software, we investigate the response of the model to different infusion patterns, explore how these patterns affect the overall levels of glucose and insulin, and how this can lead to entrainment. By doing so, we provide a road-map of system responses that can potentially help identify new, less-invasive, test strategies for detecting abnormal responses to glucose uptake without falling into lockstep with the infusion pattern.
The Bray–Liebhafsky reaction is one of many intricate chemical systems that is known to exhibit periodic behaviour. Although the underlying chemistry is somewhat complicated and involves at least ten chemical species, in a recent work we suggested a reduced two-component model of the reaction involving the concentrations of iodine and iodous acid. Although it is drastically simplified, this reduced system retains enough structure so as to exhibit many of the oscillatory characteristics seen in experimental analyses. Here, we consider the possibility of spatial patterning in a nonuniformly mixed solution. Since many practical demonstrations of chemical oscillations are undertaken using circular containers such as beakers or Petri dishes, we develop both linearized and nonlinear pattern solutions in terms of cylindrical coordinates. These results are complemented by an analysis of the patterning that might be possible within a rectangular domain. The simulations give compelling evidence that spatial patterning may well be feasible in the Bray–Liebhafsky process.
We present a method for reconstructing evolutionary trees from high-dimensional data, with a specific application to bird song spectrograms. We address the challenge of inferring phylogenetic relationships from phenotypic traits, like vocalizations, without predefined acoustic properties. Our approach combines two main components: Poincaré embeddings for dimensionality reduction and distance computation, and the neighbour-joining algorithm for tree reconstruction. Unlike previous work, we employ Siamese networks to learn embeddings from only leaf node samples of the latent tree. We demonstrate our method’s effectiveness on both synthetic data and spectrograms from six species of finches.
Engineering mechanics is the branch of engineering that applies the laws of mechanics in design, and is at the core of every machine that is designed. This book offers a comprehensive discussion of the fundamental theories and principles of engineering mechanics. It begins by explaining the laws and idealization of mechanics, and then establishes the equation of equilibrium for a rigid body and free body diagram (FBD), along with their applications. Chapters on method of virtual work and mechanical vibration discuss in detail important topics such as principle of virtual work, potential energy and equilibrium and free vibration. The book also introduces the elastic spring method for finding deflection in beams and uses a simple integration method to calculate centroid and moment of inertia. This volume will serve as a useful textbook for undergraduates and engineering students studying engineering mechanics.
Take anything in the universe, put it in a box, and heat it up. Regardless of what you start with, the motion of the substance will be described by the equations of fluid mechanics. This remarkable universality is the reason why fluid mechanics is important. The key equation of fluid mechanics is the Navier-Stokes equation. This textbook starts with the basics of fluid flows, building to the Navier-Stokes equation while explaining the physics behind the various terms and exploring the astonishingly rich landscape of solutions. The book then progresses to more advanced topics, including waves, fluid instabilities, and turbulence, before concluding by turning inwards and describing the atomic constituents of fluids. It introduces ideas of kinetic theory, including the Boltzmann equation, to explain why the collective motion of 1023 atoms is, under the right circumstances, always governed by the laws of fluid mechanics.
In this chapter, we explore the basics of fluid mechanics. We will think about how to describe fluids and look at the kinds of things they can do.
Unusually, and a little defensively, the title of this chapter highlights what we won’t talk about, rather than what we will. Fluids have a property known as viscosity. This is an internal friction force acting within the fluid as diferent layers rub together. It is crucially important in many applications. In spite of its importance, we will start our journey into the world of fluids by ignoring viscosity altogether. Such flows are called inviscid. This will allow us to build intuition for the equations of fluid mechanics without the complications that viscosity brings. Moreover, the flows that we find in this section will not be wasted work. As we will see later, they give a good approximation to viscous flows in certain regimes where the more general equations reduce to those studied here.
Take anything in the universe, put it in a box, and heat it up. Regardless of what you start with, the motion of the substance will be described by the equations of fluid mechanics. This remarkable universality is the reason why fluid mechanics is important.
The key equation of fluid mechanics is the Navier-Stokes equation. This textbook starts with the basics of fluid flows, building to the Navier-Stokes equation while explaining the physics behind the various terms and exploring the astonishingly rich landscape of solutions. The book then progresses to more advanced topics, including waves, fluid instabilities, and turbulence, before concluding by turning inwards and describing the atomic constituents of fluids. It introduces ideas of kinetic theory, including the Boltzmann equation, to explain why the collective motion of 1023 atoms is, under the right circumstances, always governed by the laws of fluid mechanics.
We all know what a wave is. But you may not know just how many different kinds of waves there are and what strange and interesting properties they have. We start this chapter with something very familiar from everyday life: waves on the surface of an ocean. While they may be familiar, their mathematical description is surprisingly subtle. This can be traced, like so many other things in fluid mechanics, to the boundary conditions.
The chapter then goes on to explore many other different kinds of waves that arise in different situations, from the atmosphere, to supersonic aircraft to traffic jams.
There are two great equations of classical physics: one is Einstein’s equation of general relativity, the other the Navier-Stokes equation that describes how fluids flow. In this chapter, we meet Navier-Stokes.
This equation differs from the Euler equation by the addition of a viscosity term. This is not a small change and makes solutions to the Navier-Stokes equation much richer and more subtle than those of the Euler equation. In this chapter, we begin our exploration of these solutions.
Drop some ink in a glass of water. It will slowly spread through the whole glass, moving in a manner known as diffusion. This process is so common that it gets its own chapter. We will describe the basics of diffusion, as captured by the heat equation, before understanding how diffusion comes about from an underlying randomness. We will see this through the eyes of the Langevin and Fokker-Planck equations.
Take anything in the universe, put it in a box, and heat it up. Regardless of what you start with, the motion of the substance will be described by the equations of fluid mechanics. This remarkable universality is the reason why fluid mechanics is important.
The key equation of fluid mechanics is the Navier-Stokes equation. This textbook starts with the basics of fluid flows, building to the Navier-Stokes equation while explaining the physics behind the various terms and exploring the astonishingly rich landscape of solutions. The book then progresses to more advanced topics, including waves, fluid instabilities, and turbulence, before concluding by turning inwards and describing the atomic constituents of fluids. It introduces ideas of kinetic theory, including the Boltzmann equation, to explain why the collective motion of 1023 atoms is, under the right circumstances, always governed by the laws of fluid mechanics.
Take water and push it through a pipe. If the flow is slow, then everything proceeds in a nice, orderly fashion. But as you force the water to move faster and faster, it starts to wobble. And then those wobbles get bigger until, at some point the flow loses all coherence as it tumbles and turn, tripping over itself in an attempt to push forwards. This is turbulent flow.
Understanding turbulence remains one of the great outstanding questions of classical physics. Why does it occur? How does it occur? How should we characterise such turbulent flows? The purpose of this chapter is to take the first tiny steps towards addressing these questions.
Many of the most interesting things in fluid mechanics occur because simple flows are unstable. If they get knocked a little bit, the fluid curls up into interesting shapes, or dissolves into some messy turbulent flow. In this chapter, we start to understand how these processes can happen.