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Bloodstream fungal infections have a high mortality rate. There is little data about the long-term mortality rate of fungaemia.This study aimed to explore the mortality of fungaemia and the influencing factors associated with death. In total, 204 intensive care unit (ICU) patients with fungaemia from Multi-parameter Intelligent Monitoring in Intensive Care-III (MIMIC-III) Database were studied. Age, gender, major underlying diseases, data about vital signs and blood test results were analysed to identify the predictors of the mortality and prognosis of fungaemia in ICU patients. Cox regression models were constructed, together with Kaplan−Meier survival curves. The 30-day, 1-year, 2-year, 3-year and 4-year mortality rates were 41.2%, 62.3%, 68.1%, 72.5% and 75%, respectively. Age (P < 0.001, OR = 1.530; P < 0.001, OR = 1.485),serum bilirubin (P = 0.016, OR = 2.125;P = 0.001, OR = 1.748) and international normalised ratio (INR) (P = 0.001, OR = 2.642; P < 0.001 OR = 2.065) were predictors of both the 30-day and 4-year mortality rates. Renal failure (P = 0.009, OR = 1.643) performed good in prediction of the 4-year mortality. The mortality of fungaemia is high. Age,the serum bilirubin and INR are good predictors of the 30-day and 4-year mortality rates of fungaemia. Renal failure has good performance in predicting the long-term mortality.
While in theory systems with traffic intensity rho > 1 blow up, in reality they are stabilized by abandonments. We study limiting results for many-server systems with abandonments.
We introduces some more general processing networks and the maximum pressure policy, which uses local information for decentralized control of the network. Maximum pressure policies can guarantee the stability of MCQN as well as of more general processing networks, under some simple structure conditions, whenever traffic intensity rho < 1.
We present the ingenious scheme devised by Loynes to show that G/G/1 with stationary arrival and service processes is stable when the traffic intensity rho < 1, and transient if rho > 1. Under the stronger assumption that interarrivals and services are i.i.d., we explore the connection of the GI/GI/1 queue with the general random walk and obtain an insightful upper bound on waiting time.
We discuss the case in which arrivals, service, and routing are all memoryless, which is the classic Jackson network, and some related systems. For all of these, the stationary distribution is obtainable and is of product form.
Because time is not scaled, limiting results for many-server scaling retains dependence on the service time distribution, as we saw in the scaling of M/GI/1. We extend these infinite server results to general time-dependent arrival streams.
We discuss the classic Jackson network with general i.i.d. interarrivals and service times, the generalized Jackson network. Like the GI/GI/1 system, the generalized Jackson network cannot be analyzed in detail, and we discuss fluid and diffusion approximations to the network process.
We consider Brownian problems of scheduling and admission control, where we force congestion to be kept at the least costly nodes, and use admission control to regulate congestion.
We define fluid limits and show that stability of the fluid limits implies stability of the stochastic queueing system. This enables us to study stability of MCQN under various policies.
Vaccine hesitancy remains a serious global threat to achieve herd immunity, and this study aimed to assess the magnitude and associated factors of coronavirus disease-19 (COVID-19) vaccine hesitancy among healthcare workers (HCWs) in Amhara regional referral hospitals. A web-based anonymised survey was conducted among 440 HCWs in the Amhara region referral hospitals. The questionnaire was designed using Google Forms and distributed using telegram and e-mail from 15 May to 10 June 2021 to the randomly selected participants in each hospital. The data were analysed with Stata 14.0 and described using frequency tables. A multivariable binary logistic regression model was fitted and model fitness was checked with the Hosmer–Lemeshow goodness of fit test. Out of 440 participants, 418 were willing to participate in the study and the mean age was about 30 years. Overall, 45.9% (n = 192) of participants reported vaccine hesitancy. After applying multivariate analysis, age ≤25 years (adjusted odds ratio (aOR) = 5.6); do not wear a mask (aOR = 2.4); not compliance with physical distancing (aOR = 3.6); unclear information by public health authorities (aOR = 2.5); low risk of getting COVID-19 infection (aOR = 2.8); and not sure about the tolerability of the vaccine (aOR = 3.76) were associated with COVID-19 vaccine hesitancy. A considerable proportion of HCWs were hesitant towards COVID-19 vaccine, and this can be tackled with the provision of clear information about the vaccine.
We define the single queue, introduce notation and some relations and properties, and present simple examples of queues. We also discuss simulation of queues.
Queueing networks are all pervasive; they occur in service, manufacturing, communication, computing, the internet, and transportation. Much of queueing theory is aimed at performance evaluation of stochastic systems. Extending the methods of deterministic optimization to stochastic models so as to achieve both performance evaluation and control is an important and notoriously hard area of research. In this book our aim is to familiarize the reader with recent techniques for scheduling and control of queueing networks, with emphasis on both evaluation and optimization.
We study a queueing system with memoryless Poisson arrivals and generally distributed processing times, the so-called M/G/1 system. Performance measures of this system can be derived exactly, using the principle of work conservation and the property of PASTA (Poisson arrivals see time averages).
We look at control of networks in balanced heavy traffic. We consider routing to parallel servers; this illustrates our aim to always pool system resources. We also observe state space collapse and biriefly discuss the diffusion limit for MCQN.