Efforts to decolonize archaeology have gained significant momentum in the last few decades, but have yet to extend robustly to zooarchaeology. Zooarchaeology is, however, well positioned to make unique contributions to decolonial practice. Drawing on insights from Indigenous studies, animal studies, and models of Indigenous science, we argue that North American zooarchaeology must engage in decolonization if reconstructions of past human–animal relationships are to be robust and ethically grounded. We identify some of the colonial legacies embedded in zooarchaeology’s methods, classifications, and interpretive frameworks, and highlight how these structures constrain knowledge production. We offer a series of interventions and actionable recommendations—from analytical protocols to disciplinary practice—that create pathways for zooarchaeologists to participate in the wider decolonial project.