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Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?
Published online by Cambridge University Press: 06 March 2019
Abstract
Neurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.
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Author response
Reductionism in retreat