This article traces the visual culture of human genetic engineering over the past decade, focusing on the CRISPR genome editing technology. We argue that the representations surrounding CRISPR exemplify, and to an extent define, this visual culture. We examine the history of CRISPR, particularly its human applications from 2012 to 2022, through a periodization that includes the CRISPR craze, gene therapy initiatives, the He Jiankui controversy and clinical trials. Employing an expanded interpretation of intermediality within science communication, this work addresses the role of figuration across the relationships between specialist science reporting and the mainstream press and between traditional and social media. Using a mixed-methods approach combining visual and social-media analysis, the article presents an empirical analysis of three key figures – the double helix, the scientist and the human subject – and their roles across the discussed phases. The study concludes by articulating the stabilizing, amplifying and affective functions of intermedial figuration within science communication.