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Chapter 12 - Semantic dementia (semantic variant primary progressive aphasia)

Published online by Cambridge University Press:  01 December 2016

By
John R. Hodges ,
Sharon Savage  and
Karalyn E. Patterson
Edited by
Bruce L. Miller  and
Bradley F. Boeve
Bruce L. Miller
Affiliation:
University of California, San Francisco
Bradley F. Boeve
Affiliation:
Mayo Clinic, Minnesota
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The Behavioral Neurology of Dementia , pp. 178 - 193
Publisher: Cambridge University Press
Print publication year: 2016

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References

Neary, D, Snowden, JS, Gustafson, L, Passant, U, Stuss, D, Black, S, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998;51(6):1546–54.CrossRefGoogle ScholarPubMed
Gorno-Tempini, ML, Hillis, AE, Weintraub, S, Kertesz, A, Mendez, M, Cappa, SF, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006–14.CrossRefGoogle ScholarPubMed
Leyton, CE, Villemagne, VL, Savage, S, Pike, KE, Ballard, KJ, Piguet, O, et al. Subtypes of progressive aphasia: application of the International Consensus Criteria and validation using beta-amyloid imaging. Brain. 2011;134(Pt 10):3030–43.CrossRefGoogle ScholarPubMed
Josephs, KA, Duffy, JR, Strand, EA, Machulda, MM, Senjem, ML, Master, AV, et al. Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Brain. 2012;135:1522–36.Google Scholar
Snowden, JS, Goulding, PJ, Neary, D. Semantic dementia: A form of circumscribed cerebral atrophy. Behav Neurol. 1989;2(3):167–82.Google Scholar
Pick, A. Uber die Beziehungen der senilen Hirnatrophie zur Aphasie. Prager Medische Wochenschrift. 1892;17:165–7.Google Scholar
Pick, A. Zur symptomatologie der linksseitigen Schlafenlappenatrophie. Monatschrift fur Psychiatrie und Neurologie. 1904;16:378–88.Google ScholarPubMed
Warrington, EK. The selective impairment of semantic memory. Q J Exp Psychol A. 1975;27(4):635–57.CrossRefGoogle ScholarPubMed
Rogers, TT, Lambon Ralph, MA, Garrard, P, Bozeat, S, McClelland, JL, Hodges, JR, et al. Structure and deterioration of semantic memory: a neuropsychological and computational investigation. Psychol Rev. 2004;111(1):205–35.Google Scholar
Tulving, E. Episodic and semantic memory. In Tulving, E, Donaldson, W, editors. Organisation of Memory. New York: Academic Press; 1972. pp.381–403.CrossRefGoogle ScholarPubMed
Mesulam, M. Slowly progressive aphasia without generalized dementia. Ann Neurol. 1982;11:592–8.Google Scholar
Mehler, MF, Dickson, D, Davies, P, Horoupian, DS. Primary dysphasic dementia: clinical, pathological, and biochemical studies. Ann Neurol. 1986;20(1):126.CrossRefGoogle Scholar
Poeck, K, Luzzatti, C. Slowly progressive aphasia in three patients: the problem of accompanying neuropsychological deficit. Brain. 1988;111:151–68.CrossRefGoogle ScholarPubMed
Grossman, M, Ash, S. Primary progressive aphasia: A review. Neurocase. 2004;10(1):3–18.Google ScholarPubMed
Hodges, JR, Patterson, K, Oxbury, S, Funnell, E. Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain. 1992;115 (Pt 6):1783–806.CrossRefGoogle ScholarPubMed
Hodges, JR, Patterson, K. Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol. 2007;6(11):1004–14.CrossRefGoogle ScholarPubMed
Garrard, P, Hodges, JR. Semantic dementia: clinical, radiological and pathological perspectives. J Neurol. 2000;247(6):409–22.CrossRefGoogle ScholarPubMed
Thompson, SA, Patterson, K, Hodges, JR. Left/right asymmetry of atrophy in semantic dementia. Behavioral–cognitive implications. Neurology. 2003;61(9):1196–203.CrossRefGoogle ScholarPubMed
Mion, M, Patterson, K, Acosta-Cabronero, J, Pengas, G, Izquierdo-Garcia, D, Hong, YT, et al. What the left and right anterior fusiform gyri tell us about semantic memory. Brain. 2010;133:3256–68.CrossRefGoogle ScholarPubMed
Woollams, AM, Cooper-Pye, E, Hodges, JR, Patterson, K. Anomia: A doubly typical signature of semantic dementia. Neuropsychologia. 2008;46(10):2503–14.CrossRefGoogle ScholarPubMed
Woollams, AM, Ralph, MAL, Plaut, DC, Patterson, K. SD-squared: On the association between semantic dementia and surface dyslexia. Psychol Rev. 2007;114(2):316–39.CrossRefGoogle ScholarPubMed
Meteyard, L, Patterson, K. The relation between content and structure in language production: an analysis of speech errors in semantic dementia. Brain Lang. 2009;110(3):121–34.CrossRefGoogle ScholarPubMed
Evans, JJ, Heggs, AJ, Antoun, N, Hodges, JR. Progressive prosopagnosia associated with selective right temporal lobe atrophy. A new syndrome? Brain. 1995;118(Pt 1):1–13.CrossRefGoogle ScholarPubMed
Snowden, JS, Thompson, JC, Neary, D. Knowledge of famous faces and names in semantic dementia. Brain. 2004;127(Pt 4):860–72.CrossRefGoogle ScholarPubMed
Papagno, C, Semenza, C, Girelli, L. Meeting an “impossible challenge” in semantic dementia: Outstanding performance in numerical Sudoku and quantitative number knowledge. Neuropsychology. 2013;27(6):690–90.CrossRefGoogle ScholarPubMed
Green, HA, Patterson, K. Jigsaws – a preserved ability in semantic dementia. Neuropsychologia. 2009;47(2):569–76.CrossRefGoogle ScholarPubMed
Ikeda, M, Brown, J, Holland, AJ, Fukuhara, R, Hodges, JR. Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer’s disease. J Neurol Neurosur. 2002;73(4):371–6.CrossRefGoogle ScholarPubMed
Edwards Lee, T, Miller, B, Benson, F, Cummings, JL, Russell, GL, Boone, K, et al. The temporal variant of frontotemporal dementia. Brain. 1997;120(6):1027–40.Google ScholarPubMed
Perry, RJ, Rosen, HR, Kramer, JH, Beer, JS, Levenson, RL, Miller, BL. Hemispheric dominance for emotions, empathy and social behaviour: evidence from right- and left-handers with frontotemporal dementia. Neurocase. 2001;7(2):145–60.CrossRefGoogle ScholarPubMed
Seeley, WW, Bauer, AM, Miller, BL, Gorno-Tempini, ML, Kramer, JH, Weiner, M, et al. The natural history of temporal variant frontotemporal dementia. Neurology. 2005;64(8):1384–90.CrossRefGoogle ScholarPubMed
Davies, RR, Dawson, K, Mioshi, E, Erzinclioglu, S, Hodges, JR. Differentiation of semantic dementia and Alzheimer’s disease using the Addenbrooke’s Cognitive Examination (ACE). Int J Geriatr Psychiatry. 2008;23(4):370–5.CrossRefGoogle ScholarPubMed
Pengas, G, Patterson, K, Arnold, RJ, Bird, CM, Burgess, N, Nestor, PJ. Lost and found: bespoke memory testing for Alzheimer’s disease and semantic dementia. J Alzheimers Dis. 2010;21(4):1347–65.CrossRefGoogle ScholarPubMed
Leyton, CE, Hornberger, M, Mioshi, E, Hodges, JR. Application of Addenbrooke’s Cognitive Examination to diagnosis and monitoring of progressive primary aphasia. Dement Geriatr Cogn Disord. 2010;29(6):504–9.CrossRefGoogle ScholarPubMed
Hodges, JR, Patterson, K. Is semantic memory consistently impaired early in the course of Alzheimers-disease – neuroanatomical and diagnostic implications. Neuropsychologia. 1995;33(4):441–59.CrossRefGoogle ScholarPubMed
Hodges, JR, Patterson, K. Nonfluent progressive aphasia and semantic dementia: a comparative neuropsychological study. J Int Neuropsychol Soc. 1996;2(6):511–24.CrossRefGoogle ScholarPubMed
Hodges, JR, Patterson, K, Ward, R, Garrard, P, Bak, T, Perry, R, et al. The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer’s disease: A comparative neuropsychological study. Neuropsychology. 1999;13(1):31–40.CrossRefGoogle ScholarPubMed
Hodges, JR, Patterson, K, Graham, N, Dawson, K. Naming and knowing in dementia of Alzheimer’s type. Brain Lang. 1996;54(2):302–25.CrossRefGoogle Scholar
Rogers, TT, Ivanoiu, A, Patterson, K, Hodges, JR. Semantic memory in Alzheimer’s disease and the fronto-temporal dementias: A longitudinal study of 236 patients. Neuropsychology. 2006;20(3):319–35.CrossRefGoogle ScholarPubMed
Adlam, AL, Patterson, K, Bozeat, S, Hodges, JR. The Cambridge Semantic Memory Test Battery: detection of semantic deficits in semantic dementia and Alzheimer’s disease. Neurocase. 2010;16(3):193–207.CrossRefGoogle ScholarPubMed
Savage, S, Hsieh, S, Leslie, F, Foxe, D, Piguet, O, Hodges, JR. Distinguishing subtypes in primary progressive aphasia: application of the Sydney Language Battery. Dement Geriatr Cogn Disord. 2013;35(3–4):208–18.Google Scholar
Rogers, TT, Patterson, K, Jefferies, E, Lambon Ralph, MA. The impact of concept familiarity, typicality and specificity in semantic dementia vs. semantic aphasia. Neuropsychologia. 2015:76:220–39.CrossRefGoogle ScholarPubMed
Bozeat, S, Lambon Ralph, MA, Patterson, K, Garrard, P, Hodges, JR. Non-verbal semantic impairment in semantic dementia. Neuropsychologia. 2000;38(9):1207–15.CrossRefGoogle ScholarPubMed
Hsieh, S, Hornberger, M, Piguet, O, Hodges, JR. Neural basis of music knowledge: evidence from the dementias. Brain. 2011;134:2523–34.CrossRefGoogle Scholar
Rogers, TT, Patterson, K, Graham, K. Colour knowledge in semantic dementia: It is not all black and white. Neuropsychologia. 2007;45(14):3285–98.CrossRefGoogle ScholarPubMed
Rogers, TT, Ralph, MAL, Hodges, JR, Patterson, K. Natural selection: The impact of semantic impairment on lexical and object decision. Cogn Neuropsychol 2004;21(2–4):331–52.CrossRefGoogle ScholarPubMed
Bozeat, S, Ralph, MAL, Graham, KS, Patterson, K, Wilkin, H, Rowland, J, et al. A duck with four legs: Investigating the structure of conceptual knowledge using picture drawing in semantic dementia. Cogn Neuropsychol 2003;20(1):27–47.CrossRefGoogle ScholarPubMed
Patterson, K, Ralph, MAL, Jefferies, E, Woollams, A, Jones, R, Hodges, JR, et al. “Presemantic” cognition in semantic dementia: Six deficits in search of an explanation. J Cogn Neurosci 2006;18(2):169–83.CrossRefGoogle Scholar
Patterson, K, Erzinçlioğlu, S. Drawing as a ‘window’ on deteriorating conceptual knowledge in neurodegenerative disease. In Drawing and the Non-Verbal Mind: A Life-Span Perspective, ed. Lange-Kuettner, C, Vinter, A. Cambridge: Cambridge University Press; 2008: pp. 281–304.CrossRefGoogle ScholarPubMed
Lambon Ralph, MA, Patterson, K. Generalization and differentiation in semantic memory: insights from semantic dementia. Ann NY Acad Sci 2008;1124:61–7.CrossRefGoogle Scholar
Patterson, K, Nestor, PJ, Rogers, TT. Where do you know what you know? The representation of semantic knowledge in the human brain. Nat Rev Neurosci 2007;8(12):976–87.CrossRefGoogle ScholarPubMed
Mesulam, MM, Wieneke, C, Hurley, R, Rademaker, A, Thompson, CK, Weintraub, S, et al. Words and objects at the tip of the left temporal lobe in primary progressive aphasia. Brain. 2013;136:601–18.CrossRefGoogle ScholarPubMed
Gainotti, G. The format of conceptual representations disrupted in semantic dementia: A position paper. Cortex. 2012;48(5):521–9.CrossRefGoogle Scholar
Buxbaum, LJ, Schwartz, MF, Carew, TG. The role of semantic memory in object use. Cogn Neuropsychol 1997;14:219–54.CrossRefGoogle ScholarPubMed
Lauro-Grotto, R, Piccini, C, Shallice, T. Modality-specific operations in semantic dementia. Cortex. 1997;33(4):593–622.CrossRefGoogle ScholarPubMed
Hodges, JR, Bozeat, S, Ralph, MAL, Patterson, K, Spatt, J. The role of conceptual knowledge in object use: Evidence from semantic dementia. Brain. 2000;123:1913–25.CrossRefGoogle ScholarPubMed
Bozeat, S, Lambon Ralph, MA, Patterson, K, Hodges, JR. When objects lose their meaning: what happens to their use? Cogn Affect Behav Neurosci. 2002;2(3):236–51.CrossRefGoogle ScholarPubMed
Bozeat, S, Ralph, MA, Patterson, K, Hodges, JR. The influence of personal familiarity and context on object use in semantic dementia. Neurocase. 2002;8(1–2):127–34.CrossRefGoogle Scholar
Snowden, JS, Griffiths, HL, Neary, D. Semantic dementia: Autobiographical contribution to preservation of meaning. Cogn Neuropsychol 1994;11:265–88.CrossRefGoogle Scholar
Hodges, JR, Spatt, J, Patterson, K. “What” and “how”: Evidence for the dissociation of object knowledge and mechanical problem-solving skills in the human brain. Proc Natl Acad Sci USA. 1999;96(16):9444–8.Google ScholarPubMed
Graham, KS, Simons, JS, Pratt, KH, Patterson, K, Hodges, JR. Insights from semantic dementia on the relationship between episodic and semantic memory. Neuropsychologia. 2000;38(3):313–24.CrossRefGoogle ScholarPubMed
Simons, JS, Graham, KS, Galton, CJ, Patterson, K, Hodges, JR. Semantic knowledge and episodic memory for faces in semantic dementia. Neuropsychology. 2001;15(1):101–14.CrossRefGoogle ScholarPubMed
Ikeda, M, Patterson, K, Graham, KS, Ralph, MAL, Hodges, JR. A horse of a different colour: Do patients with semantic dementia recognise different versions of the same object as the same? Neuropsychologia. 2006;44(4):566–75.CrossRefGoogle ScholarPubMed
Tulving, E, Hayman, CAG, MacDonald, CA. Long-lasting perceptual priming and semantic learning in amnesia: a case experiment. J Exp Psychol Learn Mem Cogn. 1991;17:595–617.Google Scholar
Tulving, E. Organization of memory: Quo Vadis. In Gazzaniga, MS, editor. The Cognitive Neurosciences. Cambridge, MA: MIT Press; 1995. pp. 839–47.CrossRefGoogle ScholarPubMed
Adlam, AL, Patterson, K, Hodges, JR. "I remember it as if it were yesterday": memory for recent events in patients with semantic dementia. Neuropsychologia. 2009;47(5):1344–51.CrossRefGoogle Scholar
Graham, KS, Hodges, JR. Differentiating the roles of the hippocampal complex and the neocortex in long-term memory storage: Evidence from the study of semantic dementia and Alzheimer’s disease. Neuropsychology. 1997;11(1):77–89.CrossRefGoogle ScholarPubMed
Maguire, EA, Kumaran, D, Hassabis, D, Kopelman, MD. Autobiographical memory in semantic dementia: a longitudinal fMRI study. Neuropsychologia. 2010;48(1):123–36CrossRefGoogle ScholarPubMed
McKinnon, MC, Black, SE, Miller, B, Moscovitch, M, Levine, B. Autobiographical memory in semantic dementia: implication for theories of limbic–neocortical interaction in remote memory. Neuropsychologia. 2006;44(12):2421–9.CrossRefGoogle ScholarPubMed
Irish, M, Hornberger, M, Lah, S, Miller, L, Pengas, G, Nestor, PJ, et al. Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer’s disease. Neuropsychologia. 2011;49(9):2694–702.CrossRefGoogle ScholarPubMed
Hou, CE, Miller, BL, Kramer, JH. Patterns of autobiographical memory loss in dementia. Int J Geriatr Psychiatry. 2005;20(9):809–15.CrossRefGoogle ScholarPubMed
Matuszewski, V, Piolino, P, Belliard, S, de la Sayette, V, Laisney, M, Lalavee, C, et al. Patterns of autobiographical memory impairment according to disease severity in semantic dementia. Cortex. 2009;45(4):456–72.CrossRefGoogle Scholar
Nestor, PJ, Graham, KS, Bozeat, S, Simons, JS, Hodges, JR. Memory consolidation and the hippocampus: Further evidence from the study of autobiographical memory in semantic dementia and the frontal variant of frontotemporal dementia. Neuropsychologia. 2002;40(6):633–54.CrossRefGoogle Scholar
Snowden, JS, Griffiths, HL, Neary, D. Semantic–episodic memory interactions in semantic dementia: implications for retrograde memory function. Cogn Neuropsychol 1996;13:1101–37.CrossRefGoogle Scholar
Hodges, JR, Patterson, K, Tyler, LK. Loss of semantic memory: implications for the modularity of mind. Cogn Neuropsychol 1994;11:505–42.CrossRefGoogle ScholarPubMed
Julien, CL, Thompson, JC, Neary, D, Snowden, JS. Arithmetic knowledge in semantic dementia: Is it invariably preserved? Neuropsychologia. 2008;46(11):2732–44.CrossRefGoogle Scholar
Cappelletti, M, Butterworth, B, Kopelman, M. Spared numerical abilities in a case of semantic dementia. Neuropsychologia. 2001;39(11):1224–39.CrossRefGoogle Scholar
Jefferies, E, Frankish, CR, Ralph, MAL. Lexical and semantic binding in verbal short-term memory. J Mem Lang. 2006;54(1):81–98.CrossRefGoogle ScholarPubMed
Knott, R, Patterson, K, Hodges, JR. The role of speech production in auditory–verbal short-term memory. Neuropsychologia. 2000;38:125–42.CrossRefGoogle Scholar
Knott, R, Patterson, K, Hodges, JR. Lexical and semantic binding effects in short-term memory: Evidence from semantic dementia. Cognitive Neuropsych 1997;14(8):1165–218.CrossRefGoogle ScholarPubMed
Patterson, K, Graham, N, Hodges, JR. The impact of semantic memory loss on phonological representations. J Cogn Neurosci. 1994;6(1):57–69.CrossRefGoogle ScholarPubMed
Schacter, DL, Addis, DR, Buckner, RL. Remembering the past to imagine the future: the prospective brain. Nat Rev Neurosci 2007;8(9):657–61.CrossRefGoogle ScholarPubMed
Duval, C, Desgranges, B, de La Sayette, V, Belliard, S, Eustache, F, Piolino, P. What happens to personal identity when semantic knowledge degrades? A study of the self and autobiographical memory in semantic dementia. Neuropsychologia. 2012;50:254–65.CrossRefGoogle ScholarPubMed
Irish, M, Addis, DR, Hodges, JR, Piguet, O. Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia. Brain. 2012;135(Pt 7):2178–91.CrossRefGoogle ScholarPubMed
Irish, M, Addis, DR, Hodges, JR, Piguet, O. Exploring the content and quality of episodic future simulations in semantic dementia. Neuropsychologia. 2012;50(14):3488–95.CrossRefGoogle ScholarPubMed
Addis, DR, Sacchetti, DC, Ally, BA, Budson, AE, Schacter, DL. Episodic simulation of future events is impaired in mild Alzheimer’s disease. Neuropsychologia. 2009;47(12):2660–71.CrossRefGoogle ScholarPubMed
Irish, M, Piguet, O. The pivotal role of semantic memory in remembering the past and imagining the future. Front Behav Neurosci. 2013;7(27).CrossRefGoogle ScholarPubMed
Kumfor, F, Piguet, O. Disturbance of emotion processing in frontotemporal dementia: A synthesis of cognitive and neuroimaging findings. Neuropsychol Rev. 2012;22(3):280–97.CrossRefGoogle ScholarPubMed
Hsieh, S, Foxe, D, Leslie, F, Savage, S, Piguet, O, Hodges, JR. Grief and joy: Emotion word comprehension in the dementias. Neuropsychology. 2012;26(5):624–30.CrossRefGoogle ScholarPubMed
Rosen, HJ, Perry, RJ, Murphy, J, Kramer, JH, Mychack, P, Schuff, N, et al. Emotion comprehension in the temporal variant of frontotemporal dementia. Brain. 2002;125(Pt 10):2286–95.CrossRefGoogle ScholarPubMed
Hsieh, S, Hornberger, M, Piguet, O, Hodges, JR. Brain correlates of musical and facial emotion recognition: Evidence from the dementias. Neuropsychologia. 2012;50(8):1814–22.CrossRefGoogle ScholarPubMed
Omar, R, Henley, S, Bartlett, JW, Hailstone, JC, Gordon, E, Sauter, DA, et al. The structural neuroanatomy of music emotion recognition: Evidence from frontotemporal lobar degeneration. Neuroimage. 2011;56(3):1814–21.CrossRefGoogle ScholarPubMed
Kumfor, F, Miller, L, Lah, S, Hsieh, S, Savage, S, Hodges, JR, et al. Are you really angry? The effect of intensity on facial emotion recognition in frontotemporal dementia. Soc Neurosci. 2011;6(5–6):502–14.CrossRefGoogle Scholar
Miller, LA, Hsieh, S, Lah, S, Savage, S, Hodges, JR, Piguet, O. One size does not fit all: face emotion processing impairments in semantic dementia, behavioural-variant frontotemporal dementia and Alzheimer’s disease are mediated by distinct cognitive deficits. Behav Neurol. 2012;25(1):53–60.CrossRefGoogle ScholarPubMed
Kumfor, F, Irish, M, Hodges, JR, Piguet, O. Discrete neural correlates for the recognition of negative emotions: insights from frontotemporal dementia. Plos One. 2013;8(6):e67457.CrossRefGoogle ScholarPubMed
Sturm, VE, McCarthy, ME, Yun, I, Madan, A, Yuan, JW, Holley, SR, et al. Mutual gaze in Alzheimer’s disease, frontotemporal and semantic dementia couples. Soc Cogn Affect Neurosci. 2011;6(3):359–67.CrossRefGoogle ScholarPubMed
Miller, LA, Mioshi, E, Savage, S, Lah, S, Hodges, JR, Piguet, O. Identifying cognitive and demographic variables that contribute to carer burden in dementia. Dement Geriatr Cogn Disord. 2013;36(1–2):43–9.Google ScholarPubMed
Eslinger, PJ, Moore, P, Troiani, V, Antani, S, Cross, K, Kwok, S, et al. Oops! Resolving social dilemmas in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2007;78(5):457–60.CrossRefGoogle ScholarPubMed
Duval, C, Bejanin, A, Piolino, P, Laisney, M, de La Sayette, V, Belliard, S, et al. Theory of mind impairments in patients with semantic dementia. Brain. 2012;135(Pt 1):228–41.CrossRefGoogle ScholarPubMed
Irish, M, Hodges, JR, Piguet, O. Right anterior temporal lobe dysfunction underlies theory of mind impairments in semantic dementia. Brain. 2014;137(Pt 4):1241–53.CrossRefGoogle ScholarPubMed
Chan, D, Fox, NC, Scahill, RI, Crum, WR, Whitwell, JL, Leschziner, G. Patterns of temporal lobe atrophy in semantic dementia and Alzheimer’s disease. Ann Neurol. 2001;49:433–42.CrossRefGoogle ScholarPubMed
Galton, CJ, Patterson, K, Graham, K, Lambon-Ralph, MA, Williams, G, Antoun, N, et al. Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology. 2001;57(2):216–25.CrossRefGoogle Scholar
Davies, RR, Xuereb, JH, Hodges, JR. The human perirhinal cortex in semantic memory: an in vivo and postmortem volumetric magnetic resonance imaging study in semantic dementia, Alzheimer’s disease and matched controls. Neuropathol Appl Neurobiol. 2002;28(2):167–8.CrossRefGoogle ScholarPubMed
Rosen, HJ, Gorno-Tempini, ML, Goldman, WP, Perry, RJ, Schuff, N, Weiner, M, et al. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology. 2002;58(2):198–208.CrossRefGoogle Scholar
Acosta-Cabronero, J, Patterson, K, Fryer, TD, Hodges, JR, Pengas, G, Williams, GB, et al. Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain 2011;134(Pt 7):2025–35.CrossRefGoogle ScholarPubMed
Gorno-Tempini, ML, Dronkers, NF, Rankin, KP, Ogar, J, Phengrasamy, L, Rosen, HJ, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004;55(3):335–46.CrossRefGoogle ScholarPubMed
Davies, RR, Graham, KS, Xuereb, JH, Williams, GB, Hodges, JR. The human perirhinal cortex and semantic memory. Eur J Neurosci. 2004;20(9):2441–6.CrossRefGoogle ScholarPubMed
Williams, GB, Nestor, PJ, Hodges, JR. The neural correlates of semantic and behavioural deficits in frontotemporal dementia. NeuroImage. 2005;24(4):1042–51.CrossRefGoogle ScholarPubMed
Mummery, CJ, Patterson, K, Wise, RJ, Vandenberghe, R, Price, CJ, Hodges, JR. Disrupted temporal lobe connections in semantic dementia. Brain. 1999;122 (Pt 1):61–73.CrossRefGoogle ScholarPubMed
Whitwell, JL, Avula, R, Senjem, ML, Kantarci, K, Weigand, SD, Samikoglu, A, et al. Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia. Neurology. 2010;74(16):1279–87.CrossRefGoogle ScholarPubMed
Guo, CC, Gorno-Tempini, ML, Gesierich, B, Henry, M, Trujillo, A, Shany-Ur, T, et al. Anterior temporal lobe degeneration produces widespread network-driven dysfunction. Brain. 2013;136(Pt 10):2979–91.CrossRefGoogle ScholarPubMed
Nestor, PJ, Fryer, TD, Hodges, JR. Declarative memory impairments in Alzheimer’s disease and semantic dementia. Neuroimage. 2006;30(3):1010–20.CrossRefGoogle ScholarPubMed
Desgranges, B, Matuszewski, V, Piolino, P, Chetelat, G, Mezenge, F, Landeau, B, et al. Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study. Neurobiol Aging. 2007;28(12):1904–13.CrossRefGoogle ScholarPubMed
Chetelat, G, Desgranges, B, Landeau, B, Poline, JB, de la Sayette, V, Viader, F, et al. Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer’s disease. Brain. 2008;131(Pt 1):60–71.CrossRefGoogle Scholar
Hodges, JR, Mitchell, J, Dawson, K, Spillantini, MG, Xuereb, JH, McMonagle, P, et al. Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases. Brain. 2010;133:300–6.CrossRefGoogle ScholarPubMed
Dobson-Stone, C, Hallupp, M, Bartley, L, Shepherd, CE, Halliday, GM, Schofield, PR, et al. C9ORF72 repeat expansion in clinical and neuropathologic frontotemporal dementia cohorts. Neurology. 2012;79(10):995–1001.Google Scholar
Devenney, E, Hornberger, M, Irish, M, Mioshi, E, Burrell, J, Tan, R, et al. Frontotemporal dementia associated with the C9ORF72 mutation: a unique clinical profile. JAMA Neurology. In press.CrossRefGoogle ScholarPubMed
Josephs, KA, Hodges, JR, Snowden, JS, Mackenzie, IR, Neumann, M, Mann, DM, et al. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathologica. 2011;122(2):137–53.CrossRefGoogle Scholar
Cairns, NJ, Bigio, EH, Mackenzie, IRA, Neumann, M, Lee, VMY, Hatanpaa, KJ, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol. 2007;114(1):5–22.CrossRefGoogle ScholarPubMed
Hodges, JR, Davies, RR, Xuereb, JH, Casey, B, Broe, M, Bak, TH, et al. Clinicopathological correlates in frontotemporal dementia. Ann Neurol. 2004;56(3):399–406.CrossRefGoogle ScholarPubMed
Shi, J, Shaw, CL, Du Plessis, D, Richardson, AM, Bailey, KL, Julien, C, et al. Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation. Acta Neuropathol. 2005;110(5):501–12.CrossRefGoogle ScholarPubMed
Boxer, AL, Knopman, DS, Kaufer, DI, Grossman, M, Onyike, CU, Graff-Radford, NR, et al. Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2013;12(2):149–56.CrossRefGoogle Scholar
Croot, K, Nickels, L, Laurence, F, Manning, M. Impairment- and activity/participation-directed interventions in progressive language impairment: Clinical and theoretical issues. Aphasiology. 2009;23(2):125–60.CrossRefGoogle ScholarPubMed
Savage, SA, Ballard, KJ, Piguet, O, Hodges, JR. Bringing words back to mind – Improving word production in semantic dementia. Cortex. 2013;49(7):1823–32.CrossRefGoogle ScholarPubMed
Snowden, JS, Neary, D. Relearning of verbal labels in semantic dementia. Neuropsychologia. 2002;40:1715–28.CrossRefGoogle Scholar
Jokel, R, Rochon, E, Anderson, ND. Errorless learning of computer-generated words in a patient with semantic dementia. Neuropsychol Rehabil. 2010;20(1):16–41.CrossRefGoogle ScholarPubMed
Jokel, R, Anderson, ND. Quest for the best: Effects of errorless and active encoding on word re-learning in semantic dementia. Neuropsychol Rehabil. 2012;22(2):187–214.CrossRefGoogle Scholar
Heredia, CG, Sage, K, Ralph, MAL, Berthier, M. Relearning and retention of verbal labels in a case of semantic dementia. Aphasiology. 2009;23(2):192–209.CrossRefGoogle ScholarPubMed
Jokel, R, Rochon, E, Leonard, C. Treating anomia in semantic dementia: Improvement, maintenance, or both? Neuropsychol Rehabil. 2006;16(3):241–56.CrossRefGoogle ScholarPubMed
Savage, S, Piguet, O, Hodges, JR. Giving words new life: Generalisation of word retraining outcomes in semantic dementia. J Alzheimers Dis. 2014;40(2):309 –17.CrossRefGoogle Scholar
Graham, KS, Patterson, K, Pratt, KH, J.R. H. Relearning and subsequent forgetting of semantic category exemplars in a case of semantic dementia. Neuropsychology. 1999;13:359–80.CrossRefGoogle ScholarPubMed
Mioshi, E, Bristow, M, Cook, R, Hodges, JR. Factors underlying caregiver stress in frontotemporal dementia and Alzheimer’s disease. Dement Geriatr Cogn Disord. 2009;27(1):76–81.CrossRefGoogle ScholarPubMed
Mioshi, E, Foxe, D, Leslie, F, Savage, S, Hsieh, S, Miller, L, et al. The impact of dementia severity on caregiver burden in frontotemporal dementia and Alzheimer disease. Alz Dis Assoc Dis. 2013;27(1):68–73.CrossRefGoogle ScholarPubMed
Hsieh, S, Irish, M, Daveson, N, Hodges, JR, Piguet, O. When one loses empathy: its effect on carers of patients with dementia. J Geriatr Psychiatry Neurol. 2013;26(3):174–84.CrossRefGoogle ScholarPubMed
McKinnon, C, O’Connor, CM, Savage, S, Hodges, JR, Mioshi, E. Qualitative results of a structured group program for carers of people with frontotemporal dementia. Int J Geriatr Psychiatry. 2013;28(2):217–18.Google ScholarPubMed
Mioshi, E, McKinnon, C, Savage, S, O’Connor, CM, Hodges, JR. Improving burden and coping skills in frontotemporal dementia caregivers: a pilot study. Dement Geriatr Cogn Disord. 2013;27(1):84–6.Google Scholar

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