Misliya Cave, Mount Carmel is one of the few Levantine sites documenting the Lower Palaeolithic to Middle Palaeolithic transition. Excavations yielded rich Early Levantine Mousterian and Acheulo-Yabrudian assemblages. The Acheulo-Yabrudian lithic assemblage point to the very end of the Levantine Lower Palaeolithic characterized by bifacial shaping, production of small thin flakes, and large, thick cortical flakes, often used for manufacturing handaxes and scrapers using Quina retouch. The emergence of the Early Middle Palaeolithic (MIS7/beginning of MIS6) is marked by disappearance of bifaces and thick-flake production technology and introduction of laminar and Levallois technologies. The faunal assemblage of Mesopotamian fallow deer and mountain gazelle indicates systematic ungulate hunting and ‘modern’ carcass handling. Charred grass tissues likely represent the remains of bedding or matting, the earliest such evidence to date. High density of artefacts and repeated construction of well-defined hearths indicate recurring visits to the site and low residential mobility, exemplifying the regional centrality of the site during the Early Middle Palaeolithic.