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Food preservation, including salting and barreling meat, has played a significant role in human history; however, it remains challenging to identify cases of salting in the archaeological record. Most studies have relied on limited datasets and focus on body-part profiles observed in faunal assemblages. Known and suspected cases of barreled meat and on-site butchery, drawn from six shipwrecks and seven fur trade posts, provide a means of identifying body-part profiles for salted pork and beef. Modeled body-part profiles based on these data reveal differences in expected body-part frequency between salted and locally butchered beef, although the patterning is less obvious for pork. Comparing these models against 26 military forts reveals that, despite the prominence of salted beef and pork in historic records, many forts exhibit patterns consistent with on-site butchery of live animals.
A fully resolved numerical study was performed to investigate interfacial heat and mass transfer enhanced by the fully developed Rayleigh–Bénard–Marangoni instability in a relatively deep domain. The instability was triggered by evaporative cooling modelled by a constant surface heat flux. The latter allowed for temperature-induced variations in surface tension giving rise to Marangoni forces reinforcing the Rayleigh instability. Simulations were performed at a fixed Rayleigh number (${\textit{Ra}}_h$) and a variety of Marangoni numbers (${\textit{Ma}}_h$). In each simulation, scalar transport equations for heat and mass concentration at various Schmidt numbers (${\textit{Sc}}=16{-}200$) were solved simultaneously. Due to the fixed (warm) temperature prescribed at the bottom of the computational domain, large buoyant plumes emerged quasi-periodically both at the top and bottom. With increasing Marangoni number a decrease in the average convection cell size at the surface was observed, with a simultaneous improvement in near-surface mixing. The presence of high aspect ratio rectangular convection cell footprints was found to be characteristic for Marangoni-dominated flows. Due to the promotion of interfacial mass transfer by Marangoni forces, the power in the scaling of the mass transfer velocity, $K_{\!L}\!\propto\! \textit{Sc}^{-n}$, was found to decrease from $n=0.50$ at ${\textit{Ma}}_h=0$ to $\approx 0.438$ at ${\textit{Ma}}_h=13.21\times 10^5$. Finally, the existence of a buoyancy-dominated and a Marangoni-dominated regime was investigated in the context of the interfacial heat and mass transfer scaling as a function of ${\textit{Ma}}_h+\varepsilon {\textit{Ra}}_h$, where $\varepsilon$ is a small number determined empirically.
Both experiments and direct numerical simulation (DNS) of hypersonic flow over a compression ramp show streamwise aligned streaks/vortices near the corner as the ramp angle is increased. The origin of this three-dimensional disturbance growth is not definitively known in the existing literature, but is typically connected to flow deceleration, centrifugal (Görtler) and/or baroclinic effects. In this work we consider the hypersonic problem with moderate wall cooling in the high Reynolds/Mach number, weak interaction limit. In the lower deck of the corresponding asymptotic triple-deck description we pose the linearised, three-dimensional, Görtler stability equations. This formulation allows computation of both receptivity and biglobal stability problems for linear spanwise-periodic disturbances with a spanwise wavelength of the same order as the lower-deck depth. In this framework the dominant response near the ramp surface is of constant density and temperature (at leading order) ruling out baroclinic mechanisms. Nevertheless, we show that there remains strong energy growth of upstream spanwise-varying perturbations and ultimately a bifurcation from two-dimensional to three-dimensional ramp flow. The unstable eigenmodes are localised to the separation region. The bifurcation points are obtained over a range of ramp angle, wall-cooling parameter and disturbance wavelength. Consistent with DNS results, the three-dimensional perturbations in this asymptotic formulation are streamwise aligned streaks/vortices, displaced above the separation region. In addition, the growth of upstream disturbances peaks near to the reattachment point, whilst the streaks persist beyond it, decaying relatively slowly downstream along the deflected ramp.
Early life adversity (ELA) is common and cross-sectionally associated with brain gray matter structure, including cortical thickness, cortical surface area, and subcortical volumes in childhood. However, to which degree ELA influences the trajectory of gray matter macrostructural and microstructural development during childhood and adolescence remains largely unexplored.
Methods
We included 6414 participants from the Adolescent Brain Cognitive Development study at ages 9–11, where 1923 were followed to ages 11–13. We used linear mixed-effects models to test for associations between MRI-derived longitudinal measures of gray matter macro- (cortical thickness, surface area, subcortical volume) or microstructure (T1w/T2w ratio) and trauma exposure, parental acceptance, household abuse, and being resilient or susceptible to trauma in terms of developing an internalizing disorder.
Results
At ages 9–11, higher levels of parental acceptance, trauma exposure, and being trauma resilient were associated with lower levels of cortical thickness. In contrast, being trauma susceptible was negatively related to hippocampal volume and cortical surface area. Longitudinally, more parental acceptance at baseline was associated with more cortical thinning between ages 9–11 and 11–13, while more household abuse was associated with less change in T1w/T2w ratio over time.
Conclusions
Parental acceptance and trauma resilience are linked to accelerated pace of apparent cortical thinning in youth aged 9–13 years, while household abuse is associated with slower microstructural development, as reflected by smaller longitudinal changes in the T1w/T2w ratio. Threat and deprivation may be distinctly associated with gray matter developmental trajectories in late childhood.
Mastitis, an inflammation of the mammary gland, is a disease of significant clinical and economic importance. In recent years, advances in omics technologies have provided powerful tools to unravel the complex biological mechanisms underlying mastitis. These approaches encompass diverse fields such as genomics, proteomics, transcriptomics, metagenomics, metabolomics, epigenomics, lipidomics, glycomics, pharmacogenomics, foodomics, interactomics and exposomics. However, despite the rapid growth of omics research, the thematic structure of this literature has not been systematically examined. In this study, latent dirichlet allocation (LDA) was employed to perform topic modelling on publications related to omics and mastitis retrieved from Scopus and Web of Science. The LDA analysis revealed ten distinct topics, labelled according to the most frequent terms within each cluster: ‘proteomics’, ‘pathogen genomics’, ‘differential expression’, ‘metabolism’, ‘genetic selection’, ‘disease economy’, ‘molecular diagnostics’, ‘microbiome’, ‘antimicrobial resistance’ and ‘genetic variation.’ Among these, the topics of ‘genomics’, ‘differential expression’ and ‘antimicrobial resistance’ accounted for the highest number of publications, while ‘metabolism’ emerged more recently. All topics exhibited an increasing trend in publication volume over time, likely driven by the declining costs and greater accessibility of high-throughput omics technologies. This study provides a comprehensive thematic overview of omics research on mastitis, identifies key areas of emphasis and emerging directions, and highlights knowledge gaps that may inform future investigations and the development of targeted strategies for disease control and prevention.
Maintaining appetite in older adults is important for preventing malnutrition. Previous studies have shown seasonal variations in dietary intake, suggesting that appetite itself may vary with the seasons. Nevertheless, few studies have directly examined seasonal changes in appetite in older adults, particularly those living alone, who are at higher risk of malnutrition. Thus, the purpose of the present study was to identify when appetite declines throughout the year in older adults living alone and with others. Of the 60 adults aged 65 and older who participated in the study, 57 completed the longitudinal study over four seasons. Appetite for each season was assessed using the Simple Nutritional Appetite Questionnaire (SNAQ) and the visual analogue scale for hunger, satiety, and expectation of food intake. Nutritional status was assessed using the Mini Nutritional Assessment and the Food Frequency Questionnaire. The living arrangements of the participants were determined based on whether they were living alone or with others. The stratified analysis revealed seasonal changes in SNAQ scores exclusively among individuals living alone (p = 0.029, effect size = 0.280), who exhibited diminished appetite during summer compared to winter (p = 0.026, 95% CI: 0.076–1.258). No seasonal variation in appetite or nutritional status was observed in those living with others (p > 0.05). These findings highlight the importance of an approach that considers living arrangement and seasonality to ensure that older people maintain adequate appetite status throughout the year.
Memory for emotional information is greater than for non-emotional information and is enhanced by sleep-related consolidation. Previous studies have focused on emotional arousal and valence of established stimuli, but what is the effect of sleep on newly acquired emotional information? Figurative expressions, which are pervasive in everyday communication, are often rated as higher in emotionality than their literal counterparts, but the effect of emotionality on the learning of metaphors, and the effect of sleep on newly acquired emotionally negative, positive and neutral language, is as yet poorly understood. In this study, participants were asked to memorise conventional (e.g. ‘sunny disposition’) and novel (e.g. ‘cloudy disposition’) metaphorical word pairs varying in valence, accompanied by their definitions. After a 12-hour period of sleep or wake, participants were tested on their recognition of word pairs and recall of definitions. We found higher arousal ratings were related to increased recognition and recall performance. Furthermore, sleep increased the accurate recognition of all word pairs compared to wake but also reduced the valence of word pairs. The results indicate better memory for newly acquired emotional stimuli, a benefit of sleep for memory, but also a reduction in emotional arousal as a consequence of sleep consolidation.
The Food and Drug Administration (FDA) recently published a final rule regarding preharvest irrigation requirements for leafy greens production. We use an equilibrium displacement model (EDM) to quantify the effects of this policy. The model is modified to allow for nonlinear equilibrium trajectories. The results show that the FDA rule will cause North American leafy greens production to decline by 0.99% and farmgate prices to increase by 0.59%. A proposal to increase land buffer areas around confined animal feeding operations (CAFOs) and large composting sites would further increase leafy greens prices and reduce consumption.
The purpose of the study is to analyze bloodstream infection (BSI) data reported by outpatient hemodialysis facilities to understand temporal trends, the potential impact of infection prevention practices and the COVID-19 pandemic on BSI rates.
Methods:
Outpatient hemodialysis facilities report BSI data to the National Healthcare Safety Network. We used interrupted time series with mixed effects negative binomial modeling to estimate the annual change of BSI rates from 2012 to 2021, using March 2020 as the COVID-19 inflection point. The model controlled for seasonal factors, vascular access types, and facility characteristics.
Results:
The number of facilities used for analysis increased from 5,581 in 2012 to 7,313 in 2021. Most facilities were freestanding (range: 90%–93%) and belonged to for-profit organizations (range: 85%–88%). The annual adjusted BSI rates decreased by an average of 8.90% (95% CI: −9.10 %, −8.71%) January 2012-February 2020. The annual decrease in BSI rate was not significant during March 2020-December 2021 (P = 0.15). There was a level drop of 32.03% (95%CI: −33.84%, −30.17%) in BSI rates in the period of March 2020-December 2021 compared with the period of January 2012-February 2020.
Conclusions:
BSI rates decreased steadily from January 2012 to February 2020 likely due to the identification and adoption of evidence-based prevention practices. BSI rates plateaued at lower levels during March 2020-December 2021. This suggests that infection prevention measures implemented by facilities prior to the emergence of COVID-19 contributed to substantial decreases in BSI rates and may have helped to stabilize BSI rates after March 2020.
To identify behavioral factors explored in the literature and the theoretical frameworks used to understand antimicrobial prescribing behaviors of ICU physicians.
Design:
Scoping review following the JBI methodology.
Setting:
Studies conducted in intensive care units (ICUs) across various healthcare systems.
Participants:
Physicians working in ICUs; studies involving other healthcare professionals or aggregating data from multiple specialties were excluded.
Interventions:
Not applicable.
Results:
From 995 records identified through PubMed, Embase, Scopus, CINAHL, and Web of Science, 18 studies met inclusion criteria. Fourteen were cross-sectional surveys and four used qualitative semi-structured interviews. Knowledge about antimicrobial use and its role in resistance was generally adequate. Attitudes reflected that beliefs, clinical uncertainty, and contextual factors influenced prescribing behaviors. Reported practices highlighted the role of adherence to institutional protocols and guidelines. Despite the behavioral focus, most studies lacked explicit use of theoretical frameworks to guide data collection or interpretation.
Conclusions:
Antimicrobial prescribing in ICUs is influenced by behavioral determinants that are not consistently evaluated using theoretical models. Future research on Knowledge, Attitudes, and Practices (KAP) should integrate behavioral science frameworks to enhance understanding and enable better design of stewardship interventions.
Sea surface films significantly influence air–sea interaction. While their damping effect on gravity–capillary waves is well recognised, the detailed mechanisms by which surface films alter small-scale wave dynamics – particularly energy dissipation and near-surface flow patterns – remain insufficiently understood. This paper presents experimental observations focusing on small-scale wave profiles and surface-flow dynamics in the presence of surfactants, providing direct experimental evidence of underlying mechanisms such as Marangoni effects. The experiments demonstrate enhanced energy dissipation and significant alterations in near-surface flow caused by surfactants, including the transformation of typical circular motion into elliptical-like trajectories and the emergence of reverse surface drift.
Frameworks are widespread in developmental psychology. They provide general ideas about what to study in human development: which concepts to focus on (e.g., systems, timescales), which processes to test (e.g., micro–macro, bidirectional), and which methods to use (e.g., interview, dynamical equations). However, despite their prominence, there exists very little consensus or guidance on how to use frameworks in research. As such, they have an obscure role, influencing our research questions, methods, and theory, but often in ways we cannot articulate for ourselves, let alone for others. This Views paper presents our perspective on how different frameworks can inform the assumptions, targets, goals, context, timing, and methods of a research project. As an illustrative example, we use Bronfenbrenner’s bioecological framework to inform research investigating how parent–child relationships shape the development of executive self-regulation. We also show how different frameworks relevant to developmental psychopathology can inform a research project in distinct ways. Thus, this Views paper provides a practical guide for developmental researchers to more explicitly use and benefit from frameworks in their research.
Passive gust load alleviation systems have the potential to significantly reduce airframe mass without reliance on complex systems of sensors and actuators. Recent experimental work by the authors has shown that a passive, strain-actuated spoiler can rapidly reduce the lift coefficient of an aerofoil. In this work, we numerically investigate the efficacy of a strain-actuated spoiler in alleviating loads within the wider airframe. The airframe is represented by a beam model which is exposed to a series of One-Minus-Cosine gusts. The effect of the spoiler on the wing is captured by locally reducing lift when wingbox strains meet a triggering condition. The model spoiler is shown to be capable of reducing the sizing wing root bending moment by up to $17$% for the airframe and spoiler parameters considered. In addition, the sensitivity of this load alleviation to key spoiler design parameters is investigated. It is found that deploying the spoiler as early as possible in the gust provides the best load alleviation performance. In a few cases, the spoiler is found to induce a limit cycle oscillation in the wing by repeatedly deploying and stowing. This may be an artefact caused by the low fidelity structural model employed in this work. Nonetheless, two ways of preventing this behaviour are demonstrated. Our work demonstrates for the first time that a strain-actuated spoiler is capable of alleviating loads at the scale of a full aircraft.
Team innovation is nurtured by the combination of team members’ diverse knowledge and collaborative teamwork. Previous research predominantly assumed a linear interaction between knowledge diversity and network density in predicting team innovation. A pivotal question arises: How do varying levels of knowledge diversity and network density interact to influence team innovation? To address this complex question, we conducted a machine-learning inductive study, leveraging its ability to uncover curvilinear interactive patterns between knowledge diversity and network density in fostering team innovation. We collected comprehensive, multisource data from 1,883 teams within a prominent high-technology firm in China over a four-year period from 2014 to 2017. The results indicate that knowledge diversity and network density exhibit a curvilinear interactive effect on team innovation. The two factors reinforce each other in the initial stage and foster peak innovation with an optimal balance at a medium-to-high level. Beyond this threshold, however, the two factors begin to restrain each other’s effectiveness. Consistent with the perspective of yin-yang balancing, this study deepens our understanding of the paradoxical joint effects of knowledge diversity and network density on team innovation.
Forthcoming changes to clozapine monitoring present an opportunity to expand, not dilute, specialist care for chronic schizophrenia. Reduced administrative burden should support timely clozapine use, structured assessment, access to psychological therapies and embedded physical health care. Experience from Cambridgeshire shows that secondary-plus clinics within community mental health teams can deliver sustained, equitable long-term care.
What happens when scientists, dedicated to basic scientific research, are called forth to participate in politically fraught scenarios? We explore this question through a qualitative study of the intimate experiences of scientists who developed the first Argentine National Glacier Inventory (2010–2018). This inventory was entrusted to IANIGLA, a state-funded scientific institute. It arose from the world’s first glacier protection law, drafted to protect all glacier and periglacial environments as hydrological reserves as mining megaprojects encroached on them. This article examines the failed attempts to turn periglacial environments into “governable objects” (Hellgren 2022). Interviews and an auto-ethnography among scientists involved reveal that these failures can be attributed to unresolved tensions in upscaling and downscaling practices that are needed to simultaneously produce world-class climate science and locally relevant policy science. The failure to anticipate or resolve those tensions, in the context of grassroots opposition to mining, undermined trust in science and government, pointing to the local limits of global climate science.
This study investigates the potential of rumination-focused cognitive behavioural therapy (RFCBT) to address core issues in adolescents with social anxiety disorder (SAD). Specifically, it examines RFCBT’s effectiveness in reducing internalized shame, negative interpretation biases, and rumination, which contribute significantly to their social anxiety. The present study employed a quasi-experimental design with a pre-test, post-test, and follow-up phase. The population of the study included all adolescents with SAD in Ahvaz, Iran, in 2023. The sample consisted of 48 adolescents with SAD who were selected using convenience sampling and then randomly assigned to either the RFCBT group or the control group (24 participants per group). The research instruments included the Social Anxiety Questionnaire, the Child Internalized Shame Scale, the Interpretation Bias Questionnaire, and the Rumination Response Scale (RRS). Repeated measures analysis of variance (ANOVA) was used to analyse the data. The findings indicate that RFCBT had a significant effect on reducing internalized shame, interpretation bias, and rumination (p<0.01) in adolescents with SAD, with results maintained at follow-up. This study adds to the evidence that RFCBT can be helpful for anxiety disorders in adolescents. RFCBT seems to work by addressing negative self-views, biased interpretations, and repetitive negative thinking patterns. More research is needed to determine if these benefits are sustained long-term and if RFCBT can improve social skills and overall well-being for adolescents with social anxiety.
Key learning aims
(1) Understand the efficacy of RFCBT in reducing internalized shame, negative interpretation bias, and rumination in adolescents with SAD.
(2) Gain insight into the cognitive and behavioural mechanisms through which RFCBT addresses core maintaining factors of SAD, such as negative self-perceptions and avoidance behaviours.
(3) Learn about the application of functional analysis, self-compassion training, and cognitive restructuring within RFCBT to disrupt maladaptive thought patterns in adolescents.
(4) Recognize the potential of group-based RFCBT to foster peer support and enhance treatment engagement among adolescents with SAD.
(5) Explore the study’s findings on the sustainability of RFCBT outcomes at follow-up and their implications for long-term management of social anxiety symptoms.
Interest in psilocybin as a treatment for depression has risen over the past decade, fuelled by promising clinical trials and a rapidly evolving regulatory landscape. Media coverage plays a critical role in shaping public perceptions, yet little is known about how psilocybin is portrayed in global anglophone online news for the treatment of depression.
Methods:
This study examines the comprehensiveness and sentiment of English-language online news articles (n = 125) discussing psilocybin as a treatment for depression from January 2000 to May 2024. Articles were sourced from the top 30 global anglophone news outlets, assessed using a 13-item instrument for comprehensiveness, and analysed for sentiment across five thematic categories. A separate sub-analysis was completed for Irish media.
Results:
Findings indicate a significant increase in coverage over time, with 43.2% of articles published between 2022 and 2024, predominantly from the USA (68%). While 90.4% of articles cited researchers, fewer addressed risks (47.2%), long-term evidence (46.4%), or patient perspectives (25%). Sentiment analysis revealed a very positive sentiment across articles which was 2.27 on a scale from −5 (most negative) to + 5 (most positive) (SD 1.33), with no significant changes over the time period. Reporting on psilocybin’s onset and duration of effects increased significantly, reflecting growing clinical evidence. However, coverage remains concentrated in prominent outlets, with limited attention to patient experiences and long-term safety.
Conclusions:
These findings highlight the media’s role in shaping discourse on emerging treatments and suggest a need for more balanced reporting to align public understanding with scientific evidence. This study provides a foundation for future research on media portrayals of psilocybin and implications for public perception and policy.