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There is a pressing need for sensitive, non-invasive indicators of cognitive impairment in those at risk for Alzheimer’s disease (AD). One group at an increased risk for AD is APOEε4 carriers. One study found that cognitively normal APOEε4 carriers are less likely to produce low frequency (i.e., less common) words on semantic fluency tasks relative to non-carriers, but this finding has not yet been replicated. This study aims to replicate these findings within the Wake Forest ADRC clinical core population, and examine whether these findings extend to additional semantic fluency tasks.
Participants and Methods:
This sample includes 221 APOEε4 non-carriers (165 females, 56 males; 190 White, 28 Black/African American, 3 Asian; Mage = 69.55) and 79 APOEε4 carriers (59 females, 20 males; 58 White, 20 Black/African American, 1 Asian; Mage = 65.52) who had been adjudicated as cognitively normal at baseline. Semantic fluency data for both the animal task and vegetable task was scored for total number of items as well as mean lexical frequency (attained via the SUBTLEXus database). Demographic variables and additional cognitive variables (MMSE, MoCA, AMNART scores) were also included from the participants’ baseline visit.
Results:
APOEε4 carriers and non-carriers did not differ on years of education, AMNART scores, or gender (ps > 0.05). APOEε4 carriers were slightly younger and included more Black/African American participants (ps < 0.05). Stepwise linear regression was used to determine the variance in total fluency score and mean lexical frequency accounted for by APOEε4 status after including relevant demographic variables (age, sex, race, years of education, and AMNART score). As expected, demographic variables accounted for significant variance in total fluency score (p < 0.0001). Age accounted for significant variance in total fluency score for both the animal task (ß = -0.32, p <0.0001) and the vegetable task (ß = -0.29, p < 0.0001), but interestingly, not the lexical frequency of words produced. After accounting for demographic variables, APOEε4 status did not account for additional variance in lexical frequency for either fluency task (ps > 0.05). Interestingly, APOEε4 status was a significant predictor of total words for the vegetable semantic fluency task only (ß = 0.13, p = 0.01), resulting in a model that accounted for more variance (R2 = 0.25, F(6, 292) = 16.11, p < 0.0001) in total words than demographic variables alone (R2 = 0.23, F(5, 293) = 17.75, p < 0.0001).
Conclusions:
Unsurprisingly, we found that age, AMNART, and education were significant predictors of total word fluency. One unexpected finding was that age did not predict the lexical frequency - that is - regardless of age, participants tended to retrieve words of the same lexical frequency, which stands in contrast to the notion that retrieval efficiency of infrequent words declines with age. With regard to APOEε4, we did not replicate existing work demonstrating differences in lexical frequency and semantic fluency tasks for ε4 carriers and non-carriers; possibly due to differences in the demographic characteristics of the sample.
The present paper concerns the linear fate of transverse perturbations in a gravity-driven, thin-film flow over a soluble substrate. We propose a reduced-order model, based on a boundary-layer treatment of the solute transport and a depth-integration of the Stokes equations, using two extended lubrication methodologies found in the literature. We obtain a closed-form dispersion relation, which we compare to a previous, fully resolved analytical investigation (Bertagni and Camporeale, J. Fluid Mech., vol. 913, 2021, A34). The results allow us to distil the essential physical mechanisms behind the instability.
The limited genetic resource of chickpea (Cicer arietinum L.) is one of the most critical issue impeding its improvement and production. Collection and characterization of chickpea for agronomic traits is prerequisite to build a successful breeding programme through expanding chickpea's genepool to fulfil the needs of farmers and breeders, such as grain size and yield which supply food to a world rising population. To reach such an objective, numerous collection missions were carried out in Algeria, covering the northern agro-ecological environments, this allows us to gather 56 national and international genotypes that report a phenotypic variability and may provide a valuable diversity of useful features. Characterization experiments of 19 agro-morphological traits were set up at the Technical Institute of Field Crops over two successive seasons 2020 and 2021. All traits were statistically significant and the cluster analysis classified the genotypes into three major group, where local and improved accessions revealed an interesting outcome in terms of seed yield and resistance to Ascochyta blight. In general, the current study's findings clearly demonstrated that plant and seed morphological characteristics could be used to distinguish and identify chickpea genotypes. More often, it might participate as a source of variation in breeding programmes to meet the desirable improvement targets.
We show that the Hausdorff dimension of any slice of the graph of the Takagi function is bounded above by the Assouad dimension of the graph minus one, and that the bound is sharp. The result is deduced from a statement on more general self-affine sets, which is of independent interest. We also prove that Marstrand’s slicing theorem on the graph of the Takagi function extends to all slices if and only if the upper pointwise dimension of every projection of the length measure on the x-axis lifted to the graph is at least one.
This study aims to develop an understanding of how different communicative strategies used by case officers in asylum interviews may position applicants in various ways. The analysis focuses on a relatively standardised sequence at the start of asylum interviews, where the communicative situation and its legal framework are explained to the applicant. Case officers use guidelines to support them with this process. Using a comparative discourse analysis of excerpts from two asylum interviews, I examine the discursive means by which the applicants are positioned in the case officers’ utterances, drawing mainly on the concepts of positioning and recontextualisation. The findings show how case officers’ instructive statements could be used as a resource not only to provide information to the applicants but also to position asylum seekers in a respectful way. (Asylum interview, intertextuality, positioning, recontextualisation, speaker role)*
This article focuses on the essays that évolués wrote and Félix Eboué presented to participants at the Brazzaville Conference in 1944 and specifically analyzes how this group of elite Africans understood and participated in debates on citizenship, empire, and rights and how they articulated their arguments about the future of French colonialism to the most important decision-makers in the francophone world. For these évolué writers, the continuation of French colonialism was a necessity with no immediate end in sight. Their arguments, which ranged from expanded citizenship rights for elites to the dangers of assimilation, captured the fraught social, political, economic, and intellectual landscapes of wartime French colonial Africa. As a result, their letters tell us a great deal about both not only their beliefs and desires for the future but also the nature of reform that Félix Eboué felt comfortable sharing at the Brazzaville Conference with other colonial administrators and stakeholders in 1944.