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Despite the recent methodological advancements in causal panel data analysis, concerns remain about unobserved unit-specific time-varying confounders that cannot be addressed by unit or time fixed effects or their interactions. We develop a Bayesian sensitivity analysis (BSA) method to address the concern. Our proposed method is built upon a general framework combining Rubin’s Bayesian framework for model-based causal inference (Rubin [1978], The Annals of Statistics 6(1), 34–58) with parametric BSA (McCandless, Gustafson, and Levy [2007], Statistics in Medicine 26(11), 2331–2347). We assess the sensitivity of the causal effect estimate from a linear factor model to the possible existence of unobserved unit-specific time-varying confounding, using the coefficients of the treatment variable and observed confounders in the model for the unobserved confounding as sensitivity parameters. We utilize priors on these coefficients to constrain the hypothetical severity of unobserved confounding. Our proposed approach allows researchers to benchmark the assumed strength of confounding on observed confounders more systematically than conventional frequentist sensitivity analysis techniques. Moreover, to cope with convergence issues typically encountered in nonidentified Bayesian models, we develop an efficient Markov chain Monte Carlo algorithm exploiting transparent parameterization (Gustafson [2005], Statistical Science 20(2), 111–140). We illustrate our proposed method in a Monte Carlo simulation study as well as an empirical example on the effect of war on inheritance tax rates.
The latest books by Martha Nussbaum and Peter Franklin, on the music and life of Benjamin Britten, both come from positions notionally outside music studies. Nussbaum – the liberal philosopher, as close to an academic celebrity as one can find nowadays – writes about the War Requiem (1962) as a (mostly) appreciative visitor to the discipline. Franklin, by contrast, is well known in nineteenth- and twentieth-century music studies. Britten Experienced nevertheless adopts the institutionally detached, less inhibited perspective of the emeritus. It would not be too far from the truth to call Franklin’s book a career retrospective. Crucially, though, it takes in not only the things that he has taught and published over the years, but also the personal encounters and enthusiasms that have (often invisibly) shaped this teaching and scholarship – the very things, in other words, that typically lie outside the professional purview of music studies.
This study is the first study in Middle Eastern population that aimed to investigate the association between global diet quality score (GDQS) and risk of hypertension (HTN) in Iranian adults.
Design:
This population-based cohort study was conducted on 5718 individuals aged ≥ 18 years from the third and fourth Tehran Lipid and Glucose Study surveys, who were followed until the sixth survey (mean follow-up: 7·8 years). Dietary data were collected using a validated FFQ to calculate GDQS as a novel food-based metric designed to assess diet quality across diverse populations. It evaluates the adequacy of healthy food groups (e.g. fruits, vegetables and whole grains) while monitoring the moderation of unhealthy or excessive intake (e.g. refined grains, processed meats and sugary foods).
Setting:
Tehran Lipid and Glucose Study.
Participants:
Iranian men and women.
Results:
Participants had a mean (sd) age of 37·7 (sd 12·8) years, BMI of 26·6 (sd 4·7) kg/m2 and GDQS of 25·3 (sd 4·4). During the 7·8-year follow-up, 1302 (18 %) new cases of HTN were identified. Higher GDQS and its healthy components were associated with reduced HTN risk (hazard ratio (HR): 0·83; 95 % CI: 0·70, 0·98; Ptrend = 0·034 and HR: 0·78; 95 % CI: 0·65, 0·92; Ptrend = 0·005, respectively), while unhealthy components of GDQS showed no association with HTN risk (HR: 1·14; 95 % CI: 0·98, 1·33; Ptrend = 0·059). These protective associations were observed across all weight categories and both genders, with stronger effects among obese individuals (for GDQS: HR: 0·75; 95 % CI: 0·58, 0·98; P = 0·041; for healthy components: HR: 0·75; 95 % CI: 0·57, 0·99; P = 0·044) and females (for GDQS: HR: 0·77; 95 % CI: 0·62, 0·97; P = 0·028; for healthy components: HR: 0·76; 95 % CI: 0·60, 0·96; P = 0·023).
Conclusions:
A higher GDQS was associated with a reduced risk of incident HTN among Iranian adults. Adherence to a high-quality diet, particularly focusing on the healthy dietary components of GDQS, may serve as an effective strategy for preventing HTN, especially among obese individuals and women.
This study offers a phenomenological exploration of unchosen pregnancy as a distinct temporal experience. By bracketing the traditionally dominant concept of pregnancy as culminating in birth, this study unveils the unique temporal contours of early pregnancy, particularly when it is not chosen. Through a critical phenomenology analysis, this study demonstrates how unchosen pregnancy is characterized by extreme temporal disorientation, a heightened experience of multiple temporal layers, and a profound loss of temporal grounding. This description of unchosen pregnancy is intended to open new pathways of thought on the ethical issue of abortions and expand the phenomenological understanding of pregnancy.
The Tropical Andes stand out as one of the mountain regions most affected by global warming. Here, we present a synthesis of recent glacier evolution in the Cordillera Blanca, based on the glaciers that have been monitored with in situ glaciological measurements over the past decades. In particular, we describe the evolution of the Glacier Yanamarey, a reference glacier in the Peruvian Andes in the World Glacier Monitoring Service database. This glacier is currently on the verge of vanishing—similar to several other glaciers in the Cordillera Blanca. Finally, we address the current state of glacier monitoring in the region and the main challenges to ensure the continuity and sustainability of these monitoring programs.
Impaired muscle function, aerobic capacity, and fatigue are common in individuals with Fontan circulation. Knowledge regarding the effects of strength training in this population is limited. Therefore, the study aimed to investigate the effects of strength training on dynamic muscle function, aerobic capacity, and fatigue in adults with Fontan circulation compared to matched controls.
Methods:
In this pilot non-randomised controlled trial, nine patients with Fontan circulation (median age 28.9 years [IQR: 23.4–35.0], 44.4% women) and nine age- and sex-matched controls completed a 10-week strength training intervention. Dynamic muscle function was assessed through shoulder flexion, heel rise, elbow flexion, and knee extension tests. Aerobic capacity was evaluated using cardiopulmonary exercise testing, and fatigue using the questionnaire Multidimensional Fatigue Inventory. All assessments were conducted pre- and post-intervention. Within-group changes were analysed using the Wilcoxon signed rank test and between-group differences using the Mann–Whitney U test.
Results:
Patients showed improvements in all muscle function tests post-intervention (shoulder flexions 39.3% [IQR: 18.9–69.7], p = 0.008; heel rise 26.7% [IQR:17.5–58.1], p = 0.008; elbow flexions 57.1% [IQR: 50.0–173.8], p = 0.007; knee extensions 66.7% [24.3–92.9], p = 0.008). The improvements were at comparable levels to controls. Only controls reported reduced fatigue (–19.4% [IQR: –28.7, –10.5], p = 0.01), while patients showed no change (–5.9% [IQR: −25.5, 3.2], p = 0.1). Aerobic capacity remained unchanged. No severe adverse events occurred.
Conclusion:
Strength training is safe and improves dynamic muscle function in patients with Fontan circulation, with changes comparable to those of healthy controls. However, the effect of strength training on fatigue and aerobic capacity requires further investigation.
The Sundarbans in the short stories by Dalit writer Shyamal Kumar Pramanik is not some geographical setting but is instead a living environmental being that reinvents the relationship between man and the nonhuman world. Dalit, a word translating to “oppressed” and applied to groups that were traditionally marginalised by the caste system of India, becomes a key category through which Pramanik explores the ethics of survival, belonging and ecological resistance. This paper argues that the mangrove forest in Pramanik’s narratives such as “Life in the Forest” and “In Dakshin Rai’s Land” operates as a responsive vegetal agent that shapes the social, ethical and ontological dynamics of forest life for marginalised communities. Drawing on Michael Marder’s Plant-Thinking (2013), J. C. Ryan’s (2018) botanical imagination, Jeffrey T. Nealon’s Plant Theory (2015) and Matthew Hall’s (2011) articulation of vegetal life as a moral force – this paper develops the concept of “Dalit Botanics” – a term for a theoretical framework that understands forest life as a pedagogical and ethical system in which trees act as epistemic agents, to theorise the Sundarbans as a sentient pedagogical ecology and to examine how caste and plant life co-constitute each other in Dalit experience.
Hate speech is widely seen as a significant obstacle to constructive online discourse, but the most effective strategies to mitigate its effects remain unclear. We claim that understanding its distribution across users is key to developing and evaluating effective content moderation strategies. We address this missing link by first examining the distribution of hate speech in five original datasets that collect user-generated posts across multiple platforms (social media and online newspapers) and countries (Switzerland and the United States). Across these diverse samples, the vast majority of hate speech is produced by a small fraction of users. Second, results from a pre-registered field experiment on Twitter indicate that counterspeech strategies obtain only small reductions of future hate speech, mainly because this approach proves ineffective against the most prolific contributors of hate. These findings suggest that complementary content moderation strategies may be necessary to effectively address the problem.
Research on gender-based violence has shown the influence of Dark Tetrad personality traits (i.e. Machiavellianism, narcissism, psychopathy and sadism) on the development and perpetuation of sexist attitudes and cognitions that justify or condone harmful behaviours.
Aims
This study explored the potential mediating role of empathy in the relationship between the Dark Tetrad personality traits and support for vindictive rape, as a form of revenge for the perceived violation of traditional sexual norms.
Method
A sample of 1548 adult individuals from the general community (67.3% female, age range 18–83 years) completed the Dark Triad Dirty Dozen, the Short Sadistic Impulse Scale, the Basic Empathy Scale and the Vindictive Rape Attitude Questionnaire.
Results
The results showed that empathy partially mediated the relationship between sadism and attitudes supportive of vindictive rape, while a full mediation of empathy was found in the association between Machiavellianism, psychopathy and attitudes supportive of vindictive rape. Conversely, no significant association between empathy or vindictive rape and narcissism was observed.
Conclusions
Empathy plays an important role in mitigating the effects of Dark Tetrad personality traits on support for vindictive rape. Given the global prevalence of violence against women, these findings are discussed in the context of a social climate that may reinforce the perpetuation of gender inequalities and sex-based stereotypes that are at the root of the acceptance of violence.
The Maudsley 3-item visual analogue scale (M3VAS) was developed as a novel and intuitive patient-reported measure for depression, focusing on core symptoms and suicidality.
Aims
To evaluate the longitudinal validity of M3VAS for capturing symptom change over time.
Method
Both M3VAS and the Patient Health Questionnaire (PHQ-9, as reference standard) were administered in an observational study (RHAPSODY, no. NCT04939818) at weeks 0, 2 and 4 to both depressed patients (n = 50) and matched controls (n = 24). We serially tested factor structure, internal consistency and convergence (correlation) over time, assessing responsiveness by both correlation of change in score and effect of time across scales (analysis of variance and effect size).
Results
M3VAS exhibited strong factor loadings and high item interrelatedness (Cronbach’s alpha 0.78–0.83) at all time points. Total scores correlated strongly with PHQ-9 at each time point (r > 0.8, P < 0.001). Correlation of score change over the study period (r = 0.65, P < 0.001) also confirmed responsiveness. In the depressed group, an effect of time on score was seen for both M3VAS (F = 4.942, P = 0.010) and PHQ-9 (F = 12.505, P < 0.001), with standard response mean (Cohen’s d) of 0.58 and 0.74, respectively. No effect of time was seen in the control group.
Conclusions
Following previous cross-sectional validation against the Quick Inventory of Depressive Symptomatology–Self-report, this present study demonstrated appropriate longitudinal measurement properties for M3VAS as a measure of depression, including responsiveness. Evaluating the ability of M3VAS to discern responses with a variety of treatments is a key future goal.
Sarcopenia, the age-related decline in muscle mass and strength, is a contributor to frailty and reduced quality of life. Emerging evidence suggests an emerging role of the gut microbiome in modulating skeletal muscle through microbial species and metabolites, such as short-chain fatty acids (SCFAs), potentially influencing inflammation, nutrient absorption, and glucose and protein metabolism. This review considers the potential of probiotics, prebiotics, and synbiotics as interventions to mitigate sarcopenia based on animal and human studies, while providing a critique of present barriers that need to be addressed. Preclinical models, including germ-free mice and faecal microbiota transplantation, demonstrate that gut microbiota from healthy or young donors may enhance overall muscle health via reductions in inflammatory and muscle atrophy markers. Limited human studies show that probiotics such as Lactobacillus and Bifidobacterium could improve branched-chain amino acid (BCAA) bioavailability and potentially sarcopenia indices, although findings have been inconsistent. Particularly, challenges including inconsistent microbial assessments, lack of dietary control and interindividual variability due to diet, age, genetics, comorbidities and medications may hinder progress in this field. Delivery methods (e.g. capsules, fermented foods or fortified products) could further complicate efficacy through probiotic stability and dietary restrictions in older adults. Standardised protocols [e.g. Strengthening The Organisation and Reporting of Microbiome Studies (STORMS) checklist] and multi-omics approaches may be critical to address these limitations and identify microbial signatures linked to sarcopenia outcomes. While preclinical evidence highlights mechanistic pathways pertinent to amino acid metabolism, translating findings to humans requires rigorous experimental trials.
The origins and correlates of war are historically contentious in anthropology, with researchers divided over its relationship to the development of agriculture, sedentism, and centralized states. Although this research tends not to focus on norms of wartime conduct, its arguments can be extended to how the levels and forms of violence directed at enemies vary with social complexity. For this study, variables on social complexity and warfare were coded from ethnographic and historical sources into a cross-cultural data set of 73 societies. The likelihood of different individuals who were enemies of the focal society being targeted or killed during war was tested for relationships with measures of social complexity and violent conquest of external populations. The results of the analyses provided little to no evidence for increased or decreased indiscriminate violence with social complexity (as measured by population size, governance levels, and centralization), or for a strong relationship with formal military structures and political/territorial expansion. A multidisciplinary literature review of how wartime violence relates to social structures is also presented. Interpretations, limitations, and future directions are discussed in the context of comparative cultural databases and their applications to cultural evolution research.
By deriving the Euler equations and Rankine–Hugoniot equations in the orthogonal frame field of the shock surface, the three-dimensional curved shock theory based on orthogonal frame of shock surface (3D-CST-boos) is established. In steady flow, this theory can be applied to three-dimensional (3-D) shocks without constraints on the incoming flow conditions. The derived equations elucidate the relationship between the first-order gradients of the preshock and postshock flow parameters and the geometric properties (curvature) of the 3-D curved shock. The correctness of 3D-CST-boos is verified for two-dimensional plane shocks and axisymmetric shocks. The analysis is then extended to the flow patterns of 3-D elliptical convex/concave shocks. Variations in the flow field behind a 3-D elliptical convex shock are explained based on different incoming flow conditions. Simultaneously, the fundamental mechanics underlying the differences between the flow fields of elliptical concave shocks and axisymmetric concave shocks are revealed using 3D-CST-boos. Finally, a concise analysis of the first-order flow parameters is presented for more complex 3-D shocks, including saddle-shaped shocks and cubic surface shocks.
Doubly diffusive convection describes the fluid motion driven by the competing buoyancy forces generated by temperature and salinity gradients. While the resulting convective motions usually occupy the entire domain, parameter regions exist where the convection is spatially localised. Although well studied in planar geometries, spatially localised doubly diffusive convection has never been investigated in a spherical shell, a geometry of relevance to astrophysics. In this paper, numerical simulation is used to compute spatially localised solutions of doubly diffusive convection in an axisymmetric spherical shell. Several families of spatially localised solutions, named using variants of the word convecton, are found and their bifurcation diagram computed. The various convectons are distinguished by their symmetry and by whether they are localised at the poles or at the equator. We find that, because the convection rolls that develop in the spherical shell are not straight but curve around the inner sphere, their strength varies with latitude, making the system prone to spatial modulation. As a consequence, spatially periodic states do not form from primary bifurcations and localised states are forced to arise via imperfect bifurcations. While the direct relevance of this work is to doubly diffusive convection, parallels drawn with the Swift–Hohenberg equation suggest a wide applicability to other pattern-forming systems in similar geometries.
Humans possess the capacity to make sense of stories unfolding across different and difficult times with nuanced understanding and to unlearn and relearn what once seemed familiar. All human beings are storytellers, and the narratives of minorities deserve recognition and value within Westernised contexts. Drawing on sociocultural perspectives and employing a narrative inquiry approach, I share stories from my lived experiences as a former graduate student and current educator. These stories focus on pedagogical practices, dynamic identity formation and reflective engagements with place as valid and vital ways of knowing, doing, being and becoming. I highlight how choice often entails challenge, how agency and struggle can be intertwined with empowerment, and how marginalisation can coexist with celebration. This inquiry aims to reveal the layered complexity and sometimes paradoxical dimensions of learner and teacher identities within the assemblage of learning and teaching in higher education.
Groundwater iron varies geographically and iron intake through drinking water can minimise iron deficiency (ID). Rice, a major share of daily meals (∼70% of total energy) in Bangladesh, absorbs a substantial amount of water. This study aimed to estimate the contribution of groundwater iron entrapped in cooked rice and its implications on the recommended iron intake. A cross-sectional study was conducted among 25 households, selected by the iron content of their drinking groundwater source in Sirajganj district, Bangladesh. Each household pre-supplied with 600 g of raw rice (300 g for each cooking), was instructed to cook ‘water-draining rice’ (WDR) and ‘water-sitting rice’ (WSR). Using atomic absorption spectrophotometry, iron content in filtered and non-filtered water was measured as 0.4 ± 0.2 mg/L and 6.1 ± 2.0 mg/L, respectively. After adjusting for water filtration, the weighted mean of total iron content in WDR and WSR was 6.18 mg and 5.70 mg, respectively. Assuming the average rice intake, iron content in WDR and WSR fulfilled approximately 98.15% and 90.62% of the average requirement for non-pregnant and non-lactating women (NPNL). The water-entrapped iron in cooked WDR and WSR fulfilled about 23.77% and 20.4% of Recommended Dietary Allowances, and 52.83% and 45.30% of Estimated Average Requirements, respectively in NPNL women, suggesting that groundwater entrapped in cooked rice is an influential dietary iron source. The substantial amount of iron from cooked rice can make an additional layer to the environmental contribution of iron in this setting with the potential to contribute ID prevention.
The Taiwan Incident of 1874 – a prolonged Sino-Japanese confrontation over the killing of Ryukyu castaways, whom Japan claimed as its subjects – marked the full maturation of a new mode of Qing war preparation. This mode was characterized by global coordination, domestic and international competition, and the swift mobilization of personal connections to secure foreign weapons and loans – resources that were often interconnected. Facilitated by the efforts of various actors, this internationalized approach became a standard practice during the empire’s final decades. As the empire could no longer rely on domestic self-sufficiency in arms and funding, Qing military operations came to reflect the broader influence of global military and financial resources. The Qing empire’s capacity to mobilize global resources in pursuit of national objectives helps explain its resilience in an era dominated by imperial powers.
In Jishishan County, Linxia Prefecture, Gansu Province, China, the altitude ranges from 1,787 meters to 4,308 meters. At 23:59 Beijing time on December 18, 2023, a magnitude 6.2 earthquake struck Jishishan County. The objective is to report the injury characteristics and medical treatments of those injured in the earthquake.
Methods:
The injury and treatment data were retrospectively collected and analyzed for earthquake-related injuries among patients admitted to the People’s Hospital of Linxia Hui Autonomous Prefecture and the Traditional Chinese Medicine Hospital of Linxia Hui Autonomous Prefecture.
Observations:
A total of 166 patients were hospitalized: 142 at the People’s Hospital of Linxia Hui Autonomous Prefecture and 24 at the Traditional Chinese Medicine Hospital of Linxia Hui Autonomous Prefecture. Among the injured, 40.3% presented with a single injury. The others had multiple injuries: 28.3% had two injuries, 14.5% had three injuries, 12.1% had four injuries, 4.2% presented with five injuries, while only 0.6% were diagnosed with six injuries. Additionally, 78.9% involved fractures alone, 36.8% involved lung contusions, and 34.9% involved both fractures and lung contusions. Conservative treatment was used slightly more than surgery (54.8% versus 45.2%). Among the 75 surgical cases, internal fixation and sutures were the most common (17.4% each). In total, 53.0% of the injured were treated and discharged and 47.0% were transferred to provincial hospitals. In addition, the outcome of injured patients with differing injury conditions was different.
Analysis:
Fractures and multiple injuries were the primary injury types in this study. Suturing and internal fixation were the most common surgical interventions. The core findings of this study provide an important reference for regionalized prevention and treatment of rural earthquake injuries in high-altitude regions.
Anomalously high amounts of orthopyroxene are an unexpected feature of some depleted peridotite xenoliths from the cratonic lithosphere. This investigation presents new petrographic, geochemical and thermodynamic modelling data for silica-rich spinel harzburgites and one garnet–spinel harzburgite from the Kaapvaal Craton, South Africa, to constrain the pressure–temperature (P–T) conditions of orthopyroxene formation. At the time of sampling by the host kimberlite, the garnet–spinel harzburgite resided on the geotherm at 25 kbar, 765°C, wheras the compositionally similar garnet-free samples probably equilibrated at broadly comparable P–T conditions. The samples are subdivided into ‘bronzite type’ peridotites characterised by orthopyroxene with micrometre scale exsolutions of spinel ± clinopyroxene, and ‘normal type’ peridotites in which orthopyroxene does not contain visible exsolved phases. The presence of these exsolved phases indicates unmixing from a more Al-Cr-(Ca)-rich precursor orthopyroxene i.e. an original orthopyroxene that precipitated from, and was, in equilibrium with the Si-enriching agent at high temperature, before cooling and undergoing sub-solidus re-equilibration to form the exsolved orthopyroxene we observe now. Major and trace element compositions, geochemical interpretation and thermodynamic modelling of the samples show that the precursor orthopyroxene coexisted with melt at high pressure and temperature (~40–50 kbar, 1600–1700°C) within the garnet stability field. We consider these to be the conditions of orthopyroxene formation, and thus silica enrichment. These conditions, together with the refractory composition of the host peridotite (olivine forsterite contents > 92) suggest that silica enrichment is a secondary process potentially resulting from interaction with komatiitic melts. Our observations demonstrate that orthopyroxene enrichment in spinel-facies peridotites is not limited to low-pressure processes but can also occur via high-pressure melt–rock interaction, offering new insights into the thermal and chemical evolution of the sub-cratonic lithospheric mantle.