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Social determinants of health (SDHs) exert a significant influence on various health outcomes and disparities. This study aimed to explore the associations between combined SDHs and mortality, as well as adverse health outcomes among adults with depression.
Methods
The research included 48,897 participants with depression from the UK Biobank and 7,771 from the US National Health and Nutrition Examination Survey (NHANES). By calculating combined SDH scores based on 14 SDHs in the UK Biobank and 9 in the US NHANES, participants were categorized into favourable, medium and unfavourable SDH groups through tertiles. Cox regression models were used to evaluate the impact of combined SDHs on mortality (all-cause, cardiovascular disease [CVD] and cancer) in both cohorts, as well as incidences of CVD, cancer and dementia in the UK Biobank.
Results
In the fully adjusted models, compared to the favourable SDH group, the hazard ratios for all-cause mortality were 1.81 (95% CI: 1.60–2.04) in the unfavourable SDH group in the UK Biobank cohort; 1.61 (95% CI: 1.31–1.98) in the medium SDH group and 2.19 (95% CI: 1.78–2.68) in the unfavourable SDH group in the US NHANES cohort. Moreover, higher levels of unfavourable SDHs were associated with increased mortality risk from CVD and cancer. Regarding disease incidence, they were significantly linked to higher incidences of CVD and dementia but not cancer in the UK Biobank.
Conclusions
Combined unfavourable SDHs were associated with elevated risks of mortality and adverse health outcomes among adults with depression, which suggested that assessing the combined impact of SDHs could serve as a key strategy in preventing and managing depression, ultimately helping to reduce the burden of disease.
Greenland’s peripheral glaciers and ice caps contribute disproportionately to sea-level rise relative to their small area. Winter snow accumulation directly influences glacier mass balance and downstream hydrology, but spatially extensive observations of this important mass balance component remain sparse. In this study, we present a unique multi-year (2008–2024) dataset of winter snow accumulation over A.P. Olsen Ice Cap, Northeast Greenland, from ground-penetrating radar surveys covering an average of 47 km per survey year. Our results reveal strong spatial heterogeneity that is likely influenced by wind redistribution and local topography, especially in the ablation zone. We compare our findings with automatic weather station data from three sites and outputs from the Copernicus Arctic Regional Reanalysis (CARRA). Governed by the high spatial variability, the automatic weather station point-based observations significantly underestimate regional accumulation by 40–45%. Despite the high spatial variability, the CARRA accumulated precipitation variable provides a reasonable overall mean winter snow accumulation (RMSE of 0.07 m w.e.); however, it fails to reproduce the complex non-linear relationship between snow depth and elevation observed in the radar data. Our findings emphasize the need for high-resolution, spatially extensive measurements to better understand snow accumulation on ice caps and glaciers and improve reanalysis assessments.
Al-Hoorie, Hiver, and In’nami (2024) offer compelling arguments for why L2 motivational self-system research is currently in a state of validation crisis. Seeking a constructive resolution to the crisis, in this response we argue that two fundamental conditions are needed for the field to emerge stronger: psychological readiness and methodological maturity. For psychological readiness, we call for a reframing of the “crisis” narrative. We highlight the need to value controversy, to normalize failure and (self-)correction, and to resist the allure of novelty. For methodological maturity, we suggest that an argument-based approach to validation can provide a constructive solution to current controversies. We present an integrated framework that can guide systematic validation efforts, and we demonstrate its application using a recent validation study as an example.
It is often inferred that rising sea levels will result in widespread coastal recession. Erosion appeared prevalent in a worldwide compilation of evidence derived from maps and aerial photographs undertaken in the 1980s by the Commission on the Coastal Environment. Eric Bird, chair of the commission, inferred that >70% of sandy coastlines had retreated, a generalisation that has been widely cited. We reconsider these findings in respect of subsequent advances in shoreline mapping, including greater precision possible using geographical information systems and more frequent remote sensing imagery with increased spatial, spectral and temporal resolution. Satellite-derived shorelines now enable broad global and regional generalisations about shoreline position. Beaches fluctuate over a range of timescales, meaning that trends in their position are highly dependent on techniques and temporal scales adopted for monitoring. Recent global- and regional-scale shoreline assessments indicate that many sandy shorelines have been stable, and that detectable retreat has occurred on fewer beaches than previously inferred. Accretion is apparent on some coasts, particularly where engineering interventions protect or have reclaimed land. There is considerable variability in the behaviour of monitored beaches, and it is not yet possible to decipher a response to the gradual centimetre-scale rise in sea level of recent decades. Instead, we re-emphasise the several other factors that were considered to contribute to recession by the Commission, many of which relate to a change in sediment budget. To provide insights into future coastline behaviour, a better understanding of the multiple drivers on individual beaches is needed to discriminate between erosional events and longer-term trends in shoreline position.
Small-leaf spiderwort (Tradescantia fluminensis Vell.) is a low-growing perennial ground cover that has become increasingly problematic in Florida due to its ability to quickly spread vegetatively over large areas and outcompete native vegetation. Prior research has identified several herbicides that can be used to manage T. fluminensis, but the effect of application timing on herbicidal efficacy is unknown. Therefore, the objective of this study was to evaluate the efficacy of selected postemergence herbicide applications and to understand differences in the efficacy of these timings (i.e., spring and fall), including on the rate of regrowth of target plants. Specific herbicides evaluated in this study included 2,4-D, 2,4-D + triclopyr amine, aminopyralid, glyphosate, and triclopyr (as acid and amine). An additional aspect of this study was to reapply treatments when coverage ratings exceeded 25% to assess the impact of sequential applications when using less efficacious herbicides that might provide greater selectivity to non-target plants. Overall, the data showed that initial treatment timing had little to no impact on efficacy for most of the herbicides evaluated. Triclopyr (acid or amine) tended to provide the highest level of control and required no retreatment over a 12-mo evaluation period. Other effective options included glyphosate and 2,4-D + triclopyr amine, which provided results similar to triclopyr on most evaluation dates. The 2,4-D and aminopyralid treatments were in general the least efficacious options, requiring retreatment at either 3, 6, or 9 mo following the initial application to achieve less than 25% T. fluminensis coverage. Results indicate that practitioners would likely achieve similar levels of T. fluminensis control regardless of application timing. Data also suggest triclopyr would be the most effective option, while a low level of control would be expected with 2,4-D, even following multiple applications.
A wall-modelled large eddy simulation approach is proposed in a discontinuous Galerkin (DG) setting, building on the slip-wall concept of Bae et al. (J. Fluid Mech., vol. 859, 2019, pp. 400–432) and the universal scaling relationship by Pradhan and Duraisamy (J. Fluid Mech., vol. 955, 2023, A6). The effect of the order of the DG approximation is introduced via the length scales in the formulation. The level of under-resolution is represented by a slip Reynolds number and the model attempts to incorporate the effects of the numerical discretization and the subgrid-scale model. The dynamic part of the new model is based on a modified form of the Germano identity -- performed on the universal scaling parameter -- and is coupled with the dynamic Smagorinsky model. A sharp modal cutoff filter is used as the test filter for the dynamic procedure, and the dynamic model can be easily integrated into any DG solver. Numerical experiments on channel flows show that grid independence of the statistics is achievable and predictions for the mean velocity and Reynolds stress profiles agree well with the direct numerical simulation, even with significant under-resolution. When applied to flows with separation and reattachment, the model also consistently predicts one-point statistics in the reverse flow and post-reattachment regions in good agreement with experiments. The performance of the model in accurately predicting equilibrium and separated flows using significantly under-resolved meshes can be attributed to several aspects that work synergistically: the optimal finite-element projection framework, the interplay of the scale separation and numerical discretization within the DG framework, and the consistent dynamic procedures for subgrid and wall modelling.
Theories, models, and frameworks (TMFs) are essential tools in dissemination and implementation (D&I) research, yet selecting and applying the most appropriate TMF is routinely a challenge, particularly for those new to the field. To address this need, we developed the Dissemination and Implementation Models in Health webtool (www.dissemination-implementation.org) a free, interactive, and evolving online resource designed to support the thoughtful use of D&I TMFs across all phases of research and practice – from planning through assessment. Created through a multi-institutional collaboration and refined using human-centered design, the webtool includes features such as logic model development, D&I TMF selection and comparison, guidance on combining and adapting models, strategies for application, and linkages to measurement tools. Since its initial release in 2014, the webtool has expanded to include over 110 D&I TMFs and new thematic content areas, including a section dedicated to health equity. It can be used in D&I trainings, proposal development, consultations, and academic coursework. Usage analytics and community feedback reflect ongoing relevance, utility, and evolving needs. The webtool continues to address a significant gap in D&I infrastructure by guiding users in selecting and operationalizing D&I TMFs, ultimately supporting more rigorous, context-sensitive translational research and practice.
This article offers a view of the prospects of nuclear fusion as a sustainable energy source, with a focus on magnetic confinement fusion and tokamaks. It highlights the key theme of integration and presents the EUROfusion programme as a model for coordinated fusion R&D in Europe while stressing the need for public–private partnerships to bridge the gap between laboratory innovation and industrial implementation. A crucial element is human capital development, i.e. the training of a new, diverse generation of scientists, engineers, and technicians. A broader educational effort is called for, with industry–academia collaboration, hands-on training, and mechanisms to retain and transfer knowledge from legacy projects such as JET.
Autologous hematopoietic stem cell transplant (HCT) cancer caregivers experience significant burden and stress with limited tailored resources. Mindfulness interventions hold promise in alleviating caregiver distress. Predicated on our previous work with allogeneic HCT caregivers, this single-arm trial tested the feasibility and acceptability of a modified mindfulness-based intervention, AutoFOCUS, among autologous HCT caregivers.
Methods
Participants received the 6-session AutoFOCUS face-to-face via telehealth, with assessments at baseline, end of treatment, and 1-month post-treatment. Feasibility was assessed through recruitment, retention, and session attendance, and acceptability was measured via satisfaction and intent to continue using skills learned. Exploratory outcome measures included distress, anxiety, perceived stress, affect, and post-traumatic growth. Data from the smartphone app that supplemented the face-to-face component of the intervention were collected. In-depth interviews gathered participant feedback.
Results
Twenty-six caregivers (mean age = 57.7 years, 89% female) were enrolled and 19 completed at least 4 sessions, 14 completed all 6 sessions, and 22 completed the 1-month follow-up. High satisfaction (M = 3.56/4; SD = 0.43) and intent to utilize the skills learned in the future (M = 8.58/10; SD = 1.81/4) were reported. Significant reductions in distress (p < .001, (effect sizes [ES]) = 0.99), anxiety (p = .032, [ES] = 0.53), perceived stress (p = .035, [ES] = 0.52), and negative affect (p = .008, [ES] = 0.69) were reported, along with a significant increase in post-traumatic growth (p = .009, [ES] = 0.67) from baseline to end of treatment. App use was moderate. Interview results highlighted positive perceptions and supported quantitative results.
Significance of results
AutoFOCUS was feasible and acceptable. Future studies should explore the efficacy of this treatment on a larger scale with a comparison condition.
Carbon credits have become increasingly important for supporting sustainable forest management and mitigating climate change. However, carbon projects can be challenging for local communities and smallholders to implement due to high expenses and complicated protocols. Forest projects often suffer from inefficiency, lack of transparency, and uneven benefit distribution. This study suggests a blockchain-based framework for aggregating forest carbon projects. This framework is the first in the forest sector to provide a reward mechanism for local communities or smallholders with a direct integration into an accredited registry protocol of Monitoring, Reporting, and Verification. The system combines digital identities, smart contracts, and automated incentives to improve transparency, responsibility, and trust among stakeholders. Two types of tokens are introduced: (i) Carbon Coin represents verified carbon credits within the system; and (ii) Forest Coin functions as a security token used to proportionally distribute project revenue among stakeholders. The revenue distribution was demonstrated in scenarios of afforestation, reforestation, and conservation. In addition, a web application was developed so that users can monitor project details. Unlike most blockchain carbon platforms that focus on investment and trading, this framework addresses upstream challenges, prioritising equitable benefit-sharing. The framework supports project aggregation and prioritises community ownership, advancing inclusive access to the carbon market. This study demonstrates how technological advantages can be transferred to community-driven ecological conservation.
Construction Grammar and Systemic Functional Grammar take different approaches to the study of lexico-grammar, based on language as a cognitive and as a social phenomenon respectively. This is the first book to bring the two approaches together, using corpus-based Pattern Grammar as an underlying descriptive framework, in order to present a comprehensive and original treatment of verb-based patterns in English. It describes in detail two processes: deriving over 800 verb argument constructions from 50 verb complementation patterns; and using those constructions to populate systemic networks based on 9 semantic fields. The result is an approach to the lexis and grammar of English that unifies disparate theories, finding synergies between them and offering a challenge to each. Pattern Grammar, Construction Grammar and Systemic-Functional Grammar are introduced in an accessible way, making each approach accessible to readers from other backgrounds. This title is also available as open access on Cambridge Core.
Faces, faces, faces – faces everywhere! Modernism was obsessed with the ubiquity of the human face. Thomas Mann, Marcel Proust, Virginia Woolf, Gertrude Stein, and, later, Kōbō Abe framed their literary projects around the question of the face, its dynamic of legibility and opacity. In literary modernism, the face functioned as a proxy for form, memory, intermediality, or difference – and combinations thereof. The old pseudo-science of physiognomy, which assumed faces to be sites of legible meaning, was in the process reconfigured. Modernist faces lost their connection to interiority, but remained surfaces of reading and interpretation. As such, they also became canvases for creative appropriation, what Mina Loy called auto-facial-construction. The modernist overinvestment in faces functions as a warning against the return of physiognomy in contemporary technologies of facial recognition. This title is also available as open access on Cambridge Core.
Financial flows and financial structures are fueling climate instability and worsening inequities around the world. A stable future now requires urgent change including transformative financial innovations. Yet the pandemic and recent financial disruptions reveal how financial architecture designed to promote stability in times of crises exacerbates economic inequities and vulnerabilities. Recognizing the division in climate politics among those advocating for stable policies and a smooth transition and those calling for more radical, disruptive politics, this chapter reviews the critical role of financial innovations, including central banks’ monetary policies, in redirecting society toward a more just and stable future. We propose a paradigm shift to reconceptualize stability and politicization in finance and central banking for climate justice. We argue that current depoliticized perspectives on financial stability are worsening climate instability, and that finance, central banks, and their monetary policies are an underappreciated part of climate politics. Transformative climate policy to promote stability requires repoliticizing finance and financial innovations.
California is often seen as a homogeneous entity that uniformly values environmentalism and climate action. This image universalizes the idea of climate change and detaches it from its cultural and political settings. It also obscures how the localization of environmental policy and science within the state involves processes of public contestation and legitimation. This chapter examines the culturally contingent nature of climate policy – the assumptions and worldviews that often create conflict between community understandings of local environmental conditions and the prevailing global regulatory culture of climate change. I argue that through a reoccurring process of conflict and collaboration, a broad range of individuals and organizations is co-constituting what climate change and environmental justice mean. California’s climate change programs are fostered by certain conditions of privilege – a robust economy, racial and ethnic plurality, and progressive statewide leaders. Nonetheless, they offer clear models of how to broaden climate change worldviews and imagine various relationships among the atmosphere, economic and racial disparities, and climate change policy.
Edited by
Grażyna Baranowska, Friedrich-Alexander-Universität Erlangen-Nürnberg,Milica Kolaković-Bojović, Institute of Criminological and Sociological Research, Belgrade
This chapter explores three particular circumstances where integrity has been found to be breached in tennis, namely doping, match-fixing and other less serious offenses, such as failure to report or failure to cooperate. The chapter goes on to explain anti-doping jurisprudence in tennis, the nature of proceedings, the relevant burden of proof and the intricacies of “intent” and “fault,” as well as the standard of “no fault or negligence” and “no significant fault or negligence.” The section on anti-corruption examines match-fixing by athletes and third parties, and also by umpires and other officials, as well as the sanctions imposed under relevant rules. These offenses are typically associated with legitimate betting and may involve money laundering and other non-predicate offenses.