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Pulmonary arteriovenous fistulas are a frequent complication after a Kawashima procedure. We present a 15-year-old patient with a significant left pulmonary arteriovenous fistula managed via embolisation using three Micro Vascular Plugs. This technique achieved effective occlusion through the left internal jugular vein, since these are low-profile flexible devices that accommodate through an acute angle without long and stiff sheath.
This report describes a 41-year-old female with left isomerism, interrupted inferior caval vein with azygos continuation, dextrocardia, and repaired tetralogy of Fallot, who underwent percutaneous pulmonary valve implantation using the Venus P-valve system. Due to anatomical constraints, left jugular venous access was utilised. A Venus P-valve (30 by 25 mm) was successfully implanted in the right ventricular outflow tract using a simplified, one-curve trajectory directly on its delivery system without a delivery sheath. Contrast injections during valve implantation were not possible, and the pre-implanted duct occluder was our anatomical landmarks. This case highlights the adaptability of the Venus P-valve and the importance of individualised procedural strategies in addressing anatomical challenges and achieving optimal outcomes.
This chapter examines the rights situation of religious and ethnic minorities in the Islamic Republic. All state institutions are in some ways responsible for the Islamic Republic’s discriminatory policies. The intelligence and security apparatus intimidate and arrest members of minority groups, and the judiciary usually issues harsh sentences against them. The executive branch also engages in discriminatory action, such as denying higher education and public sector employment to minorities. The parliament, having passed discriminatory laws, does not hold other state organs responsible for extra-legal actions against minorities. Nor has it conducted investigations necessary to determine the extent of discriminatory practices in the country. Courts have reacted to minority cases in diverse ways, often validating discrimination but in some cases also protecting them against rights abuses. If this diversity in court rulings indicates anything, it is that not all courts are completely on the government’s line but retain some modicum of political independence. The bigger picture is, however, that minority cases are often treated as politically sensitive irrespective of the nature of the case and are therefore tried in the revolutionary rather than the general courts.
The High Court has not definitively explained the legal status of the constitutionally implied freedom of political association since its existence was first raised in 1992. Tajjour v New South Wales affirmed the majority view that any constitutional protection enjoyed by political association is derived from the freedom of political communication; or, in the words of the Court, a ‘corollary to’ that freedom. In this article, we argue that the High Court should acknowledge the freedom of political association as a free-standing freedom rather than a corollary of political communication. The reasoning that gave rise to the implied freedom of political communication can also be applied to political association. The Court’s approach to the implication of freedom of communication, of building on the text of ss 7, 24 and 128 of the Constitution and the structures they establish, does not appear to be at odds with the implication of freedom of association. Consequently, we argue the Court has erred in favouring the corollary form of political association (pt IV). The corollary freedom has not been justified and appears either entirely unnecessary (being subsumed by political communication) or overly subjective in application. By contrast, the free-standing freedom could adopt the well-established Lange test of validity with only minor adjustments and therefore represent only a modest development of existing jurisprudence.
Breast milk is a dynamic type of nourishment that changes based on the needs of the child. An increasing amount of data suggests that mental health may be an important factor in such modulation. In addition, breast milk contains extracellular vesicles (EVs), which are currently considered an important dynamic system of communication between cells, even of different individuals.
Objectives
Purpose of this article is to investigate whether changes in breast milk in terms of EVs concentrations are related to maternal mental health.
Methods
This is a case-control study for which we enrolled mothers of infants with bronchiolitis (N=33) and mothers of healthy infants (N=13). Breast milk samples were taken and EVs concentrations were quantified. Maternal mental health was assessed by administration of five different psychometric scales: Edinburgh Postnatal Depression Scale (EPDS), State Trait Anxiety Inventory (STAI-S, STAI-T), Barkin Index of Maternal Functioning (BIMF), The Connor-Davidson Resilience Scale 10 items (CD-RISC). Subsequently, scale scores were related to evs concentrations by negative binomial regressions adjusted for case-control.
Results
As maternal resilience increases, the EVs of neutrophilic origin (p=0.0447) and those of endothelial origin (p=0.0078) decrease¹. In contrast, an increased EPDS score is associated with higher levels of B-lymphocyte EVs (p=0.0376). Scores on the STAI-S scale impact many more populations of EVs²: we observed an increased Incidence Rate Ratio (IRR) of neutrophil-derived EVs (p<0.0001), T-lymphocyte- derived EVs (p=0.0214), NK-cell-derived EVs (p=0.0202), T-reg CD4+ CD25+ (p=0.0141) and endothelial marked EVs (p=0.0180). An increase in STAI-T scale scores also was associated with a significant increase in CD177+ neutrophil-derived EVs (p=0.0028) and endothelial-derived EVs (p=0.0111)³.
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Conclusions
EVs concentrations in breast milk are associated with maternal mental health. Specifically, stress and related severity of anxiety is able to increase the concentrations of EVs derived from inflammatory cells, which suggests an increase in their number and activity. Further research is needed to confirm these preliminary findings.
Invasion by nonnative woody species poses a major threat to the environment, biodiversity, and economies worldwide. Nahuel Huapi National Park in Argentina is a protected area for habitat conservation that harbors several invasive Pinaceae species, where Douglas-fir [Pseudotsuga menziesii (Mirb.) Franco] is one of the most aggressive and abundant conifer tree invaders. Management of invasions in protected areas must include efficient, easy to deploy, and cost-effective techniques, while reducing the impact on native ecosystems. Because the region has no control measures applied other than conventional felling, we analyzed the effectiveness of two systemic herbicides (glyphosate and aminopyralid + triclopyr) at two different concentrations, applied with the drill and fill method. We then quantified defoliation of P. menziesii trees 6, 12, and 24 mo after application and performed an economic cost analysis to determine profitability. For the application, the trees were grouped into diameter at breast height classes and randomly assigned to one of the four treatments. Herbicide doses were adjusted according to tree size. We found that glyphosate at high concentrations completely defoliated 33% of the trees after 6 mo and 87% after 12 and 24 mo. Glyphosate at low concentrations defoliated almost 30% of the trees after 24 mo, most of which were smaller trees. The aminopyralid + triclopyr treatment did not produce significant defoliation at any of the tested concentrations. When compared with conventional felling, the drill and fill method was found to reduce removal costs by 98%. We observe that differences in costs are mainly due to dead trees that remain standing, decompose slowly, and do not generate costs associated with their removal and debris management. Drill and fill is a suitable method for treating scattered trees in a native forest community, with reduced environmental consequences compared with other removal techniques currently applied within conservation areas of the Patagonian forest.
To investigate the effects of cannabidiol (CBD) on emotional and cognitive symptoms in rats with intra-nigral 6-hydroxydopamine (6-OHDA) lesions.
Methods:
Adult male Wistar rats received bilateral intranigral 6-OHDA infusions and were tested in a battery of behavioural paradigms to evaluate non-motor symptoms. The brains were obtained to evaluate the effects of CBD on hippocampal neurogenesis.
Results:
6-OHDA-lesioned rats exhibited memory impairments and despair-like behaviour in the novelty-suppressed feeding test and forced swim test, respectively. The animals also exhibited dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc), striatum, and ventral tegmental area and a reduction of hippocampal neurogenesis. CBD decreased dopaminergic neuronal loss in the SNpc, reduced the mortality rate and decreased neuroinflammation in 6-OHDA-lesioned rats. In parallel, CBD prevented memory impairments and attenuated despair-like behaviour that were induced by bilateral intranigral 6-OHDA lesions. Repeated treatment with CBD favoured the neuronal maturation of newborn neurons in the hippocampus in Parkinsonian rats.
Conclusion:
The present findings suggest a potential beneficial effect of CBD on non-motor symptoms induced by intra-nigral 6-OHDA infusion in rats.
Groundnut plants can obtain N from N2 fixation via symbiosis with rhizobia, and inoculation with selected strains can improve grain yields. We report the results of four field experiments carried out under subtropical conditions to confirm whether microbial inoculants can improve groundnut performance through the effects of single inoculation with Bradyrhizobium arachidis (SEMIA6144), coinoculation with Arthrospira platensis (IPR7059) or Synechocystis sp. (IPR7061), or N fertilization with 100 kg ha-1 N on plant growth, nodulation, N accumulation in tissues, grain protein concentration (GPC), and grain yield. There were no effects of inoculation treatment or N fertilizer on shoot or root dry weight. In clayey soil, coinoculation with B. arachidis and cyanobacteria increased grain productivity by an average of 19% compared to that in the noninoculated control. In this clayey soil with a higher P content, regardless of whether coinoculated with B. arachidis or cyanobacteria or single inoculated, grain productivity was 16% greater on average than that resulting from N fertilizer addition. In conclusion, the success of rhizobial inoculation in groundnuts is dependent on the soil, probably due to P limitation and weather conditions.
Economic sanctions have inflicted various economic difficulties on Iranian families. The extent to which these sanctions-induced calamities have affected Iranian older adults’ material well-being remains unknown. Meanwhile, inadequate institutional support for the disadvantaged older population may worsen their precarious economic well-being. We use household-level surveys and quantile regression analysis to explore changes in Iranian older persons’ material well-being during the sanctions era. We also examine whether Iran’s pension system has alleviated the adverse effects of economic sanctions. Our investigation indicates that older adults’ material well-being decreases during sanctions. However, those without pension coverage are economically more vulnerable compared with pensioners. Among the non-pensioners, low-income and low-consumption ones are susceptible to relatively more considerable material well-being losses. To protect these vulnerable groups, policymakers should implement appropriate policy interventions, such as expansions in non-contributory anti-poverty schemes.
Landscape is analyzed here principally in terms of its aesthetic value and function. As an expression of a sentimental response it is concerned not only with natural beauty but also the world of human beings, since it has always been integral to the creativity of our visionary sensibility. In it we find ethical truth since we celebrate not only the wildness of nature but also the life-space that unifies human beings and the site of the contingent and the possible, that which Aristotle referred to as endekhomenon. Modern history serves as a starting point for an examination of the present significance of the landscape in Europe. The image of its countless particulars and nature’s “spiritual physiognomy” seem to respond to the full spectrum of our most intimate emotions; we are convinced that something that transcends the vast panorama of discrete elements must exist, namely the landscape. It is more than the sum of the parts, the individual fragments of our perception scattered along the continuum of our sensibility or the attraction of mental processes. It is the spirit of an infinite and magical connectedness of forms. The notion of landscape and beautiful landscape develops both in history and in individuals, bound up with the rhythm of lines and surfaces that human beings invent almost instinctively. It is the outcome of the art of culture, the poesis of individuals and communities.
This chapter aims to explore the emotional processes associated with parenting stress and competence, as specific risk factors in child maltreatment. We consider two key aspects of the relationship between emotion regulation (ER) and child maltreatment: (1) ER as an important antecedent of child maltreatment and (2) violent parenting behaviors as an ER strategy. The theoretical framework of the social information processing model guides our treatment of the subject. Gender differences and clinical implications are discussed.
We report a 20-year-old female patient (76 Kg/164 cm) with an extra-cardiac Fontan circulation who was referred to our institution for exertional dyspnoea and desaturation. The patient was diagnosed with a large calcified thrombus at the level of the Fontan fenestration, protruding inside the lumen of the conduit and reducing the diameter by half with a 3 mmHg pressure gradient. Transcatheter stent expansion of the obstructed extra-cardiac conduit was done with a 48 mm long XXL PTFE-covered Optimus-CVS® under temporary cerebral embolic protection with a TriGUARD-3™ deflection filter device (Keystone Heart). There was no procedural complication and the 3 months clinical outcomes are good.
The deleterious effects of adversity are likely intergenerational, such that one generation’s adverse experiences can affect the next. Epidemiological studies link maternal adversity to offspring depression and anxiety, possibly via transmission mechanisms that influence offspring fronto-limbic connectivity. However, studies have not thoroughly disassociated postnatal exposure effects nor considered the role of offspring sex. We utilized infant neuroimaging to test the hypothesis that maternal childhood maltreatment (CM) would be associated with increased fronto-limbic connectivity in infancy and tested brain-behavior associations in childhood. Ninety-two dyads participated (32 mothers with CM, 60 without; 52 infant females, 40 infant males). Women reported on their experiences of CM and non-sedated sleeping infants underwent MRIs at 2.44 ± 2.74 weeks. Brain volumes were estimated via structural MRI and white matter structural connectivity (fiber counts) via diffusion MRI with probabilistic tractography. A subset of parents (n = 36) reported on children’s behaviors at age 5.17 ± 1.73 years. Males in the maltreatment group demonstrated greater intra-hemispheric fronto-limbic connectivity (b = 0.96, p= 0.008, [95%CI 0.25, 1.66]), no differences emerged for females. Fronto-limbic connectivity was related to somatic complaints in childhood only for males (r = 0.673, p = 0.006). Our findings suggest that CM could have intergenerational associations to offspring brain development, yet mechanistic studies are needed.
Low-profile stent implantation remains a rescue treatment for aortic coarctation and branch pulmonary arteries stenosis in small children. Stent re-expansion to cope with vascular growth remains problematic.
Objectives:
To evaluate ex vivo feasibility and mechanical behaviour of over-dilating BeSmooth peripheral stents (Bentley InnoMed, Germany).
Methods:
Three BeSmooth peripheral stents in diameters of 7, 8, and 10 mm were dilated to nominal pressure and then 13 atm. BeSmooth Ø7 × 23 mm was sequentially post-dilated using 12, 14, and 16 mm high-pressure balloons. BeSmooth Ø10 × 57 mm was post-dilated with a 14 mm balloon and then with a 48 mm bare-metal Optimus XXL stent hand-mounted on a 14 mm balloon (stent-in-stent). BeSmooth Ø8 × 57 mm was directly post-dilated with a 48 mm bare-metal Optimus XXL stent hand-mounted on a 16 mm balloon (stent-in-stent). The stents’ diameter and length were measured. Digital inflation pressure was noted. Balloon rupture and stent fracture patterns were closely evaluated.
Results:
At 20atm pressure, BeSmooth Ø7 × 23 mm shortened to 2 mm forming a 12 mm diameter solid ring circle and the woven balloon ruptured radially. At 10 atm pressure, BeSmooth Ø10 × 57 mm fractured longitudinally in various dispatched breaking points at a diameter of 13 mm without shortening and ruptured the balloon with multiple pinholes. At 10 atm pressure, BeSmooth Ø8 × 57 mm fractured centrally at three different points at a diameter of 11.5 mm without shortening and the balloon broke radially in half.
Conclusions:
In our benchmark tests, extreme shortening, severe balloon rupture, or unpredictable stent fracture patterns at small balloon diameters limits safe post-dilation of BeSmooth stents beyond 13 mm. BeSmooth stents are not ideal candidates for off-label stent interventions in smaller patients.
In neonatal Ebstein’s anomaly of the tricuspid valve, prolonged ductal patency in patients without anatomic pulmonary valve atresia can be deleterious. Circular shunts may develop in patients with different degrees of pulmonary and tricuspid insufficiency. Closure of the arterial duct may result in haemodynamic improvement in particular scenarios. The transcatheter approach is a valuable closure alternative despite some technical difficulties in large-sized arterial ducts and low birth weight neonates. Herein, we report on two consecutive term newborns with Ebstein’s anomaly and large arterial ducts in whom mechanical stimulus of the arterial duct during failed attempts of transcatheter closure led after two days to definitive closure followed by good clinical outcomes.
KONAR-MultifunctionalTM VSD Occluder (Lifetech, Shenzhen, China) is one of the most recent additions to the armamentarium of device closure interventions offering special features to tackle complex cardiac anatomies. Herein, we report the first use of the KONAR-MFO in an 8.5-year-old female patient (27 kg/129 cm) with stage III palliated univentricular heart to close an acquired post-operative tunnel-like communication (5 mm long × 2.6 mm large) between the right anterior non-coronary aortic sinus and the rudimentary right ventricular cavity. The shunt was diagnosed two and a half years after bulboventricular foramen surgical enlargement. The 5× 3 mm KONAR-MFO was retrogradely implanted under ultrasound and biplane fluoroscopic guidance. Immediate and 12-month follow-up confirmed successful outcomes with complete shunt closure and preserved aortic valve competence.
Censorship has been as much a part of Iran's literary history as betrayed love, bewitched lovers, and broken love affairs. In other words, it began long before the establishment of the "Imperial Printing Office" during the reign of Naser al-Din Shah Qajar (ruled 1848-1896).
In earlier times some dissident writers were forced to lick off the ink from pages of their writings. Others had their mouths filled with gold or silver. Some were thrown in dungeons or seas. Others were exiled or executed.
Modern rulers have been no less adamant or imaginative in their methods of silencing opposition artists. "Mohammad 'Ali Shah had the two writers and orators, Malek-ol-Motakallamin and Sur-e Esrafil, hanged in the Bagh-e Shah Garrison, while he himself sat on the balcony facing the gallows and ate an entire plateful of rice and kabob as he watched." Farrokhi Yazdi (1889-1939) had his lips sewn together.