People living with HIV/AIDS (PLWH) often experience co-morbid/co-occurring mental health conditions, e.g., depression, anxiety, and post-traumatic stress disorder (PTSD). In resource-limited settings, where provider shortages are common, task shifting and task sharing (i.e., service delivery by non-professionals) are recommended strategies to promote access to and utilization of mental health and psychosocial support (MHPSS) services among PLWH. We conducted a global scoping review of the literature on MHPSS task shifting and sharing intervention studies for PLWH. Data extracted and summarized included study characteristics, intervention components, whether trauma informed study design, how lay health workers (LHWs) were identified and trained to deliver MHPSS services, and findings related to mental health outcomes. Results indicated that from 2013 through 2022, published intervention research concerning task shifting and sharing approaches was much more prolific in low- and middle-income countries than in high-income countries. MHPSS interventions delivered by a variety of LHWs yielded promising associations on an array of mental health outcomes, including PTSD/trauma and suicidality, though understudied. Underreported details regarding LHW recruitment/selection, compensation, supervision and assessment made it difficult to identify common or best practices. Further research is needed to facilitate the adoption and implementation of MHPSS task shifting and sharing interventions.

We report the case of a 16-year-old female with previously diagnosed bilateral sub-segmental pulmonary emboli who presented in cardiogenic shock from depressed biventricular function with cardiac MRI demonstrating concern for microvascular coronary injury. She was ultimately diagnosed with catastrophic antiphospholipid antibody syndrome-induced ischaemic cardiomyopathy, potentially associated with an underlying autoimmune connective tissue disease.

In this article, I offer an account of the “linguistic landscapes” associated with the commodification and purchase of internet services in southern Peru. Through an account of public signage deployed by internet lounges in this area as well as the ideologies that make sense of it, the analysis reveals one of the ways in which moral panic over digital gaming gets semiotically mediated. To do this, the article develops a theoretical machinery that makes sense of the ways in which public signs—relative to their infrastructural contexts—come to project channels for their uptake. When these relationships are considered relative to the ideologies that target them, what gets revealed are the moral contours of Southern Peruvian public life. The analysis ultimately shows how the concept “linguistic landscape” can be useful for the semiotic study of infrastructure as well as the forms of the public life that it helps to mediate.

A new model of the steady boundary layer flow around a rotating sphere is developed that includes the widely observed collision and subsequent eruption of boundary layers at the equator. This is derived following the Segalini & Garrett (J. Fluid Mech., vol. 818, 2017, pp. 288–318) asymptotic approach for large Reynolds numbers but replacing the Smith & Duck (Q. J. Mech. Appl. Maths, vol. 30, issue 2, 1977, pp. 143–156) correction with a higher-order version of the Stewartson (Grenzschichtforschung/Boundary Layer Research, 1958, pp. 59–71. Springer) model of the equatorial flow. The Stewartson model is then numerically solved, for the first time, via a geometric multigrid method that solves the steady planar Navier–Stokes equations in streamfunction-vorticity form on large rectangular domains in a quick and efficient manner. The results are then compared with a direct numerical simulation of the full unsteady problem using the Semtex software package where it is found that there is broad qualitative agreement, namely the separation and reattachment of the boundary layer at the equator. However, the presence of unobserved behaviour such as a large area of reverse flow seen at lower Reynolds numbers than those observed in other studies, and that the absolute error increases with Reynolds number suggest the model needs improvement to better capture the physical dynamics.

Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index ⩾25 kg/m2, and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition.

We present detailed characterization of laser-driven fusion and neutron production ($\sim {10}^5$/second) using 8 mJ, 40 fs laser pulses on a thin (<1 μm) D${}_2$O liquid sheet employing a measurement suite. At relativistic intensity ($\sim 5\times {10}^{18}$ W/cm${}^2$) and high repetition rate (1 kHz), the system produces deuterium–deuterium (D-D) fusion, allowing for consistent neutron generation. Evidence of D-D fusion neutron production is verified by a measurement suite with three independent detection systems: an EJ-309 organic scintillator with pulse-shape discrimination, a ${}^3\mathrm{He}$ proportional counter and a set of 36 bubble detectors. Time-of-flight analysis of the scintillator data shows the energy of the produced neutrons to be consistent with 2.45 MeV. Particle-in-cell simulations using the WarpX code support significant neutron production from D-D fusion events in the laser–target interaction region. This high-repetition-rate laser-driven neutron source could provide a low-cost, on-demand test bed for radiation hardening and imaging applications.

Rifts are full-thickness fractures that propagate laterally across an ice shelf. They cause ice-shelf weakening and calving of tabular icebergs, and control the initial size of calved icebergs. Here, we present a joint inverse and forward computational modeling framework to capture rifting by combining the vertically integrated momentum balance and anisotropic continuum damage mechanics formulations. We incorporate rift–flank boundary processes to investigate how the rift path is influenced by the pressure on rift–flank walls from seawater, contact between flanks, and ice mélange that may also transmit stress between flanks. To illustrate the viability of the framework, we simulate the final 2 years of rift propagation associated with the calving of tabular iceberg A68 in 2017. We find that the rift path can change with varying ice mélange conditions and the extent of contact between rift flanks. Combinations of parameters associated with slower rift widening rates yield simulated rift paths that best match observations. Our modeling framework lays the foundation for robust simulation of rifting and tabular calving processes, which can enable future studies on ice-sheet–climate interactions, and the effects of ice-shelf buttressing on land ice flow.