Premised on the Developmental Origins of Health and Disease theory and on the limited effectiveness of antenatal interventions, interventions in the preconception period are being conducted to potentially improve intergenerational health and non-communicable disease burdens. The Healthy Life Trajectories Initiative (HeLTI) is an international health research consortium primarily investigating the intergenerational effects of behavioural interventions on obesity via a complex four-phase intervention initiated preconceptionally, through pregnancy, and into early childhood. HeLTI, in partnership with the World Health Organization, aims to generate evidence that will shape health policy focused on preconception as part of a life course approach to population health. It is necessary to ensure that a renewed public health focus on preconception prioritises justice and equity in its framing. This article presents collaborative interdisciplinary work with HeLTI-South Africa. It applies a feminist bioethics methodology, which is empirical, situated, intersectional, and fundamentally concerned with justice, to investigate what South African HeLTI community health workers, or ‘Health Helpers’, who deliver the complex behavioural intervention, think about preconception health and responsibility. Seven semi-structured interviews were conducted with HeLTI-SA Health Helpers, and data were analysed using reflexive thematic analysis. Our findings show that Health Helpers’ perceptions of preconception health and related responsibility were significantly gendered, heteronormative, and concerned with child-bearing intentionality and desires. These themes were inflected with Health Helpers’ perceptions about how attributions of responsibility are shaped by culture, demonstrating the situated nature of epistemologies. Their ideas also highlight how preconception health knowledge can distribute responsibility unjustly. Understanding the contextual impact and relevance of values around responsibility is critical to prospectively design preconception health interventions that promote equity and fairness. This understanding can then be used for effective policy translation, with the goal that public health policy is founded upon contextual responsivity and justice for the public it aims to serve.

In 2022, Russia invoked Articles V and VI of the Biological and Toxin Weapons Convention (BTWC), requesting a formal meeting to discuss, and subsequent investigation of, alleged U.S.-funded biological weapons laboratories in Ukraine. Such allegations have been dismissed as false by scholars and diplomats alike, many of whom have argued that Russia’s actions represented an abuse of BTWC provisions and risked undermining the Convention. However, few scholars have assessed the implications of Russia’s ongoing efforts to level false allegations in BTWC meetings following the Article V and VI procedures. Using mixed-methods analysis of BTWC meeting recordings, transcripts, and documents, we assessed the volume, consequences, and framing of Russian false allegations at the BTWC Ninth Review Conference. Analysis revealed that discussion of Russian allegations took over three hours and contributed to a stunted Final Document. Additional potential consequences are discussed, including increased division among states parties and the erosion of nonproliferation norms.

Intracellular levels of glutathione, the major mammalian antioxidant, are reported to decline with age in several species. To understand whether ageing affects circulating glutathione levels in cats, blood was sampled from two age groups, < 3 years and > 9 years. Further, to determine whether dietary supplementation with glutathione precursor glycine (GLY) affects glutathione concentrations in senior cats (> 8 years), a series of free GLY inclusion level dry diets were fed. Subsequently, a 16-week GLY feeding study was conducted in senior cats (> 7 years), measuring glutathione, and markers of oxidative stress. Whole blood and erythrocyte total, oxidised and reduced glutathione levels were significantly decreased in senior cats, compared with their younger counterparts (P ≤ 0·02). The inclusion level study identified 1·5 % free GLY for the subsequent dry diet feeding study. Significant increases in erythrocyte total and reduced glutathione were observed between senior cats fed supplemented and control diets at 4 weeks (P ≤ 0·03; maximum difference of 1·23 µM). Oxidative stress markers were also significantly different between groups at 8 (P = 0·004; difference of 0·68 nG/ml in 8-hydroxy-2'-deoxyguanosine) and 12 weeks (P ≤ 0·049; maximum difference of 0·62 nG/mG Cr in F2-isoprostane PGF2α). Senior cats have lower circulating glutathione levels compared with younger cats. Feeding senior cats a complete and balanced dry diet supplemented with 1·5 % free GLY for 12 weeks elevated initial erythrocyte glutathione and altered markers of oxidative stress. Dietary supplementation with free GLY provides a potential opportunity to restore age-associated reduction in glutathione in cats.

“Social isolation among older adults is associated with increased change of premature death; depression; dementia, disability from chronic diseases; poor mental health; increased use of health and support services; reduced quality of life; poor general health; and an increased number of falls.” (National Academies of Sciences, Engineering, and Medicine (2020).

Without question, the global pandemic has significantly exacerbated both the prevalence and awareness of social isolation and loneliness as a growing health and societal challenge for older populations.

“Because of growing calls for Canada’s health-care systems to identify, prevent and mitigate loneliness as part of COVID-19-related public health efforts, there is a unique opportunity to build capacity to identify and intervene with older adults who are experiencing social isolation or loneliness.” National Institute on Aging (2022).

Over the past two decades, the Canadian Coalition for Seniors’ Mental Health (CCSMH) has developed a number of internationally recognized clinical guidelines in support of mental health for older adults. CCSMH is responding to the growing mental health crisis of isolation and loneliness with the development of evidence-based guidelines, to support the vital work of health and social service providers across Canada. The focus of these guidelines is to develop a broad range of evidence-based, manageable, and stepped care approaches to identify and address social isolation and loneliness in older adults. It is recognized that this topic is extremely complex and vast in potential scope. Through the guidance of a national working group of experts, these guidelines will draw upon both academic and grey literature, as well as on the experience of a diversity of health and social service providers, older adults, and their caregivers. This project will also provide guidance, promoting wellness and reducing the risk of social isolation with targeted messaging, knowledge translation and useful tools for supporting social connection among those at highest risk.

This presentation will share the Guidelines’ preliminary recommendations, as well as data from two national surveys alongside other insights gained from ongoing research and stakeholder engagement.

Maternal fish consumption exposes the fetus to beneficial nutrients and potentially adverse neurotoxicants. The current study investigated associations between maternal fish consumption and child neurodevelopmental outcomes. Maternal fish consumption was assessed in the Seychelles Child Development Study Nutrition Cohort 1 (n 229) using 4-day food diaries. Neurodevelopment was evaluated at 9 and 30 months, and 5 and 9 years with test batteries assessing twenty-six endpoints and covering multiple neurodevelopmental domains. Analyses used multiple linear regression with adjustment for covariates known to influence child neurodevelopment. This cohort consumed an average of 8 fish meals/week and the total fish intake during pregnancy was 106·8 (sd 61·9) g/d. Among the twenty-six endpoints evaluated in the primary analysis there was one beneficial association. Children whose mothers consumed larger quantities of fish performed marginally better on the Kaufman Brief Intelligence Test (a test of nonverbal intelligence) at age 5 years (β 0·003, 95 % CI (0, 0·005)). A secondary analysis dividing fish consumption into tertiles found no significant associations when comparing the highest and lowest consumption groups. In this cohort, where fish consumption is substantially higher than current global recommendations, maternal fish consumption during pregnancy was not beneficially or adversely associated with children’s neurodevelopmental outcomes.

Blindfolding is routinely used to aid the handling and loading of horses that are difficult to control. Fifteen relatively well-behaved horses of varying ages and disciplines were used to investigate the effects of blinkering and blindfolding on behaviour and heart rate in three situations: whilst stabled, when being led in a ménage, and during loading onto a lorry. Heart rate increased in all three situations when a blindfold was used, and when animals were handled by the least experienced of three handlers. The effects of blinkering on heart rate and behaviour were small compared with blindfolding. Overall, blindfolding appeared to make the horses more nervous and difficult to handle. However, the study does not discount the practical application that blindfolding may have for improving welfare and safety when handling certain individual horses. This work forms the basis for further studies involving animals less accustomed or disposed to being handled.