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We investigate the scaling properties of the primary flow modes and their sensitivity to aspect ratio in a liquid gallium (Prandtl number $Pr = 0.02$) convection system through combined laboratory experiments and numerical simulations. We survey cylindrical aspect ratios $1.4 \le \varGamma \le 3$ and Rayleigh numbers $10^{4} \lesssim Ra \lesssim 10^{6}$. In this range the flow is dominated by a large-scale circulation (LSC) subject to low-frequency oscillations. In line with previous studies, we show robust scaling of the Reynolds number $Re$ with $Ra$ and we confirm that the LSC flow is dominated by a jump-rope vortex (JRV) mode whose signature frequency is present in velocity and temperature measurements. We further show that both $Re$ and JRV frequency scaling trends are relatively insensitive to container geometry. The temperature and velocity spectra consistently show peaks at the JRV frequency, its harmonic and a secondary mode. The relative strength of these peaks changes and the presence of the secondary peak depend highly on aspect ratio, indicating that, despite having a minimal effect on typical velocities and frequencies, the aspect ratio has a significant effect on the underlying dynamics. Applying a bandpass filter at the secondary frequency to velocity measurements reveals that a clockwise twist in the upper half of the fluid layer coincides with a counterclockwise twist in the bottom half, indicating a torsional mode. For aspect ratio $\varGamma = 3$, the unified LSC structure breaks down into multiple rolls in both simulation and experiment.
Although genetic and environmental factors operating before or around the time of birth have been demonstrated to be relevant to the aetiology of the major psychoses, a seasonal variation in the rates of admission of such patients has long been recognised. Few studies have compared first and readmissions. This study examined for seasonal variation of admission in the major psychoses, and compared diagnostic categories by admission status. Patients admitted to Irish psychiatric inpatient facilities between 1989 and 1994 with an ICD-9/10 diagnosis of schizophrenia or affective disorder were identified from the National Psychiatric Inpatient Reporting System (NPIRS). The data were analysed using a hierarchical log linear model, the chi-square test, a Kolmogorov-Smirnov (KS) type statistic, and the method of Walter and Elwood. The hierarchical log linear model demonstrated significant interactions between the month of admission and admission order (change in scaled deviance 28.77, df = 11, P < 0.003). Both first admissions with mania, and readmissions with bipolar affective disorder exhibited significant seasonality. In contrast, only first admissions with schizophrenia showed significant seasonal effects. Although first admissions with mania and readmissions with bipolar disorder both show seasonality, seasonal influences appear to be more relevant to onset of schizophrenia than subsequent relapse.
Mitochondrial disorders are a highly diverse group of conditions that can affect almost every major system in the human body, often mimicking common disorders. This clinical variety often results in prolonged and often dangerous, diagnostic delays. This textbook provides a practical framework, to enable rapid identification, investigation, and treatment of mitochondrial disorders across the spectrum of clinical practice. Clinically relevant and comprehensive, this textbook employs a system- and case-based approach for practitioners of all levels. It focuses on major phenotypic features, syndromes and management relevant for clinical practice, within a broad overview of the field. This interactive book supports readers with knowledge distilled from over 20 internationally recognized, mitochondrial experts.