The present study examined the impact of children's maltreatment experiences on the emergence of externalizing problem presentations among children during different developmental periods. The sample included 788 youth and their caregivers who participated in a multisite, prospective study of youth at-risk for maltreatment. Externalizing problems were assessed at ages 4, 8, and 12, and symptoms and diagnoses of attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder were assessed at age 14, during interviews with youth and caregivers. Information about maltreatment allegations was coded from official records. Latent transition analysis identified three groups of youth with similar presentations of externalizing problems (“well adjusted,” “hyperactive/oppositional,” and “aggressive/rule-breaking”) and transitions between groups from ages 4, 8, and 12. A “defiant/deceitful” group also emerged at age 12. Girls were generally more likely to present as well adjusted than boys. Children with recent physical abuse allegations had an increased risk for aggressive/rule-breaking presentations during the preschool and preadolescent years, while children with sexual abuse or neglect allegations had lower probabilities of having well-adjusted presentations during middle childhood. These findings indicate that persistently severe aggressive conduct problems, which are related to the most concerning outcomes, can be identified early, particularly among neglected and physically and sexually abused children.

Laryngopharyngeal reflux is a controversial but increasingly made diagnosis used in patients with a collection of often non-specific laryngeal symptoms. It is a clinical diagnosis, and its pathophysiology is currently poorly understood.

Previous reflux research has focused on injurious agents, acid, pepsin and biomarker expression. Failure of intrinsic defences in the larynx may cause changes in laryngeal epithelia, particularly alterations in carbonic anhydrases and E-cadherin. Carbonic anhydrase III levels vary in the larynx in response to laryngopharyngeal reflux, depending on location. Expression of E-cadherin, a known tumour suppressor, is reduced in the presence of reflux. Mucin expression also varies according to the severity of reflux.

Further research is required to define the clinical entity of laryngopharyngeal reflux, and to identify a definitive mechanism for mucosal injury. Understanding this mechanism should allow the development of a comprehensive model, which would enable future diagnostic and therapeutic interventions to be developed.

The collection of Finlay Papers in the British School at Athens though throwing invaluable light on the character of George Finlay and on conditions in the Greece and western Europe of his day, are by no means complete in their coverage. The diaries cover only certain years; the Letter Book records mainly family and business correspondence; the actual copies of surviving letters both to and from Finlay—apart from Finlay to Leake or Leicester Warren—seem to owe their preservation to chance rather than policy. Yet Finlay was no less interested in the history of Trebizond than in Greek topography or in numismatics, and a stray survival among his papers seems to indicate that he had closer relations with Fallmerayer than is suggested by the almost total omission of any reference to him in the works on the Fragmentist (as Fallmerayer called himself). The editor of Fallmerayer’s collected works, his best friend G. M. Thomas (the ‘carissimus Thomas’ of the Tagebücher), does mention the generosity of Fallmerayer’s attitude towards Finlay’s work on Trebizond, but that is about all.

George Finlay died at the age of seventy-five on 24 January a hundred years ago and I am honoured to pay tribute to this distinguished Scottish scholar and philhellene on the occasion of his centenary. It is indeed fitting that this should take place in the School which possesses many of his books and papers.

It might well be asked why there has as yet—to the best of my knowledge—been no full biography of Finlay. A glance at the available material may suggest the answer. What are usually known as the Finlay Papers housed in the British School comprise a formidable collection. Perhaps the best-known items are the so-called Journals. They are in part genuine journals in the sense of a day to day record, particularly of Finlay's experiences when travelling round the Aegean, or in Turkey, or on a visit to Scotland, journeying via Malta and France or Switzerland.