The current small study utilised prospective data collection of patterns of prenatal alcohol and tobacco exposure (PAE and PTE) to examine associations with structural brain outcomes in 6-year-olds and served as a pilot to determine the value of prospective data describing community-level patterns of PAE and PTE in a non-clinical sample of children. Participants from the Safe Passage Study in pregnancy were approached when their child was ∼6 years old and completed structural brain magnetic resonance imaging to examine with archived PAE and PTE data (n = 51 children–mother dyads). Linear regression was used to conduct whole-brain structural analyses, with false-discovery rate (FDR) correction, to examine: (a) main effects of PAE, PTE and their interaction; and (b) predictive potential of data that reflect patterns of PAE and PTE (e.g. quantity, frequency and timing (QFT)). Associations between PAE, PTE and their interaction with brain structural measures demonstrated unique profiles of cortical and subcortical alterations that were distinct between PAE only, PTE only and their interactive effects. Analyses examining associations between patterns of PAE and PTE (e.g. QFT) were able to significantly detect brain alterations (that survived FDR correction) in this small non-clinical sample of children. These findings support the hypothesis that considering QFT and co-exposures is important for identifying brain alterations following PAE and/or PTE in a small group of young children. Current results demonstrate that teratogenic outcomes on brain structure differ as a function PAE, PTE or their co-exposures, as well as the pattern (QFT) or exposure.

The High Throughput Experimentation (HTE) project of the Joint Center for Artificial Photosynthesis (JCAP, http://solarfuelshub.org/) performs accelerated discovery of new earth-abundant photoabsorbers and electrocatalysts. Through collaboration within the DOE solar fuels hub and with the broader research community, the new materials will be utilized in devices that efficiently convert solar energy, water and carbon dioxide into transportation fuels. JCAP-HTE builds high-throughput pipelines for the synthesis, screening and characterization of photoelectrochemical materials. In addition to a summary of these pipelines, we will describe several new screening instruments for high throughput (photo-)electrochemical measurements. These instruments are not only optimized for screening against solar fuels requirements, but also provide new tools for the broader combinatorial materials science community. We will also describe the high throughput discovery, follow-on verification, and device implementation of a new quaternary metal oxide catalyst. This rapid technology development from discovery to device implementation is a hallmark of the multi-faceted JCAP research effort.

Structures of the current layer between two magnetized anisothermal plasmas are studied on the basis of a kinetic formulation. It is shown that the structure of the current layer is dominantly controlled by the hotter species of the plasmas. The thickness is characterized by the ion gyroradius if the ion temperature is much greater than the electron temperature. The structure is, in general, insensitive to the asymptotic potential difference and the relative flow velocity between plasmas on the two sides.

The field of a test charge at rest in a plasma is known to be shielded via the collective interaction between the test charge and the particles of the plasma. In a thermal equilibrium plasma, the shielded potential has a spatial variation of the Debye form exp (— r)/r. In this note we will show that, in a collisionless current-carrying plasma, the potential profile along the radial direction parallel to the current changes from the Debye form to a potential well form, and causes a reversal of the ele ctric field of the test charge. The formation of the Debye potential well is attributed to the resonant interaction between the particles and the waves stationary in the test charge frame when the net flux of charged particles is different from zero. This is the same type of resonant interaction which leads to the well-known Landau damping (Landau 1946).

The Sonnerup merging model for an incompressible plasma is extended to allow a flow component along the field lines in the inflow regions. Solutions are found to exist as long as the difference between the quantities B. V for the two inflow regions does not exceed a critical magnitude dependent on the inflow field magnitudes and plasma densities. All such solutions satisfy Vasyliunas' definition of merging, but some classes of solution have radically altered geometries, i.e. geometries in which the inflow regions are much smaller than the outflow regions. The necessary but not sufficient condition for these unusual geometries is that the field-aligned flow component in at least one inflow region be super Alfvénic. A solution for the case of a vacuum field in one inflow region is obtained in which any flow velocity is allowed in the non-vacuum inflow region, although super-Alfvénic flow can still result in an unusual geometry. For symmetric configurations, the usual geometry, that of Petschek and Sonnerup, is retained as long as both field-aligned flow components in the inflow regions are less than twice the inflow Alfvén speed. For the case of a vacuum field on one side and fields approximating the boundary between the solar wind and the earth's dayside magnetosphere, the usual geometry is retained for flow less than about 2·5 times the local Alfvén speed.

A class of equilibrium configurations of Vlasov plasmas carrying a current component along an external magnetic field is presented. The present slab model contains the diamagnetic current jy, and the field-aligned current jz for arbitrary βc (= particle pressure/magnetic pressure of the applied constant field). For fixed βc and field-aligned current, our model admits a family of equilibrium solutions in which the diamagnetic currents range from zero to a maximum value. The amount of diamagnetic current flowing in a machine depends on the width of the machine, the field-aligned current and other plasma parameters. The Helmholtz free energy of the system is calculated under the constraints that the total number of particles and the field-aligned current are conserved. The least unstable equilibrium configuration in a machine is obtained by minimizing the free energy under the stated constraints among all equilibria whose plasma widths do not exceed the width of the machine.

In this paper we develop a Brownian dynamics model applied to position metal nanoparticles from the gas phase onto electrostatic-patterns generated by biasing P-N junction substrates. Brownian motion and fluid convection of nanoparticles, as well as the interactions between the charged nanoparticles and the patterned substrate, including electrostatic force, image force and van der Waals force, are accounted for in the simulation. Using both experiment and simulation we have investigated the effects of the particle size, electric field intensity, and the convective flow on coverage selectivity. Coverage selectivity is most sensitive to electric field, which is controlled by the applied reverse bias voltage across the p-n junction. A non-dimensional analysis of the competition between the electrostatic and diffusion force is found to provide a means to collapse a wide range of process operating conditions and an effective indicator or process performance.

More than 4000 stars observed in both MOA and DENIS projects showing periodic or quasi-periodic light curves are studied. Almost all Mira stars are located on the classical period-luminosity relation, and the multiplicity of the period-luminosity relation is confirmed for small-amplitude stars. The colour-magnitude diagrams based on the MOA red band, Rm , and Ks constructed for the sequences, form a single strip with small successive shifts.

Ultrahigh molecular weight polyethylene, an important biomaterial for orthopedic implants, was irradiated with 2.6- and 3-MeV H+ ions at low doses from 5.7 × 1011 to 2.3 × 1014 ions/cm2. Fourier transform infrared spectroscopy showed that irradiation resulted in increased free radicals, carbon double bonds, and increased methyl and vinyl end groups. The free radicals resulted in poor polymer oxidative stability, as measured by increased carbonyl concentration. Hydrogen annealing after ion irradiation reacted with the free radicals generated during proton irradiation resulted in a 40–50% decrease in infrared absorption associated with carbonyl and prevented further oxidation.

For future CMOS GSI technology, Si/SiO2 interface micro-roughness becomes a non-negligible problem. Interface roughness causes fluctuations of the surface normal electric field, which, in turn, change the gate oxide Fowler-Nordheim tunneling behavior. In this research, we used a simple two-spheres model and a three-dimensional Laplace solver to simulate the electric field and the tunneling current in the oxide region. Our results show that both quantities are strong functions of roughness spatial wavelength, associated amplitude, and oxide thickness. We found that RMS roughness itself cannot fully characterize surface roughness and that roughness has a larger effect for thicker oxide in terms of surface electric field and tunneling behavior.

This study reports on the use of zirconolite-rich Synroc to demonstrate the safe immobilisation of ‘high-fired’ Pu02. The zirconolite-rich Synroc used in this study was prepared by adding 13 wt% Pu with equimolar amounts of Gd and Hf, relative to Pu, as neutron absorbers. The incorporation of the Pu and neutron absorbers has been studied microstructurally as well as by longer-term leach testing. This work has shown that the sintered ceramic can immobilise 13 wt% of Pu with almost complete incorporation of the Pu (≃ 98%) into the zirconolite phase. Durability studies have shown that under a wide range of leaching conditions there is no major separation of the Pu and neutron absorbers, with the majority of these elements either remaining in the matrix or leaching at low (< 10−4 g m−2 d−1) and comparable rates from the waste form.

Ninety-three patients with histolofically or radiolofically confiemd unilateral vestibular schwannomas were recruited. Audiological testing for retrocochelar pathology was undertaken. Patients' hospital records were examined for previous audiological and radiological results.

The audiometric configuration was designated as one of the following normal, sloping, low frequency, peak, through or falt. A sloping sensorneural audiometric configuration was present in 68 pec cent of cases. No significant correlation was found between tumour size and average pure tone threshold 500 HZ to 4000 HZ, optimum discrimination score or interaural differences for wave V. Ninety-one per cent of cases had abnoramalities on auditory evoked potential; 92 per cent of cases showed abnormalities on stapedial reflex testing.

The limitations of audiologica testing in the investigation of patients with suspected unilateral vestibular schwannomas are discussed. A protocol for the investigation of such patients is presented.

Linoleic acid (LA) transport in rats with experimental short-term and long-term renal failure (RF) was compared with that of sham-operated normal animals on liberal food intake and pair-fed animals. The perfusions in vivo and incubations in vitro were conducted using a micellar solution containing a wide range of LA concentrations. Both absorption in vivo and uptake in vitro of LA were significantly reduced in animals with short-term RF. Lipid extraction and separation by thin-layer chromatography revealed a marked LA trapping as trilinolein (TL) in the perfused intestinal tissue in the short-term RF group. The esterification process, as defined by the rate of LA incorporation into TL, was moderately reduced in short-term RF animals. The thickness of the unstirred water layer showed no significant difference among the groups studied. In contrast, animals with long-term RF exhibited normal absorption of LA in vivo at all concentrations tested. In conclusion, LA absorption is reduced in short-term RF and restored in long-term RF. Several steps including LA transport into and TL transport out of the enterocyte and the esterification process were impaired in short-term RF. These changes are not due to alteration in the unstirred water layer, anorexia, weight loss or a rapid effect of uraemic chemical environment or circulatory factors.

Ion beam channeling analysis has recently been applied to lattice strain measurements on strained-layer superlattices (SLS). In this review talk, we outline three different methods of strain measurement: axial dechanneling, angular scans, and planar resonance. We describe the principles and illustrate them with examples; we also give a detailed theoretical treatment of the planar resonance effect in SLS's.