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We present the serendipitous radio-continuum discovery of a likely Galactic supernova remnant (SNR) G305.4–2.2. This object displays a remarkable circular symmetry in shape, making it one of the most circular Galactic SNRs known. Nicknamed Teleios due to its symmetry, it was detected in the new Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) radio–continuum images with an angular size of 1 320$^{\prime\prime}$$\times$1 260$^{\prime\prime}$ and PA = 0$^\circ$. While there is a hint of possible H$\alpha$ and gamma-ray emission, Teleios is exclusively seen at radio–continuum frequencies. Interestingly, Teleios is not only almost perfectly symmetric, but it also has one of the lowest surface brightnesses discovered among Galactic SNRs and a steep spectral index of $\alpha$=–0.6$\pm$0.3. Our best estimates from Hi studies and the $\Sigma$–D relation place Teleios as a type Ia SNR at a distance of either $\sim$2.2 kpc (near-side) or $\sim$7.7 kpc (far-side). This indicates two possible scenarios, either a young (under 1 000 yr) or a somewhat older SNR (over 10 000 yr). With a corresponding diameter of 14/48 pc, our evolutionary studies place Teleios at the either early or late Sedov phase, depending on the distance/diameter estimate. However, our modelling also predicts X-ray emission, which we do not see in the present generation of eROSITA images. We also explored a type Iax explosion scenario that would point to a much closer distance of $\lt$1 kpc and Teleios size of only $\sim$3.3 pc, which would be similar to the only known type Iax remnant SN1181. Unfortunately, all examined scenarios have their challenges, and no definitive Supernova (SN) origin type can be established at this stage. Remarkably, Teleios has retained its symmetrical shape as it aged even to such a diameter, suggesting expansion into a rarefied and isotropic ambient medium. The low radio surface brightness and the lack of pronounced polarisation can be explained by a high level of ambient rotation measure (RM), with the largest RM being observed at Teleios’s centre.
We present a broadband radio study of the transient jets ejected from the black hole candidate X-ray binary MAXI J1535–571, which underwent a prolonged outburst beginning on 2017 September 2. We monitored MAXI J1535–571 with the Murchison Widefield Array (MWA) at frequencies from 119 to 186 MHz over six epochs from 2017 September 20 to 2017 October 14. The source was quasi-simultaneously observed over the frequency range 0.84–19 GHz by UTMOST (the Upgraded Molonglo Observatory Synthesis Telescope) the Australian Square Kilometre Array Pathfinder (ASKAP), the Australia Telescope Compact Array (ATCA), and the Australian Long Baseline Array (LBA). Using the LBA observations from 2017 September 23, we measured the source size to be $34\pm1$ mas. During the brightest radio flare on 2017 September 21, the source was detected down to 119 MHz by the MWA, and the radio spectrum indicates a turnover between 250 and 500 MHz, which is most likely due to synchrotron self-absorption (SSA). By fitting the radio spectrum with a SSA model and using the LBA size measurement, we determined various physical parameters of the jet knot (identified in ATCA data), including the jet opening angle ($\phi_{\rm op} = 4.5\pm1.2^{\circ}$) and the magnetic field strength ($B_{\rm s} = 104^{+80}_{-78}$ mG). Our fitted magnetic field strength agrees reasonably well with that inferred from the standard equipartition approach, suggesting the jet knot to be close to equipartition. Our study highlights the capabilities of the Australian suite of radio telescopes to jointly probe radio jets in black hole X-ray binaries via simultaneous observations over a broad frequency range, and with differing angular resolutions. This suite allows us to determine the physical properties of X-ray binary jets. Finally, our study emphasises the potential contributions that can be made by the low-frequency part of the Square Kilometre Array (SKA-Low) in the study of black hole X-ray binaries.
Danon disease is an X-linked cardioskeletal myopathy related to a primary deficiency in lysosome-associated membrane protein-2. Danon disease manifests with the triad of hypertrophic cardiomyopathy, myopathy and intellectual disability.Psychiatric symptoms related to the disease have only been studied in a few case reports (Hatz et al, 2010 and Tanidir et al, 2015) and a case series (Yardeni et al, 2016), leaving its pathophysiological mechanisms understudied.
Objectives
Provide scientific data on psychotic symptoms in patients with Danon disease.
Methods
We report an unusual case of a 25-year-old-patient affected by Danon disease that showed an acute psychotic episode.
Results
Mr P is a 25 year-old white male, with past medical history for Danon disease. Mr P presents hypertrophic cardiomyopathy, Wolf Parkinson White arrhythmia and carries an implantable cardioverter-defibrillator. There are previous records of mild intellectual disability and the patient had experienced anxiety symptoms as well as obsessive thoughts in the past without receiving any specific diagnosis or treatment. He was admitted to the Neurology inpatient unit to study behavioural symptoms with atypical visual and auditory hallucinations, accompanied by paranoid delusions during the last 4 days. He was examined by the liaison psychiatric team. Psychosis remitted within 72 hours after introducing risperidone 3mg per day, with good tolerability. Magnetic resonance imaging (MRI) scan was normal.
Conclusions
Danon disease is caused by heterogeneity genetic mutation which means that patients can present different levels of clinical manifestations. The current case report highlights the variety of psychiatric symptoms in patients with Danon disease, and raises awareness towards its identification and treatment.
In this article the erratic coupling that can occur in screeching supersonic twin jets is characterised. Non-stationary acoustic analysis is used to investigate the temporal behaviour of the coupling phenomena. The results show that where the phase between the jets is time varying, the screech tone experiences interruptions. The interruptions are either correlated and experienced by both jets or are anti-correlated and only by one. During the anti-correlated interruption, the uninterrupted jet screeches as an isolated jet. The instantaneous velocity field shows that for the majority of snapshots during an acoustic interruption, the jets do not exhibit a coupled oscillation. When the jets are uninterrupted, they are oscillating in either a coupled symmetric or anti-symmetric mode. This behaviour manifests at a condition between two operating points characterised by different coupling modes. It suggests the interruptions arise due to a competition between two global modes of the flow. Despite the existence of multiple acoustic tones in the region where these modes are competing, analysis of the individual jets reveals energetic structures with only a single wavelength. It is found that jets whose own oscillation is characterised by a single wavelength can, through coupling either symmetrically or anti-symmetrically about their symmetry plane, produce different acoustic tones. These findings are consistent across three experimental facilities. The observed modes are a function of the jet spacing and nozzle pressure, therefore future studies investigating other spacings must recharacterise the encountered coupled modes. This article provides the signatures to characterise the behaviour for future studies.
Human-computer hybrid teams can meet challenges in designing complex engineered systems. However, the understanding of interaction in the hybrid teams is lacking. We review the literature and identify four key attributes to construct design research platforms that support multi-phase design, hybrid teams, multiple design scenarios, and data logging. Then, we introduce a platform for unmanned aerial vehicle (UAV) design embodying these attributes. With the platform, experiments can be conducted to study how designers and intelligent computational agents interact, support, and impact each other.
A statistical description of flow regions with negative streamwise velocity is provided based on simulations of turbulent plane channels in the Reynolds number range $547\leqslant Re_{\unicode[STIX]{x1D70F}}\leqslant 2003$. It is found that regions of backflow are attached and their density per surface area – in wall units – is an increasing function of $Re_{\unicode[STIX]{x1D70F}}$. Their size distribution along the three coordinates reveals that, even though in the mean they appear to be circular in the wall-parallel plane, they tend to become more elongated in the spanwise direction after reaching a certain height. Time-tracking of backflow regions in a $Re_{\unicode[STIX]{x1D70F}}=934$ simulation showed they convect downstream at the mean velocity corresponding to $y^{+}\approx 12$, they seldom interact with other backflow events, their statistical signature extends in the streamwise direction for at least $300$ wall units, and they result from a complex interaction between regions of high and low spanwise vorticity far beyond the viscous sublayer. This could explain why some statistical aspects of these near-wall events do not scale in viscous units; they are dependent on the $Re_{\unicode[STIX]{x1D70F}}$-dependent dynamics further away from the wall.
The rocky intertidal of the Argentinean coast extends 7,000 km from Río de la Plata (36°S) to Tierra del Fuego (54°S). Intertidal rocky platforms increase in frequency and extent from north to south. In the north, part of this extension has a microtidal nature changing to meso- and macro-tidal in southern Patagonia. The rocky shores of Argentina are characterised by low biodiversity and low biomass compared with other parts of the world. There is an increase in biodiversity at high latitudes, an opposite trend to the current paradigm. Facilitation, competition and grazers shape these patterns at local scales, while there are few predators and their size is frequently small, having lower effects than predators in other coasts. The role of invasive species and anthropogenic impacts on the rocky shores are reviewed as well as the global change effect along the coast. We conclude by considering the knowledge gaps and the special features of Argentine rocky shores which are shaped by their environmental setting and phylogeographic history leading to low diversity, missing functional groups for some taxa and a gradient of increasing diversity towards the poles.
Copper-sepiolites exchanged at different levels have been studied by ESR, IR, and TG. The results indicate that in the unheated samples the Cu2+ ions are located in octahedral edge positions. After dehydration, the Cu2+ ions occur in two positions with different environments. Some of the Cu2+ ions lose the two molecules of coordinated water in one step, at low dehydration temperatures, and adopt a square pyramidal geometry. Other Cu2+ ions lose the coordination water in two steps, at lower temperature than the natural sepiolite, and adopt a tetrahedral symmetry.
Vertical axis wind turbine blades are subject to rapid, cyclical variations in angle of attack and relative airspeed which can induce dynamic stall. This phenomenon poses an obstacle to the greater implementation of vertical axis wind turbines because dynamic stall can reduce turbine efficiency and induce structural vibrations and noise. This study seeks to provide a more comprehensive description of dynamic stall in vertical axis wind turbines, with an emphasis on understanding its parametric dependence and scaling behaviour. This problem is of practical relevance to vertical axis wind turbine design but the inherent coupling of the pitching and velocity scales in the blade kinematics makes this problem of more broad fundamental interest as well. Experiments are performed using particle image velocimetry in the vicinity of the blades of a straight-bladed gyromill-type vertical axis wind turbine at blade Reynolds numbers of between 50 000 and 140 000, tip speed ratios between $\unicode[STIX]{x1D706}=1$ to $\unicode[STIX]{x1D706}=5$, and dimensionless pitch rates of $0.10\leqslant K_{c}\leqslant 0.20$. The effect of these factors on the evolution, strength and timing of vortex shedding from the turbine blades is determined. It is found that tip speed ratio alone is insufficient to describe the circulation production and vortex shedding behaviour from vertical axis wind turbine blades, and a scaling incorporating the dimensionless pitch rate is proposed.
The statistical properties are presented for the direct numerical simulation of a self-similar adverse pressure gradient (APG) turbulent boundary layer (TBL) at the verge of separation. The APG TBL has a momentum thickness-based Reynolds number range from $Re_{\unicode[STIX]{x1D6FF}_{2}}=570$ to 13 800, with a self-similar region from $Re_{\unicode[STIX]{x1D6FF}_{2}}=10\,000$ to 12 300. Within this domain the average non-dimensional pressure gradient parameter $\unicode[STIX]{x1D6FD}=39$, where for a unit density $\unicode[STIX]{x1D6FD}=\unicode[STIX]{x1D6FF}_{1}P_{\!e}^{\prime }/\unicode[STIX]{x1D70F}_{w}$, with $\unicode[STIX]{x1D6FF}_{1}$ the displacement thickness, $\unicode[STIX]{x1D70F}_{w}$ the mean shear stress at the wall and $P_{\!e}^{\prime }$ the far-field pressure gradient. This flow is compared with previous zero pressure gradient and mild APG TBL ($\unicode[STIX]{x1D6FD}=1$) results of similar Reynolds number. All flows are generated via the direct numerical simulation of a TBL on a flat surface with far-field boundary conditions tailored to apply the desired pressure gradient. The conditions for self-similarity, and the appropriate length and velocity scales, are derived. The mean and Reynolds stress profiles are shown to collapse when non-dimensionalised on the basis of these length and velocity scales. As the pressure gradient increases, the extent of the wake region in the mean streamwise velocity profiles increases, whilst the extent of the log-layer and viscous sublayer decreases. The Reynolds stress, production and dissipation profiles of the APG TBL cases exhibit a second outer peak, which becomes more pronounced and more spatially localised with increasing pressure gradient. This outer peak is located at the point of inflection of the mean velocity profiles, and is suggestive of the presence of a shear flow instability. The maximum streamwise velocity variance is located at a wall normal position of $\unicode[STIX]{x1D6FF}_{1}$ of spanwise wavelength of $2\unicode[STIX]{x1D6FF}_{1}$. In summary as the pressure gradient increases the flow has properties less like a zero pressure gradient TBL and more akin to a free shear layer.
VLBI observations of SiO masers recover at most 40-50% of the total flux obtained by single dish observations at any spectral channel. Some previous studies seems to indicate that, at least, part of the lost flux is divided up into many weak components rather than in a large resolved emission area. Taking benefit of the high sensitivity and resolution of the HSA, we investigate the problem of the missing flux in VLBI observations of SiO maser emission at 7 mm in the AGB stars and obtain a high dynamic range map of IRC+10011. We conclude that the missing flux is mostly contained in many very weak maser components.
Open cavity flows are known to select and enhance locked-on modes or tones. High-energy self-sustained oscillations arise within the shear layer, impinging onto the trailing edge of the cavity. These self-sustained oscillations are subject to amplitude modulations (AMs) at multiple low frequencies. However, only a few studies have addressed the identification of the lowest modulating frequencies. The present work brings to light salient AMs of the shear layer waves and identifies their source as three-dimensional dynamics existing inside the cavity. Indeed, the recirculating inner flow gives rise to centrifugal instabilities, which entail broad-band frequencies down two orders of magnitude lower than those of the self-sustained oscillations. Using time-resolved PIV (TRPIV) in two planes, the nonlinearly saturated dynamics is analysed in both space and time by means of proper orthogonal decomposition, global Fourier decomposition and Hilbert–Huang transforms. The inner flow can be decomposed as three-dimensional waves carried by the main recirculation. Bicoherence distributions are computed to highlight the nonlinear interactions between these spanwise-travelling waves inside the cavity and the locked-on modes. The modulated envelope of the shear layer oscillations is extracted and investigated with regards to the inner-flow dynamics. Strong cross-correlations, in time rather than in space, reveal a global coupling mechanism, possibly related to the beating of the spanwise-travelling waves.
Three-dimensional instabilities arising in open cavity flows are responsible for complex broad-banded dynamics. Existing studies either focus on theoretical properties of ideal simplified flows or observe the final state of experimental flows. This paper aims to establish a connection between the onset of the centrifugal instabilities and their final expression within the fully saturated flow. To that end, a linear three-dimensional modal instability analysis of steady two-dimensional states developing in an open cavity of aspect ratio $L/D=2$ (length over depth) is conducted. This analysis is performed together with an experimental study in the same geometry adding spanwise endwalls. Two different Reynolds numbers are investigated through spectral analyses and modal decomposition. The physics of the flow is thoroughly described exploiting the strengths of each methodology. The main flow structures are identified and salient space and time scales are characterised. Results indicate that the structures obtained from linear analysis are mainly consistent with the fully saturated experimental flow. The analysis also brings to light the selection and alteration of certain wave properties, which could be caused by nonlinearities or the change of spanwise boundary conditions.
Although post-weaning mortality (PWM) in pig farming is mainly due to the effect of pathogens, farm type or swine management are also directly or indirectly involved. In this work, we used null models and the partial least squares approach (PLS) to structural equation modelling, also known as PLS path modelling (PLS-PM), to explore whether farm type, swine management and pathogens, including porcine circovirus type 2, swine influenza virus, porcine reproductive and respiratory syndrome virus and Aujeszky's disease virus, directly or indirectly influenced PWM in 42 Spanish indoor pig farms. The null model analysis revealed that contact with multiple combinations of viruses could occur by chance. On the other hand, PLS-PM showed that farm characteristics do not influence virus infections, and thus neither farm type nor associated management practices shaped PWM due to pathogens. Accordingly, preventive programmes aimed at controlling PWM in intensive farming should prioritize the control of major pig pathogens.
The Australian Square Kilometre Array Pathfinder (ASKAP) will give us an unprecedented opportunity to investigate the transient sky at radio wavelengths. In this paper we present VAST, an ASKAP survey for Variables and Slow Transients. VAST will exploit the wide-field survey capabilities of ASKAP to enable the discovery and investigation of variable and transient phenomena from the local to the cosmological, including flare stars, intermittent pulsars, X-ray binaries, magnetars, extreme scattering events, interstellar scintillation, radio supernovae, and orphan afterglows of gamma-ray bursts. In addition, it will allow us to probe unexplored regions of parameter space where new classes of transient sources may be detected. In this paper we review the known radio transient and variable populations and the current results from blind radio surveys. We outline a comprehensive program based on a multi-tiered survey strategy to characterise the radio transient sky through detection and monitoring of transient and variable sources on the ASKAP imaging timescales of 5 s and greater. We also present an analysis of the expected source populations that we will be able to detect with VAST.
Several European countries have timely all-cause mortality monitoring. However, small changes in mortality may not give rise to signals at the national level. Pooling data across countries may overcome this, particularly if changes in mortality occur simultaneously. Additionally, pooling may increase the power of monitoring populations with small numbers of expected deaths, e.g. younger age groups or fertile women. Finally, pooled analyses may reveal patterns of diseases across Europe. We describe a pooled analysis of all-cause mortality across 16 European countries. Two approaches were explored. In the ‘summarized’ approach, data across countries were summarized and analysed as one overall country. In the ‘stratified’ approach, heterogeneities between countries were taken into account. Pooling using the ‘stratified’ approach was the most appropriate as it reflects variations in mortality. Excess mortality was observed in all winter seasons albeit slightly higher in 2008/09 than 2009/10 and 2010/11. In the 2008/09 season, excess mortality was mainly in elderly adults. In 2009/10, when pandemic influenza A(H1N1) dominated, excess mortality was mainly in children. The 2010/11 season reflected a similar pattern, although increased mortality in children came later. These patterns were less clear in analyses based on data from individual countries. We have demonstrated that with stratified pooling we can combine local mortality monitoring systems and enhance monitoring of mortality across Europe.
The aerodynamically driven annular liquid sheet exhibits a complex nonlinear instability. Novel interfacial velocimetry experiments suggest that two distinct physical sources of instability may be present. The first is the well-known free shear layer instability, which is quasi-sinusoidal and nonlinear. The second is a distinct nonlinear rupturing instability, modulated on the previous one. It may be directly driving primary atomization. This instability has not been previously observed in isolation and is inherently nonlinear and non-sinusoidal. Novel application of Koopman analysis and the Hilbert transform permit investigation of these distinct instabilities. A greater understanding of the rupturing instability may lead to a better understanding of atomization phenomena.
We present the results of SiO maser observations at 43 GHz toward two AGB stars using the VLBA. Our preliminary results on the relative positions of the different J=1–0 SiO masers (v=1,2 and 3) indicate that the current ideas on SiO maser pumping could be wrong at some fundamental level. A deep revision of the SiO pumping models could be necessary.
The present study is motivated by a need to produce stability modes to assist in the understanding and control of unsteady separated flows. The flow configuration is a NACA 0015 aerofoil with laminar leading-edge separation and turbulent recirculation. In previous water tunnel experiments, this flow configuration was measured in an unperturbed (uncontrolled) separated state, and a harmonically perturbed (controlled) reattached state. This study presents numerical data of the unperturbed case, and recovers stability modes to describe the evolution of perturbations in this environment. The unperturbed flow is numerically generated using large eddy simulation. Its temporal properties are quantified via a Fourier analysis of the velocity time history at selected points in space. The leading-edge shear layer instability is characterized by instantaneous vortex structures, and the bluff body shedding is illustrated by proper orthogonal decomposition modes. Statistical measures of the velocity field agree well with the water tunnel measurements. Finally a stability analysis is undertaken using a triple decomposition to distinguish between the time averaged field, the unsteady scales of motion, and a coherent wave (perturbation). This analysis identifies that perturbations in the region immediately downstream of the separated shear layer have the highest spatial growth rates. The associated frequency is of the order of the sub-harmonic of the shear layer instability.