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Steinernema populi n. sp. was recovered by baiting from beneath poplar trees in China. Morphological and molecular features provided evidence for placing the new species into the Kushidai clade. The new species is characterized by the following morphological features: third-stage infective juveniles (IJ) with a body length of 1095 (973–1172) μm, a distance from the anterior end to excretory pore of 77 (70–86) μm and a tail length of 64 (55–72) μm. The Body length/Tail length (c) ratio and Anterior end to Excretory pore/ Tail length × 100 (E%) of S. populi n. sp. are substantially greater than those of all other ‘Feltiae–Kushidai–Monticolum’ group members. The first-generation males can be recognized by a spicule length of 66 (57–77) μm and a gubernaculum length of 46 (38–60) μm. The new species is further characterized by sequences of the internal transcribed spacer and partial 28S regions of the ribosomal DNA. Phylogenetic analyses show that Steinernema akhursti and Steinernema kushidai are the closest relatives to S. populi n. sp.
Hypoxia that occurs in conjunction with sleep-related breathing disorders, such as Obstructive Sleep Apnea, as well as processes associated with cerebral ischemia, have deleterious effects on the morphology and functioning of the hippocampus. In previous studies, we determined that a decrease in oxygenation produces neuroexcitotoxicity that eventuates in apoptosis, i.e., programmed cell death, that can be reduced by the activation of GABAergic processes.
Methods:
In the present experiment, which was conducted in adult guinea pigs, in vivo, we examined the effects of the administration of eszopiclone, which is a hypnotic that activates various GABAA subunit receptors, on apoptosis in various CNS sites.
Results:
Recurrent periods of apnea, which were induced for a period of 3-5 hours, produced significant apoptosis in various brain regions. Compared with control data, there was a highly statistically significant decrease in the number of apoptotic cells in the forebrain (hippocampus, amygdala, and prefrontal, cingulate, and insular cortices) and in the brainstem (e.g., dorsal raphe) in animals that were administered eszopiclone prior to the induction of recurrent apnea.
Conclusions:
We conclude that eszopiclone is capable of providing neuroprotection for the degradative, apoptotic consequences of a decrease in oxygenation of cerebral tissue that arises as a consequence of disease and disorders that involve hypoxia or ischemia. We therefore suggest, in addition to its hypnotic effects, that eszopiclone produces neuroprotection for hypoxia-induced neurodegeneration in the forebrain as well as in the brainstem.
Support for this study provided by Sepracor Inc., Marlborough, MA.
Anxiety disorder in adolescents is a common mental disorder seen in the clinics. It can impair the psychosocial wellbeing of adolescents, influence their academic achievement and increase the family burden. Now cognitive-behavior therapy (CBT) may be the best provided psychotherapy for the treatment of it with a comparable effect with pharmacological treatment. And evidence based medicine had recommended the combining usage of the two treatments.
Purpose:
The aim of the present study was to examine the effectiveness of manual-guided cognitive-behaviour therapy (CBT) for adolescents with anxiety disorder.
Methods:
With the help of foreign manual and consideration of characteristics of Chinese anxiety disorder adolescents, a treatment manual for the treatment of adolescent anxiety disorder in China is established.Clinical control test is formed to test the effect of manual. A cases analyze of the adolescent patients who received the CBT treatment.
Results:
A multimodular and several stage treatment manual for the treatment of Chinese anxious adolescents is established with objectives as oriented.63.7% of the adolescent anxiety disorder patients who received the CBT treatment is recovered. Analyze of patients who receive CBT result three models of requirements.
Conclusions:
The treatment manual in this research is fitted with the characteristics of the adolescent anxiety disorder in China, and it is proved useful in the clinical work.In the CBT treatment of adolescent anxiety disorder, the patients can be classified to three requirement models which should be treated with different focus.
High-energy electron radiography (HEER) has been proposed for time-resolved imaging of materials, high-energy density matter, and for inertial confinement fusion. The areal-density resolution, determined by the image intensity information is critical for these types of diagnostics. Preliminary experimental studies for different materials with the same thickness and the same areal-density target have been imaged and analyzed. Although there are some discrepancies between experimental and theory analysis, the results show that the density distribution can indeed be attained from HEER. The reason for the discrepancies has been investigated and indicates the importance of the uniformity in the transverse distribution beam illuminating the target. Furthermore, the method for generating a uniform transverse distribution beam using octupole magnets was studied and verified by simulations. The simulations also confirm that the octupole field does not affect the angle-position correlation in the center part beam, a critical requirement for the imaging lens. A more practical method for HEER using collimators and octupoles for generating more uniform beams is also described. Detailed experimental results and simulation studies are presented in this paper.
Here a compact three orthogonal planes high-energy electron radiography system was proposed. One of the critical technologies, the ultra-fast beam bunches split from the bunch train are studied. The separated bunches could be transported to the three orthogonal planes of the target for dynamic radiography diagnostics. The key elements of the ultra-fast bunches split system are transverse deflecting cavity (TDC) and the twin septum magnet (TSM). The principle of TDC and TSM are briefly introduced. An example of the beam bunches split system for test experiment (40 MeV electron beam) with TDC and TSM is designed and studied by particle-tracking simulation and it confirms this method is valid and feasible. Especially with TSM, a compact three orthogonal planes radiography system can be realized. The evolution of the beam parameters along the beam line from simulation are investigated. The detailed design of the beam split system and beam dynamics simulation study are presented in this paper.
In our previous research (Zhao et al., 2016), we focus on the transport processes from hot electrons to Kα X-ray emission in a copper foil and nanobrush target when the electron refluxing effect is not taken into account. In this work, considering the refluxing effect, the transport of hot electrons in a solid target is studied by adding the electric fields both at the front and rear surfaces of the target with Monte Carlo code Geant4. Simulation results show that the electron refluxing has an important influence on Kα photon yield and the size of Kα radiation source. Kα yield from the 10-μm-thick target with the electron refluxing effect is 2.7–3.7 times more than that without the refluxing for the electron temperatures from 0.4 to 1.4 MeV. The laser-to-Kα photon energy conversion efficiency ${\rm \eta} _{L \to K_{\rm \alpha}} $ with the refluxing effect is always higher than that without the refluxing, and both of them decrease gradually with laser strength Iλ2. Considering the electron refluxing effect or not, the variations of Kα yield with the target thickness d are very different. A critical thickness of the target dc (~30 μm) is achieved to confirm whether the refluxing effect is valid for the target. For the target with the thickness d less than dc, the refluxing effect can enhance Kα yield with several times, while for the target with the thickness d larger than dc, the refluxing effect is not so effective. The full-width at half-maximum increases from 23 to 56 µm after including the refluxing effect by the electron beam with the radius of 10 µm and the temperature of 400 keV.
A new approach is proposed to analyze Bremsstrahlung X-rays that are emitted from laser-produced plasmas (LPP) and are measured by a stack type spectrometer. This new method is based on a spectral tomographic reconstruction concept with the variational principle for optimization, without referring to the electron energy distribution of a plasma. This approach is applied to the analysis of some experimental data obtained at a few major laser facilities to demonstrate the applicability of the method. Slope temperatures of X-rays from LPP are determined with a two-temperature model, showing different spectral characteristics of X-rays depending on laser properties used in the experiments.
This study examined sequence variability in internal transcribed spacers (ITS) of nuclear ribosomal DNA among Syphacia obvelata and Aspiculuris tetraptera isolates from laboratory mice from different geographical locations in China. ITS1, 5.8S and ITS2 rDNA were amplified separately from adult S. obvelata and A. tetraptera individuals by polymerase chain reaction (PCR), and the amplicons were subjected to sequencing from both directions. The lengths of the sequences of ITS1, 5.8S and ITS2 rDNA from both nematodes were 314 bp and 456 bp, 157 bp, and 273 bp and 419 bp, respectively. The intraspecific sequence variations in S. obvelata ITS1 were 0–0.3%. For A. tetraptera they were 0–0.7% in ITS1 and 0–1.0% in ITS2. However, the interspecific sequence differences among members of the infraorder Oxyuridomorpha were significantly higher, being 54.0–65.5% for ITS1 and 55.3–64.1% for ITS2. Phylogenetic analysis based on the combined partial sequences of ITS1 and ITS2 using three inference methods – Bayesian inference, maximum likelihood and maximum parsimony – revealed that all the S. obvelata and A. tetraptera samples formed independent monophyletic groups. Syphacia obvelata was closer to Syphacia muris than to A. tetraptera, consistent with morphological classification. These results demonstrate that ITS1 and ITS2 rDNA sequences are useful markers for population genetic studies of oxyurid nematodes.
Hexagonal boron nitride (hBN) crystals enriched in 10B and 11B isotopes were synthesized using a high temperature (1500° C) Ni-Cr-B reactive-precipitation growth under a N2 atmosphere. Two growth mechanisms were observed: conventional defect-facilitated bulk growth which produced crystals with a platelet-like habit with width and thickness of 20-30 μm and 5 μm, respectively, and vapor-liquid-solid interface growth of hBN whiskers with lengths and diameters as large as 70 μm and 5 μm, respectively. Similar growth mechanisms were seen for samples enriched in either isotope. Isotopic analysis via secondary-ion mass spectrometry showed boron concentrations of 84.4 at% and 93.0 at% for the majority isotopes in the 10B-rich and 11B-rich samples, respectively. Raman spectroscopy showed an increase in peak Raman shift for the 10B-rich sample, having two barely resolved peaks at 1393.5 and 1388.8 cm-1, and a decrease for the 11B-rich sample, having peak at 1359.5 cm-1 (FWHM of 9.4 cm-1), compared to that of natural hBN, with its peak at 1365.8 cm-1 (FWHM of 10.3 cm-1). Raman shift showed a linear trend with increasing 10B concentration allowing for a calibration curve to be developed to estimate 10B enrichment in hBN using non-destructive methods.
In this paper, the tape-helix model is firstly introduced in the field of intense electron beam accelerator to analyze the dispersion effects on the electromagnetic parameters of helical Blumlein pulse forming line (PFL). Work band and dispersion relation of the PFL are analyzed, and the normalized coefficients of spatial harmonics are calculated. Dispersion effects on the important electromagnetic parameters of PFL, such as phase velocity, slow-wave coefficient, electric length and pulse duration, are analyzed as the central topic. In the PFL, electromagnetic waves with different frequencies in the work band of PFL have almost the same phase velocity. When de-ionized water, transformer oil and air are used as the PFL filling dielectric, respectively, the pulse duration of the helical Blumlein PFL is calculated as 479.6 ns, 81.1 ns and 53.1 ns in order. Electromagnetic wave simulation and experiments are carried out to demonstrate the theoretical calculations of the electric length and pulse duration which directly describe the phase velocity and dispersion of the PFL. Simulation results prove the theoretical analysis and calculation on pulse duration. Experiment is carried out based on the tape-helix Blumlein PFL and magnetic switch system. Experimental results show that the pulse durations are tested as 460 ns, 79 ns and 49 ns in order when de-ionized water, transformer oil and air are used respectively. Experimental results basically demonstrate the theoretical calculations and the analyses of dispersion.
With a wide band gap of greater than 3.0 eV and the ability to self-heal from radiation damage, icosahedral boron arsenide (B12As2) is an apt candidate for use in next-generation betavoltaics. By capturing and converting high energy electrons from radioisotopes into usable electricity, “nuclear batteries” made from B12As2 could potentially power devices for decades. Compared to bulk crystals or epitaxial films, B12As2 nanowires may have lower defect densities or may even be defect-free, leading to better electrical properties and device performance. In our study, B12As2 nanowires were synthesized via vapor-liquid-solid (VLS) growth using platinum powder and nickel powder on silicon carbide and 20 nm thick nickel film on silicon substrates from 700 °C to 1200 °C. Platinum yielded the highest quality nanowires from 900 °C to 950 °C, resulting in platinum particles densely covered with wires formed by straight segments connected by sharp angular kinks. At these growth temperatures, diameters ranged from less than 30 nm to about 300 nm as determined by scanning electron microscopy and transmission electron microscopy. Growth temperatures of 850 °C or less produced curled wires 200-1000 nm in diameter. Transmission electron microscopy and selected area electron diffraction revealed excellent crystallinity in wires grown above 850 °C, while wires grown at or below 850 °C were partially amorphous. Wires grown from the 20 nm nickel film displayed similar morphologies at temperatures up to 850 °C; from 900 °C to 950 °C, straight, isolated wires were grown with diameters of 200-400 nm. Nickel powder only produced wires larger than 1 μm in diameter. The comparative quality and growth of B12As2nanowires will be discussed.
The present work reports on the defect-selective etching (DSE) for estimating dislocation densities in icosahedral boron arsenide (B12As2) crystals using molten potassium hydroxide (KOH). DSE takes advantage of the greater reactivity of high-energy sites surrounding a dislocation, compared to the surrounding dislocation-free regions. The etch pits per area are indicative of the defect densities in the crystals, as confirmed by x-ray topography (XRT). Etch pit densities were determined for icosahedral boron arsenide crystals produced from a molten nickel flux as a function of etch time (1-5 minutes) and temperature (400-700°C). The etch pits were predominately triangle shaped, and ranged in size from 5-25μm. The average etch pit density of the triangle and oval etch-pits was on the order of 5x107cm-2 and 3x106cm-2 (respectively), for crystals that were etched for two minutes at 550°C.
The crystallographic properties of bulk icosahedral boron arsenide (B12As2) crystals grown by precipitation from molten nickel solutions were characterized. Large crystals (5-8 mm) were produced by dissolving the boron in nickel at 1150°C for 48-72 hours, reacting with arsenic vapor, and slowly cooling to room temperature. The crystals varied in color from black and opaque to clear and transparent. Raman spectroscopy, x-ray topography (XRT), and defect selective etching revealed that the B12As2 single crystals were high quality with low dislocation densities. Furthermore, XRT results suggest that the major face of the plate-like crystals was (111) type, while (100), (010) and (001) type facets were also observed optically. The predominant defect in these crystals was edge character growth dislocations with a <001> Burgers vector, and <-110> line direction. In short, XRT characterization shows that solution growth is a viable method for producing good quality B12As2 crystals.
Objective: To investigate the effects of various activation methods on freeze–thawed rabbit oocytes developmental potential. Methods: Rabbit oocytes were vitrified by cryoleafs and cryoprotected with ethylene glycol and propanediol. After thawing, the oocytes were fertilized by intracytoplasmic sperm injection (ICSI). Surviving oocytes after ICSI were divided into five groups at random. Group 1: Oocytes (n = 30) activated 1 h after ICSI by calcium ionomycin (I0634); Group 2: Oocytes (n = 26) activated by strontium chloride an hour after ICSI; Group 3: Oocytes (n = 33) activated by I0634 twice; Group 4: Oocytes (n = 28) were activated by strontium chloride twice; Control Group: Inactivated oocytes (n = 39). Blastocysts derived from each group were transplanted to recipient rabbits. Results: Rates of fertilization, cleavage and blastocyst formation of Group 3 were higher than those of Group 1 and Group 2 (81.8% vs 33.3% vs 53.8%, 54.5% vs 16.7% vs 26.9%, p < 0.05; 15.2% vs 3.3% vs 7.7%, p > 0.05). The rabbit transplanted with embryos derived from Group 3 became pregnant. Embryos derived from double activation could implant into endometrium. Conclusion: Double activation may increase freeze–thawed oocytes developmental potential. After activation, oocytes cleavage velocity may be faster than that of oocytes without activation.
The Pb(ZrxTi1–x)O3(PZT) films sputter deposited on LaNiO3(LNO)/Si(100) substrates were recrystallized to highly (l00)-oriented perovskite structure by high oxygen-pressure processing (HOPP) and high argon-pressure processing (HAPP), which were performed at a relatively low temperature 400 °C compared to the normally required temperature condition above 600 °C. Ferroelectricity of PZT films was investigated by a measurement of P-E hysteresis loop. The P-E hysteresis loops of the PZT(52/48) and PZT(30/70) films after HOPP showed better squareness and larger remnant polarization than those of as-sputtered ones prepared at a high temperature of 600 °C. Although the PZT films with HAPP also showed a high (l00)-oriented perovskite structure and obvious ferroelectricity, their P-E loops suggested relatively poor ferroelectricity compared to those of the PZT films with HOPP. This means that a further optimization for HAPP is needed to improve ferroelectricity of PZT films.
Glass-forming ability (GFA) in relation to microstructure evolution in the ternary Fe–Nb–B and Fe–Zr–B and quaternary Fe–(Nb,Zr)–B systems was systematically studied in a three-dimensional composition space. Through navigating, it was revealed that alloys with the optimum glass-forming ability (GFA) are coupled with composition regions surrounded by competing crystalline phases. Alloys Fe71Nb6B23, Fe77Zr4B19, and Fe71(Nb0.8Zr0.2)6B23 were illustrated to be the best glass formers in the ternary Fe–Nb–B and Fe–Zr–B systems and the quaternary Fe–(Nb,Zr)–B system, respectively, with a critical size for amorphous formation up to 2 mm. They were compared with the theoretical predictions on the basis of an efficient dense-packing model, and good agreements were obtained.
An electron-beam accelerator based on spiral water pulse forming line which consists of a primary storage capacitor system, an air core spiral strip transformer, a spiral pulse forming line of water dielectric, and a field-emission diode, is described. The experimental results showed that the diode voltage is more than 500 kV, the electron beam current of diode is about 24 kA, and the pulse duration is about 200 ns. The main parameters of the accelerator were calculated theoretically. The distributions for electrical field in the pulse forming line were obtained by the simulations. In addition, the process of the accelerator charging a spiral pulse forming line was simulated through the Pspice software to get the waveforms of charging voltage of pulse forming line, the diode voltage and diode current of accelerator. The theoretical and simulated results agree with the experimental results. This accelerator is very compact and works stably and reliably.
We demonstrated a facile route based on the use of acetone and polyvinylpyrrolidone (PVP) to prepare polystyrene (PS)/Ag/TiO2 multilayered colloids with controllable shell thickness. In this route, PVP absorbed directly onto PS colloid surface, and the Ag seed shell composed of Ag nanoparticles was synthesized directly under the PVP shell by swelling the surface layer of the PS core. Because the PVP shell increased the affinity of the Ag shell to TiO2, the hydrolyzed titania particles could deposit directly onto the core to form the outer TiO2 shell. A seed growth technique and the controllable hydrolysis reaction of tetra-n-butyl titanate were developed to grow the shell thickness of Ag and TiO2, respectively. Studies of the absorption properties indicate that the optical properties of these multilayered composite colloids can be modified by changing the coating species and shell thickness.
On 28 Oct 2003, one of the biggest flares (4B/X17.2) seen in recent years occurred in Active Region (AR) NOAA 10486 associated with a violent halo coronal mass ejection. It was a complex $\beta\gamma\delta$ region. After studying the evolution of the AR and the phenomena of this powerful flare, we obtained the following result. (1) Highly sheared transverse field was formed gradually on both sides of the neutral line by squeeze during the AR development; (2) Rotations of penumbra of main polarities were discerned, and the average horizontal velocities was as large as 0.55 km/s; (3) The spiral transverse field of main positive polarity was diffused after the large flare; (4) Some magnetic features submerged or emerged in the vicinity of the flare onset point. The emergence of this rotational and complex magnetic topology implies a transport of magnetic energy and complexity from the low atmosphere to the corona. Moreover, the rapidly submergence (emergence) and movements of the small magnetic features which represent the enhancement (cancellation) and squeeze of the magnetic field play a key role in the onset of the flare.To search for other articles by the author(s) go to: http://adsabs.harvard.edu/abstract_service.html