We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Routine immunization programs may reduce antibiotic use, but few studies have comprehensively examined their impact on antibiotic utilization. We aimed to explore temporal trends in vaccination and antibiotic use among young children in the United States.
Design:
Ecological study using the Merative® MarketScan Commercial Claims and Encounters database.
Methods:
We analyzed claims data on pediatric vaccine uptake (pneumococcal conjugate, Haemophilus influenzae type b, diphtheria-tetanus-pertussis, and influenza) and antibiotic prescriptions and antibiotic-treated respiratory tract infections among US children <5 years during 2000–2019. Vaccination status was assessed annually, and children were categorized based on receipt of all four vaccines, 1–3 vaccines, or no vaccines. Antibiotic prescriptions were classified by spectrum and drug class. Respiratory infections included otitis media, pharyngitis, pneumonia, sinusitis, and viral infections.
Results:
Among 6.7 million children, vaccine uptake increased from 32.5% receiving all four vaccines in 2004 to 66.8% in 2019. During this period, overall antibiotic prescriptions decreased from 1.89 to 1.01 per person-year, with the greatest reductions in macrolides (73.3%) and broad-spectrum antibiotics (57.0%). Antibiotic-treated respiratory tract infections declined from 2.43 to 1.61 episodes per person-year, with the largest decreases in sinusitis (64.7%) and pharyngitis (39.8%).
Conclusions:
The findings suggest a temporal association between routine childhood immunization uptake and reduced antibiotic utilization. Although immunization programs are primarily aimed at protecting children from vaccine-preventable diseases, their potential role in complementing antimicrobial stewardship efforts and other factors influencing antibiotic reduction warrants further investigation through more rigorous study designs.
Background: The WHO grade of meningioma was updated in 2021 to include homozygous deletions of CDKN2A/B and TERT promotor mutations. Previous work including the recent cIMPACT-NOW statement have discussed the potential value of including chromosomal copy number alterations to help refine the current grading system. Methods: Chromosomal copy number profiles were inferred from from 1964 meningiomas using DNA methylation. Regularized Cox regresssion was used to identify CNAs independenly associated with post-surgical and post-RT PFS. Outcomes were stratified by WHO grade and novel CNAs to assess their potential value in WHO critiera. Results: Patients with WHO grade 1 tumours and chromosome 1p loss had similar outcomes to those with WHO grade 2 tumours (median PFS 5.83 [95% CI 4.36-Inf] vs 4.48 [4.09-5.18] years). Those with chromosome 1p loss and 1q gain had similar outcomes to those with WHO grade 3 cases regardless of initial grade (median PFS 2.23 [1.28-Inf] years WHO grade 1, 1.90 [1.23-2.25] years WHO grade 2, compared to 2.27 [1.68-3.05] years in WHO grade 3 cases overall). Conclusions: We advocate for chromosome 1p loss being added as a criterion for a CNS WHO grade of 2 meningioma and addition of 1q gain as a criterion for a CNS WHO grade of 3.
Background: Meningiomas exhibit considerable heterogeneity. We previously identified four distinct molecular groups (immunogenic, NF2-wildtype, hypermetabolic, proliferative) which address much of this heterogeneity. Despite their utility, the stochasticity of clustering methods and the requirement of multi-omics data limits the potential for classifying cases in the clinical setting. Methods: Using an international cohort of 1698 meningiomas, we constructed and validated a machine learning-based molecular classifier using DNA methylation alone. Original and newly-predicted molecular groups were compared using DNA methylation, RNA sequencing, whole exome sequencing, and clinical outcomes. Results: Group-specific outcomes in the validation cohort were nearly identical to those originally described, with median PFS of 7.4 (4.9-Inf) years in hypermetabolic tumors and 2.5 (2.3-5.3) years in proliferative tumors (not reached in the other groups). Predicted NF2-wildtype cases had no NF2 mutations, and 51.4% had others mutations previously described in this group. RNA pathway analysis revealed upregulation of immune-related pathways in the immunogenic group, metabolic pathways in the hypermetabolic group and cell-cycle programs in the proliferative group. Bulk deconvolution similarly revealed enrichment of macrophages in immunogenic tumours and neoplastic cells in hypermetabolic/proliferative tumours. Conclusions: Our DNA methylation-based classifier faithfully recapitulates the biology and outcomes of the original molecular groups allowing for their widespread clinical implementation.
The 1994 discovery of Shor's quantum algorithm for integer factorization—an important practical problem in the area of cryptography—demonstrated quantum computing's potential for real-world impact. Since then, researchers have worked intensively to expand the list of practical problems that quantum algorithms can solve effectively. This book surveys the fruits of this effort, covering proposed quantum algorithms for concrete problems in many application areas, including quantum chemistry, optimization, finance, and machine learning. For each quantum algorithm considered, the book clearly states the problem being solved and the full computational complexity of the procedure, making sure to account for the contribution from all the underlying primitive ingredients. Separately, the book provides a detailed, independent summary of the most common algorithmic primitives. It has a modular, encyclopedic format to facilitate navigation of the material and to provide a quick reference for designers of quantum algorithms and quantum computing researchers.
Ice shelves affect the stability of ice sheets by supporting the mass balance of ice upstream of the grounding line. Marine ice, formed from supercooled water freezing at the base of ice shelves, contributes to mass gain and affects ice dynamics. Direct measurements of marine ice thickness are rare due to the challenges of borehole drilling. Here we assume hydrostatic equilibrium to estimate marine ice distribution beneath the Amery Ice Shelf (AIS) using meteoric ice-thickness data obtained from radio-echo sounding collected during the Chinese National Antarctic Research Expedition between 2015 and 2019. This is the first mapping of marine ice beneath the AIS in nearly 20 years. Our new estimates of marine ice along two longitudinal bands beneath the northwest AIS are spatially consistent with earlier work but thicker. We also find a marine ice layer exceeding 30 m of thickness in the central ice shelf and patchy refreezing downstream of the grounding line. Thickness differences from prior results may indicate time-variation in basal melting and freezing patterns driven by polynya activity and coastal water intrusions masses under the ice shelf, highlighting that those changes in ice–ocean interaction are impacting ice-shelf stability.
This chapter covers quantum algorithmic primitives for loading classical data into a quantum algorithm. These primitives are important in many quantum algorithms, and they are especially essential for algorithms for big-data problems in the area of machine learning. We cover quantum random access memory (QRAM), an operation that allows a quantum algorithm to query a classical database in superposition. We carefully detail caveats and nuances that appear for realizing fast large-scale QRAM and what this means for algorithms that rely upon QRAM. We also cover primitives for preparing arbitrary quantum states given a list of the amplitudes stored in a classical database, and for performing a block-encoding of a matrix, given a list of its entries stored in a classical database.
This chapter covers the multiplicative weights update method, a quantum algorithmic primitive for certain continuous optimization problems. This method is a framework for classical algorithms, but it can be made quantum by incorporating the quantum algorithmic primitive of Gibbs sampling and amplitude amplification. The framework can be applied to solve linear programs and related convex problems, or generalized to handle matrix-valued weights and used to solve semidefinite programs.
This chapter covers quantum algorithmic primitives related to linear algebra. We discuss block-encodings, a versatile and abstract access model that features in many quantum algorithms. We explain how block-encodings can be manipulated, for example by taking products or linear combinations. We discuss the techniques of quantum signal processing, qubitization, and quantum singular value transformation, which unify many quantum algorithms into a common framework.
In the Preface, we motivate the book by discussing the history of quantum computing and the development of the field of quantum algorithms over the past several decades. We argue that the present moment calls for adopting an end-to-end lens in how we study quantum algorithms, and we discuss the contents of the book and how to use it.
This chapter covers the quantum adiabatic algorithm, a quantum algorithmic primitive for preparing the ground state of a Hamiltonian. The quantum adiabatic algorithm is a prominent ingredient in quantum algorithms for end-to-end problems in combinatorial optimization and simulation of physical systems. For example, it can be used to prepare the electronic ground state of a molecule, which is used as an input to quantum phase estimation to estimate the ground state energy.
This chapter covers quantum linear system solvers, which are quantum algorithmic primitives for solving a linear system of equations. The linear system problem is encountered in many real-world situations, and quantum linear system solvers are a prominent ingredient in quantum algorithms in the areas of machine learning and continuous optimization. Quantum linear systems solvers do not themselves solve end-to-end problems because their output is a quantum state, which is one of its major caveats.
This chapter presents an introduction to the theory of quantum fault tolerance and quantum error correction, which provide a collection of techniques to deal with imperfect operations and unavoidable noise afflicting the physical hardware, at the expense of moderately increased resource overheads.
This chapter covers the quantum algorithmic primitive called quantum gradient estimation, where the goal is to output an estimate for the gradient of a multivariate function. This primitive features in other primitives, for example, quantum tomography. It also features in several quantum algorithms for end-to-end problems in continuous optimization, finance, and machine learning, among other areas. The size of the speedup it provides depends on how the algorithm can access the function, and how difficult the gradient is to estimate classically.
This chapter covers quantum algorithms for numerically solving differential equations and the areas of application where such capabilities might be useful, such as computational fluid dynamics, semiconductor chip design, and many engineering workflows. We focus mainly on algorithms for linear differential equations (covering both partial and ordinary linear differential equations), but we also mention the additional nuances that arise for nonlinear differential equations. We discuss important caveats related to both the data input and output aspects of an end-to-end differential equation solver, and we place these quantum methods in the context of existing classical methods currently in use for these problems.
This chapter covers the quantum algorithmic primitive of approximate tensor network contraction. Tensor networks are a powerful classical method for representing complex classical data as a network of individual tensor objects. To evaluate the tensor network, it must be contracted, which can be computationally challenging. A quantum algorithm for approximate tensor network contraction can provide a quantum speedup for contracting tensor networks that satisfy certain conditions.
This chapter provides an overview of how to perform quantum error correction using the surface code, which is the most well-studied quantum error correcting code for practical quantum computation. We provide formulas for the code distance—which determines the resource overhead when using the surface code—as a function of the desired logical error rate and underlying physical error rate. We discuss several decoders for the surface code and the possibility of experiencing the backlog problem if the decoder is too slow.