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This study assesses the relationship between adverse childhood experiences (ACE) occurring before the age of 18 years and patterns of fast-food consumption and sugary beverage consumption in adulthood. The study also examines how perceived stress and socio-economic status (SES) (college educational attainment and income) in adulthood mediate this relationship.
Design:
Using data from the National Longitudinal Study of Adolescent to Adulthood Health (N 8599), multinomial logistic regression analyses were carried out to assess the association between ACE and unhealthy dietary behaviours in adulthood. Karlson–Holm–Breen mediation analysis is used to determine the mediating effects of SES and perceived stress.
Setting:
Persons living in the USA in 2016–2018.
Participants:
Adults (n 8599) aged 33–44 years.
Results:
The findings show an association between four or more ACE and high fast-food (relative risk ratio (RRR) = 1·436, 95 % CI = 1·040, 1·983) and high sugary beverage consumption (RRR = 1·435, 95 % CI = 1·002, 2·055). The association between ACE and high fast-food consumption is partially mediated by college educational attainment, and the association between ACE and high sugary beverage consumption is partially mediated by perceived stress and college educational attainment.
Conclusions:
ACE can have long-term consequences for unhealthy dietary behaviours in adulthood, and this relationship is partially due to a lower likelihood of higher perceived stress and college educational attainment among ACE-exposed persons. Future research is needed to understand further the influence of ACE on dietary patterns over the life course.
Binge eating disorder (BED) is a pernicious psychiatric disorder which is linked with broad medical and psychiatric morbidity, and obesity. While BED may be characterized by altered cortical morphometry, no evidence to date examined possible sex-differences in regional gray matter characteristics among those with BED. This is especially important to consider in children, where BED symptoms often emerge coincident with rapid gray matter maturation.
Methods
Pre-adolescent, 9–10-year old boys (N = 38) and girls (N = 33) with BED were extracted from the 3.0 baseline (Year 0) release of the Adolescent Brain Cognitive Development Study. We investigated sex differences in gray matter density (GMD) via voxel-based morphometry. Control sex differences were also assessed in age and body mass index and developmentally matched control children (boys N = 36; girls N = 38). Among children with BED, we additionally assessed the association between dorsolateral prefrontal (dlPFC) GMD and parent-reported behavioral approach and inhibition tendencies.
Results
Girls with BED uniquely demonstrate diffuse clusters of greater GMD (p < 0.05, Threshold Free Cluster Enhancement corrected) in the (i) left dlPFC (p = 0.003), (ii) bilateral dmPFC (p = 0.004), (iii) bilateral primary motor and somatosensory cortex (p = 0.0003) and (iv) bilateral precuneus (p = 0.007). Brain-behavioral associations suggest a unique negative correlation between GMD in the left dlPFC and behavioral approach tendencies among girls with BED.
Conclusions
Early-onset BED may be characterized by regional sex differences in terms of its underlying gray matter morphometry.
Behavioral features of binge eating disorder (BED) suggest abnormalities in reward and inhibitory control. Studies of adult populations suggest functional abnormalities in reward and inhibitory control networks. Despite behavioral markers often developing in children, the neurobiology of pediatric BED remains unstudied.
Methods
58 pre-adolescent children (aged 9–10-years) with BED (mBMI = 25.05; s.d. = 5.40) and 66 age, BMI and developmentally matched control children (mBMI = 25.78; s.d. = 0.33) were extracted from the 3.0 baseline (Year 0) release of the Adolescent Brain Cognitive Development (ABCD) Study. We investigated group differences in resting-state functional MRI functional connectivity (FC) within and between reward and inhibitory control networks. A seed-based approach was employed to assess nodes in the reward [orbitofrontal cortex (OFC), nucleus accumbens, amygdala] and inhibitory control [dorsolateral prefrontal cortex, anterior cingulate cortex (ACC)] networks via hypothesis-driven seed-to-seed analyses, and secondary seed-to-voxel analyses.
Results
Findings revealed reduced FC between the dlPFC and amygdala, and between the ACC and OFC in pre-adolescent children with BED, relative to controls. These findings indicating aberrant connectivity between nodes of inhibitory control and reward networks were corroborated by the whole-brain FC analyses.
Conclusions
Early-onset BED may be characterized by diffuse abnormalities in the functional synergy between reward and cognitive control networks, without perturbations within reward and inhibitory control networks, respectively. The decreased capacity to regulate a reward-driven pursuit of hedonic foods, which is characteristic of BED, may in part, rest on this dysconnectivity between reward and inhibitory control networks.
To estimate the association between food insufficiency and mental health service utilisation in the USA during the COVID-19 pandemic.
Design:
Cross-sectional study. Multiple logistic regression models were used to estimate the associations between food insufficiency and mental health service utilisation.
Setting:
US Census Household Pulse Survey data collected in October 2020.
Participants:
Nationally representative sample of 68 611 US adults.
Results:
After adjusting for sociodemographic factors, experiencing food insufficiency was associated with higher odds of unmet mental health need (adjusted OR (AOR) 2·90; 95 % CI 2·46, 3·43), receiving mental health counselling or therapy (AOR 1·51; 95 % CI 1·24, 1·83) and psychotropic medication use (AOR 1·56; 95 % CI 1·35, 1·80). Anxiety and depression symptoms mediated most of the association between food insufficiency and unmet mental health need but not the associations between food insufficiency and either receiving mental health counselling/therapy or psychotropic medication use.
Conclusions:
Clinicians should regularly screen patients for food insufficiency, especially in the wake of the COVID-19 pandemic. Expanding access to supplemental food programmes may help to mitigate the need for higher mental health service utilisation during the COVID-19 pandemic.
We sought to provide the first point prevalence estimates of muscle dysmorphia (MD), a form of body dysmorphic disorder characterized by a preoccupation with perceived insufficient muscularity, in adolescents.
Methods
Data were taken from a survey of 3618 Australian adolescents (11.172–19.76 years; 49.3% girls). Measures captured demographic characteristics, symptoms of MD and eating disorders, psychological distress and functional impairment. Diagnostic criteria for MD developed by Pope et al. (1997, Psychosomatics, 38(6), 548–557) were applied, entailing preoccupation with insufficient muscularity causing significant levels of distress or disability that cannot be better accounted for by an eating disorder.
Results
The point prevalence of MD was 2.2% [95% confidence interval (CI) 1.6–3.0%] among boys and 1.4% (95% CI 0.9–2.0%) among girls. Prevalence was not associated with gender (V = 0.031) or socioeconomic status (SES) (partial η2< 0.001), but was marginally associated with older age (partial η2 = 0.001). Boys with MD were more likely than girls with MD to report severe preoccupation with muscularity (V = 0.259) and a weight-lifting regime that interfered with their life (V = 0.286), whereas girls with MD were more likely to report discomfort with body exposure (V = 0.380).
Conclusions
While future epidemiological research using diagnostic interviews is needed to verify these estimates, the findings suggest that MD is relatively common from early to late adolescence. Gender differences in MD prevalence may be minimal; however, the symptom profile appears to diverge between boys and girls. These findings provide a platform for future, analytical research designed to inform clinical and public health interventions.
In November 2016, a woman in her 30s who stayed at an insecure, temporary housing facility, a manga café in Tokyo, Japan, for a year was diagnosed with sputum smear-positive tuberculosis (TB). Since the café had 31 staff members and provided with accommodation to many people, the local health office initiated a contact investigation. This study aims to characterise the cases found in the outbreak. A TB case was defined as a person tested bacteriologically positive for TB, or was determined to have TB by a physician. A latent TB infection case was defined as a person tested positive by interferon-γ release assay. From January 2016 through November 2017, there were 31 staff members at the manga café, of which, six developed TB disease (one smear-negative, culture-positive and five smear- and culture-negative) in addition to seven LTBI. Another long-term customer was found having sputum smear-positive TB. Variable numbers tandem repeat (VNTR) test revealed that the index patient and the long-term customer had the identical type of VNTR; however, one staff member had a different VNTR. Local health authorities should intensify screening long-term customers of such facilities for TB regularly as well as once a TB outbreak occurs.
High dietary energy density (ED) has been associated with weight gain. However, little is known about the long-term effects of ED on weight changes among free-living subjects, particularly in Japanese and other Asian populations. In this study, we assessed dietary habits and weight changes in participants (5778 males and 7440 females, 35–69 years old) of the Takayama study. ED was estimated using a validated FFQ at baseline only. Information on body weight (BW) was obtained by self-administered questionnaires at baseline and follow-up. Mean BW difference in 9·8 years was 17 (se 4221) g for men and −210 (se 3889) g for women. In men, ED was positively associated with BW at follow-up after controlling for age, BW, height, physical activity score, alcohol consumption, energy intake, years of education at the baseline and change of smoking status during the follow-up. On average, men in the highest quartile of ED (>5·322 kJ/g (>1·272 kcal/g)) gained 138 (se 111) g, whereas men in the lowest ED (<1·057) lost 22 (se 111) g (Pfor trend=0·01). The association between ED and BW gain was stronger in men with normal weight. In women, the association between ED and weight change was not statistically significant. In conclusion, contrary to some studies that report an association between ED and weight gain in the overweight only, our data suggest that high-ED diets may be associated with weight gain in the lean population as well, at least in male subjects.
Three spatially extended travelling wave exact coherent states, together with one spanwise-localised state, are presented for channel flow. Two of the extended flows are derived by homotopy from solutions to the problem of channel flow subject to a spanwise rotation investigated by Wall & Nagata (J. Fluid Mech., vol. 727, 2013, pp. 523–581). Both these flows are asymmetric with respect to the channel centreplane, and feature streaky structures in streamwise velocity flanked by staggered vortical structures. One of these flows features two streak/vortex systems per spanwise wavelength, while the other features one such system. The former substantially reduces the value of the lowest Reynolds number at which channel flow solutions ,other than the basic flow, are known to exist down to 665. The third flow has, in contrast, half-turn rotational symmetry about a streamwise axis through a point on the channel centreplane, and is found to be the flow from which one of the asymmetric flows bifurcates in a symmetry-breaking bifurcation. This flow is found to exist on an isolated bifurcation branch, whose upper and lower branches both lie on the boundary basin separating initial conditions that lead to turbulent events, and those that directly decay back to laminar flow. The structure of this flow, in which the disturbance to the basic flow is concentrated in a core region in a spanwise period, allowed the derivation of a corresponding spanwise-localised flow, which is also discussed.
Two new families of exact coherent states are found in plane Poiseuille flow. They are obtained from the stationary and the travelling-wave mirror-symmetric solutions in plane Couette flow by a homotopy continuation. They are characterized by the mirror symmetry inherited from those continued solutions in plane Couette flow. The first family arises from a saddle-node bifurcation and the second family bifurcates by breaking the top–bottom symmetry of the first family. We find that both families exist below the minimum saddle-node-point Reynolds number known to date (Waleffe, Phys. Fluids, vol. 15, 2003, pp. 1517–1534).
Three-dimensional exact, finite-amplitude solutions are presented for the problem of channel flow subject to a system rotation about a spanwise axis. The solutions are of travelling wave form, and may bifurcate as tertiary flows from the two-dimensional streamwise-independent secondary flow, or as secondary flows directly from the basic flow. For the tertiary flows, we consider solutions of spanwise superharmonic and subharmonic type. We distinguish flows on the basis of symmetry, originating eigenmode and major solution branch, and thus identify 15 distinct flows: 5 superharmonic tertiary, 5 subharmonic tertiary and 5 secondary flows. The tertiary flows all feature a single layer of vortical structures in the spanwise–wall-normal plane, the secondary flows feature single-, double-, triple- or quadruple-layer flow structures in this plane. All flows feature low-speed streamwise-orientated streaks in the streamwise velocity component and/or pulses of low-speed streamwise velocity. The streaks may be sinusoidal or varicose. Sinusoidal streaks are flanked by staggered streamwise vortices, varicose streaks and pulses are flanked by aligned vortices. A comparison with previous simulation and experimental studies finds that the simplest three-dimensional flows observed previously correspond to superharmonic tertiary flows bifurcating from the upper branch of the secondary flow. The mean absolute vorticity of the present flows is also considered. A flattening of the profile of this vorticity is observed in the central region of the channel for two-dimensional secondary and many of the three-dimensional flows, with two-step profiles also observed. This phenomenon is attributed to mixing of the vorticity across zones of the channel in which streamwise vortex structures exist, and is demonstrated by a two-dimensional model. The phenomenon appears to be distinct to that observed in fully turbulent rotating channel flows.
We note that the mirror-symmetric solution in plane Couette flow, found recently by Gibson, Halcrow & Cvitanović (J. Fluid Mech., vol. 611, 2009, pp. 107–130) and Itano & Generalis (Phys. Rev. Lett., vol. 102, 2009, p. 114501), belongs to the solution group classified as ‘ribbon’ in rotating-plane Couette flow (RPCF). It represents a subcritical (in terms of the system rotation) solution at zero rotation rate on the three-dimensional tertiary flow branch which bifurcates from the second streamwise-independent flow in RPCF. The way of its appearance is similar to that of the Nagata solution (J. Fluid Mech., vol. 217, 1990, pp. 519–527), which lies on the subcritical three-dimensional tertiary flow branch bifurcating from the first streamwise-independent flow in RPCF.
We present a large-scale view of the magnetic field (MF) in the central 3° × 2° region of our Galaxy. There is a smooth transition of the large-scale MF configuration in this region.
Trauma care is one of the key components of disaster medicine. However, it is difficult in Japan to gain extensive experience in trauma surgery, especially penetrating trauma. The Advanced Trauma Operative Management (ATOM) course was developed as a model for teaching operative trauma techniques to surgical residents, fellows, and attending surgeons as the number of these cases decreases in the US. In 2008, a new ATOM training site was established at Jichi Medical University in Japan, and as of December, 2010, five courses have been offered.
Methods
The ATOM course consists of lectures and a porcine operative experience. Comprehensive evaluation of ATOM was designed to assess participant learning in the cognitive, affective, and psychomotor domains. Data on the first 36 participants was retrospectively collected and analyzed.
Results
Participants included: 20 expert trauma surgeons, and 16 general surgeons. All groups showed improvement in knowledge (pre-test score: 61.9 ± 16.4 (mean ± standard deviation), post-test score: 70.6 ± 16.5, p-value < 0.001) with results in the expert and fellow groups reaching statistical significance. Self-confidence also improved (pre-evaluation score: 65.4 ± 17.6, post-evaluation score: 82.0 ± 9.4, p-value < 0.001), with all groups reaching statistical significance.
Discussion
This course creates real operative situations in a standardized fashion that improves knowledge and operative confidence for trauma operations, which may be of great benefit in disaster medicine training.
Disaster preparedness is one of the national priorities. In Japan, disaster medicine is defined as a part of the national medical plan initiated by Ministry of Health, Welfare and Labor. The Japan Medical Association is the largest professional physicians' group in Japan, and has contributed to all kinds of disaster relief work regionally and nation-wide for years. Based on past successes, the Japan Medical Association proposes a new disaster action plan named Japan Medical Association Team (JMAT). The primary mission of JMAT is to deploy to the disaster scene requested and work for disaster relief. JMAT covers the acute to sub-acute phase of disaster response, and also collaborate with other agencies. In the preparation and mitigation phases, the Japan Medical Association work for establishing mutual disaster aid partnerships, disaster plans, networks with other agencies, team building, disaster medicine training and education, etc. In Japan, the Disaster Medical Assistant Team (DMAT) has been established based on the experience of the 1995 Kobe Earthquake, when lots of preventable trauma deaths occurred because of delayed medical response. The mission of DMAT is to deploy to the scene immediately and triage/transfer the most serious disaster victims outside the scene for advanced medical care. DMAT covers the first 48 hours of disaster response phase, and then JMAT takes charge of the work. JMAT will also respond to chemical, biological, radiological and nuclear disasters, and international humanitarian work. The present issues of establishing JMAT are 1.training and education for Japan Medical Association members, 2.establising cooperation with other agencies, and 3.having presence at the Central Disaster Committee, Cabinet Office, Government of Japan.
We carry out linear and nonlinear analyses on a flow between two infinitely long concentric cylinders with the radii a and b subject to a sliding motion of the inner cylinder in the axial direction. We confirm the linear stability result of Gittler (Acta Mechanica, vol. 101, 1993, p. 1) for the axisymmetric case, namely the flow is linearly stable against axisymmetric perturbations when the radius ratio η = a/b is greater than 0.1415. We extend his analysis to the non-axisymmetric case and find that the stability of the flow is still determined by axisymmetric perturbations. Our nonlinear analysis exhibits that (i) finite-amplitude axisymmetric solutions exist far below the linear critical Reynolds number for η < 0.1415 and (ii) non-axisymmetric travelling wave solutions appear abruptly at a finite Reynolds number even for η > 0.1415 where the linear critical state is absent.
A new nonlinear travelling-wave solution for a flow through an isothermal square duct is discovered. The solution is found by a continuation approach in parameter space, starting from a case where the fluid is heated internally. The Reynolds number for which the travelling wave emerges is much lower than that of the solutions discovered recently by an analysis based on the self-sustaining process (Wedin et al., Phys. Rev. E, vol. 79, 2009, p. 065305; Uhlmann et al., Advances in Turbulence XII, 2009, pp. 585–588). Furthermore, the new travelling-wave solution is shown to be unstable from the onset.
We improve our previously derived addition to the BGK collision term, and express it in a simple form. The collision frequency for scattering now depends anisotropically on the velocity vector. We also apply the improved macroscopic equation of momentum flow to the Hall effect, the cold plasma dispersion relation and the cyclotron resonance. The Hall coefficient which is constant in the case of the BGK collision term now depends on the magnetic field. It is also shown that, compared with the almost symmetric classical curves of cyclotron resonance, the new curves are considerably asymmetric and their half-widths are about 3/2 times the classical ones.
Previous work on non-relativistic electrons isotropically scattered by neutral atoms is extended to the relativistic case, and an equation is derived for the electron drift velocity. In the non-relativistic case the drift-velocity equation contains a corrected momentum-transfer term arising from the fact that the collision phenomenon is characterized by the mean free path rather than by the mean collision time. In the present work it is found that the time variation of the electron mass has a very complicated effect on the relativistic equation for the drift velocity. In addition, an unexpected theoretical result is obtained: a negative magneto-resistance effect in which the magneto-resistance decreases as the magnitude of a magnetic field imposed on the plasma increases. However, this effect is not a relativistic one but is rather due to the correction in the momentum-transfer term.
A calculation with respect to momentum transfer by the electron–neutral collisions is carried out, based on an idea that collision phenomena should be characterized by mean free path rather than by the collision time, and correction terms are derived for the previous equation of momentum conservation and the previous approach to the Boltzmann collision integral.
We analyse the stability of plane Poiseuille flow with a streamwise system rotation. It is found that the instability due to two-dimensional perturbations, which sets in at the well-known critical Reynolds number, Rc = 5772.2, for the non-rotating case, is delayed as the rotation is increased from zero, showing a stabilizing effect of rotation. As the rotation is increased further, however, the laminar flow becomes most unstable to perturbations which are three-dimensional. The critical Reynolds number due to three-dimensional perturbations at this higher rotation case is many orders of magnitude less than the corresponding value due to two-dimensional perturbations. We also perform a nonlinear analysis on a bifurcating three-dimensional secondary flow. The secondary flow exhibits a spiral vortex structure propagating in the streamwise direction. It is confirmed that an antisymmetric mean flow in the spanwise direction is generated in the secondary flow.