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The Indian Pulsar Timing Array (InPTA) employs unique features of the upgraded Giant Metrewave Radio Telescope (uGMRT) to monitor dozens of the International Pulsar Timing Array (IPTA) millisecond pulsars (MSPs), simultaneously in the 300-500 MHz and the 1260-1460 MHz bands. This dual-band approach ensures that any frequency-dependent delays are accurately characterized, significantly improving the timing precision for pulsar observations, which is crucial for pulsar timing arrays. We present details of InPTA’s second data release that involves 7 yrs of data on 27 IPTA MSPs. This includes sub-banded Times of Arrival (ToAs), Dispersion Measures (DM), and initial timing ephemerides for our MSPs. A part of this dataset, originally released in InPTA’s first data release, is being incorporated into IPTA’s third data release which is expected to detect and characterize nanohertz gravitational waves in the coming years. The entire dataset is reprocessed in this second data release providing some of the highest precision DM estimates so far and interesting solar wind related DM variations in some pulsars. This is likely to characterize the noise introduced by the dynamic inter-stellar ionised medium much better than the previous release thereby increasing sensitivity to any future gravitational wave search.
Every year in the month of September, National Suicide Prevention Week is celebrated. The goal of suicide prevention week is to inform the public about suicide prevention, primarily the warning signs of suicide. However, the impact of this month on the general population is unknown. The Google trends show how frequent web searches have been performed for a particular search-term, which provide an approximation of the people’s interest.
Objectives
To evaluate public interest in suicide prevention by analyzing the google trends of “Suicide Prevention” search-term.
Methods
We estimated the interest in such topics by running the google trends data of the last decade by using the filter [Search Term:“Suicide Prevention”, Locations: “United States” and Time Ranges “ 2010 to 2020”].
Results
During this specific interval, people have searched “Suicide Prevention” most frequently during the month of September (month of National Suicide Prevention week). Conversely, in the other months, interest in “suicide prevention” fluctuated between little to none. The only other time people have shown interest in Suicide prevention, other than the month of September, was with suicide news in the media, such as the death of a celebrity by suicide, or suicide-related TV shows. [Figure]
Conclusions
Although it is not definitive, it gives some idea that National Suicide Prevention week has a considerable impact on population interest. Since we did not observe sufficient public interest in other months, there should be frequent and systematic efforts to spread suicide prevention awareness among the general population.
Pharmacogenetic studies in obsessive-compulsive disorder (OCD) primarily focussing on serotonergic and dopaminergic polymorphisms, provided inconsistent findings. There is recent evidence for glutamatergic abnormalities in OCD.
Aims
Examine the association glutamatergic genes with serotonin reuptake inhibitor (SRI) response in OCD.
Objectives
To study pharmacogenetic association between SLC1A1 and GRIN2B polymorphisms with SRI response in OCD.
Methods
DSM-IV OCD patients were recruited from a specialty OCD clinic and evaluated using the Yale-Brown obsessive compulsive scale (YBOCS), Mini International Neuropsychiatric Interview (MINI) plus, Clinical Global Impression scale (CGI). They were subsequently reassessed with YBOCS and CGI. To study extreme phenotypes, we included only full responders (> 35% YBOCS improvement and CGI-I score of 1 or 2) to any SRI (n = 191) and non-responders (< 25% YBOCS improvement and CGI-I score ≥ 4) to adequate trial of at least two SRIs (n = 84). Partial responders were excluded. Genotyping was performed using an ABI9700 PCR machine.
Results
Genotype frequencies did not deviate significantly from the values predicted by the Hardy-Weinberg equation. Case-control association analyses revealed no significant association between genotype/allele frequencies with SRI response.
Conclusion
Our data does not show any association between polymorphisms in glutamatergic genes and SRI response in OCD though such associations have been found in other studies. More SNP's in the same gene could be responsible for the pharmacogenetic associations. More homogenous sample considering symptom dimensions and other phenotypic variables may be needed. It may be critical to go beyond “usual suspect” candidate gene research. In this regard, a novel approach to identify SRI response biomarkers is the use of cellular models.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
In preparation for a multisite antibiotic stewardship intervention, we assessed knowledge and attitudes toward management of asymptomatic bacteriuria (ASB) plus teamwork and safety climate among providers, nurses, and clinical nurse assistants (CNAs).
Design:
Prospective surveys during January–June 2018.
Setting:
All acute and long-term care units of 4 Veterans’ Affairs facilities.
Methods:
The survey instrument included 2 previously tested subcomponents: the Kicking CAUTI survey (ASB knowledge and attitudes) and the Safety Attitudes Questionnaire (SAQ).
Results:
A total of 534 surveys were completed, with an overall response rate of 65%. Cognitive biases impacting management of ASB were identified. For example, providers presented with a case scenario of an asymptomatic patient with a positive urine culture were more likely to give antibiotics if the organism was resistant to antibiotics. Additionally, more than 80% of both nurses and CNAs indicated that foul smell is an appropriate indication for a urine culture. We found significant interprofessional differences in teamwork and safety climate (defined as attitudes about issues relevant to patient safety), with CNAs having highest scores and resident physicians having the lowest scores on self-reported perceptions of teamwork and safety climates (P < .001). Among providers, higher safety-climate scores were significantly associated with appropriate risk perceptions related to ASB, whereas social norms concerning ASB management were correlated with higher teamwork climate ratings.
Conclusions:
Our survey revealed substantial misunderstanding regarding management of ASB among providers, nurses, and CNAs. Educating and empowering these professionals to discourage unnecessary urine culturing and inappropriate antibiotic use will be key components of antibiotic stewardship efforts.
Geomorphic analysis and optically stimulated luminescence (OSL) ages from undated Lake Agassiz beaches and adjacent fluvial sediments on Riding Mountain in Manitoba provide insight into their early history. New OSL ages of 14.5±2.4 and 13.4±0.7 ka on the oldest (Herman to Norcross) beaches of Lake Agassiz near the Canada-U.S. border indicate that the Laurentide Ice Sheet (LIS) retreated from that part of the Agassiz basin by ~14.5 ka. To the north along Riding Mountain, the Herman strandlines are absent, and OSL ages on the oldest beach there average 12.9 ka, which links it to the younger Norcross-Tintah strandlines. In adjacent Riding Mountain, OSL ages and geomorphological relationships of a large abandoned glacial spillway >200 m above the oldest beaches of Lake Agassiz indicate that this channel predates retreat of the LIS and formation of beaches in this part of the Agassiz basin, with ice remaining in this area until after 14.5 ka. OSL ages on the Gimli beach 170 km to the east are >3000 yr older than conventional assignments, suggesting that it formed during the Moorhead low-water phase 12.8–10.6 ka. Luminescence ages support the conclusion that the Campbell beach formed ~10.9 ka near the end of the Moorhead low-water phase.
We surveyed resident physicians at 2 academic medical centers regarding urinary testing and treatment as they progressed through training. Demographics and self-reported confidence were compared to overall knowledge using clinical vignette-based questions. Overall knowledge was 40% in 2011 and increased to 48%, 55%, and 63% in subsequent years (P<.001).
Influenza A(H1N1) viruses of the 2009 pandemic (A(H1N1)pdm09) continue to cause outbreaks in the post-pandemic period. During January to May 2015, an upsurge of influenza was recorded that resulted in high fatality in central India. Genetic lineage, mutations in the hemagglutinin (HA) gene and infection by quasi-species are reported to affect disease severity. The objective of this study is to present the molecular and epidemiological trends during the 2015 influenza outbreak in central India. All the referred samples were subjected to qRT–PCR for diagnosis. HA gene sequencing (23 survivors and 24 non-survivors) and cloning were performed and analyzed using Molecular Evolutionary Genomic Analyzer (MEGA 5·05). Of the 3625 tested samples, 1607 (44·3%) were positive for influenza A(H1N1)pdm09, of which 228 (14·2%) individuals succumbed to death. A significant trend was observed in positivity (P = 0·003) and mortality (P < 0·0001) with increasing age. The circulating A(H1N1)pdm09 virus was characterized as belonging to clade-6B. Clinically significant mutations were detected. Patients infected with the quasi-species of the virus had a greater risk of death (P = 0·009). This study proposes a robust molecular and clinical surveillance program for the detection and characterization of the virus, along with prompt treatment protocols to prevent outbreaks.
Dengue is regarded as the most important arboviral disease. Although sporadic cases have been reported, serotypes responsible for outbreaks have not been identified from central India over the last 20 years. We investigated two outbreaks of febrile illness, in August and November 2012, from Korea district (Chhattisgarh) and Narsinghpur district (Madhya Pradesh), respectively. Fever and entomological surveys were conducted in the affected regions. Molecular and serological tests were conducted on collected serum samples. Dengue-specific amplicons were sequenced and phylogenetic analyses were performed. In Korea and Narsinghpur districts 37·3% and 59% of cases were positive, respectively, for dengue infection, with adults being the worst affected. RT–PCR confirmed dengue virus serotype 1 genotype III as the aetiology. Ninety-six percent of infections were primary. This is the first time that dengue virus 1 outbreaks have been documented from central India. Introduction of the virus into the population and a conducive mosquitogenic environment favouring increased vector density caused the outbreak. Timely diagnosis and strengthening vector control measures are essential to avoid future outbreaks.
A relativistically hot electron, positron and ion (e–p–i) plasma relaxes to a triple curl Beltrami (TCB) field. The TCB field being the superposition of three Beltrami fields is characterized by three scale parameters and hence there exist multiscale structures in the system. It is shown that temperatures of the plasma constituents strongly affect the scale parameters. Generally, the scale parameters associated with the TCB field may be a combination of real and complex roots. The numerical results show that for given Beltrami parameters, an increase in the thermal energy of plasma particles could transform the real eigenvalues to complex ones. It is also observed that one component is more strongly affected relative to other components on increasing temperatures of plasma species. Two different vortices become the same at higher thermal energies. This suggests that it is possible to create high β (kinetic to magnetic pressure ratio) and fully diamagnetic plasma configurations. The study has a potential relevance to space, astrophysics and laboratory plasmas.
Solitary waves are investigated in a charge-varying dusty plasma involving dust trapping. A potentially useful neuronal method that may handle a wide variety of non-analytic pseudo-potentials is used. This method could be advantageously exploited in rendering a cumbersome pseudo-potential analytically more tractable. Making use of the approximate Sagdeev pseudo-potential, our results show the possibility of development of localized dust structures in a dusty plasma with variable charge trapped dust grains.
By
Arnulf Grubler, International Institute for Applied Systems Analysis, Austria and Yale University,
Xuemei Bai, Australian National University,
Thomas Buettner, United Nations Department of Economic and Social Affairs,
Shobhakar Dhakal, Global Carbon Project and National Institute for Environmental Studies,
David J. Fisk, Imperial College London,
Toshiaki Ichinose, National Institute for Environmental Studies,
James E. Keirstead, Imperial College London,
Gerd Sammer, University of Natural Resources and Applied Life Sciences,
David Satterthwaite, International Institute for Environment and Development,
Niels B. Schulz, International Institute for Applied Systems Analysis, Austria and Imperial College,
Nilay Shah, Imperial College London,
Julia Steinberger, The Institute of Social Ecology, Austria and University of Leeds,
Helga Weisz, Potsdam Institute for Climate Impact Research,
Gilbert Ahamer, University of Graz,
Timothy Baynes, Commonwealth Scientific and Industrial Research Organisation,
Daniel Curtis, Oxford University Centre for the Environment,
Michael Doherty, Commonwealth Scientific and Industrial Research Organisation,
Nick Eyre, Oxford University Centre for the Environment,
Junichi Fujino, National Institute for Environmental Studies,
Keisuke Hanaki, University of Tokyo,
Mikiko Kainuma, National Institute for Environmental Studies,
Shinji Kaneko, Hiroshima University,
Manfred Lenzen, University of Sydney,
Jacqui Meyers, Commonwealth Scientific and Industrial Research Organisation,
Hitomi Nakanishi, University of Canberra,
Victoria Novikova, Oxford University Centre for the Environment,
Krishnan S. Rajan, International Institute of Information Technology,
Seongwon Seo, Commonwealth Scientific and Industrial Research Organisation,
Ram M. Shrestha, Asian Institute of Technology,
Priyadarshi R. Shukla, Indian Institute of Management,
Alice Sverdlik, International Institute for Environment and Development,
Jayant Sathaye, Lawrence Berkeley National Laboratory
More than 50% of the global population already lives in urban settlements and urban areas are projected to absorb almost all the global population growth to 2050, amounting to some additional three billion people. Over the next decades the increase in rural population in many developing countries will be overshadowed by population flows to cities. Rural populations globally are expected to peak at a level of 3.5 billion people by around 2020 and decline thereafter, albeit with heterogeneous regional trends. This adds urgency in addressing rural energy access, but our common future will be predominantly urban. Most of urban growth will continue to occur in small-to medium-sized urban centers. Growth in these smaller cities poses serious policy challenges, especially in the developing world. In small cities, data and information to guide policy are largely absent, local resources to tackle development challenges are limited, and governance and institutional capacities are weak, requiring serious efforts in capacity building, novel applications of remote sensing, information, and decision support techniques, and new institutional partnerships. While ‘megacities’ with more than 10 million inhabitants have distinctive challenges, their contribution to global urban growth will remain comparatively small.
Energy-wise, the world is already predominantly urban. This assessment estimates that between 60–80% of final energy use globally is urban, with a central estimate of 75%. Applying national energy (or GHG inventory) reporting formats to the urban scale and to urban administrative boundaries is often referred to as a ‘production’ accounting approach and underlies the above GEA estimate.
Properties of the coupled dust ion-acoustic drift wave instability in a radially bounded dusty magnetoplasma with an equilibrium sheared parallel ion (SPI) flow are investigated. By using the two-fluid model for the electrons and ions, a wave equation for the low-frequency coupled dust ion-acoustic drift waves in a bounded plasma with stationary charged dust grains is derived. The wave equation admits a linear dispersion relation, which exhibits that the radial boundary affects the growth rate of the coupled ion-acoustic drift wave instability which is excited by the SPI flow. The results should be relevant to dusty magnetoplasma experiments with an SPI flow.
A possibility of relaxation of relativistically hot electron and positron (e − p) plasma with a small fraction of hot or cold ions has been investigated analytically. It is observed that a strong interaction of plasma flow and field leads to a non-force-free relaxed magnetic field configuration governed by the triple curl Beltrami (TCB) equation. The triple curl Beltrami (TCB) field composed of three different Beltrami fields gives rise to three multiscale relaxed structures. The results may have the strong relevance to some astrophysical and laboratory plasmas.
The effect of radial boundaries on the ion-dust streaming instability is investigated. Possible applications of our work to certain low-temperature dusty plasma experiments are discussed.
This paper focuses on the progress in understanding the shielding around a test charge in the presence of ion-acoustic waves in multispecies plasmas, whose constituents are positive ions, two negative ions, and Boltzmann distributed electrons. By solving the linearized Vlasov equation with Poisson equation, the Debye–Hückel screening potential and wakefield (oscillatory) potential distribution around a test charge particle are derived. It is analytically found that both the Debye–Hückel potential and the wakefield potential are significantly modified due to the presence of two negative ions. The present results might be helpful to understand and to form new materials from plasmas containing two negative ions such as Xe+ − F− − SF−6 and Ar+ − F− − SF−6 plasmas, as well as to tackle extension of the test charge problem in multinegative ions' coagulation/agglomeration.
The influence of the intrinsic spin of electrons on the propagation of circularly polarized waves in a magnetized plasma is considered. New eigenmodes are identified, one of which propagates below the electron cyclotron frequency, one above the spin-precession frequency, and another close to the spin-precession frequency. The latter corresponds to the spin modes in ferromagnets under certain conditions. In the non-relativistic motion of electrons, the spin effects become noticeable even when the external magnetic field B0 is below the quantum critical magnetic field strength, i.e. B0 < BQ = 4.4138 × 109T and the electron density satisfies n0 ≫ nc ≃ 1032m−3. The importance of electron spin (paramagnetic) resonance (ESR) for plasma diagnostics is discussed.
Nonlinear wave-driven processes in plasmas are normally described by either a monochromatic pump wave that couples to other monochromatic waves, or as a random phase wave coupling to other random phase waves. An alternative approach involves a random or broadband pump coupling to monochromatic and/or coherent structures in the plasma. This approach can be implemented through the wave-kinetic model. In this model, the incoming pump wave is described by either a bunch (for coherent waves) or a sea (for random phase waves) of quasi-particles. This approach has been applied to both photon acceleration in laser wakefields and drift wave turbulence in magnetized plasma edge configurations. Numerical simulations have been compared to experiments, varying from photon acceleration to drift mode-zonal flow turbulence, and good qualitative correspondences have been found in all cases.
Healthcare-associated hepatitis B virus (HBV) outbreaks have been reported in the USA and from several countries in Europe. Patient-to-patient transmission of HBV in these settings has been linked to several different types of exposure but one of the most common exposures implicated is the use of ‘finger-stick’ lancet devices for blood glucose testing. This article is an account of the investigations into a series of HBV outbreaks linked to the use of lancing devices in community healthcare settings in the UK. Between February 2004 and December 2006, nine individuals with acute HBV infection were reported to five local units of the Health Protection Agency. Investigations identified a further 12 individuals with HBV infection in residents in these settings. The epidemiological and environmental evidence suggests that HBV transmission occurred mostly from a significant breakdown in infection control measures in blood glucose testing. The occurrence of these outbreaks has highlighted the confusion that exists and the need for clear recommendations regarding the use of such devices in the UK.