We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This study aimed to determine the incidence of laryngeal penetration and aspiration in elderly patients who underwent supracricoid laryngectomy with cricohyoidoepiglottopexy for laryngeal cancer.
Method
A retrospective analysis of dynamic videofluoroscopic swallowing studies was performed in patients who had received supracricoid laryngectomy with cricohyoidoepiglottopexy as a treatment for laryngeal cancers. Digital analysis of videofluoroscopic swallowing studies included measurements of displacement and timing related to swallowing safety.
Results
Videofluoroscopic swallowing studies from 52 patients were analysed. All participants were male and over 65 years old. Studies were performed five years after surgery. Among 52 videofluoroscopic swallowing studies, analysis showed that elevated pharyngeal constriction ratio (pharyngeal constriction ratio more than 0.0875, odds ratio = 5.2, p = 0.016), reduced pharyngoesophageal sphincter opening time (pharyngoesophageal sphincter open less than 0.6 seconds, odds ratio = 11.6, p = 0.00018) and reduced airway closure time (airway close less than 0.6 seconds, odds ratio = 10.6, p = 0.00057) were significantly associated with aspiration.
Conclusion
Deteriorated pharyngeal constriction, shortened airway closure and reduced pharyngoesophageal sphincter opening time are key factors for predicting laryngeal penetration or aspiration after supracricoid laryngectomy with cricohyoidoepiglottopexy.
This study aimed to clarify the association between both hypoxia-inducible factor-1α and glucose transporter type-1 expression and survival outcome in advanced pharyngeal cancer without human papillomavirus infection.
Method
Twenty-five oropharyngeal and 55 hypopharyngeal cancer patients without human papillomavirus infection were enrolled. All patients had stage III–IV lesions and underwent concurrent chemoradiotherapy or surgery. Hypoxia-inducible factor-1α and glucose transporter type-1 expression were investigated in primary lesions by immunohistochemistry.
Results
There were 41 and 39 cases with low and high hypoxia-inducible factor-1α expression, and 28 and 52 cases with low and high glucose transporter type-1 expression, respectively. There was no significant correlation between hypoxia-inducible factor-1α and glucose transporter type-1 expression. In univariate analysis, nodal metastasis, clinical stage and high hypoxia-inducible factor-1α expression, but not glucose transporter type-1 expression, predicted significantly worse prognosis. In multivariate analysis, hypoxia-inducible factor-1α overexpression was significantly correlated with poor overall survival, disease-specific survival and recurrence-free survival.
Conclusion
High hypoxia-inducible factor-1α expression was an independent risk factor for poor prognosis for advanced human papillomavirus-unrelated pharyngeal cancer.
The risk for developing and preserving symptoms of anorexia nervosa (AN) in children seems to be multifactorial: individual, familial, socio-cultural, and biological factors interact within the developmental framework. A disruption of attachment processes with the mother in an early stage of child development has been proposed as a contributing factor; however, the evidence is controversial.
Objectives
To address the research question of how childhood AN patients recognize disorder-specific provocative factors such as body type, high-calorie food, and attachment between mother and child.
Aims
The aim of this study was to investigate the prefrontal activation in childhood AN patients when imaging those symptom-provocative factors.
Methods
The prefrontal activations during each task, in terms of blood volume changes, were measured by near infrared spectroscopy. Twelve females with childhood AN (mean age, 14.4 years old) and 13 age-matched healthy female controls participated in this study.
Results
Both groups showed increased prefrontal blood volume when viewing images of each symptom-provocative factor. Unexpectedly, there was no significant difference in the prefrontal blood volume increases between the control group and the childhood AN group when viewing images of slender and obese body types and high-calorie food. On the other hand, images of mother-child attachment resulted in significantly greater increases in prefrontal blood volume in the childhood AN group than in the control group.
Conclusions
These results indicated that prefrontal activation in AN might be associated with imaging attachment between mother and child, but not associated with imaging body type or high-calorie food.
Optical properties of infrared-bright (IR-bright) dust-obscured galaxies (DOGs) are reported. DOGs are faint in optical but very bright in mid-IR, which are powered by active star formation (SF) or active galactic nucleus (AGN), or both. The DOGs is a candidate population that are evolving from a gas-rich merger to a quasar. By combining three catalogs of optical (Subaru Hyper Suprime-Cam), near-IR (VIKING), and mid-IR (ALLWISE), we have discovered 571 IR-bright DOGs. Using their spectral energy distributions, we classified the selected DOGs into the SF-dominated DOGs and the AGN-dominated DOGs. We found that the SF-dominated DOGs show a redder optical color than the AGN-dominated DOGs. Interestingly, some DOGs shows extremely blue color in optical (blue-excess DOGs: bluDOGs). A possible origin for this blue excess is either the leaked AGN light or stellar UV light from nuclear starbursts. The BluDOGs may be in the transition phase from obscured AGNs to unobscured AGNs.
Cognitive–behavioral therapy (CBT) is thought to be useful for chronic pain, with the pathology of the latter being closely associated with cognitive–emotional components. However, there are few resting-state functional magnetic resonance imaging (R-fMRI) studies. We used the independent component analysis method to examine neural changes after CBT and to assess whether brain regions predict treatment response.
Methods
We performed R-fMRI on a group of 29 chronic pain (somatoform pain disorder) patients and 30 age-matched healthy controls (T1). Patients were enrolled in a weekly 12-session group CBT (T2). We assessed selected regions of interest that exhibited differences in intrinsic connectivity network (ICN) connectivity strength between the patients and controls at T1, and compared T1 and T2. We also examined the correlations between treatment effects and rs-fMRI data.
Results
Abnormal ICN connectivity of the orbitofrontal cortex (OFC) and inferior parietal lobule within the dorsal attention network (DAN) and of the paracentral lobule within the sensorimotor network in patients with chronic pain normalized after CBT. Higher ICN connectivity strength in the OFC indicated greater improvements in pain intensity. Furthermore, ICN connectivity strength in the dorsal posterior cingulate cortex (PCC) within the DAN at T1 was negatively correlated with CBT-related clinical improvements.
Conclusions
We conclude that the OFC is crucial for CBT-related improvement of pain intensity, and that the dorsal PCC activation at pretreatment also plays an important role in improvement of clinical symptoms via CBT.
Metal Organic Decomposition (MOD)-made BaTiO3 (BT) thin films were prepared for Resistive Random Access Memory (ReRAM) under various annealing conditions and investigated for improving the properties of bipolar-type resistive switching, focusing on the relation between oxygen vacancies and the behavior of resistive hysteresis. BT thin films with both pre- and final- annealing in nitrogen showed the resistive hysteresis of bipolar-type switching with current ON/OFF ratios of 2 orders of magnitude for both bias polarities. Finally they showed the endurance property with the 106 switching cycles. It was suggested that oxygen vacancies near the oxide surface (both interfaces at metal electrode/oxide and between layer-by-layered oxide layers) are increased by N2 annealing and enhanced the interface-type resistive switching. Pre-annealing in N2 was also found to be very effective to improve endurance properties, implying that not only the electrode/oxide interface but also the middle part of the film would contribute the interface-type mechanism.
By
M. Fukushima, ATR Neural Information Analysis Laboratories,
O. Yamashita, ATR Neural Information Analysis Laboratories,
M. Sato, ATR Neural Information Analysis Laboratories
Elucidating how the human brain is structured and how it functions is a fundamental aim of human neuroscience. To achieve such an aim, the activity of the human brain has been measured using noninvasive neuroimaging techniques, the most popular of which is functional magnetic resonance imaging (fMRI) (Ogawa et al. 1990). The fMRI signals are obtained at a spatial resolution of typically 3mm and measure changes of blood flow and blood oxygen consumption whose temporal dynamics are slower than that of neuronal electrical activities, resulting in a poor temporal resolution of the order of seconds. In contrast, magnetoencephalography (MEG) and electroencephalography (EEG) can detect changes of neuronal activities by the millisecond measurement of magnetic and electric fields, respectively, outside the skull (Hämäläinen et al. 1993; Nunez & Srinivasan 2006). The high temporal resolution of MEG (and EEG) is useful, especially for studying the dynamic integration of functionally specialized brain regions, which is a subject of growing interest in human neuroscience (de Pasquale et al. 2012).
The major problem of MEG is that spatial brain activity patterns are not easily understandable from sensor measurements. This is because the magnetic fields produced by neuronal current sources are superimposed to form rather uninterpretable spatial patterns of signals on sensors. Estimating the position and intensity of these current sources from the sensor measurements is called source reconstruction, or source localization. Solving the source reconstruction problem allows the mapping of temporally dynamic electrical activities in the human brain (Baillet et al. 2001). Since how brain regions are dynamically integrated to produce a variety of functions is of great interest in human neuroscience research, the mission of MEG source reconstruction is not only to localize position of the current sources, but also to identify directed interactions between these sources. A possible approach to this involves constructing a dynamic model of brain electrical activities, as well as developing an estimation algorithm for the source positions and interactions that are parametrized in this model.
Introduction: race and ethnicity and population ageing
The race and ethnic composition of the older population in the United States (US) is expected to change in the coming decades. The older population is becoming more racially and ethnically diverse as the overall race and minority ethnic population grows (Administration on Aging, 2010). Furthermore, minority populations aged 65 and older are expected to increase from 8.0 million in 2010 (20.1% of the older population) to 12.9 million in 2020 (23.6%) (Administration on Aging, 2010). These trends have important implications for the racial/ ethnic composition of America's ageing population and for how we think about inequality over the lifecourse. The goal of this chapter is to trace the significance of race/ethnicity for the population ageing. Specifically, using the available demographic data, we focus on the diversity of the older population itself as well as on the diversity of younger cohorts in view of future workforce and implications for health/long-term care in the ageing American society.
This chapter describes the significance of race and ethnicity – mainly by focusing on non-Hispanic white, non-Hispanic black and Hispanic peoples in the US – for population ageing in the US (that is, an increase in the numbers or proportions of older people at the societal level), which results from a combination of three main demographic factors: fertility, mortality and migration1 (Weeks, 2008). In this chapter, we trace the pathways that link race and ethnicity to population ageing, with an emphasis on social inequality and health in American society (Link and Phelan, 1995; Kawachi and Kennedy, 1997). We adopt a relatively narrow definition of ‘inequality’, focusing on socioeconomic status and health, although inequality could also be considered the general differences between racial/ethnic groups in other contexts. We also highlight the complex relationship between race and ethnicity, and social inequality, which may directly and indirectly impact on population ageing through various processes and outcomes related to health (Williams and Wilson, 2001).
This chapter consists of four sections. The first section explains race and ethnicity in the American historical context. In the second section, we discuss the theoretical relationships between race and ethnicity, social inequality and population ageing. The third section summarises recent sociodemographic and socioeconomic trends, and their relationship to health and population ageing vis-á-vis race and ethnicity.
This review discusses the clenching-grinding spectrum from the neuropsychiatric/neuroevolutionary perspective. In neuropsychiatry, signs of jaw clenching may be a useful objective marker for detecting or substantiating a self-report of current subjective emotional distress. Similarly, accelerated tooth wear may be an objective clinical sign for detecting, or substantiating, long-lasting anxiety. Clenching-grinding behaviors affect at least 8% of the population. We argue that during the early paleolithic environment of evolutionary adaptedness, jaw clenching was an adaptive trait because it rapidly strengthened the masseter and temporalis muscles, enabling a stronger, deeper and therefore more lethal bite in expectation of conflict (warfare) with conspecifics. Similarly, sharper incisors produced by teeth grinding may have served as weaponry during early human combat. We posit that alleles predisposing to fear-induced clenching-grinding were evolutionarily conserved in the human clade (lineage) since they remained adaptive for anatomically and mitochondrially modern humans (Homo sapiens) well into the mid-paleolithic. Clenching-grinding, sleep bruxism, myofacial pain, craniomaxillofacial musculoskeletal pain, temporomandibular disorders, oro-facial pain, and the fibromyalgia/chronic fatigue spectrum disorders are linked. A 2003 Cochrane meta-analysis concluded that dental procedures for the above spectrum disorders are not evidence based. There is a need for early detection of clenching-grinding in anxiety disorder clinics and for research into science-based interventions. Finally, research needs to examine the possible utility of incorporating physical signs into Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition posttraumatic stress disorder diagnostic criteria. One of the diagnostic criterion that may need to undergo a revision in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition is Criterion D (persistent fear-circuitry activation not present before the trauma). Grinding-induced incisor wear, and clenching-induced palpable masseter tenderness may be examples of such objective physical signs of persistent fear-circuitry activation (posttraumatic stress disorder Criterion D).
A sudden break-down of a heat-exchanger in vinyl chloride plant resulted in that 141 °C, 23% concentration of hydrochloric acid spouted out over the workers around it. Eight workers suffered and Ichihara City Fire Department was deployed in response to the call 3 minutes after the onset of the incident, 17 vehicles including 5 fire engines, 6 ambulances, and two helicopters. Finally three severely (> 80% of TBSA) burned, two moderately (20–80%) burned, and three slightly (< 20%) burned victims were identified and triaged. One severely burned was transferred at first to the closest tertiary care hospital (TUCMC) which existed within 2.5 km distance by an ambulance and other two and one moderately burned were transferred by helicopters to the neighboring tertiary care hospitals. Another moderately burned one was sent to TUCMC by an ambulance about 30 minutes later than the first one. Three slightly burned victims were sent to a local hospital and treated as an outpatient. This casualty mission was ended by 120 minutes after the call. Two among the three severely burned patients lost their lives but another severe one and two moderately burned were survived. Conclusions: With these considerations, the management of this multiple burn casualty was successful, partly because of small number of the victims and of that the incident occurred in a weekday morning.
The assay system for antibody responses against Em2, the most specific antigen for serodiagnosis of alveolar echinococcosis (AE), has been established by enzyme-linked immunosorbent assay (ELISA) but not by Western blot assay, since Em2 antigen is not protein but carbohydrate in nature. Recently we reported that previously undescribed protein epitopes, designated Em18 and Em16 due to their molecular weights, were good serologic markers for AE by Western blot analysis. It has been shown that Em18 and Em16 are the only two epitopes recognized by commercially available weak positive (cut off) sera for the Em2plus-ELISA.
Effects of the antiparasitic drug, ivermectin, on the dung beetles, Caccobius jessoensis Harold, 1867 and the rare species, Copris ochus Motschulsky, 1860 and Copris acutidens Motschulsky, 1860 were studied in laboratory and field experiments in Hokkaido, Japan. Ivermectin was detected in dung from 1 to 21 or 28 days following treatment, with a peak on the first day after treatment in two pour-on administrations (500 μg kg−1), although there were considerable differences between the two peaks. In C. jessoensis, brood balls constructed by the female were not reduced in the dung of treated cattle except for seven days after treatment in experiment 2. Also, there was no significant difference in the mean weight of brood balls between dung from treated and control cattle. However, the emergence rates were significantly reduced in dung 1–3 days after treatment. In the field study, brood balls constructed by C. jessoensis were more abundant in dung from treated cattle in experiment 1, but adult emergence was significantly reduced at one and seven days after treatments. Adult mortality of C. ochus Motschulsky at 90 days after the beginning of rearing was 11.1% in dung from control cattle with 22 brood balls constructed, whereas it was 84% in dung from treated cattle with no brood balls and/or ovipositioning. Also, in C. acutidens Motschulsky, adult mortality at 90 days after the beginning of rearing was 3.6% in dung from control cattle with 13 brood balls constructed, whereas it was 94.1% in dung from treated cattle with no brood balls or ovipositioning. The environmental risk in the use of ivermectin during breeding period of dung beetles in pasture is discussed.
We present an overview of recent astrometric results with VERA. Since 2004, we have been conducting astrometry of tens of Galactic maser sources with VERA, and recently obtained trigonometric parallaxes for several sources, with distances ranging from 180 pc to 5.3 kpc. In this paper, we briefly summarize the results for Galactic star-forming regions, including S269, Orion-KL, NGC 1333, ρ-oph, NGC 281 and others.
We present results of astrometric observations of S269 H2O maser performed with VERA (VLBI Exploration of Radio Astrometry). We have monitored the positions of S269 H2O masers for 1 year and successfully detected its parallax to be 189±8 micro-arcsecond. This corresponds to a source distance of 5.28+0.24−0.22 kpc, and is the smallest parallax (and thus the largest distance) that has ever been measured by means of annual parallax. Proper motions of S269 H2O maser were also measured and used to determine the Galactic rotation velocity at the position of S269. Our measurements show that the Galactic rotation velocity at S269 is the same to that at the Sun within 3%, indicating that the Galactic rotation curve is flat out to R~13 kpc.
We have carried out multi-epoch VLBI observations of the H2O maser sources associated with young stellar objects (YSOs) in nearby molecular clouds with VERA (VLBI Exploration of Radio Astrometry), which is a newly constructed VLBI network in Japan (Kobayashi et al. 2003). The main goal of our study is to measure the absolute proper motions and distances to nearby molecular clouds within 1 kpc from the Sun, to reveal their 3-dimensional structures and dynamical properties. Using the VERA dual-beam receiving system (Honma et al. 2003), we have carried out phase-referencing VLBI observations and measured annual parallaxes and absolute proper motions of the H2O maser features with respect to the extragalactic radio sources. We have successfully detected the annual parallax of one of the H2O maser features in Orion KL to be 2.29±0.10 mas, corresponding to the distance of 437±19 pc from the Sun (Hirota et al. 2007). In addition, the annual parallax of SVS13 in NGC 1333 is also determined to be4.10±0.17 mas, corresponding to the distance of 244±10 pc from the Sun, although the life time of the maser features are only 6 months. The absolute proper motions of the H2O maser features associated with Orion KL and NGC 1333 are derived, possibly indicating the outflow motions from the YSOs as well as the systemic motions of the powering sources.
The near-edge electronic structures of several dyes and phtalocyanines were investigated using Photo-Electron Spectroscopy in Air (PESA). The ionization potentials (IPs) of N3, N719, Z907, D102, D149 and D205 were derived from observed photoemission threshold energies to be 5.88, 5.47, 5.44, 5.53, 5.44 and 5.49eV, respectively. Density of states (DOS) of Fe-, Ni-, Cu- and H2-phthalocyanines were deduced from differentiation of observed photoemission yields with incident photon energies. DOS thus obtained were well compared with calculated ones estimated with use of the DV-Xα molecular orbital calculation method.
Experiments and numerical simulations are carried out to verify the existence of the acoustic solitary wave in an air-filled tube with an array of Helmholtz resonators connected. Following up previous work (Sugimoto et al. 1999), the experiments are improved by using a newly designed piston driver to launch an initially plane pressure pulse and also by extending the tube length from 7.4 m to 10.6 m. To highlight the effect of the array of resonators, the case with no array is also examined in parallel. Direct and indirect checks are made to verify the existence of the solitary wave. The former compares the profiles and propagation speeds of pulses measured experimentally to the solitary-wave solution. The latter checks the validity of nonlinear wave equations in describing real wave evolution in the tube. Solving an initial-value problem numerically with weakly lossy effects of boundary layers and jet loss at the throat of the resonator, comparison is made between measured and simulated evolution. The validity of the equations in the lossy case is necessary to maintain the existence of the solitary wave in the lossless limit. It is revealed that nonlinear wave equations originally derived for unidirectional propagation in the tube can provide a good description of the real evolution, with some allowance for phase shifts on reflection at both ends of the tube. In particular, it turns out that the lossy effects are described quantitatively well. By establishing the validity of the equations, it is concluded that the acoustic solitary wave exists.
We have simulated the 3D growth of a Rayleigh-Taylor instability in the expanding envelope of SN 1987A using the Adaptive Mesh Refinement Scheme utilizing a resolution of 4096−3. When the sinusoidal velocity perturbation amplitude is 10%, heavy element tongues of the He/H interface penetrate into the envelope with a high velocity.
The prevention of arterial thrombotic diseases has a high priority in developed
countries. An inappropriate diet may be an important risk factor for thrombotic
events. The daily intake of an anti-thrombotic diet may offer a convenient and
effective way of prevention. The aim of the present study was to test tomato
extracts for anti-thrombotic effects and to identify those varieties that have
such an effect. A shear-induced platelet-function test (haemostatometry) was
used to test anti-thrombotic potential in
vitro. Extracts from those tomato varieties that showed a
significant anti-thrombotic activity in vitro
were further assessed in vivo, using a
laser-induced thrombosis test in mice. One tomato variety (KG99-4) showed
significant anti-thrombotic activity both in
vitro and in vivo. KG99-4
inhibited not only platelet-rich thrombus formation but also had a thrombolytic
effect. It is concluded that haemostatometry can detect and classify the
anti-thrombotic potential of fruits and vegetables and offers a simple way of
screening for such effects.